well thank you Angus are you know it’s really my great pleasure to be a more
really my great pleasure to be a more
really my great pleasure to be a more fantastic talks we’ve heard today it’s
fantastic talks we’ve heard today it’s
fantastic talks we’ve heard today it’s kind of hard to follow the last one
kind of hard to follow the last one
kind of hard to follow the last one everyone’s tired home so I I thought for
everyone’s tired home so I I thought for
everyone’s tired home so I I thought for my talk I would try and be as enormous
my talk I would try and be as enormous
my talk I would try and be as enormous ly+ as I could and I want to talk about
ly+ as I could and I want to talk about
ly+ as I could and I want to talk about biotechnology and I want to show you
biotechnology and I want to show you
biotechnology and I want to show you that we are living in a golden age where
that we are living in a golden age where
that we are living in a golden age where everything is really really good it’s
everything is really really good it’s
everything is really really good it’s fantastic and I want to teach you Krusty
fantastic and I want to teach you Krusty
fantastic and I want to teach you Krusty academic I want to teach you something
academic I want to teach you something
academic I want to teach you something about well teach you something about
about well teach you something about
about well teach you something about biotechnology so you appreciate how
biotechnology so you appreciate how
biotechnology so you appreciate how important it is for your life and we
important it is for your life and we
important it is for your life and we talked about future proofing the reason
talked about future proofing the reason
talked about future proofing the reason we’re in this amazing position is
we’re in this amazing position is
we’re in this amazing position is because we’re standing on the back of 50
because we’re standing on the back of 50
because we’re standing on the back of 50 a hundred hundred now 150 years of
a hundred hundred now 150 years of
a hundred hundred now 150 years of outstanding scientific research which
outstanding scientific research which
outstanding scientific research which has now come to fruition and put our
has now come to fruition and put our
has now come to fruition and put our society in this amazing position okay so
society in this amazing position okay so
society in this amazing position okay so when I started thinking about this talk
when I started thinking about this talk
when I started thinking about this talk I guess I thought about you know
I guess I thought about you know
I guess I thought about you know everyone always says you know we don’t
everyone always says you know we don’t
everyone always says you know we don’t make anything anymore we need to make
make anything anymore we need to make
make anything anymore we need to make stuff you know we speak white
stuff you know we speak white
stuff you know we speak white manufacturing economy let’s stop making
manufacturing economy let’s stop making
manufacturing economy let’s stop making stuff again we make loads of stuff we
stuff again we make loads of stuff we
stuff again we make loads of stuff we make brilliant stuff but make stuff like
make brilliant stuff but make stuff like
make brilliant stuff but make stuff like planes and things we go into space and
planes and things we go into space and
planes and things we go into space and you know energy and we’re in
you know energy and we’re in
you know energy and we’re in construction we’re doing all these
construction we’re doing all these
construction we’re doing all these amazing things and they’re high-tech
amazing things and they’re high-tech
amazing things and they’re high-tech industries I guess you could call them
industries I guess you could call them
industries I guess you could call them that we make a lot of stuff and we can
that we make a lot of stuff and we can
that we make a lot of stuff and we can do really really well the stuff I’ve
do really really well the stuff I’ve
do really really well the stuff I’ve highlighted there I guess is where
highlighted there I guess is where
highlighted there I guess is where biotechnology actually is really
biotechnology actually is really
biotechnology actually is really important and really underpinning I’m
important and really underpinning I’m
important and really underpinning I’m not construction up there I put that one
not construction up there I put that one
not construction up there I put that one in a bit cheeky simply because we have
in a bit cheeky simply because we have
in a bit cheeky simply because we have research going on the University of Bath
research going on the University of Bath
research going on the University of Bath with colleagues of mine who are working
with colleagues of mine who are working
with colleagues of mine who are working on self-healing concrete so there you
on self-healing concrete so there you
on self-healing concrete so there you guys it’s all going on but really I
guys it’s all going on but really I
guys it’s all going on but really I think the interesting thing about
think the interesting thing about
think the interesting thing about biotechnology is that it’s so powerful
biotechnology is that it’s so powerful
biotechnology is that it’s so powerful is so sustainable it’s kind of easy to
