I would like to start by giving you a few facts about the human brain they say
few facts about the human brain they say
few facts about the human brain they say that one human brain can store as much
that one human brain can store as much
that one human brain can store as much information as that stored on the entire
information as that stored on the entire
information as that stored on the entire Internet
Internet
Internet the human brain is the CPU of the
the human brain is the CPU of the
the human brain is the CPU of the internet of the human body
internet of the human body
internet of the human body another type of Internet it’s made of 37
another type of Internet it’s made of 37
another type of Internet it’s made of 37 trillion users the users of this
trillion users the users of this
trillion users the users of this Internet are the biological cells of
Internet are the biological cells of
Internet are the biological cells of which the human body is made to compare
which the human body is made to compare
which the human body is made to compare the actual Internet is made of only 3
the actual Internet is made of only 3
the actual Internet is made of only 3 billion users so the human Internet is
billion users so the human Internet is
billion users so the human Internet is orders of magnitude larger and the brain
orders of magnitude larger and the brain
orders of magnitude larger and the brain makes sure that the communication
makes sure that the communication
makes sure that the communication between the cells the users of the human
between the cells the users of the human
between the cells the users of the human Internet is flawless throughout the
Internet is flawless throughout the
Internet is flawless throughout the entire life span of a human being so you
entire life span of a human being so you
entire life span of a human being so you can see what a powerful computing
can see what a powerful computing
can see what a powerful computing machine the brain is if for some reason
machine the brain is if for some reason
machine the brain is if for some reason the communication between cells in the
the communication between cells in the
the communication between cells in the internet of the human body fails in
internet of the human body fails in
internet of the human body fails in there that’s one we get diseases such as
there that’s one we get diseases such as
there that’s one we get diseases such as cancer Alzheimer’s Parkinson’s in other
cancer Alzheimer’s Parkinson’s in other
cancer Alzheimer’s Parkinson’s in other devastating diseases right now in a
devastating diseases right now in a
devastating diseases right now in a couple of sentences I define for you in
couple of sentences I define for you in
couple of sentences I define for you in new emerging science and technology
new emerging science and technology
new emerging science and technology field known as techno biology is
field known as techno biology is
field known as techno biology is different from biotechnology that
different from biotechnology that
different from biotechnology that traditional approach in medical science
traditional approach in medical science
traditional approach in medical science according to biotechnology diseases are
according to biotechnology diseases are
according to biotechnology diseases are treated at a relatively the local level
treated at a relatively the local level
treated at a relatively the local level of cells and tissues with techni biology
of cells and tissues with techni biology
of cells and tissues with techni biology diseases are treated not only at that
diseases are treated not only at that
diseases are treated not only at that local level but also at the level of the
local level but also at the level of the
local level but also at the level of the entire Internet of the human body when
entire Internet of the human body when
entire Internet of the human body when we treat cells and tissues locally we
we treat cells and tissues locally we
we treat cells and tissues locally we also have to make sure we recover the
also have to make sure we recover the
also have to make sure we recover the communication between these treated
communication between these treated
communication between these treated cells and the entire Internet and to
cells and the entire Internet and to
cells and the entire Internet and to make sure cancers and other diseases
make sure cancers and other diseases
make sure cancers and other diseases don’t come back don’t relapse it’s vital
don’t come back don’t relapse it’s vital
don’t come back don’t relapse it’s vital to implement this approach techno
to implement this approach techno
to implement this approach techno biology
biology
biology and this is my field my expertise is in
and this is my field my expertise is in
and this is my field my expertise is in the fields of physics and electrical and
the fields of physics and electrical and
the fields of physics and electrical and computer engineering until about a
computer engineering until about a
computer engineering until about a decade ago together with my team of
decade ago together with my team of
decade ago together with my team of talented graduate students I focused on
talented graduate students I focused on
talented graduate students I focused on using principles of quantum physics to
using principles of quantum physics to
using principles of quantum physics to build much better and faster computers
build much better and faster computers
build much better and faster computers we were pretty good in that some of the
we were pretty good in that some of the
