everyone wins themselves now when I was a kid I broke my son my fingers and toes
a kid I broke my son my fingers and toes
a kid I broke my son my fingers and toes and our regular misadventures but 20
and our regular misadventures but 20
and our regular misadventures but 20 years ago I flew off my push bike and
years ago I flew off my push bike and
years ago I flew off my push bike and used my face as a brake on the bitumen I
used my face as a brake on the bitumen I
used my face as a brake on the bitumen I don’t recommend it
don’t recommend it
don’t recommend it but all I had to do was keep the winds
but all I had to do was keep the winds
but all I had to do was keep the winds clean and covered and I healed but not
clean and covered and I healed but not
clean and covered and I healed but not everyone does some people suffer from
everyone does some people suffer from
everyone does some people suffer from chronic wounds
chronic wounds
chronic wounds these are wounds that just don’t heal
these are wounds that just don’t heal
these are wounds that just don’t heal imagine getting a cut in your foot and a
imagine getting a cut in your foot and a
imagine getting a cut in your foot and a week later it hasn’t healed you go to
week later it hasn’t healed you go to
week later it hasn’t healed you go to the doctor get antibiotics and it still
the doctor get antibiotics and it still
the doctor get antibiotics and it still doesn’t seem to help a month later you
doesn’t seem to help a month later you
doesn’t seem to help a month later you go to hospital and with a weepy mess all
go to hospital and with a weepy mess all
go to hospital and with a weepy mess all they can do is scratch clean out the
they can do is scratch clean out the
they can do is scratch clean out the gunk and bandage it every day this
gunk and bandage it every day this
gunk and bandage it every day this happens to a lot of people especially
happens to a lot of people especially
happens to a lot of people especially military personnel the elderly smokers
military personnel the elderly smokers
military personnel the elderly smokers and diabetics it sounds horrific and it
and diabetics it sounds horrific and it
and diabetics it sounds horrific and it is but it’s not as uncommon as you think
is but it’s not as uncommon as you think
is but it’s not as uncommon as you think one to two percent of people will have
one to two percent of people will have
one to two percent of people will have these chronic wounds at some point now
these chronic wounds at some point now
these chronic wounds at some point now diabetes is a big problem
diabetes is a big problem
diabetes is a big problem it affects five to fifteen percent of
it affects five to fifteen percent of
it affects five to fifteen percent of the world that’s 500 million people
the world that’s 500 million people
the world that’s 500 million people diagnosed with diabetes in Australia
diagnosed with diabetes in Australia
diagnosed with diabetes in Australia it’s 7 percent and that’s 1.7 million of
it’s 7 percent and that’s 1.7 million of
it’s 7 percent and that’s 1.7 million of us and it’s increasing by a hundred
us and it’s increasing by a hundred
us and it’s increasing by a hundred thousand people every year now you’ve
thousand people every year now you’ve
thousand people every year now you’ve heard of insulin injection there’s a
heard of insulin injection there’s a
heard of insulin injection there’s a treatment for diabetes and that helps
treatment for diabetes and that helps
treatment for diabetes and that helps some but it doesn’t help chronic wounds
some but it doesn’t help chronic wounds
some but it doesn’t help chronic wounds 15 percent of these diabetics will have
15 percent of these diabetics will have
15 percent of these diabetics will have a chronic wound at some point and this
a chronic wound at some point and this
a chronic wound at some point and this one gets deep it just keeps getting
one gets deep it just keeps getting
one gets deep it just keeps getting deeper often gets to the mind and one in
deeper often gets to the mind and one in
deeper often gets to the mind and one in ten of these will require an amputation
ten of these will require an amputation
ten of these will require an amputation even those that don’t have an amputation
even those that don’t have an amputation
even those that don’t have an amputation often require 4 to 5 months in hospital
often require 4 to 5 months in hospital
often require 4 to 5 months in hospital with regular daily treatment and this is
with regular daily treatment and this is
with regular daily treatment and this is all really really expensive it costs the
all really really expensive it costs the
all really really expensive it costs the world 50 billion dollars to treat
world 50 billion dollars to treat
world 50 billion dollars to treat despite all this treatment 12 wuzzies a
despite all this treatment 12 wuzzies a
despite all this treatment 12 wuzzies a day losing a foot to diabetes and around
day losing a foot to diabetes and around
day losing a foot to diabetes and around the world every 30 seconds someone is
the world every 30 seconds someone is
the world every 30 seconds someone is losing a foot to diabetes now for a
losing a foot to diabetes now for a
losing a foot to diabetes now for a little bit about me I love worms not the
little bit about me I love worms not the
little bit about me I love worms not the ones in your garden
ones in your garden
ones in your garden the web’s in your guts ooh the gross
the web’s in your guts ooh the gross
the web’s in your guts ooh the gross disgusting and you’re right but they’re
disgusting and you’re right but they’re
disgusting and you’re right but they’re amazing
amazing
amazing over the millennia they’ve developed an
over the millennia they’ve developed an
over the millennia they’ve developed an amazing array of biological defenses to
amazing array of biological defenses to
amazing array of biological defenses to dodge and hide in our immune system
dodge and hide in our immune system
dodge and hide in our immune system the parasitic blood slick for example is
the parasitic blood slick for example is
the parasitic blood slick for example is like a Marine sniper hiding in the
like a Marine sniper hiding in the
