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Smile to see if you have Parkinson’s Disease | Erin Smith | TEDxYouth@KC


there’s an old Japanese legend about

there’s an old Japanese legend about love that says that each of us is born

love that says that each of us is born

love that says that each of us is born possessing a single red thread the

possessing a single red thread the

possessing a single red thread the attaches from our pointer finger and

attaches from our pointer finger and

attaches from our pointer finger and runs to the arteries of our heart then

runs to the arteries of our heart then

runs to the arteries of our heart then as we go about lives and former nameless

as we go about lives and former nameless

as we go about lives and former nameless strangers become friends we form

strangers become friends we form

strangers become friends we form connections and our red strings

connections and our red strings

connections and our red strings intertwine with other people’s until we

intertwine with other people’s until we

intertwine with other people’s until we die a network of intertwined connected

die a network of intertwined connected

die a network of intertwined connected red strings further as research suggests

red strings further as research suggests

red strings further as research suggests we are no more than six degrees

we are no more than six degrees

we are no more than six degrees separated from anyone which likewise

separated from anyone which likewise

separated from anyone which likewise suggests that we are no more than six

suggests that we are no more than six

suggests that we are no more than six red strings separated from anyone else

red strings separated from anyone else

red strings separated from anyone else in this crowd

in this crowd

in this crowd I believe the ideas function largely in

I believe the ideas function largely in

I believe the ideas function largely in the same way as we go about life and we

the same way as we go about life and we

the same way as we go about life and we have different experiences and different

have different experiences and different

have different experiences and different interactions these separate

interactions these separate

interactions these separate opportunities come together to form

opportunities come together to form

opportunities come together to form powerful ideas my own story starts back

powerful ideas my own story starts back

powerful ideas my own story starts back when I was about 12 years old so during

when I was about 12 years old so during

when I was about 12 years old so during this time I was obsessed with the TV

this time I was obsessed with the TV

this time I was obsessed with the TV show called lie to me it was based off

show called lie to me it was based off

show called lie to me it was based off of the work of researcher dr. Paul Ekman

of the work of researcher dr. Paul Ekman

of the work of researcher dr. Paul Ekman and it was this detective who would

and it was this detective who would

and it was this detective who would determine whether or not people are

determine whether or not people are

determine whether or not people are lying by reading their facial

lying by reading their facial

lying by reading their facial expressions I was captivated not only by

expressions I was captivated not only by

expressions I was captivated not only by the storyline and plotline but more so

the storyline and plotline but more so

the storyline and plotline but more so by the science behind what the face

by the science behind what the face

by the science behind what the face could reveal Google became my new best

could reveal Google became my new best

could reveal Google became my new best friend and I spent hours reading and

friend and I spent hours reading and

friend and I spent hours reading and researching about the research of behind

researching about the research of behind

researching about the research of behind this TV show then fast forward to two

this TV show then fast forward to two

this TV show then fast forward to two years ago when I was a sophomore in high

years ago when I was a sophomore in high

years ago when I was a sophomore in high school and I was watching a video by the