we were pretty good in that some of the technologies we developed I used today
technologies we developed I used today
technologies we developed I used today in industry however ten years ago our
in industry however ten years ago our
in industry however ten years ago our focus changed dramatically from building
focus changed dramatically from building
focus changed dramatically from building better computers to engineering better
better computers to engineering better
better computers to engineering better medicines and that happened when we when
medicines and that happened when we when
medicines and that happened when we when we visited by my old friend
we visited by my old friend
we visited by my old friend a physician who happened to love science
a physician who happened to love science
a physician who happened to love science we are showing him how we could use
we are showing him how we could use
we are showing him how we could use quantum physics to wirelessly control
quantum physics to wirelessly control
quantum physics to wirelessly control molecules make them self assemble into
molecules make them self assemble into
molecules make them self assemble into perfect periodic shapes he was amazed
perfect periodic shapes he was amazed
perfect periodic shapes he was amazed and he said why don’t use if you experts
and he said why don’t use if you experts
and he said why don’t use if you experts in such powerful approach why don’t use
in such powerful approach why don’t use
in such powerful approach why don’t use this quantum physics to cure cancer
this quantum physics to cure cancer
this quantum physics to cure cancer instead of building better computer
instead of building better computer
instead of building better computer seems like a much more rewarding and
seems like a much more rewarding and
seems like a much more rewarding and noble goal to me it was an eye-opener
noble goal to me it was an eye-opener
noble goal to me it was an eye-opener soon after that visit we were relocating
soon after that visit we were relocating
soon after that visit we were relocating our lab of Electrical and Computer
our lab of Electrical and Computer
our lab of Electrical and Computer Engineering in the middle of the
Engineering in the middle of the
Engineering in the middle of the recently established medical school at
recently established medical school at
recently established medical school at Florida International University in
Florida International University in
Florida International University in Miami Florida that move was very
Miami Florida that move was very
Miami Florida that move was very important to us we immediately got a
important to us we immediately got a
important to us we immediately got a chance to work side by side with
chance to work side by side with
chance to work side by side with physicians medical researchers we could
physicians medical researchers we could
physicians medical researchers we could participate in and witness heart and
participate in and witness heart and
participate in and witness heart and brain surgeries every day and we
brain surgeries every day and we
brain surgeries every day and we actually could experience real medical
actually could experience real medical
actually could experience real medical problems firsthand that was very
problems firsthand that was very
problems firsthand that was very important to us I think that immediately
important to us I think that immediately
important to us I think that immediately distinguished us from all the other
distinguished us from all the other
distinguished us from all the other similar centers not nanomedicine centers
similar centers not nanomedicine centers
similar centers not nanomedicine centers in the country and across the globe
in the country and across the globe
in the country and across the globe all those other centers they focus on
all those other centers they focus on
all those other centers they focus on the traditional biotechnology approach
the traditional biotechnology approach
the traditional biotechnology approach to three diseases we could develop that
to three diseases we could develop that
to three diseases we could develop that new angle techno biology now go back to
new angle techno biology now go back to
new angle techno biology now go back to the problem
the problem
the problem to the challenge of techno biology so
to the challenge of techno biology so
to the challenge of techno biology so the techni biology approach is driven by
the techni biology approach is driven by
the techni biology approach is driven by the brain to be able to use it to kill
the brain to be able to use it to kill
the brain to be able to use it to kill to kill cancer zammis and so on we have
to kill cancer zammis and so on we have
to kill cancer zammis and so on we have to figure out how the brain works
to figure out how the brain works
to figure out how the brain works that that was a serious challenge the
that that was a serious challenge the
that that was a serious challenge the brain is made of approximately 80
brain is made of approximately 80
brain is made of approximately 80 billion neurons so you can save eighty
billion neurons so you can save eighty
billion neurons so you can save eighty billion parts and to understand how it
billion parts and to understand how it
billion parts and to understand how it works you enough
works you enough
works you enough as kids we all try to understand how the
as kids we all try to understand how the
as kids we all try to understand how the toys work and we reverse engineered it
toys work and we reverse engineered it
toys work and we reverse engineered it by taking the part of course you cannot
