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The Scientific Inspiration of Everyday Items for Diagnostic Needs | Dr. David Wright | TEDxNashville


thank you there are over six billion

thank you there are over six billion people on the planet who live on less

people on the planet who live on less

people on the planet who live on less than two dollars a day what happens when

than two dollars a day what happens when

than two dollars a day what happens when those people get sick how can they

those people get sick how can they

those people get sick how can they afford to go to a doctor and take a test

afford to go to a doctor and take a test

afford to go to a doctor and take a test and find out what what’s wrong with them

and find out what what’s wrong with them

and find out what what’s wrong with them the answers to the diagnostic needs of

the answers to the diagnostic needs of

the answers to the diagnostic needs of the patients at the bottom of the health

the patients at the bottom of the health

the patients at the bottom of the health care pyramid can be found in our

care pyramid can be found in our

care pyramid can be found in our children’s toy boxes on the kitchen

children’s toy boxes on the kitchen

children’s toy boxes on the kitchen counter on the poster for this weekend’s

counter on the poster for this weekend’s

counter on the poster for this weekend’s rave all we have to do is open our eyes

rave all we have to do is open our eyes

rave all we have to do is open our eyes to the possibilities of everyday objects

to the possibilities of everyday objects

to the possibilities of everyday objects and phenomena this map shows that the

and phenomena this map shows that the

and phenomena this map shows that the world is a dangerous place the darker

world is a dangerous place the darker

world is a dangerous place the darker the color of red the more deaths due to

the color of red the more deaths due to

the color of red the more deaths due to infectious disease diseases like flu

infectious disease diseases like flu

infectious disease diseases like flu diarrheal disease malaria tuberculosis

diarrheal disease malaria tuberculosis

diarrheal disease malaria tuberculosis hiv/aids scarier sounding things like

hiv/aids scarier sounding things like

hiv/aids scarier sounding things like Ebola chikungunya the Zika virus but the

Ebola chikungunya the Zika virus but the

Ebola chikungunya the Zika virus but the other thing that you should notice from

other thing that you should notice from

other thing that you should notice from this map is that the vast majority of

this map is that the vast majority of

this map is that the vast majority of this burden resides in the developing

this burden resides in the developing

this burden resides in the developing world in my lab we study malaria malaria

world in my lab we study malaria malaria

world in my lab we study malaria malaria is a parasitic disease that you can

is a parasitic disease that you can

is a parasitic disease that you can contract when you’re bitten by a female

contract when you’re bitten by a female

contract when you’re bitten by a female infected mosquito the map on the top

infected mosquito the map on the top

infected mosquito the map on the top shows the some 91 countries and over 200

shows the some 91 countries and over 200

shows the some 91 countries and over 200 million clinical cases of the disease

million clinical cases of the disease

million clinical cases of the disease that occurred in 2015 the bottom part of

that occurred in 2015 the bottom part of

that occurred in 2015 the bottom part of that map shows that unfortunately

that map shows that unfortunately

that map shows that unfortunately everywhere on the planet that we have

everywhere on the planet that we have

everywhere on the planet that we have malaria we have drug-resistant malaria

malaria we have drug-resistant malaria

malaria we have drug-resistant malaria which means it’s more difficult to fight

which means it’s more difficult to fight

which means it’s more difficult to fight but how can I relate the massive burden

but how can I relate the massive burden

but how can I relate the massive burden of this disease to everybody in this

of this disease to everybody in this

of this disease to everybody in this auditorium let’s try this out on a

auditorium let’s try this out on a

auditorium let’s try this out on a preform well’ve

preform well’ve

preform well’ve the ocean liner rms titanic struck an

the ocean liner rms titanic struck an

the ocean liner rms titanic struck an iceberg at about 11pm within three hours

iceberg at about 11pm within three hours

iceberg at about 11pm within three hours she sucked to the bottom and 1517 men

she sucked to the bottom and 1517 men

she sucked to the bottom and 1517 men women and children perished in the

women and children perished in the

women and children perished in the frigid waters of the North Atlantic in

2015 in sub-saharan Africa four hundred

2015 in sub-saharan Africa four hundred and thirty-five thousand people died

and thirty-five thousand people died

and thirty-five thousand people died from malaria most of them were children

from malaria most of them were children

from malaria most of them were children under the age of five that’s almost a

under the age of five that’s almost a

under the age of five that’s almost a Titanic a day of death from a disease

Titanic a day of death from a disease

Titanic a day of death from a disease that is largely curable now if James

that is largely curable now if James

