precursor of the slab is more than 11
eme qu’ulysse remains will see chrome then
you can believe me
today still the treatments
against aging remains pretty
medieval that said we will not spit
on some pals and at more levels
I was about twenty years
like some of you when I
executed
we were facing a convergence
technologies that could we
allow to slow down or even
to stop knotted hands decades to
come in and make us potentially
the first generation of humans a
mortal then notice that I say is
mortal and not immortal because the
aging or not we can not
prevent people from dying or even from
win to darwin to look forward to and stop at
our greatest eg the emperor
maximilian first of the dead love in
1519 at the rank of a hunting party a
indigestion of mollo we see well
aging at the bar will not be able
prevent means but this said I
finds that the idea of no longer having
expiry date is rather attractive
and that’s why I dedicated my life to
one thing give the choice given the choice
as soon as possible to the humanity of
to be able to live or mail each
individual to age or not
to get old
then I have given a long enough
on the school benches
I exceeded
but a good PhD student 6 and post
PhD student in biology
the cdh is ideal to stop led this
months ago and it was great that is
researcher to say that we have kept a soul
baby
the researchers that is to push back
the limits of science have day
drinks euro happiness
unfortunately for me from the very ceni
rezaï only to reach what I
wanted to do in life but that
was strictly for nothing redeemed in
public research
then I left everything behind for an even launched
in creative strands
innovative companies in the field
Biotechnology
ja is to tell you if I believe in my
topic imagine we will live a package
of years to swing ten years of studies
with dill
I was stuck because when I
executed
we could perhaps create the first
generation of words sapiens morten plus
nothing else made sense any paris
it’s insignificant even developed to our
iphone and yet never afraid towards I
always afraid and you should
probably deny being scared because
who knows tomorrow what humanity will do
of the power to modify the human genome
that 100% poignant today as
benefits will outweigh the risks
because if we look at it, it will depend on
decisions of our policies defeat them
in 40 years it will depend on the people who
vote for them it partly depends on us
I do not know you suddenly it myself
scared
you have understood the I nevertheless made
my choice why because it’s
today in the laboratories of
search that is decided otherwise 20 30 or
40 years old people will be able to choose from
grow old do not read there and I decided to
do not send him this freedom then
luckily for me and for you too
because it would not be before it’s
well soon I realized that I was not
alone there was a real
world revolution in the field of
the fight against aging
have you ever wondered for example
why google invested 1.5 billion
of dollars for I quote kill death and
stop from the human ismans or why
mark zuckerberg the founder of facebook
said this year invest 3
billion dollars too but he for
eradicate all human diseases
by the end of the century
and above all what can do them
think that their investments are
profitable in the coming decades
I let you think about it not a
little if we look closely at the expectation of
books of humanity did not really move
in the last 48 years the
flat calm if not during the 150
last years where all of a sudden we
went on to win six hours
life expectancy every 24 hours
so for the revelers hexagon the
quilt understand that it’s a
weekend to win every week
I seize in parallel there is something that
did not move an iota
it is the longevity of the human species
that is the maximum age that can
to reach an individual we stayed
taped to 101 years and more remarkable
is that this expiry date was
marked in the Gospels
I quote that my mind is not
indefinitely and conducted in the noticed
the little baritone voice when I
take the place I ‘m giving you
notice how expensive his life is
will be more than 120 years old genesis chapter
6 verse 3 so I can tell you I
was not impressed by the old
testament to all the pages but there I
do not know how he’s milling is
impressive and the question that
pose today is to know what
that they mainly limit
the life expectancy of humanity and its
longevity and honda see us this is the
aging
a kind of genetic program
of self-destruction present in everyone
of you buddhism en route to
around 20 years and leads to a death
the some hundreds of years after the
feels a tank is also the year
20 years old you have a chance in a thousand
to die for good handbags or
bad news
it’s already watching you know it’s
mainly from this one of diseases
infectious this accident but me this
that I draw from it is that in the absence of
aging
the life expectancy of an average French
would be from Milan and if we look at that
walk the same for all animals
almost all the animals we need and
a mouse or a man from a
certain age at the chances of dying in
the year exponentially increases for
the man from 20 years old your chances
to die in the year
double every seven years you can me
believe it goes up fast and a child
it was for homo sapiens 1.0 we are here
to see that this
of exchanged and besides it exists on
land of species that seems not
to age at all is the case of the fox
it is not too heavy
and besides how am I here a
Surprising it’s my side proselyte
I call on the entire community
scientist to revive
clam research is all these
little years to make sure
understand the secrets their longevity and
especially their ticket everything that works
the spaghetti dish nerves it’s all
things that can kill you and
chances she gets there every year
become so I know that’s a lot
what can we notice these
exams she’s increasing pretty much from
the same way with NATO – almost
all
the good news is that I studied
precisely this list and assist a
ted with me does not belong woods
and in Peru for the next 15
minutes when you are with me or you
are safe
the second thing we can learn
this dish of spaghetti is that from
of a certain age if one eradicates a
sickness class an ode will take
immediately relay
for example if we eradicate and
all cancers in
the entirety of humanity hope
of human life would increase by 3.5
years it’s sad but like them and
Kennedy, you must not let yourself be defeated
and if like me you want to increase
drastically the life expectancy of
mankind
just do not treat them
consequences but tackle the causes
so even if you tell me she got
found small that at the age of 20 to
to die of cancer or alzheimer
it’s still pretty statistics
insignificant when we look at all
these diseases all economist at the iese and
increased over time we say
that there is a cause
so pale to all these diseases the time that
happening aging is so the
question that arises for me
today does not revolve around the dish
of this name the question that arises for
me is whether humanity has
technological tools that could
allow us to reprogram this
genetic program of self-destruction
in the coming decades
and the good news is that the
ongoing revolution in the field of