by taking the part of course you cannot
by taking the part of course you cannot do it to the brain and our brains if
do it to the brain and our brains if
do it to the brain and our brains if made of so many parts 80 billion neurons
made of so many parts 80 billion neurons
made of so many parts 80 billion neurons so we had to figure out how we can
so we had to figure out how we can
so we had to figure out how we can understand how the neurons communicate
understand how the neurons communicate
understand how the neurons communicate with each other
with each other
with each other that was a serious challenge because
that was a serious challenge because
that was a serious challenge because it’s well known that communication
it’s well known that communication
it’s well known that communication between neurons and the other cells in
between neurons and the other cells in
between neurons and the other cells in the Internet of the human body is driven
the Internet of the human body is driven
the Internet of the human body is driven by electric signals there are electric
by electric signals there are electric
by electric signals there are electric signals coming in and out from each
signals coming in and out from each
signals coming in and out from each neuron and there is no way to be able to
neuron and there is no way to be able to
neuron and there is no way to be able to see it in real-time to understand what
see it in real-time to understand what
see it in real-time to understand what actually happens in the brain so the
actually happens in the brain so the
actually happens in the brain so the only way you can do it by physically
only way you can do it by physically
only way you can do it by physically attaching context to all the 80 billion
attaching context to all the 80 billion
attaching context to all the 80 billion neurons in the brain of course you’re
neurons in the brain of course you’re
neurons in the brain of course you’re not going to have 80 billion wires
not going to have 80 billion wires
not going to have 80 billion wires coming from the brain the brain is not
coming from the brain the brain is not
coming from the brain the brain is not gonna work right so we had to figure out
gonna work right so we had to figure out
gonna work right so we had to figure out how to do it wirelessly that was very
how to do it wirelessly that was very
how to do it wirelessly that was very important to us our Eureka moment
important to us our Eureka moment
important to us our Eureka moment happened when we were working on our
happened when we were working on our
happened when we were working on our first task in the new medical setting we
first task in the new medical setting we
first task in the new medical setting we had to figure out how to deliver drugs
had to figure out how to deliver drugs
had to figure out how to deliver drugs inside so-called multi drug-resistant
inside so-called multi drug-resistant
inside so-called multi drug-resistant cancer cells multi-drug resistance is
cancer cells multi-drug resistance is
cancer cells multi-drug resistance is the property of cells to resist drugs
the property of cells to resist drugs
the property of cells to resist drugs right that’s designed by nature that’s
right that’s designed by nature that’s
right that’s designed by nature that’s the reason why chemotherapy it becomes
the reason why chemotherapy it becomes
the reason why chemotherapy it becomes quite ineffective after being used a few
quite ineffective after being used a few
quite ineffective after being used a few times and that’s the reason why by a
times and that’s the reason why by a
times and that’s the reason why by a technology approach which relies on
technology approach which relies on
technology approach which relies on finding certain antibodies which can
finding certain antibodies which can
finding certain antibodies which can target certain biomarker specific to a
target certain biomarker specific to a
target certain biomarker specific to a disease doesn’t work well
disease doesn’t work well
disease doesn’t work well with this multidrug-resistant cells so
with this multidrug-resistant cells so
with this multidrug-resistant cells so our claim was techni biology is more
our claim was techni biology is more
our claim was techni biology is more fundamental techni biology deals with
fundamental techni biology deals with
fundamental techni biology deals with laws of physics which underlie the
laws of physics which underlie the
laws of physics which underlie the principles of biology so and we got a
principles of biology so and we got a
principles of biology so and we got a chance to test it so in this experiment
chance to test it so in this experiment
chance to test it so in this experiment what we see is it’s we use the petri
what we see is it’s we use the petri
what we see is it’s we use the petri dish we put the media with this
dish we put the media with this
dish we put the media with this particular cell lines that
particular cell lines that
particular cell lines that multidrug-resistant cancer cell lines in
multidrug-resistant cancer cell lines in
multidrug-resistant cancer cell lines in the petri dish and with sprinkles
the petri dish and with sprinkles
the petri dish and with sprinkles sprinkled special nanoparticles in the
sprinkled special nanoparticles in the
sprinkled special nanoparticles in the media there’s no new particles are very
media there’s no new particles are very
media there’s no new particles are very special I’ll talk about them in a second
special I’ll talk about them in a second
