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The Gift of Adversity | Sophie Edelstein | TEDxYale


I ask of you the audience to envision a

I ask of you the audience to envision a gift it may have a big bow on top or be

gift it may have a big bow on top or be

gift it may have a big bow on top or be pristinely wrapped the size does not

pristinely wrapped the size does not

pristinely wrapped the size does not necessarily matter it could be large or

necessarily matter it could be large or

necessarily matter it could be large or small

small

small perhaps it looks something like this or

perhaps it looks something like this or

perhaps it looks something like this or along these lines now that you have this

along these lines now that you have this

along these lines now that you have this image in your mind and on the screen

image in your mind and on the screen

image in your mind and on the screen you’re probably wondering what is inside

you’re probably wondering what is inside

you’re probably wondering what is inside of this random box but before I tell you

of this random box but before I tell you

of this random box but before I tell you what is actually inside I’m going to

what is actually inside I’m going to

what is actually inside I’m going to give you a few hints first off it’s not

give you a few hints first off it’s not

give you a few hints first off it’s not the game boy you asked for when you’re 8

the game boy you asked for when you’re 8

the game boy you asked for when you’re 8 years old and while it can’t purchase on

years old and while it can’t purchase on

years old and while it can’t purchase on Amazon so most definitely does not

Amazon so most definitely does not

Amazon so most definitely does not qualify for Amazon Prime and lastly well

qualify for Amazon Prime and lastly well

qualify for Amazon Prime and lastly well there is no return to sender option

there is no return to sender option

there is no return to sender option however it is a gift of impact it is not

however it is a gift of impact it is not

however it is a gift of impact it is not a gift I would ever expect anyone else

a gift I would ever expect anyone else

a gift I would ever expect anyone else to want in fact I didn’t want it at

to want in fact I didn’t want it at

to want in fact I didn’t want it at first either but I’ve come to love it

first either but I’ve come to love it

first either but I’ve come to love it for everything that it’s worth I call it

for everything that it’s worth I call it

for everything that it’s worth I call it my gift of impact because it has led me

my gift of impact because it has led me

my gift of impact because it has led me to some of the greatest successes and

to some of the greatest successes and

to some of the greatest successes and realizations in my career thus far

realizations in my career thus far

realizations in my career thus far successes that now act as a light at the

successes that now act as a light at the

successes that now act as a light at the end of the tunnel in my constantly

end of the tunnel in my constantly

end of the tunnel in my constantly changing life these gifts look something

changing life these gifts look something

changing life these gifts look something like this completely obliterated

like this completely obliterated

like this completely obliterated cartilage in both my hip joints much of

cartilage in both my hip joints much of

cartilage in both my hip joints much of which I don’t have anymore

which I don’t have anymore

which I don’t have anymore and this severely aunt Roberta femurs

and this severely aunt Roberta femurs

and this severely aunt Roberta femurs basically for the first 16 years of my

basically for the first 16 years of my

basically for the first 16 years of my life my lights did not sit straight in

life my lights did not sit straight in

life my lights did not sit straight in my body and this femoral acetabular

my body and this femoral acetabular

my body and this femoral acetabular impingement growths on both my hip

impingement growths on both my hip

impingement growths on both my hip joints that restricted my femurs

joints that restricted my femurs

joints that restricted my femurs removing properly my body therefore

removing properly my body therefore

removing properly my body therefore affected by gait and lastly this a

affected by gait and lastly this a

affected by gait and lastly this a genetic disorder by the name of Ahlers

genetic disorder by the name of Ahlers

genetic disorder by the name of Ahlers Danlos syndrome these gifts soon turned

Danlos syndrome these gifts soon turned

Danlos syndrome these gifts soon turned into this and this an array of pretty

into this and this an array of pretty

into this and this an array of pretty awesome scars but I didn’t always view

awesome scars but I didn’t always view

awesome scars but I didn’t always view them that way nowadays we asked research

them that way nowadays we asked research

them that way nowadays we asked research scientists and physicians about that

scientists and physicians about that

scientists and physicians about that light bulb moment when they realized

light bulb moment when they realized

light bulb moment when they realized they wanted to go into a stem career

they wanted to go into a stem career

they wanted to go into a stem career some may say well when I was in seventh

some may say well when I was in seventh

some may say well when I was in seventh grade my science teacher showed me a

grade my science teacher showed me a

grade my science teacher showed me a demonstration in class and I became a

demonstration in class and I became a

demonstration in class and I became a Me’s by the reaction that occurred but

Me’s by the reaction that occurred but

Me’s by the reaction that occurred but my story well it’s a little bit

my story well it’s a little bit

my story well it’s a little bit different you see when I was a kid

different you see when I was a kid

different you see when I was a kid I mean even more of a kid than I am now

I mean even more of a kid than I am now

I mean even more of a kid than I am now I love science and engineering I loved

I love science and engineering I loved