is so sustainable it’s kind of easy to
is so sustainable it’s kind of easy to do it makes this really adaptable to the
do it makes this really adaptable to the
do it makes this really adaptable to the future and it’s kind of future proofing
future and it’s kind of future proofing
future and it’s kind of future proofing us right now I guess you know like I
us right now I guess you know like I
us right now I guess you know like I said I can’t resist an opportunity to
said I can’t resist an opportunity to
said I can’t resist an opportunity to teach something and
teach something and
teach something and when I talk about biotechnology I guess
when I talk about biotechnology I guess
when I talk about biotechnology I guess those of us of a certain age will think
those of us of a certain age will think
those of us of a certain age will think maybe of genetic modification of crops
maybe of genetic modification of crops
maybe of genetic modification of crops and of plants and that’s been going on
and of plants and that’s been going on
and of plants and that’s been going on for a very long time now it’s been
for a very long time now it’s been
for a very long time now it’s been really successful for breeding in
really successful for breeding in
really successful for breeding in drought tolerance or higher yields
drought tolerance or higher yields
drought tolerance or higher yields so actually we can start to feed the
so actually we can start to feed the
so actually we can start to feed the world it’s really important endeavor and
world it’s really important endeavor and
world it’s really important endeavor and it’s really safe and sometimes it’s
it’s really safe and sometimes it’s
it’s really safe and sometimes it’s really really good with appropriate
really really good with appropriate
really really good with appropriate caveats
caveats
caveats well not talk about biotechnology all
well not talk about biotechnology all
well not talk about biotechnology all when I think about making stuff okay and
when I think about making stuff okay and
when I think about making stuff okay and when we make things in the biotechnology
when we make things in the biotechnology
when we make things in the biotechnology well we actually look to biology how we
well we actually look to biology how we
well we actually look to biology how we can do that we look to cells to make
can do that we look to cells to make
can do that we look to cells to make things so cells are really good at
things so cells are really good at
things so cells are really good at making things they’re really good at
making things they’re really good at
making things they’re really good at making chemistry okay things like drugs
making chemistry okay things like drugs
making chemistry okay things like drugs we use them all the time to make things
we use them all the time to make things
we use them all the time to make things like drugs they’re really good at making
like drugs they’re really good at making
like drugs they’re really good at making proteins and Angus alluded to this
proteins and Angus alluded to this
proteins and Angus alluded to this proteins make up pretty much all of your
proteins make up pretty much all of your
proteins make up pretty much all of your body and they do all of the jobs and
body and they do all of the jobs and
body and they do all of the jobs and they can be like little molecular
they can be like little molecular
they can be like little molecular machines that do stuff so cells are a
machines that do stuff so cells are a
machines that do stuff so cells are a bit like a factory if you want to make
bit like a factory if you want to make
bit like a factory if you want to make something in a factory about normal
something in a factory about normal
something in a factory about normal Factory on the left you have a control
Factory on the left you have a control
Factory on the left you have a control center that’s kind of like the DNA in
center that’s kind of like the DNA in
center that’s kind of like the DNA in your cells that controls everything you
your cells that controls everything you
your cells that controls everything you have a production line there’s machinery
have a production line there’s machinery
have a production line there’s machinery in the cell that produces the chemicals
in the cell that produces the chemicals
in the cell that produces the chemicals and the proteins that we want to use and
and the proteins that we want to use and
and the proteins that we want to use and then you have all your waste management
then you have all your waste management
then you have all your waste management and cells do that and they’re very
and cells do that and they’re very
and cells do that and they’re very efficient and recycling what’s in them
efficient and recycling what’s in them
efficient and recycling what’s in them so it’s really sustainable kind of
so it’s really sustainable kind of
so it’s really sustainable kind of technology biotechnology I guess I think
technology biotechnology I guess I think
technology biotechnology I guess I think it’s important to get a sense of scale
it’s important to get a sense of scale
it’s important to get a sense of scale angers can swing into action and click
angers can swing into action and click
angers can swing into action and click that for me it’s important to get a