special I’ll talk about them in a second I’ll give a heads up what they give us a
I’ll give a heads up what they give us a
I’ll give a heads up what they give us a chance to control electric fields
chance to control electric fields
chance to control electric fields wirelessly that’s very important because
wirelessly that’s very important because
wirelessly that’s very important because it’s well known that different cell
it’s well known that different cell
it’s well known that different cell lines have different electric properties
lines have different electric properties
lines have different electric properties you can actually distinguish cancer
you can actually distinguish cancer
you can actually distinguish cancer cells from not normal cells look looking
cells from not normal cells look looking
cells from not normal cells look looking at the electric properties and the
at the electric properties and the
at the electric properties and the biotechnology approach doesn’t really
biotechnology approach doesn’t really
biotechnology approach doesn’t really take advantage of it so what we did we
take advantage of it so what we did we
take advantage of it so what we did we use those nanoparticles to apply
use those nanoparticles to apply
use those nanoparticles to apply wirelessly special electric fields which
wirelessly special electric fields which
wirelessly special electric fields which perfectly match the properties of the
perfectly match the properties of the
perfectly match the properties of the cell lines and what you see right now in
cell lines and what you see right now in
cell lines and what you see right now in the images in the red circle you see
the images in the red circle you see
the images in the red circle you see that dish with cells before we applied
that dish with cells before we applied
that dish with cells before we applied Wireless to the fields and in the white
Wireless to the fields and in the white
Wireless to the fields and in the white circle you see the same exactly petri
circle you see the same exactly petri
circle you see the same exactly petri dish with the same exact cells after we
dish with the same exact cells after we
dish with the same exact cells after we applied the fields match to the property
applied the fields match to the property
applied the fields match to the property of the cells and the experiment was
of the cells and the experiment was
of the cells and the experiment was designed so that you actually see cells
designed so that you actually see cells
designed so that you actually see cells only when the nanoparticles are inside
only when the nanoparticles are inside
only when the nanoparticles are inside the cells now the particles were
the cells now the particles were
the cells now the particles were conjugated with a fluorescent agent
conjugated with a fluorescent agent
conjugated with a fluorescent agent which is activated when it’s inside the
which is activated when it’s inside the
which is activated when it’s inside the cell and you can clearly see in the red
cell and you can clearly see in the red
cell and you can clearly see in the red circle those little green circles there
circle those little green circles there
circle those little green circles there those are cells you immediately see
those are cells you immediately see
those are cells you immediately see cells and the bright spots inside each
cells and the bright spots inside each
cells and the bright spots inside each cells inside each cell is the nucleus
cells inside each cell is the nucleus
cells inside each cell is the nucleus cell nucleus so we’re confident yes the
cell nucleus so we’re confident yes the
cell nucleus so we’re confident yes the approach work
approach work
approach work we could do something with which could
we could do something with which could
we could do something with which could not be done with traditional
not be done with traditional
not be done with traditional biotechnology approach using antibodies
biotechnology approach using antibodies
biotechnology approach using antibodies and certain biomarkers and so on so we
and certain biomarkers and so on so we
and certain biomarkers and so on so we were excited and I’ll tell you what our
were excited and I’ll tell you what our
were excited and I’ll tell you what our what’s so special about this approach
what’s so special about this approach
what’s so special about this approach like any other nano particles in nano
like any other nano particles in nano
like any other nano particles in nano particles I used today in medicine
particles I used today in medicine
particles I used today in medicine everywhere that this they are very small
everywhere that this they are very small
everywhere that this they are very small the extreme is small the size varies
the extreme is small the size varies
the extreme is small the size varies from approximately 10 nanometers to over
from approximately 10 nanometers to over
from approximately 10 nanometers to over 50 nanometers and we tell it the size
50 nanometers and we tell it the size
50 nanometers and we tell it the size depending on the disease we want to
depending on the disease we want to
depending on the disease we want to treat cancer as Imus analysis so 10
treat cancer as Imus analysis so 10
treat cancer as Imus analysis so 10 nanometer nanoparticle is about five
nanometer nanoparticle is about five
nanometer nanoparticle is about five thousand times smaller than the
thousand times smaller than the
thousand times smaller than the thickness of the average human hair so
thickness of the average human hair so
thickness of the average human hair so this picture by the way well you see