that is largely curable now if James Cameron really wanted to make a movie

Cameron really wanted to make a movie

Cameron really wanted to make a movie about a tragedy I have a suggestion now

about a tragedy I have a suggestion now

about a tragedy I have a suggestion now what could a single chemists do in light

what could a single chemists do in light

what could a single chemists do in light of these massive numbers william osler

of these massive numbers william osler

of these massive numbers william osler one of the founders of modern American

one of the founders of modern American

one of the founders of modern American medicine once said there are three

medicine once said there are three

medicine once said there are three phases to treatment diagnosis diagnosis

phases to treatment diagnosis diagnosis

phases to treatment diagnosis diagnosis and diagnosis when you go to the

and diagnosis when you go to the

and diagnosis when you go to the hospital with an unknown ailment you

hospital with an unknown ailment you

hospital with an unknown ailment you have a full service clinical diagnostic

have a full service clinical diagnostic

have a full service clinical diagnostic lab at your disposal they have the most

lab at your disposal they have the most

lab at your disposal they have the most modern medical equipment electronic

modern medical equipment electronic

modern medical equipment electronic record-keeping and some of the most

record-keeping and some of the most

record-keeping and some of the most highly trained technical staff on the

highly trained technical staff on the

highly trained technical staff on the planet all working with your team to

planet all working with your team to

planet all working with your team to find out what’s wrong with you this is

find out what’s wrong with you this is

find out what’s wrong with you this is what a full-service clinical laboratory

what a full-service clinical laboratory

what a full-service clinical laboratory looks like at my research site in Zambia

looks like at my research site in Zambia

looks like at my research site in Zambia Africa many such sites have decades old

Africa many such sites have decades old

Africa many such sites have decades old hand-me-down equipment maybe there’s a

hand-me-down equipment maybe there’s a

hand-me-down equipment maybe there’s a light microscope like the one you used

light microscope like the one you used

light microscope like the one you used in high school biology class there’s no

in high school biology class there’s no

in high school biology class there’s no reliable electricity the only clean

reliable electricity the only clean

reliable electricity the only clean water you have is the clean water you

water you have is the clean water you

water you have is the clean water you carry into the clinic every morning and

carry into the clinic every morning and

carry into the clinic every morning and instead of highly trained technical

instead of highly trained technical

instead of highly trained technical staff we have tirelessly dedicated

staff we have tirelessly dedicated

staff we have tirelessly dedicated community healthcare workers who serve

community healthcare workers who serve

community healthcare workers who serve the role as nurse technician

the role as nurse technician

the role as nurse technician and public health officer this is the

and public health officer this is the

and public health officer this is the world of a low-resource setting low

world of a low-resource setting low

world of a low-resource setting low resource medicine and low resource

resource medicine and low resource

resource medicine and low resource Diagnostics the buzzword around new

Diagnostics the buzzword around new

Diagnostics the buzzword around new innovations in low-resource diagnostics

innovations in low-resource diagnostics

innovations in low-resource diagnostics is what we call assured assured stands

is what we call assured assured stands

is what we call assured assured stands for affordable sensitive specific user

for affordable sensitive specific user

for affordable sensitive specific user friendly a rapid and robust equipment

friendly a rapid and robust equipment

friendly a rapid and robust equipment free and deliverable if we can make

free and deliverable if we can make

free and deliverable if we can make assured diagnostic devices we can then

assured diagnostic devices we can then

assured diagnostic devices we can then provide the necessary health care that

provide the necessary health care that

provide the necessary health care that our patients in low-resource settings

our patients in low-resource settings

our patients in low-resource settings need the challenge we’re facing is being

need the challenge we’re facing is being

need the challenge we’re facing is being able to give a patient an accurate

able to give a patient an accurate

able to give a patient an accurate diagnosis as quickly as possible for as

diagnosis as quickly as possible for as

diagnosis as quickly as possible for as little money as possible and assured

little money as possible and assured

little money as possible and assured Diagnostics are the first step to

Diagnostics are the first step to

Diagnostics are the first step to reaching that goal now the most common

reaching that goal now the most common

reaching that goal now the most common assured device is what we call the rapid

assured device is what we call the rapid

assured device is what we call the rapid diagnostic strip test or rdt in the most