that for me it’s important to get a
that for me it’s important to get a sense of scale for me to impress you I’m
sense of scale for me to impress you I’m
sense of scale for me to impress you I’m going to impress you I want to other
going to impress you I want to other
going to impress you I want to other things great will impress you so if we
things great will impress you so if we
things great will impress you so if we think about the scale of what we’ve got
think about the scale of what we’ve got
think about the scale of what we’ve got we’ve got things up here like coffee
we’ve got things up here like coffee
we’ve got things up here like coffee beans and grains of rice and even sesame
beans and grains of rice and even sesame
beans and grains of rice and even sesame seeds amazing so we can zoom in we won’t
seeds amazing so we can zoom in we won’t
seeds amazing so we can zoom in we won’t wear our there we go and if we zoom in
wear our there we go and if we zoom in
wear our there we go and if we zoom in we can see what the scale of things
we can see what the scale of things
we can see what the scale of things we’re talking about so we’ve got grains
we’re talking about so we’ve got grains
we’re talking about so we’ve got grains of salt right in the middle of there we
of salt right in the middle of there we
of salt right in the middle of there we kind of got cells so cells are kind of
kind of got cells so cells are kind of
kind of got cells so cells are kind of small maybe really big one so the size
small maybe really big one so the size
small maybe really big one so the size of a grain of salt human eggs are huge
of a grain of salt human eggs are huge
of a grain of salt human eggs are huge they’re really really big ok if you zoom
they’re really really big ok if you zoom
they’re really really big ok if you zoom in even more skin cells red blood cells
in even more skin cells red blood cells
in even more skin cells red blood cells they’re kind of normally sizes remember
they’re kind of normally sizes remember
they’re kind of normally sizes remember this is much smaller than a grain of
this is much smaller than a grain of
this is much smaller than a grain of salt now even more we got things like
salt now even more we got things like
salt now even more we got things like and bacteria yeasts and bacteria are the
and bacteria yeasts and bacteria are the
and bacteria yeasts and bacteria are the workhorses the cells were used to make
workhorses the cells were used to make
workhorses the cells were used to make the chemistry and the proteins that we
the chemistry and the proteins that we
the chemistry and the proteins that we actually care about if we zoom in even
actually care about if we zoom in even
actually care about if we zoom in even more discus sense a scale we’ve got
more discus sense a scale we’ve got
more discus sense a scale we’ve got viruses viruses are really small which
viruses viruses are really small which
viruses viruses are really small which makes them so nasty and hard to deal
makes them so nasty and hard to deal
makes them so nasty and hard to deal with and now if we get to this point
with and now if we get to this point
with and now if we get to this point we’ve got the stuff really it’s inside
we’ve got the stuff really it’s inside
we’ve got the stuff really it’s inside cells proteins and small molecules bits
cells proteins and small molecules bits
cells proteins and small molecules bits of chemistry how small is that well if
of chemistry how small is that well if
of chemistry how small is that well if we zoom in even more from that we can
we zoom in even more from that we can
we zoom in even more from that we can see right in the middle the scale of
see right in the middle the scale of
see right in the middle the scale of atoms so right in the center that dot
atoms so right in the center that dot
atoms so right in the center that dot that is a carbon atom that’s a smallest
that is a carbon atom that’s a smallest
that is a carbon atom that’s a smallest thing you can get yeah and that’s kind
thing you can get yeah and that’s kind
thing you can get yeah and that’s kind of how big proteins are that’s kind of
of how big proteins are that’s kind of
of how big proteins are that’s kind of how big the scale we’re talking about
how big the scale we’re talking about
how big the scale we’re talking about really Micro but really powerful
really Micro but really powerful
really Micro but really powerful technology what is biotechnology let me
technology what is biotechnology let me
technology what is biotechnology let me impress you me tell you how great is
impress you me tell you how great is
impress you me tell you how great is this washing powder you have proteins
this washing powder you have proteins
this washing powder you have proteins called enzymes in your washing powder
called enzymes in your washing powder
called enzymes in your washing powder which are little molecular machines
which are little molecular machines
which are little molecular machines there’s one of my machines moving this
there’s one of my machines moving this
there’s one of my machines moving this where my students made that and they
where my students made that and they
where my students made that and they chomp away all the food and they break
chomp away all the food and they break