I love science and engineering I loved having my hands on things but I was

having my hands on things but I was

having my hands on things but I was never able to find the motivation for

never able to find the motivation for

never able to find the motivation for the research that I found today

the research that I found today

the research that I found today everything in my childhood seemed pretty

everything in my childhood seemed pretty

everything in my childhood seemed pretty much normal despite the fact that kids

much normal despite the fact that kids

much normal despite the fact that kids at school made fun of me for the way I

at school made fun of me for the way I

at school made fun of me for the way I ran I sort of just brush that off my

ran I sort of just brush that off my

ran I sort of just brush that off my shoulder until one day when I was 13

shoulder until one day when I was 13

shoulder until one day when I was 13 years old and I was playing the game of

years old and I was playing the game of

years old and I was playing the game of lacrosse sport I’d grown up playing I

lacrosse sport I’d grown up playing I

lacrosse sport I’d grown up playing I was running straight down the field

was running straight down the field

was running straight down the field about to shoot at the top right corner

about to shoot at the top right corner

about to shoot at the top right corner of the goal when all of a sudden my hips

of the goal when all of a sudden my hips

of the goal when all of a sudden my hips locked and I immediately fell to the

locked and I immediately fell to the

locked and I immediately fell to the ground I could not get up I felt as if I

ground I could not get up I felt as if I

ground I could not get up I felt as if I needed some sort of key to unlock my

needed some sort of key to unlock my

needed some sort of key to unlock my hips a key I did not have at the time

hips a key I did not have at the time

hips a key I did not have at the time shortly after this I found myself

shortly after this I found myself

shortly after this I found myself sitting in countless doctors offices

sitting in countless doctors offices

sitting in countless doctors offices week after week being forced to look in

week after week being forced to look in

week after week being forced to look in an abundance of CT scans x-rays MRIs

an abundance of CT scans x-rays MRIs

an abundance of CT scans x-rays MRIs even ultrasound studies copious amounts

even ultrasound studies copious amounts

even ultrasound studies copious amounts of information was being thrown at me

of information was being thrown at me

of information was being thrown at me and in that moment I decided I could

and in that moment I decided I could

and in that moment I decided I could look at my situation one way or another

look at my situation one way or another

look at my situation one way or another I could either like all this confusing

I could either like all this confusing

I could either like all this confusing yet extremely interesting information go

yet extremely interesting information go

yet extremely interesting information go in one ear not the other or I can

in one ear not the other or I can

in one ear not the other or I can actually start listening and playing an

actually start listening and playing an

actually start listening and playing an active role in my health I decided to

active role in my health I decided to

active role in my health I decided to stick with option two surgeries began

stick with option two surgeries began

stick with option two surgeries began quite promptly after this realization

quite promptly after this realization

quite promptly after this realization and I found myself with a lot of free

and I found myself with a lot of free

and I found myself with a lot of free time on my hands I mean I was sitting in

time on my hands I mean I was sitting in

time on my hands I mean I was sitting in a hospital bed after all I decided to

a hospital bed after all I decided to

a hospital bed after all I decided to put this free time to what I thought was

put this free time to what I thought was

put this free time to what I thought was good use I began reading a plethora of

good use I began reading a plethora of

good use I began reading a plethora of orthopedic and biomedical engineering

orthopedic and biomedical engineering

orthopedic and biomedical engineering research journals highlighting

research journals highlighting

research journals highlighting everything I understood an orange and

everything I understood an orange and

everything I understood an orange and everything I didn’t understand it yellow

everything I didn’t understand it yellow

everything I didn’t understand it yellow turned out that most of those pages were

turned out that most of those pages were

turned out that most of those pages were covered in yellow but I didn’t let that

covered in yellow but I didn’t let that

covered in yellow but I didn’t let that discourage me I mean I had the resources

discourage me I mean I had the resources

discourage me I mean I had the resources after all I began I became that overly

after all I began I became that overly

after all I began I became that overly annoying patient who asks way too many

annoying patient who asks way too many

annoying patient who asks way too many questions but I think my doctors may

questions but I think my doctors may

questions but I think my doctors may thank me for it later early on in my

thank me for it later early on in my

thank me for it later early on in my high school career I worked on the

high school career I worked on the

high school career I worked on the development of a two-part 3-d plinth

development of a two-part 3-d plinth

development of a two-part 3-d plinth printed implant to treat internal

printed implant to treat internal

printed implant to treat internal snapping hip syndrome and he bought the

snapping hip syndrome and he bought the

snapping hip syndrome and he bought the lessons now that sounds like a mouthful

lessons now that sounds like a mouthful

lessons now that sounds like a mouthful but I’ll break it down for you basically

but I’ll break it down for you basically

but I’ll break it down for you basically I focused my study on female lessons not