school and I was watching a video by the

school and I was watching a video by the Michael J Fox foundation when I noticed

Michael J Fox foundation when I noticed

Michael J Fox foundation when I noticed that whenever Michael J Fox or another

that whenever Michael J Fox or another

that whenever Michael J Fox or another Parkinson’s patient would laugh or smile

Parkinson’s patient would laugh or smile

Parkinson’s patient would laugh or smile with one another it came off as

with one another it came off as

with one another it came off as emotionally distant or unfelt

emotionally distant or unfelt

emotionally distant or unfelt a red string instantly formed in my mind

a red string instantly formed in my mind

a red string instantly formed in my mind and my mind instantly went back to the

and my mind instantly went back to the

and my mind instantly went back to the TV show lie to me I wondered if the

TV show lie to me I wondered if the

TV show lie to me I wondered if the facial action coding system which was

facial action coding system which was

facial action coding system which was the basis of the lie to me TV show could

the basis of the lie to me TV show could

the basis of the lie to me TV show could have healthcare implications further as

have healthcare implications further as

have healthcare implications further as I started talking to local caretakers

I started talking to local caretakers

I started talking to local caretakers and clinicians they reported similar

and clinicians they reported similar

and clinicians they reported similar observations and their loved ones years

observations and their loved ones years

observations and their loved ones years before diagnosis I also found that

before diagnosis I also found that

before diagnosis I also found that current Parkinson’s disease diagnostic

current Parkinson’s disease diagnostic

current Parkinson’s disease diagnostic methods are severely hindered due to

methods are severely hindered due to

methods are severely hindered due to lack of validated biomarkers or

lack of validated biomarkers or

lack of validated biomarkers or objective in the

objective in the

objective in the of disease onset further as I once again

of disease onset further as I once again

of disease onset further as I once again returned to Google I found as I was

returned to Google I found as I was

returned to Google I found as I was reading through prior research that the

reading through prior research that the

reading through prior research that the same sections of the brain that

same sections of the brain that

same sections of the brain that experienced the earliest changes among

experienced the earliest changes among

experienced the earliest changes among Parkinson’s patients are the same

Parkinson’s patients are the same

Parkinson’s patients are the same sections of the brain responsible for

sections of the brain responsible for

sections of the brain responsible for spontaneous and post facial expression

spontaneous and post facial expression

spontaneous and post facial expression formation meaning if that we could find

formation meaning if that we could find

formation meaning if that we could find a way to discover and digitize these

a way to discover and digitize these

a way to discover and digitize these differences they could provide early

differences they could provide early

differences they could provide early external manifestations of early

external manifestations of early

external manifestations of early internal neurological pathology among

internal neurological pathology among

internal neurological pathology among parkinson’s patients as i was reading

parkinson’s patients as i was reading

parkinson’s patients as i was reading through past research i was also

through past research i was also

through past research i was also surprised to find that the number of

surprised to find that the number of

surprised to find that the number of parkinson’s cases is experiencing

parkinson’s cases is experiencing

parkinson’s cases is experiencing rampant growth globally by the year 2030

rampant growth globally by the year 2030

rampant growth globally by the year 2030 the number of parkinson’s cases is

the number of parkinson’s cases is

the number of parkinson’s cases is expected to more than double and

expected to more than double and

expected to more than double and especially vulnerable are those in

especially vulnerable are those in

especially vulnerable are those in developing and remote areas across a

developing and remote areas across a

developing and remote areas across a world where lack of early and accurate

world where lack of early and accurate

world where lack of early and accurate diagnostic methods will further

diagnostic methods will further

diagnostic methods will further complicate the disease prevent treatment

complicate the disease prevent treatment

complicate the disease prevent treatment options and pose an increasing societal

options and pose an increasing societal

options and pose an increasing societal economic and infrastructural threat on

economic and infrastructural threat on

economic and infrastructural threat on current healthcare sectors I knew that I

current healthcare sectors I knew that I

current healthcare sectors I knew that I had to change these statistics and

had to change these statistics and

had to change these statistics and challenge the way that Parkinson’s

challenge the way that Parkinson’s

challenge the way that Parkinson’s disease diagnosis was currently being

disease diagnosis was currently being

disease diagnosis was currently being approached so I designed a way to elicit

approached so I designed a way to elicit

approached so I designed a way to elicit and collect spontaneous and post facial

and collect spontaneous and post facial

and collect spontaneous and post facial expressions I sent an email to the

expressions I sent an email to the

expressions I sent an email to the Michael J Fox foundation and luckily

Michael J Fox foundation and luckily

Michael J Fox foundation and luckily they responded and I was able to launch

they responded and I was able to launch

they responded and I was able to launch an online study with that I would have

an online study with that I would have

an online study with that I would have Parkinson’s and non Parkinson’s patients

Parkinson’s and non Parkinson’s patients

Parkinson’s and non Parkinson’s patients watch a series of Super Bowl commercials