this picture by the way well you see
this picture by the way well you see that red a white spot on the human hair
that red a white spot on the human hair
that red a white spot on the human hair is not to scale you know five thousand
is not to scale you know five thousand
is not to scale you know five thousand times is much smaller than that but
times is much smaller than that but
times is much smaller than that but what’s special about the nanoparticles
what’s special about the nanoparticles
what’s special about the nanoparticles we used is they’re called magnetic
we used is they’re called magnetic
we used is they’re called magnetic electron on a particles magnetic
electron on a particles magnetic
electron on a particles magnetic electrical property allows us to
electrical property allows us to
electrical property allows us to communicate with the cells wirelessly
communicate with the cells wirelessly
communicate with the cells wirelessly unlike any other nano particles these
unlike any other nano particles these
unlike any other nano particles these particles can sense two different fields
particles can sense two different fields
particles can sense two different fields electric and magnetic at the same time
electric and magnetic at the same time
electric and magnetic at the same time only recently the materials like this
only recently the materials like this
only recently the materials like this reinvented and we were the first group
reinvented and we were the first group
reinvented and we were the first group who implemented this in medical
who implemented this in medical
who implemented this in medical applications so what admission these
applications so what admission these
applications so what admission these nanoparticles can sense electric fields
nanoparticles can sense electric fields
nanoparticles can sense electric fields and electric fields as you know they’re
and electric fields as you know they’re
and electric fields as you know they’re generated by electric charges and at the
generated by electric charges and at the
generated by electric charges and at the same electric fields are important
same electric fields are important
same electric fields are important because the electric fields is the
because the electric fields is the
because the electric fields is the language which cells used to communicate
language which cells used to communicate
language which cells used to communicate with each other and at the same time
with each other and at the same time
with each other and at the same time they sense magnetic fields and magnetic
they sense magnetic fields and magnetic
they sense magnetic fields and magnetic fields is a language which can be used
fields is a language which can be used
fields is a language which can be used to by us the magnetic fields are no one
to by us the magnetic fields are no one
to by us the magnetic fields are no one not to interfere with a complex electric
not to interfere with a complex electric
not to interfere with a complex electric circuitry of the brain so they can be
circuitry of the brain so they can be
circuitry of the brain so they can be useful
useful
useful perfect wireless control by speaking
perfect wireless control by speaking
perfect wireless control by speaking these two languages at the same time
these two languages at the same time
these two languages at the same time these particles act as messengers which
these particles act as messengers which
these particles act as messengers which can translate for us the language
can translate for us the language
can translate for us the language intrinsic language of the cells of the
intrinsic language of the cells of the
intrinsic language of the cells of the neurons
neurons
neurons and allow us to see what actually
and allow us to see what actually
and allow us to see what actually happens with electric signals at the
happens with electric signals at the
happens with electric signals at the level of each neuron and we’re talking
level of each neuron and we’re talking
level of each neuron and we’re talking about 80 billion neurons here because
about 80 billion neurons here because
about 80 billion neurons here because particles are so small and so many of
particles are so small and so many of
particles are so small and so many of them and we can sit on the computer on
them and we can sit on the computer on
them and we can sit on the computer on the screen or computer and we can
the screen or computer and we can
the screen or computer and we can control them we can do them we can make
control them we can do them we can make
control them we can do them we can make them do anything we want so our first
them do anything we want so our first
them do anything we want so our first test we were on animal smash to treat
test we were on animal smash to treat
test we were on animal smash to treat actual diseases the first test was
actual diseases the first test was
actual diseases the first test was Parkinson’s disease and mice with
Parkinson’s disease and mice with
Parkinson’s disease and mice with Parkinson’s disease we we what we did we
Parkinson’s disease we we what we did we
Parkinson’s disease we we what we did we use these particles to recover
use these particles to recover
use these particles to recover electric signals in the brain wirelessly
electric signals in the brain wirelessly
electric signals in the brain wirelessly and we’re very successful doing this
and we’re very successful doing this
and we’re very successful doing this again these particles are extremely
again these particles are extremely