I focused my study on female lessons not

I focused my study on female lessons not only because I was one myself but

only because I was one myself but

only because I was one myself but because one I was told

because one I was told

because one I was told phase in my life where I thought that

phase in my life where I thought that

phase in my life where I thought that being able to create an audible staff on

being able to create an audible staff on

being able to create an audible staff on command with my hips was something worth

command with my hips was something worth

command with my hips was something worth wanting to all of my friends and doctors

wanting to all of my friends and doctors

wanting to all of my friends and doctors but more importantly research had found

but more importantly research had found

but more importantly research had found that when female adolescents are going

that when female adolescents are going

that when female adolescents are going through puberty their hips grow faster

through puberty their hips grow faster

through puberty their hips grow faster than the rest of their body and then

than the rest of their body and then

than the rest of their body and then this iliopsoas our hip flexor tendon

this iliopsoas our hip flexor tendon

this iliopsoas our hip flexor tendon which sits right about here on my cup

which sits right about here on my cup

which sits right about here on my cup joy is then forced to span a greater

joy is then forced to span a greater

joy is then forced to span a greater surface area and becomes tight inflamed

surface area and becomes tight inflamed

surface area and becomes tight inflamed and then snaps I realized that if I

and then snaps I realized that if I

and then snaps I realized that if I could find a way to relieve the stress

could find a way to relieve the stress

could find a way to relieve the stress of this iliopsoas off of those eminences

of this iliopsoas off of those eminences

of this iliopsoas off of those eminences then I could ideally prevent the

then I could ideally prevent the

then I could ideally prevent the snapping my research is actually quite

snapping my research is actually quite

snapping my research is actually quite successful I computationally designed

successful I computationally designed

successful I computationally designed tested and 3d printed a two-part implant

tested and 3d printed a two-part implant

tested and 3d printed a two-part implant one located at the pelvis and one

one located at the pelvis and one

one located at the pelvis and one located right below the greater

located right below the greater

located right below the greater trochanter on my hip joint now like many

trochanter on my hip joint now like many

trochanter on my hip joint now like many gifts mine always seems to keep on

gifts mine always seems to keep on

gifts mine always seems to keep on giving after three years of treatment

giving after three years of treatment

giving after three years of treatment quite close to home my doctors decided

quite close to home my doctors decided

quite close to home my doctors decided that Sofie Adil’s see in the mystery

that Sofie Adil’s see in the mystery

that Sofie Adil’s see in the mystery case was truly a mystery and there was

case was truly a mystery and there was

case was truly a mystery and there was not much more they could do for me but

not much more they could do for me but

not much more they could do for me but there was one place they had in mind and

there was one place they had in mind and

there was one place they had in mind and it goes by the name of Boston Children’s

it goes by the name of Boston Children’s

it goes by the name of Boston Children’s Hospital at the time I felt confused and

Hospital at the time I felt confused and

Hospital at the time I felt confused and terrified and quite frankly abandoned I

terrified and quite frankly abandoned I

terrified and quite frankly abandoned I mean I had never been given treatment

mean I had never been given treatment

mean I had never been given treatment out of the Yale Network before but I

out of the Yale Network before but I

out of the Yale Network before but I came to learn that Boston Children’s

came to learn that Boston Children’s

came to learn that Boston Children’s Hospital was probably the best thing

Hospital was probably the best thing

Hospital was probably the best thing that would ever happen to me I was

that would ever happen to me I was

that would ever happen to me I was getting the health care I needed and I

getting the health care I needed and I

getting the health care I needed and I was getting this amazing support system

was getting this amazing support system

was getting this amazing support system in terms of research mentorship being

in terms of research mentorship being

in terms of research mentorship being the science minded kid I was I had to do

the science minded kid I was I had to do

the science minded kid I was I had to do all of my research I looked into the new

all of my research I looked into the new

all of my research I looked into the new doctors new environment and just about

doctors new environment and just about

doctors new environment and just about everything I was getting myself into

everything I was getting myself into

everything I was getting myself into even if I generally didn’t know at those

even if I generally didn’t know at those

even if I generally didn’t know at those points in time during my excessive

points in time during my excessive

points in time during my excessive research I came across an article in The

research I came across an article in The

research I came across an article in The New York Times titled doctors experiment