Biotechnology No. 2 for the first
times in the history of humanity
Serious chances to slow down
even to stop life you have to
understand that medicine to advance
faster in a century than during
the whole history of humanity meeting
and it’s even more true in the twenty
last years
today it is almost impossible
for a doctor installed same day in
his specialty besides while we
is there between us if someday you have
a serious illness
I invite you to choose your doctor
and acts the mans like you
choose your hairdresser if you want
that it ends well
I read is the good he joins our sheep
let’s discover together that the future
we reserve its fabulous optelio
technology in the first thing to
do when they are scheduled and a
genetic code
stop ismans is to identify
the genes responsible for aging
and that’s where August 1st comes in and
the technology one
the big data genetic the possibility of
sequences and his 5 billion lire on
genome of individuals
after bach or the sequencing pull the
first genome in 2003 sequencing
of a human genome
its cost has been divided by almost 3
millions today
we can sequence his genome for less
of 1000 euros and the millions of
people like me did it and that’s
reading these millions of young people
couples and an artificial intelligence
adequate that will allow us to do the
link between each gene each disease and
the life expectancy of each patient
you will come to know the genes
it’s good but you have to
to modify them
that’s where the second tool comes in
biotechnology therapies
gene therapy roughly a therapy
gene is to modify the genome
of a patient by inserting a gene to
the internee without the dom
for example if you have an illness
genetics like sickle cell disease by
example a gene therapy will come
inactivated the gene responsible for the
sickle cell disease and replace it with a
gene that works the result in the end
is that you will not have the
sickle cell disease huacana passionate
crowds
however, I’m sure it’s you who
has one by the gene therapies the
day for example we discovered that
I love hangover
we’ll talk again but some of them
Can you tell me nine years ago
but gene therapies exist
since the early eighties so yes
but at the time we have a big problem
that we could not control where
we inserted the new gene whose
genome of the patient and that in terms of
result check it was
catastrophic
it’s a bit like putting a word randomly
in a sentence it can make sense but
it’s a hell of a coup there it’s
the same when we place a gene at random
so I like swimming and this area has
experienced a real revolution in 2002
with the discovery of crisis by box
only happens to the golden words a
technology that allows us to edit
the gene we want right alan
we want danger then appointment of
my point of view chrysler cal lane en
the state will not be enough on its own for
drink stop aging but this
field advances at a tremendous speed
five years later there are already more than 2000
gene therapy during tests
clinics mainly from elsewhere for
cure cancer
it’s one more time than one
antibiotics yet our clinical tests
it’s a real tidal wave and its
little pikes of the dynamics of the
bio tech revolution sam at a speed
not possible we already have our
tools that could allow us
to a certain extent to slow down the
said
but that said it would be good
to avoid repeating the mistakes do
consistently in the past when
we find foul a great
discovered at the beginning of the 20th century by
example when I discovered the
radioactivity two decades ago
we were convinced that this energy
magic chicken heal everything and I am
go get some small ones
vintage feathers to go black we saw
go out on the soda market
radioactive gives infinite energy
like the atomic pile or that famous
suppository to makeup put the
male power
I think the pinnacle has been reached
with self heating woolen vests
for baby should have been a day assured
the fashion is past but we can see well
see who will be needed for
avoid these pitfalls of being able to test
quickly and efficiently all
experimental treatments against
aging
and that’s where the third comes in
tool derived from the huge technology
when more then rest assured of papal
cultivating miniature beings on
small lowest gargamel not wear
smurfs in the urine circus
hesitate to reproduce most faithfully
possible the operation of a
human organism by making cultures
human cells on small
microphone chips such as cis
gave also knew a huge boom
with the discovered a few years ago
good ten years besides
induced pluripotent stem cells
roughly a technology that we
allows to take skin cells
of a patient and transform them into
base cells any of its
organs liver lung heart brain and a
once intelligently organized these
human cell cultures formed
multi-program on human chip on
more and it’s them who
will test quickly
effectively the treatments so the
aging by limiting as much as possible
tests on human subjects and on
food I could not help you
tell me it’s still more
effective and especially faster test
an experimental treatment on someone
and we watched the result 70 years
after that are slips
but where humans on more will be
primordial it’s probably going to
have to change dozens or even
hundreds of genes at ja same patient
have completely stopped his
aging and that acquired a
crucial interruptions to test the
millions of therapy combinations
which will be needed for
find the most effective
so we see we have three tools
from biotechnology that could
allow us in the decades to
come
the idle and see of stopped actions
the bide to genetics to identify
the genes responsible aging
gene therapies to change the
patient’s genome accordingly and the
humans on a chip to test
millions of therapy combinations
gene needed to find the take
optima then you will tell me for the
most of you I imagine the subject
a little new just a little
open-minded
having said that I am formal opening
of mind is not a fracture of the skull
and so is not part of our dish
of spaghetti you can
interesting about it you do not risk
nothing I think some of you
may have already been in the lead the answer to
the question we were asking at the beginning of
this presentation
what is it that google and so much
Silicon valley companies
invest billions for a
establishment m
and well just because they think
that they are going to get there and who thinks that
people will be unpaid loans dear will have
you want the fastest
if he gave this choice humanity is not
not obliged otherwise he is not
necessary to invest billions
euros simply to interest you
topics to talk about around you and to
force to hear around them the
politicians will understand that
this subject interests the population because
that you have to understand
that today almost all
budgets are in the water and treating the
consequences of aging alzheimer
cancers infarctions
if we were going to be just one
thousandth of the sums used for
consequences but this time for
treat the causes aging
we would have a world-wide
budget night illiards euros parra and
I am convinced that with such a budget
everything will become possible including me
gave the joy of seeing you all here
in full health in 3 min 17
[Applause]
”
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