diagnostic strip test or rdt in the most

diagnostic strip test or rdt in the most familiar forms of this test you add a

familiar forms of this test you add a

familiar forms of this test you add a sample blood or urine at one of the

sample blood or urine at one of the

sample blood or urine at one of the tests and it runs down the strip like in

tests and it runs down the strip like in

tests and it runs down the strip like in a home pregnancy test that you buy at

a home pregnancy test that you buy at

a home pregnancy test that you buy at the drugstore a pregnancy test is

the drugstore a pregnancy test is

the drugstore a pregnancy test is looking for hormones in the urine that

looking for hormones in the urine that

looking for hormones in the urine that are produced when you become pregnant

are produced when you become pregnant

are produced when you become pregnant these hormones are the test target and

these hormones are the test target and

these hormones are the test target and over time they accumulate at the end of

over time they accumulate at the end of

over time they accumulate at the end of the strip and they form a line the more

the strip and they form a line the more

the strip and they form a line the more targets you have the dark of the line no

targets you have the dark of the line no

targets you have the dark of the line no line no targets not pregnant but the

line no targets not pregnant but the

line no targets not pregnant but the problem with rapid diagnostic tests in

problem with rapid diagnostic tests in

problem with rapid diagnostic tests in low-resource settings is it for many of

low-resource settings is it for many of

low-resource settings is it for many of the diseases that were interested in

the diseases that were interested in

the diseases that were interested in these tests simply aren’t sensitive

these tests simply aren’t sensitive

these tests simply aren’t sensitive enough that means a patient could be

enough that means a patient could be

enough that means a patient could be sick even though the tests told them he

sick even though the tests told them he

sick even though the tests told them he or she was well so how do we solve this

or she was well so how do we solve this

or she was well so how do we solve this problem how do we make these tests more

problem how do we make these tests more

problem how do we make these tests more sensitive with

sensitive with

sensitive with making them dramatically more expensive

making them dramatically more expensive

making them dramatically more expensive the answer is origami now you all

the answer is origami now you all

the answer is origami now you all probably know somebody who’s talented

probably know somebody who’s talented

probably know somebody who’s talented enough to fold the paper left and right

enough to fold the paper left and right

enough to fold the paper left and right and forwards and backwards and follow

and forwards and backwards and follow

and forwards and backwards and follow these directions and create these

these directions and create these

these directions and create these amazing paper figurines you’ve seen them

amazing paper figurines you’ve seen them

amazing paper figurines you’ve seen them the cranes whales flowers even Yoda but

the cranes whales flowers even Yoda but

the cranes whales flowers even Yoda but did you know that origami has been used

did you know that origami has been used

did you know that origami has been used to solve some really challenging

to solve some really challenging

to solve some really challenging engineering problems it was with origami

engineering problems it was with origami

engineering problems it was with origami that engineers were able to figure out

that engineers were able to figure out

that engineers were able to figure out how to pack an air bag into the

how to pack an air bag into the

how to pack an air bag into the dashboard of your car mechanical

dashboard of your car mechanical

dashboard of your car mechanical engineers use this concept of paper

engineers use this concept of paper

engineers use this concept of paper folding to design the crumple zones that

folding to design the crumple zones that

folding to design the crumple zones that protect your family from an automobile

protect your family from an automobile

protect your family from an automobile accident and biomedical engineers

accident and biomedical engineers

accident and biomedical engineers designed a stent that would collapse and

designed a stent that would collapse and

designed a stent that would collapse and be small when it was inserted into your

be small when it was inserted into your

be small when it was inserted into your vein but could be unfolded and made

vein but could be unfolded and made

vein but could be unfolded and made rigid to improve your circulation but

rigid to improve your circulation but

rigid to improve your circulation but how in the world is origami going to get

how in the world is origami going to get

how in the world is origami going to get more targets on the test to make the

more targets on the test to make the

more targets on the test to make the test more sensitive well imagine that we