chomp away all the food and they break down with the fats and the food and the
down with the fats and the food and the
down with the fats and the food and the blood and whatever else you got in your
blood and whatever else you got in your
blood and whatever else you got in your clothes and they do a great job of
clothes and they do a great job of
clothes and they do a great job of cleaning your clothes we make things we
cleaning your clothes we make things we
cleaning your clothes we make things we got here penicillin here we go got
got here penicillin here we go got
got here penicillin here we go got Peniston that’s kind of important like
Peniston that’s kind of important like
Peniston that’s kind of important like that that’s made by biotechnology that’s
that that’s made by biotechnology that’s
that that’s made by biotechnology that’s old technology now but antibacterials
old technology now but antibacterials
old technology now but antibacterials we’re all pretty much here because of
we’re all pretty much here because of
we’re all pretty much here because of them here we’ve got antibodies we’re
them here we’ve got antibodies we’re
them here we’ve got antibodies we’re going to come back to antibodies they’re
going to come back to antibodies they’re
going to come back to antibodies they’re kind of protein that cells make a really
kind of protein that cells make a really
kind of protein that cells make a really important what about beer
important what about beer
important what about beer everyone likes beer alcohol we’ve been
everyone likes beer alcohol we’ve been
everyone likes beer alcohol we’ve been making alcohol by biotechnology for
making alcohol by biotechnology for
making alcohol by biotechnology for thousands of years brewers yeast they
thousands of years brewers yeast they
thousands of years brewers yeast they for thousands of years alcohol fine you
for thousands of years alcohol fine you
for thousands of years alcohol fine you can put it in beer what about in fuel
can put it in beer what about in fuel
can put it in beer what about in fuel it’s an amazing fuel ten percent of your
it’s an amazing fuel ten percent of your
it’s an amazing fuel ten percent of your fuel now has to have been made by
fuel now has to have been made by
fuel now has to have been made by ethanol okay and that’s made by yeast –
ethanol okay and that’s made by yeast –
ethanol okay and that’s made by yeast – biotechnology it’s really sustainable
biotechnology it’s really sustainable
biotechnology it’s really sustainable it’s really really good it’s not all
it’s really really good it’s not all
it’s really really good it’s not all about things we can make it’s about
about things we can make it’s about
about things we can make it’s about sensing these molecules as well glucose
sensing these molecules as well glucose
sensing these molecules as well glucose if you’re diabetic you have to monitor
if you’re diabetic you have to monitor
if you’re diabetic you have to monitor your glucose very very carefully and
your glucose very very carefully and
your glucose very very carefully and we’ve got bio technologies we’ve got
we’ve got bio technologies we’ve got
we’ve got bio technologies we’ve got technologies for monitoring blood
technologies for monitoring blood
technologies for monitoring blood glucose level all of these things I
glucose level all of these things I
glucose level all of these things I think you’ll agree with me are kind of
think you’ll agree with me are kind of
think you’ll agree with me are kind of amazing and we kind of said them for
amazing and we kind of said them for
amazing and we kind of said them for granted but they pushed their bio
granted but they pushed their bio
granted but they pushed their bio technologies that are built on a long
technologies that are built on a long
technologies that are built on a long history of future-proofing to give us
history of future-proofing to give us
history of future-proofing to give us kind of an amazing society an amazing
kind of an amazing society an amazing
kind of an amazing society an amazing healthy productive society
healthy productive society
healthy productive society I want to talk about now antibodies
I want to talk about now antibodies
I want to talk about now antibodies antibodies are amazingly amazingly
antibodies are amazingly amazingly
antibodies are amazingly amazingly amazing they’re really new we’ve got
amazing they’re really new we’ve got
amazing they’re really new we’ve got antibodies in our body and they protect
antibodies in our body and they protect
antibodies in our body and they protect your body from infection we’re now using
your body from infection we’re now using
your body from infection we’re now using them as drugs they’re really good at
them as drugs they’re really good at
them as drugs they’re really good at finding specific cells in your body so
finding specific cells in your body so
finding specific cells in your body so what you can do is put a drug molecule
what you can do is put a drug molecule
what you can do is put a drug molecule it’s Hatchett to your antibody and it
it’s Hatchett to your antibody and it
it’s Hatchett to your antibody and it will find just the right cells to
will find just the right cells to
will find just the right cells to deliver the drug to and they’re called
deliver the drug to and they’re called