New York Times titled doctors experiment

New York Times titled doctors experiment with new ways of fixing the ACL in my

with new ways of fixing the ACL in my

with new ways of fixing the ACL in my mind I thought orthopedic score but it

mind I thought orthopedic score but it

mind I thought orthopedic score but it was even better when I came to realize

was even better when I came to realize

was even better when I came to realize that my own doctors were the ones behind

that my own doctors were the ones behind

that my own doctors were the ones behind this new treatment the team that Boston

this new treatment the team that Boston

this new treatment the team that Boston Children’s Hospital had identified that

Children’s Hospital had identified that

Children’s Hospital had identified that the ACL in the knee does not heal

the ACL in the knee does not heal

the ACL in the knee does not heal naturally due to a lack of blood supply

naturally due to a lack of blood supply

naturally due to a lack of blood supply in the area that would inevitably send

in the area that would inevitably send

in the area that would inevitably send signals throughout the rest of the body

signals throughout the rest of the body

signals throughout the rest of the body to initiate regeneration however if you

to initiate regeneration however if you

to initiate regeneration however if you can find a way stabilize the blood in

can find a way stabilize the blood in

can find a way stabilize the blood in the area then a clot forms and those

the area then a clot forms and those

the area then a clot forms and those signals can be sent

signals can be sent

signals can be sent therefore encouraging her generation I

therefore encouraging her generation I

therefore encouraging her generation I recognize that the same thing happens

recognize that the same thing happens

recognize that the same thing happens with yah sevate labrum in the hip joint

with yah sevate labrum in the hip joint

with yah sevate labrum in the hip joint so if I could develop a scaffold with

so if I could develop a scaffold with

so if I could develop a scaffold with similar properties to that in the bridge

similar properties to that in the bridge

similar properties to that in the bridge in hand Stacy Elton I and many others

in hand Stacy Elton I and many others

in hand Stacy Elton I and many others could avoid the countless favorite

could avoid the countless favorite

could avoid the countless favorite repair surgeries and allow our bodies do

repair surgeries and allow our bodies do

repair surgeries and allow our bodies do what they do best which is of course

what they do best which is of course

what they do best which is of course heal you see we have blood which is this

heal you see we have blood which is this

heal you see we have blood which is this great stimulant for healing which comes

great stimulant for healing which comes

great stimulant for healing which comes straight from the patient’s body and

straight from the patient’s body and

straight from the patient’s body and this scaffold that I worked on in the

this scaffold that I worked on in the

this scaffold that I worked on in the lab which has the ability to hold the

lab which has the ability to hold the

lab which has the ability to hold the blood in the wound site therefore

blood in the wound site therefore

blood in the wound site therefore activating the platelets and then those

activating the platelets and then those

activating the platelets and then those two things together form a stable clot

two things together form a stable clot

two things together form a stable clot that solidifies which has the ability to

that solidifies which has the ability to

that solidifies which has the ability to encourage cell engross proliferation and

encourage cell engross proliferation and

encourage cell engross proliferation and even tissue we feel like now my research