test more sensitive well imagine that we

test more sensitive well imagine that we modify the rapid diagnostic strip test

modify the rapid diagnostic strip test

modify the rapid diagnostic strip test one side is the test just like it was

one side is the test just like it was

one side is the test just like it was before but on the other side we have a

before but on the other side we have a

before but on the other side we have a filter this filter allows us to add much

filter this filter allows us to add much

filter this filter allows us to add much larger volumes of blood or urine that

larger volumes of blood or urine that

larger volumes of blood or urine that simply flow through the test without

simply flow through the test without

simply flow through the test without disturbing its performance the targets

disturbing its performance the targets

disturbing its performance the targets bind to the filter and when we’re done

bind to the filter and when we’re done

bind to the filter and when we’re done we simply fold the filter over add a

we simply fold the filter over add a

we simply fold the filter over add a reagent that releases the targets from

reagent that releases the targets from

reagent that releases the targets from the filter the targets run down the test

the filter the targets run down the test

the filter the targets run down the test and we now are looking for many many

and we now are looking for many many

and we now are looking for many many many many more targets which produce the

many many more targets which produce the

many many more targets which produce the line we need to tell people that they’re

line we need to tell people that they’re

line we need to tell people that they’re sick but this isn’t the only kind of

sick but this isn’t the only kind of

sick but this isn’t the only kind of origami RTT we can make we can make very

origami RTT we can make we can make very

origami RTT we can make we can make very complicated devices that we print on a

complicated devices that we print on a

complicated devices that we print on a piece of paper fold it up it’s

piece of paper fold it up it’s

piece of paper fold it up it’s essentially a diagnostic

essentially a diagnostic

essentially a diagnostic lab on paper we can look for multiple

lab on paper we can look for multiple

lab on paper we can look for multiple diseases at the same time and when we

diseases at the same time and when we

diseases at the same time and when we unfold the disease the the origami

unfold the disease the the origami

unfold the disease the the origami structure rather than seeing a simple

structure rather than seeing a simple

structure rather than seeing a simple test line what we have at the center is

test line what we have at the center is

test line what we have at the center is a QR code a quick response code just

a QR code a quick response code just

a QR code a quick response code just like the ones that you see in your

like the ones that you see in your

like the ones that you see in your magazine or that on the back of a soda

magazine or that on the back of a soda

magazine or that on the back of a soda bottle or advertising this weekend’s

bottle or advertising this weekend’s

bottle or advertising this weekend’s band and using the cell phone app you

band and using the cell phone app you

band and using the cell phone app you can read that QR code and it immediately

can read that QR code and it immediately

can read that QR code and it immediately links the patient to the doctor it tells

links the patient to the doctor it tells

links the patient to the doctor it tells the patient the use-by date of the test

the patient the use-by date of the test

the patient the use-by date of the test they just took it allows us to fight

they just took it allows us to fight

they just took it allows us to fight counterfeit tests we can also find out

counterfeit tests we can also find out

counterfeit tests we can also find out information about when and where the

information about when and where the

information about when and where the test was performed now these origami and

test was performed now these origami and

test was performed now these origami and QR origami tests require no additional

QR origami tests require no additional

QR origami tests require no additional technical skill other than the ability

technical skill other than the ability

technical skill other than the ability to fold paper and use a cell phone

to fold paper and use a cell phone

to fold paper and use a cell phone camera app cell phone camera app the

camera app cell phone camera app the

camera app cell phone camera app the same cell phone camera app that is used

same cell phone camera app that is used

same cell phone camera app that is used around the world they also only cost 37

around the world they also only cost 37

around the world they also only cost 37 cents a test to mass-produce but these

cents a test to mass-produce but these

cents a test to mass-produce but these QR and origami are DTS or what I like to

QR and origami are DTS or what I like to

QR and origami are DTS or what I like to think of as RTT two point oh what if you