deliver the drug to and they’re called therapeutic antibodies and there’s some
therapeutic antibodies and there’s some
therapeutic antibodies and there’s some of the biggest now they are the biggest
of the biggest now they are the biggest
of the biggest now they are the biggest drugs in the whole world and they’re
drugs in the whole world and they’re
drugs in the whole world and they’re relatively new and they’re so important
relatively new and they’re so important
relatively new and they’re so important and they’re so amazing and they’re such
and they’re so amazing and they’re such
and they’re so amazing and they’re such good drugs that by 2020 we did a bit of
good drugs that by 2020 we did a bit of
good drugs that by 2020 we did a bit of work I had say in conjunction with the
work I had say in conjunction with the
work I had say in conjunction with the Iuh in bath they helped us a lot we’ve
Iuh in bath they helped us a lot we’ve
Iuh in bath they helped us a lot we’ve worked out that by 2020 the NHS will be
worked out that by 2020 the NHS will be
worked out that by 2020 the NHS will be spending 2% of its total budget on
spending 2% of its total budget on
spending 2% of its total budget on antibodies for therapeutic purposes even
antibodies for therapeutic purposes even
antibodies for therapeutic purposes even more money in America even more money in
more money in America even more money in
more money in America even more money in China so developed economies are going
China so developed economies are going
China so developed economies are going crazy on these things because they’re
crazy on these things because they’re
crazy on these things because they’re keeping us all alive they’re curing us
keeping us all alive they’re curing us
keeping us all alive they’re curing us from cancer and sorting out our
from cancer and sorting out our
from cancer and sorting out our arthritis they’re really kind of wonder
arthritis they’re really kind of wonder
arthritis they’re really kind of wonder drugs in many respects I guess
drugs in many respects I guess
drugs in many respects I guess antibodies and the challenge with them
antibodies and the challenge with them
antibodies and the challenge with them is that ok take care of suitable aspirin
is that ok take care of suitable aspirin
is that ok take care of suitable aspirin it’s in your bedside table it’s there
it’s in your bedside table it’s there
it’s in your bedside table it’s there for years gosh you don’t want out the
for years gosh you don’t want out the
for years gosh you don’t want out the other day that’s I don’t know how long
other day that’s I don’t know how long
other day that’s I don’t know how long and it will just solve the problem it
and it will just solve the problem it
and it will just solve the problem it will work the way it was meant to work
will work the way it was meant to work
will work the way it was meant to work years down the line antibodies are
years down the line antibodies are
years down the line antibodies are proteins and they’re kind of floppy and
proteins and they’re kind of floppy and
proteins and they’re kind of floppy and floppy proteins are really unstable what
floppy proteins are really unstable what
floppy proteins are really unstable what that means is they tend to break down
that means is they tend to break down
that means is they tend to break down and degrade but when antibodies break
and degrade but when antibodies break
and degrade but when antibodies break down or degrade they aggregate and they
down or degrade they aggregate and they
down or degrade they aggregate and they clump together and in proteins that’s
clump together and in proteins that’s
clump together and in proteins that’s kind of you’re familiar with that when
kind of you’re familiar with that when
kind of you’re familiar with that when you have an egg it’s translucent and
you have an egg it’s translucent and
you have an egg it’s translucent and when you cook it it goes all the pake
when you cook it it goes all the pake
when you cook it it goes all the pake and that’s the proteins in the egg
and that’s the proteins in the egg
and that’s the proteins in the egg because it’s really protein rich
because it’s really protein rich
because it’s really protein rich aggregating together now with antibodies
aggregating together now with antibodies
aggregating together now with antibodies actually if they start to aggregate even
actually if they start to aggregate even
actually if they start to aggregate even a little bit they become really toxic so
a little bit they become really toxic so
a little bit they become really toxic so these amazing drugs which are really
these amazing drugs which are really
these amazing drugs which are really really good become toxic if they are
really good become toxic if they are
really good become toxic if they are mishandled this is not a problem you
mishandled this is not a problem you
mishandled this is not a problem you don’t need to worry in developed
don’t need to worry in developed
don’t need to worry in developed countries you’ve got the factory over
countries you’ve got the factory over
countries you’ve got the factory over here we’ve got the truck that’s got a
here we’ve got the truck that’s got a
here we’ve got the truck that’s got a fridge in it just keep it cold it will