even tissue we feel like now my research

even tissue we feel like now my research adds that presented here sounds pretty

adds that presented here sounds pretty

adds that presented here sounds pretty much perfect

much perfect

much perfect but I can assure you that it was far

but I can assure you that it was far

but I can assure you that it was far from that I met a multitude of

from that I met a multitude of

from that I met a multitude of roadblocks along the way and there were

roadblocks along the way and there were

roadblocks along the way and there were many times when I wanted to give up just

many times when I wanted to give up just

many times when I wanted to give up just like many scientists would but I had

like many scientists would but I had

like many scientists would but I had this false idea in my mind that if I

this false idea in my mind that if I

this false idea in my mind that if I gave up well then it was fair game for

gave up well then it was fair game for

gave up well then it was fair game for my doctors to give up on me something I

my doctors to give up on me something I

my doctors to give up on me something I had always feared but that is not my

had always feared but that is not my

had always feared but that is not my point here my point is that I do not

point here my point is that I do not

point here my point is that I do not rate my success on the awards I’ve won

rate my success on the awards I’ve won

rate my success on the awards I’ve won international science competitions for

international science competitions for

international science competitions for this research I just described or even

this research I just described or even

this research I just described or even the fact that I’m standing talking to

the fact that I’m standing talking to

the fact that I’m standing talking to all of you right now I rate my success

all of you right now I rate my success

all of you right now I rate my success on the feeling of walking out of the lab

on the feeling of walking out of the lab

on the feeling of walking out of the lab at the end of a long tiring and

at the end of a long tiring and

at the end of a long tiring and confusing day and knowing that there are

confusing day and knowing that there are

confusing day and knowing that there are research scientists in positions across

research scientists in positions across

research scientists in positions across the globe working on similar things as I

the globe working on similar things as I

the globe working on similar things as I am to better my life and the life of

am to better my life and the life of

am to better my life and the life of many others if I can help out too then

many others if I can help out too then

many others if I can help out too then why not I’ve come to realize that

why not I’ve come to realize that

why not I’ve come to realize that there’s a very very close tie between my

there’s a very very close tie between my

there’s a very very close tie between my research and my health challenges I know

research and my health challenges I know

research and my health challenges I know I will not be better tomorrow or next

I will not be better tomorrow or next

I will not be better tomorrow or next month or maybe even next year but when

month or maybe even next year but when

month or maybe even next year but when is there a day we walk into the lab and

is there a day we walk into the lab and

is there a day we walk into the lab and sit down at the bench and say today I am

sit down at the bench and say today I am

sit down at the bench and say today I am going to cure a colon cancer we don’t

going to cure a colon cancer we don’t

going to cure a colon cancer we don’t it is simply impractical and irrational

it is simply impractical and irrational

it is simply impractical and irrational we have been working on a cure for colon

we have been working on a cure for colon

we have been working on a cure for colon cancer for the last 10 to 15 years and

cancer for the last 10 to 15 years and

cancer for the last 10 to 15 years and still have not found it but there will

still have not found it but there will

still have not found it but there will be a day we do find it just like there

be a day we do find it just like there

be a day we do find it just like there will be a day where I will be able to

will be a day where I will be able to

will be a day where I will be able to walk up a single fly

walk up a single fly

walk up a single fly Aires and not feel as if my legs are

Aires and not feel as if my legs are

Aires and not feel as if my legs are going to collapse from underneath me it

going to collapse from underneath me it

going to collapse from underneath me it is research that will make that possible

is research that will make that possible

is research that will make that possible it is research that has allowed me to

it is research that has allowed me to

it is research that has allowed me to stand on the stage for the last 10

stand on the stage for the last 10

stand on the stage for the last 10 minutes talking all of you without

minutes talking all of you without

minutes talking all of you without eating my cane it is research that

eating my cane it is research that

eating my cane it is research that brought tears to my eyes at the sight of

brought tears to my eyes at the sight of

brought tears to my eyes at the sight of two straight legs for the first time in

two straight legs for the first time in

two straight legs for the first time in my life it is research that has allowed

my life it is research that has allowed

my life it is research that has allowed me to learn how to walk again and it is

me to learn how to walk again and it is

me to learn how to walk again and it is research that has acted as that light at

research that has acted as that light at

research that has acted as that light at the end of the tunnel you do not have to

the end of the tunnel you do not have to

the end of the tunnel you do not have to be a math or science genius to play an

be a math or science genius to play an

be a math or science genius to play an active role in your health but if you

active role in your health but if you

active role in your health but if you find something you are confident about

find something you are confident about

find something you are confident about it’ll act as the force behind you

it’ll act as the force behind you

it’ll act as the force behind you towards your success whether that be in

towards your success whether that be in

towards your success whether that be in developing a more positive or optimistic

developing a more positive or optimistic

developing a more positive or optimistic attitude these gifts are not supposed to

attitude these gifts are not supposed to

attitude these gifts are not supposed to break you down they’re supposed to build

break you down they’re supposed to build

break you down they’re supposed to build you up as cliche as that sounds these

you up as cliche as that sounds these

you up as cliche as that sounds these gifts help me realize that I love

gifts help me realize that I love

gifts help me realize that I love science and I love engineering and I

science and I love engineering and I

science and I love engineering and I love helping people at least that’s how

love helping people at least that’s how

love helping people at least that’s how I’ve managed to see it thank you very

I’ve managed to see it thank you very

I’ve managed to see it thank you very much

much

much [Applause]

[Applause]

[Applause] [Music]

”

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