think of as RTT two point oh what if you

think of as RTT two point oh what if you really wanted to think outside of the

really wanted to think outside of the

really wanted to think outside of the box and create an entirely new way to

box and create an entirely new way to

box and create an entirely new way to make a diagnostic I don’t know about you

make a diagnostic I don’t know about you

make a diagnostic I don’t know about you but for me that first cup of coffee or

but for me that first cup of coffee or

but for me that first cup of coffee or first pot of coffee is a little more

first pot of coffee is a little more

first pot of coffee is a little more important than it probably should be and

important than it probably should be and

important than it probably should be and I’m not too tidy about making that pot

I’m not too tidy about making that pot

I’m not too tidy about making that pot of coffee there are grounds on the

of coffee there are grounds on the

of coffee there are grounds on the counter there’s maybe sugar and there’s

counter there’s maybe sugar and there’s

counter there’s maybe sugar and there’s always these coffee rings stains we’ve

always these coffee rings stains we’ve

always these coffee rings stains we’ve all seen them on our kitchen counters

all seen them on our kitchen counters

all seen them on our kitchen counters but how are they made well it turns out

but how are they made well it turns out

but how are they made well it turns out that a simple cup of coffee is not a

that a simple cup of coffee is not a

that a simple cup of coffee is not a simple cup of

simple cup of

simple cup of it’s not what we chemists would call a

it’s not what we chemists would call a

it’s not what we chemists would call a solution what it is is the suspension of

solution what it is is the suspension of

solution what it is is the suspension of particles your cup of coffee is full of

particles your cup of coffee is full of

particles your cup of coffee is full of all kinds of fine grounds that were so

all kinds of fine grounds that were so

all kinds of fine grounds that were so small they just flowed straight through

small they just flowed straight through

small they just flowed straight through your filter into your cup you’ve seen

your filter into your cup you’ve seen

your filter into your cup you’ve seen these when you let your coffee get cold

these when you let your coffee get cold

these when you let your coffee get cold and that stuff gathers at the bottom of

and that stuff gathers at the bottom of

and that stuff gathers at the bottom of your cup those are the particles I’m

your cup those are the particles I’m

your cup those are the particles I’m talking about now what happens when you

talking about now what happens when you

talking about now what happens when you spill a drop of coffee is that the water

spill a drop of coffee is that the water

spill a drop of coffee is that the water begins to evaporate out of that drop and

begins to evaporate out of that drop and

begins to evaporate out of that drop and it evaporates fastest at the very edge

it evaporates fastest at the very edge

it evaporates fastest at the very edge of the drop so when the water is

of the drop so when the water is

of the drop so when the water is evaporating out here at the edge the

evaporating out here at the edge the

evaporating out here at the edge the water and the particles in the middle

water and the particles in the middle

water and the particles in the middle flow in a specific direction to the edge

flow in a specific direction to the edge

flow in a specific direction to the edge so that when all the water is gone what

so that when all the water is gone what

so that when all the water is gone what you see our coffee rings it’s called the

you see our coffee rings it’s called the

you see our coffee rings it’s called the coffee ring effect now my colleague rick

coffee ring effect now my colleague rick

coffee ring effect now my colleague rick Hazleton and i realized that we could

Hazleton and i realized that we could

Hazleton and i realized that we could take this coffee ring phenomena and turn

take this coffee ring phenomena and turn

take this coffee ring phenomena and turn it into a biological assay for the

it into a biological assay for the

it into a biological assay for the detection of malaria all we would have

detection of malaria all we would have

detection of malaria all we would have to do is make a drop of infected malaria

to do is make a drop of infected malaria

to do is make a drop of infected malaria blood look like a drop of coffee and so

blood look like a drop of coffee and so

blood look like a drop of coffee and so we added special particles to the

we added special particles to the

we added special particles to the patient’s blood that would bind a

patient’s blood that would bind a

patient’s blood that would bind a malaria target we spot that blood on a

malaria target we spot that blood on a

malaria target we spot that blood on a glass slide and as the water begins to

glass slide and as the water begins to

glass slide and as the water begins to evaporate out of the blood the particles

evaporate out of the blood the particles

evaporate out of the blood the particles with the target run to the edge now it’s