fridge in it just keep it cold it will
fridge in it just keep it cold it will be fine and the truck with the fridge in
be fine and the truck with the fridge in
be fine and the truck with the fridge in goes to the hospital and they’ve got a
goes to the hospital and they’ve got a
goes to the hospital and they’ve got a fridge too and that works really well
fridge too and that works really well
fridge too and that works really well and it goes into the fridge and then
and it goes into the fridge and then
and it goes into the fridge and then goes up to the patient and it gets
goes up to the patient and it gets
goes up to the patient and it gets administered and we know exactly when
administered and we know exactly when
administered and we know exactly when it’s getting can I go from here and it’s
it’s getting can I go from here and it’s
it’s getting can I go from here and it’s going to get up to the patient so it’s
going to get up to the patient so it’s
going to get up to the patient so it’s completely safe completely safe and the
completely safe completely safe and the
completely safe completely safe and the fantastic drugs we’re lucky what a time
fantastic drugs we’re lucky what a time
fantastic drugs we’re lucky what a time to live in I really promise you these
to live in I really promise you these
to live in I really promise you these are great drugs what about if you’ve no
are great drugs what about if you’ve no
are great drugs what about if you’ve no idea how long it will take you to get
idea how long it will take you to get
idea how long it will take you to get from here and to the patient what about
from here and to the patient what about
from here and to the patient what about if you don’t have a fridge or your
if you don’t have a fridge or your
if you don’t have a fridge or your powers so intermittent that the fridge
powers so intermittent that the fridge
powers so intermittent that the fridge only sometimes works how can you
only sometimes works how can you
only sometimes works how can you guarantee that when you administer that
guarantee that when you administer that
guarantee that when you administer that drug it won’t kill the person
therapeutic antibodies which are one the
therapeutic antibodies which are one the drugs are hardly used outside of the
drugs are hardly used outside of the
drugs are hardly used outside of the developing world of the developed world
developing world of the developed world
developing world of the developed world hardly used at all and there are a bunch
hardly used at all and there are a bunch
hardly used at all and there are a bunch of reasons for that
of reasons for that
of reasons for that one of those reasons is because they are
one of those reasons is because they are
one of those reasons is because they are so relatively unstable compared to
so relatively unstable compared to
so relatively unstable compared to paracetamol than aspirin you cannot
paracetamol than aspirin you cannot
paracetamol than aspirin you cannot guarantee that the drug that you hopes
guarantee that the drug that you hopes
guarantee that the drug that you hopes to deliver on day X or get there on day
to deliver on day X or get there on day
to deliver on day X or get there on day wrecks all that it would have been cold
wrecks all that it would have been cold
wrecks all that it would have been cold all the time and so you can’t administer
all the time and so you can’t administer
all the time and so you can’t administer it you don’t know if it will be safe we
it you don’t know if it will be safe we
it you don’t know if it will be safe we have great partners in Kenya peace of
have great partners in Kenya peace of
have great partners in Kenya peace of Korea and Francis macoco from Mount
Korea and Francis macoco from Mount
Korea and Francis macoco from Mount Kenya University and we’re trying to
Kenya University and we’re trying to
Kenya University and we’re trying to think about this problem with so here’s
think about this problem with so here’s
think about this problem with so here’s Kenya and Kenya has got an interesting
Kenya and Kenya has got an interesting
Kenya and Kenya has got an interesting problem because there’s no Roby in the
problem because there’s no Roby in the
problem because there’s no Roby in the middle and it’s got a bunch of hospitals
middle and it’s got a bunch of hospitals
middle and it’s got a bunch of hospitals all the people kind of don’t live there
all the people kind of don’t live there
all the people kind of don’t live there they live all over the country and some
they live all over the country and some
they live all over the country and some people live more than a thousand
people live more than a thousand
people live more than a thousand kilometres from a hospital so that’s the
kilometres from a hospital so that’s the
kilometres from a hospital so that’s the kind of scale of problem they’re facing
kind of scale of problem they’re facing
kind of scale of problem they’re facing so they can’t just nip to the hospital
so they can’t just nip to the hospital
so they can’t just nip to the hospital to get their treatment really you have
to get their treatment really you have
to get their treatment really you have to have local treatment but that’s a
to have local treatment but that’s a
to have local treatment but that’s a problem for antibodies because this is