like a Marine sniper hiding in the environment they wear camouflage
environment they wear camouflage
environment they wear camouflage clothing to hide into the trees and the
clothing to hide into the trees and the
clothing to hide into the trees and the blood fluke makes bits that look like us
blood fluke makes bits that look like us
blood fluke makes bits that look like us so they can hide and just like the
so they can hide and just like the
so they can hide and just like the marine covers themselves in leaves to
marine covers themselves in leaves to
marine covers themselves in leaves to further hide in the environment the
further hide in the environment the
further hide in the environment the blood slick does the same its sticks
blood slick does the same its sticks
blood slick does the same its sticks bits of your blood onto it so it’s
bits of your blood onto it so it’s
bits of your blood onto it so it’s hiding from your eternal police force
hiding from your eternal police force
hiding from your eternal police force the immune system but this is where you
the immune system but this is where you
the immune system but this is where you find the one that fascinates me the most
find the one that fascinates me the most
find the one that fascinates me the most the tile liver fluke opus orcas favor
the tile liver fluke opus orcas favor
the tile liver fluke opus orcas favor any it’s found throughout Thailand Laos
any it’s found throughout Thailand Laos
any it’s found throughout Thailand Laos and Cambodia and in fact 9 million
and Cambodia and in fact 9 million
and Cambodia and in fact 9 million people and it’s deadly it causes a
people and it’s deadly it causes a
people and it’s deadly it causes a particularly dangerous form of liver
particularly dangerous form of liver
particularly dangerous form of liver cancer that kills 26,000 tires every
cancer that kills 26,000 tires every
cancer that kills 26,000 tires every year why is it restricted to this
year why is it restricted to this
year why is it restricted to this particular region well it’s the
particular region well it’s the
particular region well it’s the environment the particular animals and
environment the particular animals and
environment the particular animals and the freshwater streams are all critical
the freshwater streams are all critical
the freshwater streams are all critical for its survival when you’re infected
for its survival when you’re infected
for its survival when you’re infected with the worm you’ll poop out the eggs
with the worm you’ll poop out the eggs
with the worm you’ll poop out the eggs every day and during the monsoon season
every day and during the monsoon season
every day and during the monsoon season they’ll get flushed into local streams a
they’ll get flushed into local streams a
they’ll get flushed into local streams a snail comes along and munches up the
snail comes along and munches up the
snail comes along and munches up the eggs within the snail the egg hatches
eggs within the snail the egg hatches
eggs within the snail the egg hatches and multiplies and bursts out like a
and multiplies and bursts out like a
and multiplies and bursts out like a fish targeting missile and this looks
fish targeting missile and this looks
fish targeting missile and this looks like a microscopic tadpole it wriggles
like a microscopic tadpole it wriggles
like a microscopic tadpole it wriggles around it eventually finds a fish until
around it eventually finds a fish until
around it eventually finds a fish until it insists in the fish flesh the locals
it insists in the fish flesh the locals
it insists in the fish flesh the locals catch these local kind of like a small
catch these local kind of like a small
catch these local kind of like a small little carp or almost a goldfish they
little carp or almost a goldfish they
little carp or almost a goldfish they catch these little fish putting the in
catch these little fish putting the in
catch these little fish putting the in giant earthenware jars and add these
giant earthenware jars and add these
giant earthenware jars and add these local ants to the dish they ferment them
local ants to the dish they ferment them
local ants to the dish they ferment them for a few days and it becomes something
for a few days and it becomes something
for a few days and it becomes something something like fish sauce before it’s
something like fish sauce before it’s
something like fish sauce before it’s fish sauce and it’s delicious they mix
fish sauce and it’s delicious they mix
fish sauce and it’s delicious they mix it up with herbs and so it’s a fisherman
it up with herbs and so it’s a fisherman
it up with herbs and so it’s a fisherman it’s called pleura once it’s eaten it
it’s called pleura once it’s eaten it
it’s called pleura once it’s eaten it activates in your guts and crawls up
activates in your guts and crawls up
activates in your guts and crawls up into your liver here it grows into a 1
into your liver here it grows into a 1
into your liver here it grows into a 1 centimeter or half inch long parasitic
centimeter or half inch long parasitic
centimeter or half inch long parasitic flatworm that’s the shape of a leaf and
flatworm that’s the shape of a leaf and
flatworm that’s the shape of a leaf and it can live for decades now as a tourist
it can live for decades now as a tourist
it can live for decades now as a tourist it’s not such a problem because you can
it’s not such a problem because you can
it’s not such a problem because you can take a pill to get rid of it but the
take a pill to get rid of it but the
take a pill to get rid of it but the locals are come
locals are come
locals are come Tinh yulie eating this fish as it’s
Tinh yulie eating this fish as it’s
Tinh yulie eating this fish as it’s their major protein source and they get
their major protein source and they get
their major protein source and they get heavily infected all the time but this
heavily infected all the time but this
heavily infected all the time but this one is munching around your liver and
one is munching around your liver and
one is munching around your liver and causing wounds as it goes it’s actually
causing wounds as it goes it’s actually
causing wounds as it goes it’s actually got an amazing superpower wound healing
got an amazing superpower wound healing