with the target run to the edge now it’s

with the target run to the edge now it’s true that when it all dries it looks

true that when it all dries it looks

true that when it all dries it looks like that pre-wash up there and that’s

like that pre-wash up there and that’s

like that pre-wash up there and that’s not very clear but because the target

not very clear but because the target

not very clear but because the target binds to the slide and binds to the

binds to the slide and binds to the

binds to the slide and binds to the particles we can dip it in water and get

particles we can dip it in water and get

particles we can dip it in water and get rid of all the gunk and what you’re left

rid of all the gunk and what you’re left

rid of all the gunk and what you’re left with is a ring that ring is the same

with is a ring that ring is the same

with is a ring that ring is the same ring that you make when you spill your

ring that you make when you spill your

ring that you make when you spill your coffee and it actually means that the

coffee and it actually means that the

coffee and it actually means that the patient would have malaria this kind of

patient would have malaria this kind of

patient would have malaria this kind of 10

10

10 costs seven cents to make and doesn’t

costs seven cents to make and doesn’t

costs seven cents to make and doesn’t need any additional technical skill

need any additional technical skill

need any additional technical skill other than the ability to spill your

other than the ability to spill your

other than the ability to spill your coffee now the last example of a toybox

coffee now the last example of a toybox

coffee now the last example of a toybox diagnostic that I want to tell you about

diagnostic that I want to tell you about

diagnostic that I want to tell you about is about glow sticks and when my kids

is about glow sticks and when my kids

is about glow sticks and when my kids were in middle school they would come

were in middle school they would come

were in middle school they would come home from parties and they always had

home from parties and they always had

home from parties and they always had glow sticks the kids loved the glow

glow sticks the kids loved the glow

glow sticks the kids loved the glow sticks we’ve seen them they’re down at

sticks we’ve seen them they’re down at

sticks we’ve seen them they’re down at the river at the fourth of July or

the river at the fourth of July or

the river at the fourth of July or they’re at the party you went to last

they’re at the party you went to last

they’re at the party you went to last night in my house the glow sticks always

night in my house the glow sticks always

night in my house the glow sticks always ended up on the floor or the sofa so one