problem for antibodies because this is
problem for antibodies because this is going to degrade in the back of the
going to degrade in the back of the
going to degrade in the back of the truck we did some work with Maria Vitara
truck we did some work with Maria Vitara
truck we did some work with Maria Vitara she’s in the school of management and
she’s in the school of management and
she’s in the school of management and she thought well what if we just put
she thought well what if we just put
she thought well what if we just put hospitals in more locations can we solve
hospitals in more locations can we solve
hospitals in more locations can we solve the problem of getting people to a
the problem of getting people to a
the problem of getting people to a hospital
hospital
hospital and unfortunately the logistics in Kenya
and unfortunately the logistics in Kenya
and unfortunately the logistics in Kenya mean that just doesn’t seem to quite
mean that just doesn’t seem to quite
mean that just doesn’t seem to quite work so we do have to take the drugs to
work so we do have to take the drugs to
work so we do have to take the drugs to the people how are we going to get them
the people how are we going to get them
the people how are we going to get them there and make sure that they’re safe I
there and make sure that they’re safe I
there and make sure that they’re safe I think well I was excited about today and
think well I was excited about today and
think well I was excited about today and thinking about this problem is we could
thinking about this problem is we could
thinking about this problem is we could share some of our really recent work
share some of our really recent work
share some of our really recent work with you and hope show you and the idea
with you and hope show you and the idea
with you and hope show you and the idea is to inspire you to think that we can
is to inspire you to think that we can
is to inspire you to think that we can solve these problems if we think
solve these problems if we think
solve these problems if we think creatively maybe the black ground
creatively maybe the black ground
creatively maybe the black ground background wasn’t such a great mover
background wasn’t such a great mover
background wasn’t such a great mover that’s fine we developed a way to shine
that’s fine we developed a way to shine
that’s fine we developed a way to shine light on antibodies and we look at the
light on antibodies and we look at the
light on antibodies and we look at the way they absorb that light and they
way they absorb that light and they
way they absorb that light and they changed that light to tell us about the
changed that light to tell us about the
changed that light to tell us about the health of the antibody and it gives us a
health of the antibody and it gives us a
health of the antibody and it gives us a fingerprint and it gives us a kind of a
fingerprint and it gives us a kind of a
fingerprint and it gives us a kind of a nice spot and if that spot moves from
nice spot and if that spot moves from
nice spot and if that spot moves from our measurement we know that the
our measurement we know that the
our measurement we know that the antibody is going to become in probably
antibody is going to become in probably
antibody is going to become in probably tending towards aggregating unsafe toxic
tending towards aggregating unsafe toxic
tending towards aggregating unsafe toxic okay so we can potentially now give you
okay so we can potentially now give you
okay so we can potentially now give you an instrument at the point of
an instrument at the point of
an instrument at the point of administration that can check to show
administration that can check to show
administration that can check to show your antibody is safe to administer and
your antibody is safe to administer and
your antibody is safe to administer and we developed this kind of little
we developed this kind of little
we developed this kind of little portable instrument it’s kind of goes in
portable instrument it’s kind of goes in
portable instrument it’s kind of goes in a suitcase it’s really cute and we’re
a suitcase it’s really cute and we’re
a suitcase it’s really cute and we’re going to send that out to our great
going to send that out to our great
going to send that out to our great collaborators in Kenya and they’re going
collaborators in Kenya and they’re going
collaborators in Kenya and they’re going to test that for us in a few weeks so
to test that for us in a few weeks so
to test that for us in a few weeks so that’s fine if you kind of know how long
that’s fine if you kind of know how long
that’s fine if you kind of know how long it’s going to take to get somewhere you
it’s going to take to get somewhere you
it’s going to take to get somewhere you can check and make sure your drug is
can check and make sure your drug is
can check and make sure your drug is safe but what about you’ve got to go a
safe but what about you’ve got to go a
safe but what about you’ve got to go a long way some of these places are a
long way some of these places are a
long way some of these places are a thousand or more kilometers away from
thousand or more kilometers away from
thousand or more kilometers away from where you might ship your drug out you
where you might ship your drug out you