watch a series of Super Bowl commercials

watch a series of Super Bowl commercials or replicate a series of emojis while

or replicate a series of emojis while

or replicate a series of emojis while their faces were recorded by their

their faces were recorded by their

their faces were recorded by their computer webcam I then broke down the

computer webcam I then broke down the

computer webcam I then broke down the footage I collected using facial

footage I collected using facial

footage I collected using facial recognition software for frame by frame

recognition software for frame by frame

recognition software for frame by frame calculations for distinct facial muscle

calculations for distinct facial muscle

calculations for distinct facial muscle movements I then took the data and was

movements I then took the data and was

movements I then took the data and was able to mine through the data to

able to mine through the data to

able to mine through the data to discover and validate previously unknown

discover and validate previously unknown

discover and validate previously unknown early indicators of Parkinson’s disease

early indicators of Parkinson’s disease

early indicators of Parkinson’s disease these included specific facial muscle

these included specific facial muscle

these included specific facial muscle movements experience differences in

movements experience differences in

movements experience differences in responses among parkinson’s patients

responses among parkinson’s patients

responses among parkinson’s patients such as that involved for the upper

such as that involved for the upper

such as that involved for the upper eyebrow contraction and then also

eyebrow contraction and then also

eyebrow contraction and then also interactions between facial muscle

interactions between facial muscle

interactions between facial muscle movements such as those involved for the

movements such as those involved for the

movements such as those involved for the formation of a smile and these are

formation of a smile and these are

formation of a smile and these are actually only a few of the larger subset

actually only a few of the larger subset

actually only a few of the larger subset of biomarkers that I was able

of biomarkers that I was able

of biomarkers that I was able determine then using these biomarkers I

determine then using these biomarkers I

determine then using these biomarkers I then want to build a series of

then want to build a series of

then want to build a series of diagnostic algorithms that could

diagnostic algorithms that could

diagnostic algorithms that could accurately determine whether or not a

accurately determine whether or not a

accurately determine whether or not a patient had Parkinson’s disease so I

patient had Parkinson’s disease so I

patient had Parkinson’s disease so I taught myself how to code and after

taught myself how to code and after

taught myself how to code and after several long nights and failed attempts

several long nights and failed attempts

several long nights and failed attempts it finally worked and this was such an

it finally worked and this was such an

it finally worked and this was such an exciting moment my research as it

exciting moment my research as it

exciting moment my research as it demonstrated that I had not only been

demonstrated that I had not only been

demonstrated that I had not only been able to discover and digitize previously

able to discover and digitize previously

able to discover and digitize previously unknown early indicators of Parkinson’s

unknown early indicators of Parkinson’s

unknown early indicators of Parkinson’s disease but I was also able to use these

disease but I was also able to use these

disease but I was also able to use these differences to determine whether or not

differences to determine whether or not

differences to determine whether or not somebody had Parkinson’s based solely on

somebody had Parkinson’s based solely on

somebody had Parkinson’s based solely on the responses to Super Bowl commercials

the responses to Super Bowl commercials

the responses to Super Bowl commercials and replication of emojis I have been

and replication of emojis I have been

and replication of emojis I have been able to create a robust means of

able to create a robust means of

able to create a robust means of diagnosis for Parkinson’s disease and as

diagnosis for Parkinson’s disease and as

diagnosis for Parkinson’s disease and as this process is data-driven I will be

this process is data-driven I will be

this process is data-driven I will be able to continue to refine the

able to continue to refine the

able to continue to refine the algorithms and improve an accuracy as I

algorithms and improve an accuracy as I

algorithms and improve an accuracy as I continue to collect responses one of the

continue to collect responses one of the

continue to collect responses one of the most fascinating elements of this

most fascinating elements of this

most fascinating elements of this diagnostic tool and that is that it

diagnostic tool and that is that it

diagnostic tool and that is that it utilizes biomarkers that may occur up to

utilizes biomarkers that may occur up to

utilizes biomarkers that may occur up to ten years before the onset of

ten years before the onset of

ten years before the onset of traditional motor symptoms and

traditional motor symptoms and

traditional motor symptoms and subsequent diagnosis this is especially

subsequent diagnosis this is especially

subsequent diagnosis this is especially critical because it opens up an exciting

critical because it opens up an exciting

critical because it opens up an exciting opportunity to start developing and

opportunity to start developing and

opportunity to start developing and testing novel therapeutics which will

testing novel therapeutics which will

testing novel therapeutics which will ultimately change the way that

ultimately change the way that

ultimately change the way that Parkinson’s disease is treated the

Parkinson’s disease is treated the

Parkinson’s disease is treated the technology I use is also specifically

technology I use is also specifically

technology I use is also specifically designed to be non-invasive and remote

designed to be non-invasive and remote

designed to be non-invasive and remote making it perfect for the developing and

making it perfect for the developing and

making it perfect for the developing and remote areas across the world most at

remote areas across the world most at

remote areas across the world most at risk to the rampant growth in the number

risk to the rampant growth in the number

risk to the rampant growth in the number of Parkinson’s cases I so I just started