again these particles are extremely small they are made of materials which
small they are made of materials which
small they are made of materials which already approved by Federal Drug
already approved by Federal Drug
already approved by Federal Drug Administration’s they are very safe and
Administration’s they are very safe and
Administration’s they are very safe and because they provide us that in
because they provide us that in
because they provide us that in unprecedented wireless control we can
unprecedented wireless control we can
unprecedented wireless control we can bring them in and out of the body
bring them in and out of the body
bring them in and out of the body whenever we want so in this case what we
whenever we want so in this case what we
whenever we want so in this case what we do we administrate a nanoparticle
do we administrate a nanoparticle
do we administrate a nanoparticle intravenously
intravenously
intravenously so we give a painless one painless shot
so we give a painless one painless shot
so we give a painless one painless shot in our before the treatment the shot
in our before the treatment the shot
in our before the treatment the shot similar to the typical flu shot we all
similar to the typical flu shot we all
similar to the typical flu shot we all use in the and when the particles get in
use in the and when the particles get in
use in the and when the particles get in the blood system we can see them on the
the blood system we can see them on the
the blood system we can see them on the screen our computer we know where they
screen our computer we know where they
screen our computer we know where they are we can wirelessly make them go any
are we can wirelessly make them go any
are we can wirelessly make them go any way we want we can see the circuit in
way we want we can see the circuit in
way we want we can see the circuit in the brain we can zoom it in with the
the brain we can zoom it in with the
the brain we can zoom it in with the precision of one neuron if necessary and
precision of one neuron if necessary and
precision of one neuron if necessary and we can repair this circuit if not
we can repair this circuit if not
we can repair this circuit if not required and that’s exactly what we did
required and that’s exactly what we did
required and that’s exactly what we did and when the treatment is done in half
and when the treatment is done in half
and when the treatment is done in half an hour so we bring them back to the
an hour so we bring them back to the
an hour so we bring them back to the blood system and from which it naturally
blood system and from which it naturally
blood system and from which it naturally gets cleared optionally you can actually
gets cleared optionally you can actually
gets cleared optionally you can actually use administrative part ecause orally
use administrative part ecause orally
use administrative part ecause orally you can mix them in a glass of water
you can mix them in a glass of water
you can mix them in a glass of water drink it one hour before the treatment
drink it one hour before the treatment
drink it one hour before the treatment and the same thing happens we apply this
and the same thing happens we apply this
and the same thing happens we apply this technology to treat other diseases as
technology to treat other diseases as
technology to treat other diseases as well including cancers very successfully
well including cancers very successfully
well including cancers very successfully we published in
we published in
we published in number of papers scientific articles on
number of papers scientific articles on
number of papers scientific articles on this world and we were very happy when
this world and we were very happy when
this world and we were very happy when researchers from all over the world
researchers from all over the world
researchers from all over the world contacted us and they wanted to test
contacted us and they wanted to test
contacted us and they wanted to test them in four different diseases
them in four different diseases
them in four different diseases remember this approach is more
remember this approach is more
remember this approach is more fundamental than biotechnology approach
fundamental than biotechnology approach
fundamental than biotechnology approach so it can be used to any disease we know
so it can be used to any disease we know
so it can be used to any disease we know we just scratch the surface
we just scratch the surface
we just scratch the surface currently we work with many researchers
currently we work with many researchers
currently we work with many researchers in this country and worldwide to extend
in this country and worldwide to extend
in this country and worldwide to extend it to different cancers Alzheimer’s
it to different cancers Alzheimer’s
it to different cancers Alzheimer’s Parkinson’s ALS and other diseases and
Parkinson’s ALS and other diseases and
Parkinson’s ALS and other diseases and every day we’re getting closer to the
every day we’re getting closer to the
every day we’re getting closer to the ultimate goal to use it on people and we
ultimate goal to use it on people and we
ultimate goal to use it on people and we hope within a couple of years we can do
hope within a couple of years we can do
hope within a couple of years we can do that and help the society get rid of
that and help the society get rid of
that and help the society get rid of these devastating diseases thank you
these devastating diseases thank you
these devastating diseases thank you [Applause]
[Applause]
[Applause] [Music]
”
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