where you might ship your drug out you just really can’t guarantee that it’s
just really can’t guarantee that it’s
just really can’t guarantee that it’s going to be any good over that period
going to be any good over that period
going to be any good over that period time and he just won’t be it will
time and he just won’t be it will
time and he just won’t be it will definitely be not a minute you won’t got
definitely be not a minute you won’t got
definitely be not a minute you won’t got to give it well with acyl survivor in
to give it well with acyl survivor in
to give it well with acyl survivor in bath she’s in chemistry she’s developed
bath she’s in chemistry she’s developed
bath she’s in chemistry she’s developed a way to wrap proteins in glass and by
a way to wrap proteins in glass and by
a way to wrap proteins in glass and by wrapping those proteins in glass those
wrapping those proteins in glass those
wrapping those proteins in glass those antibodies in glass you massively
antibodies in glass you massively
antibodies in glass you massively stabilized them and stop them from
stabilized them and stop them from
stabilized them and stop them from aggregating it’s a bit like she always
aggregating it’s a bit like she always
aggregating it’s a bit like she always likes to use this load I stole it it’s
likes to use this load I stole it it’s
likes to use this load I stole it it’s Han Solo from Star Wars he was wrapped
Han Solo from Star Wars he was wrapped
Han Solo from Star Wars he was wrapped in carbonite you doubtless will remember
in carbonite you doubtless will remember
in carbonite you doubtless will remember and he was frozen in time and when he
and he was frozen in time and when he
and he was frozen in time and when he was released from the Carbonite he was
was released from the Carbonite he was
was released from the Carbonite he was all tickety-boo that’s the idea here and
all tickety-boo that’s the idea here and
all tickety-boo that’s the idea here and it works really well so we wrap around
it works really well so we wrap around
it works really well so we wrap around he bodies in glass and then we check
he bodies in glass and then we check
he bodies in glass and then we check with our finger printing approach if it
with our finger printing approach if it
with our finger printing approach if it looks the same if it’s safe to
looks the same if it’s safe to
looks the same if it’s safe to administer and they are and these are
administer and they are and these are
administer and they are and these are real antibodies and they’ve been left
real antibodies and they’ve been left
real antibodies and they’ve been left out for months in the heat this works
out for months in the heat this works
out for months in the heat this works really really well this is an early
really really well this is an early
really really well this is an early stage of something but I hope he goes to
stage of something but I hope he goes to
stage of something but I hope he goes to show that we have to think creatively
show that we have to think creatively
show that we have to think creatively about solutions to solve problems and we
about solutions to solve problems and we
about solutions to solve problems and we mustn’t be greedy and gluttonous about
mustn’t be greedy and gluttonous about
mustn’t be greedy and gluttonous about the amazing technologies that we take
the amazing technologies that we take
the amazing technologies that we take for granted every day in our developed
for granted every day in our developed
for granted every day in our developed world that’s why I wanted to think about
world that’s why I wanted to think about
world that’s why I wanted to think about how do we empower the use of this most
how do we empower the use of this most
how do we empower the use of this most impressive of technologies I think we
impressive of technologies I think we
impressive of technologies I think we need to make sure it’s a regulatory
need to make sure it’s a regulatory
need to make sure it’s a regulatory level and a personal level we have fair
level and a personal level we have fair
level and a personal level we have fair access of these technologies we work out
access of these technologies we work out
access of these technologies we work out ways to put these technologies in
ways to put these technologies in
ways to put these technologies in people’s hands
people’s hands
people’s hands that’s about miniaturization and
that’s about miniaturization and
that’s about miniaturization and portability and rugged izing our
portability and rugged izing our
portability and rugged izing our approaches to getting technologies to
approaches to getting technologies to
approaches to getting technologies to people it’s about collaborating with
people it’s about collaborating with
people it’s about collaborating with governments and NGOs to try and find
governments and NGOs to try and find
governments and NGOs to try and find good routes forward it’s a really
good routes forward it’s a really
good routes forward it’s a really complex problem I think if we think
complex problem I think if we think
complex problem I think if we think creatively we can solve it thank you
creatively we can solve it thank you
creatively we can solve it thank you very much
very much
very much [Applause]
”
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