of Parkinson’s cases I so I just started

of Parkinson’s cases I so I just started my senior year of high school and I’m

my senior year of high school and I’m

my senior year of high school and I’m currently continuing this research so

currently continuing this research so

currently continuing this research so this fall I will be launching a series

this fall I will be launching a series

this fall I will be launching a series of longitudinal studies which will

of longitudinal studies which will

of longitudinal studies which will enable us to really pinpoint out what

enable us to really pinpoint out what

enable us to really pinpoint out what specific point before current diagnosis

specific point before current diagnosis

specific point before current diagnosis are we able to capture these responses

are we able to capture these responses

are we able to capture these responses and this process can easily be

and this process can easily be

and this process can easily be replicated for other neurological or

replicated for other neurological or

replicated for other neurological or other developmental diseases such as

other developmental diseases such as

other developmental diseases such as PTSD or postnatal depression on which I

PTSD or postnatal depression on which I

PTSD or postnatal depression on which I will also be working on this school year

will also be working on this school year

will also be working on this school year and I think that the applications of

and I think that the applications of

and I think that the applications of this technology are what most excite me

this technology are what most excite me

this technology are what most excite me so first and foremost this provides a

so first and foremost this provides a

so first and foremost this provides a robust means of diagnosis for clinicians

robust means of diagnosis for clinicians

robust means of diagnosis for clinicians around the world and pharmaceutical

around the world and pharmaceutical

around the world and pharmaceutical companies have also expressed and

companies have also expressed and

companies have also expressed and using this technology as a means to

using this technology as a means to

using this technology as a means to progressively monitor Parkinson’s

progressively monitor Parkinson’s

progressively monitor Parkinson’s disease and again test and develop novel

disease and again test and develop novel

disease and again test and develop novel therapeutics but from a personal

therapeutics but from a personal

therapeutics but from a personal standpoint one of the things I’m most

standpoint one of the things I’m most

standpoint one of the things I’m most excited about is that the facial

excited about is that the facial

excited about is that the facial recognition software I used is

recognition software I used is

recognition software I used is compatible with that used by companies

compatible with that used by companies

compatible with that used by companies such as snapchat and Facebook meaning

such as snapchat and Facebook meaning

such as snapchat and Facebook meaning these social media platforms could one

these social media platforms could one

these social media platforms could one day provide powerful health care tools

day provide powerful health care tools

day provide powerful health care tools creating a selfie that could save your

creating a selfie that could save your

creating a selfie that could save your life so I’d like to end by just taking a

life so I’d like to end by just taking a

life so I’d like to end by just taking a step back for a moment I think one of

step back for a moment I think one of

step back for a moment I think one of the most amazing aspects about the way

the most amazing aspects about the way

the most amazing aspects about the way and the process that ideas are formed is

and the process that ideas are formed is

and the process that ideas are formed is that after you start developing your

that after you start developing your

that after you start developing your idea into a tangible technology you can

idea into a tangible technology you can

idea into a tangible technology you can kind of take a step back and look at how

kind of take a step back and look at how

kind of take a step back and look at how all these separate red strings of

all these separate red strings of

all these separate red strings of inspiration came together to form

inspiration came together to form

inspiration came together to form powerful revolutionary ideas my mind

powerful revolutionary ideas my mind

powerful revolutionary ideas my mind goes back to our solar system so through

goes back to our solar system so through

goes back to our solar system so through the development of objective tools and

the development of objective tools and

the development of objective tools and technologies such as the telescope we

technologies such as the telescope we

technologies such as the telescope we have been able to better understand the

have been able to better understand the

have been able to better understand the vast complexities of outer space

vast complexities of outer space

vast complexities of outer space similarly I believe that through the

similarly I believe that through the

similarly I believe that through the development of better more accessible

development of better more accessible

development of better more accessible and objective tools and technologies

and objective tools and technologies

and objective tools and technologies such as those I’m working to develop

such as those I’m working to develop

such as those I’m working to develop within the sphere of Parkinson’s disease

within the sphere of Parkinson’s disease

within the sphere of Parkinson’s disease diagnosis we will likewise be able to

diagnosis we will likewise be able to

diagnosis we will likewise be able to come to better understand our own inner

come to better understand our own inner

come to better understand our own inner space and that is an adventure of a

space and that is an adventure of a

space and that is an adventure of a lifetime

lifetime

lifetime thank you

”

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