ended up on the floor or the sofa so one

ended up on the floor or the sofa so one morning while I was having my first cup

morning while I was having my first cup

morning while I was having my first cup of coffee I picked one up and I started

of coffee I picked one up and I started

of coffee I picked one up and I started playing with it I don’t know when the

playing with it I don’t know when the

playing with it I don’t know when the last time you played with a glow stick

last time you played with a glow stick

last time you played with a glow stick was but when you play with him you bend

was but when you play with him you bend

was but when you play with him you bend them they’re very flexible and you can

them they’re very flexible and you can

them they’re very flexible and you can hear it critical and pop and you ask

hear it critical and pop and you ask

hear it critical and pop and you ask yourself what’s going on and it turns

yourself what’s going on and it turns

yourself what’s going on and it turns out that a glow stick is a pretty

out that a glow stick is a pretty

out that a glow stick is a pretty interesting device what I discovered was

interesting device what I discovered was

interesting device what I discovered was that when you manufacture a glow stick

that when you manufacture a glow stick

that when you manufacture a glow stick you have an inner chamber an inner tube

you have an inner chamber an inner tube

you have an inner chamber an inner tube and that tube is made of some brittle

and that tube is made of some brittle

and that tube is made of some brittle material and you have a flexible

material and you have a flexible

material and you have a flexible translucent outer tube and when you flex

translucent outer tube and when you flex

translucent outer tube and when you flex that tube the inner brittle tube

that tube the inner brittle tube

that tube the inner brittle tube shatters you have a compound in the

shatters you have a compound in the

shatters you have a compound in the inner tube a compound in the outer tube

inner tube a compound in the outer tube

inner tube a compound in the outer tube and when those compounds react the

and when those compounds react the

and when those compounds react the product of that chemical reaction glows

product of that chemical reaction glows

product of that chemical reaction glows you have different chemicals you get

you have different chemicals you get

you have different chemicals you get different colored glow sticks then it

different colored glow sticks then it

different colored glow sticks then it hit me I could make my very own glow

hit me I could make my very own glow

hit me I could make my very own glow stick that could detect malaria how you

stick that could detect malaria how you

stick that could detect malaria how you ask well it just turned out that a

ask well it just turned out that a

ask well it just turned out that a student of mine had discovered a

student of mine had discovered a

student of mine had discovered a chemical compound that when it bound to

chemical compound that when it bound to

chemical compound that when it bound to a malaria tart

a malaria tart

a malaria tart get it glowed blue no malaria target no

get it glowed blue no malaria target no

get it glowed blue no malaria target no glowing blue color and so the idea was

glowing blue color and so the idea was

glowing blue color and so the idea was pretty simple we take that brittle inner

pretty simple we take that brittle inner

pretty simple we take that brittle inner chamber we fill it with the special

chamber we fill it with the special

chamber we fill it with the special compound that binds the target we put

compound that binds the target we put

compound that binds the target we put the brittle chamber inside an outer tube

the brittle chamber inside an outer tube

the brittle chamber inside an outer tube we had the patient sample to the outer

we had the patient sample to the outer

we had the patient sample to the outer tube we flex the tube just like you

tube we flex the tube just like you

tube we flex the tube just like you activate your glow stick when you go

activate your glow stick when you go

activate your glow stick when you go camping and if there’s target it glows

camping and if there’s target it glows

camping and if there’s target it glows blue no malaria no glowing whatsoever so

blue no malaria no glowing whatsoever so

blue no malaria no glowing whatsoever so this despite the fact that this test

this despite the fact that this test

this despite the fact that this test works best in the dark it requires no

works best in the dark it requires no

works best in the dark it requires no additional equipment to read cost about

additional equipment to read cost about

additional equipment to read cost about fifty cents to produce and can be made

fifty cents to produce and can be made

fifty cents to produce and can be made on the exact same equipment that

on the exact same equipment that

on the exact same equipment that mass-produces glow sticks for

mass-produces glow sticks for

mass-produces glow sticks for distribution all around the world now we

distribution all around the world now we

distribution all around the world now we have to remember that it’s true without

have to remember that it’s true without

have to remember that it’s true without Diagnostics medicine is blind but we

Diagnostics medicine is blind but we

Diagnostics medicine is blind but we also need to realize that low resource

also need to realize that low resource

also need to realize that low resource settings don’t just exist in the

settings don’t just exist in the

settings don’t just exist in the developing world we have low resource

developing world we have low resource

developing world we have low resource settings right here at home it’s a

settings right here at home it’s a

settings right here at home it’s a low-resource setting at the homeless

low-resource setting at the homeless

low-resource setting at the homeless encampment under the bridge by the river

encampment under the bridge by the river

encampment under the bridge by the river it’s a low-resource setting in many

it’s a low-resource setting in many

it’s a low-resource setting in many parts of rural america it’s a

parts of rural america it’s a

parts of rural america it’s a low-resource setting across Native

low-resource setting across Native

low-resource setting across Native American tribal reservations what we

American tribal reservations what we

American tribal reservations what we need to be thinking about is making

need to be thinking about is making

need to be thinking about is making effective assured diagnostic devices for

effective assured diagnostic devices for

effective assured diagnostic devices for everyone everywhere and we can do that

everyone everywhere and we can do that

everyone everywhere and we can do that all we have to do is play with our

all we have to do is play with our

all we have to do is play with our children clean up the kitchen counter

children clean up the kitchen counter

children clean up the kitchen counter and open our eyes to the every

and open our eyes to the every

and open our eyes to the every day objects in our lives so that we can

day objects in our lives so that we can

day objects in our lives so that we can discover new principles and new objects

discover new principles and new objects

discover new principles and new objects which we can transform into assured

which we can transform into assured

which we can transform into assured diagnostic devices thank you

diagnostic devices thank you

diagnostic devices thank you [Applause]

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