got an amazing superpower wound healing worm spit just like if you knock a hole
worm spit just like if you knock a hole
worm spit just like if you knock a hole in your wall at home you’re going to fix
in your wall at home you’re going to fix
in your wall at home you’re going to fix it up and the worms doing the same thing
it up and the worms doing the same thing
it up and the worms doing the same thing but it’s homes your liver with its wound
but it’s homes your liver with its wound
but it’s homes your liver with its wound healing won’t spit it’s healing the
healing won’t spit it’s healing the
healing won’t spit it’s healing the wounds as it goes as it munches around
wounds as it goes as it munches around
wounds as it goes as it munches around and keeping its home nice and healthy
and keeping its home nice and healthy
and keeping its home nice and healthy for decades but what does this mean for
for decades but what does this mean for
for decades but what does this mean for the rest of us who aren’t infected with
the rest of us who aren’t infected with
the rest of us who aren’t infected with the worm well maybe we can steal its
the worm well maybe we can steal its
the worm well maybe we can steal its super power maybe we could use it for
super power maybe we could use it for
super power maybe we could use it for good so that’s what we’re trying to do
good so that’s what we’re trying to do
good so that’s what we’re trying to do in the lab now we would never be able to
in the lab now we would never be able to
in the lab now we would never be able to grow enough worms to harvest all of this
grow enough worms to harvest all of this
grow enough worms to harvest all of this was fit to use of the treatment but if
was fit to use of the treatment but if
was fit to use of the treatment but if we could find the active ingredient we
we could find the active ingredient we
we could find the active ingredient we might be able to use it and that’s what
might be able to use it and that’s what
might be able to use it and that’s what I was able to do we identified the
I was able to do we identified the
I was able to do we identified the active ingredient that causes wound
active ingredient that causes wound
active ingredient that causes wound healing in worms spirit and it’s named
healing in worms spirit and it’s named
healing in worms spirit and it’s named granule and it’s similar to some
granule and it’s similar to some
granule and it’s similar to some components in us that involved in
components in us that involved in
components in us that involved in development and wound healing and it’s
development and wound healing and it’s
development and wound healing and it’s got this really amazing structure it
got this really amazing structure it
got this really amazing structure it forms a spring shape and it’s held
forms a spring shape and it’s held
forms a spring shape and it’s held together tightly with bonds now while
together tightly with bonds now while
together tightly with bonds now while this is fascinating to study it makes it
this is fascinating to study it makes it
this is fascinating to study it makes it really expensive really tricky and
really expensive really tricky and
really expensive really tricky and really messy to make so we’d never be
really messy to make so we’d never be
really messy to make so we’d never be able to turn it into a pharmaceutical
able to turn it into a pharmaceutical
able to turn it into a pharmaceutical but maybe we don’t need the whole
but maybe we don’t need the whole
but maybe we don’t need the whole molecule maybe we just need a little bit
molecule maybe we just need a little bit
molecule maybe we just need a little bit of it and that’s what we tested in the
of it and that’s what we tested in the
of it and that’s what we tested in the lab a whole range of different bits of
lab a whole range of different bits of
lab a whole range of different bits of it in the lab we’re able to make it with
it in the lab we’re able to make it with
it in the lab we’re able to make it with amino acids and gluing them together bit
amino acids and gluing them together bit
amino acids and gluing them together bit at a time to make it synthetically and
at a time to make it synthetically and
at a time to make it synthetically and thus allowed us to make these various
thus allowed us to make these various
thus allowed us to make these various different active molecules to test in
different active molecules to test in
different active molecules to test in our studies so then we ran out tests
our studies so then we ran out tests
our studies so then we ran out tests through some healing mouse winding tests
through some healing mouse winding tests
through some healing mouse winding tests here’s the mice or anesthetized and kept
here’s the mice or anesthetized and kept
here’s the mice or anesthetized and kept on painkillers when we make a small
on painkillers when we make a small
on painkillers when we make a small wound between their ears we photograph
wound between their ears we photograph
wound between their ears we photograph this over days and watch those wounds
this over days and watch those wounds
this over days and watch those wounds close and we measure how long it takes
close and we measure how long it takes
close and we measure how long it takes to get to 80% closure so here’s a
to get to 80% closure so here’s a
to get to 80% closure so here’s a baseline healing rate of 8.6 days of our
baseline healing rate of 8.6 days of our
baseline healing rate of 8.6 days of our no treatment control when compared
no treatment control when compared
no treatment control when compared against the currently available biologic
against the currently available biologic
against the currently available biologic treatment it was able to improve healing
treatment it was able to improve healing
treatment it was able to improve healing by 29% now this treatments only
by 29% now this treatments only
by 29% now this treatments only available in career in the USA and cost
available in career in the USA and cost
available in career in the USA and cost over three so
over three so
over three so and dollars of treatment our granule and
and dollars of treatment our granule and
and dollars of treatment our granule and protein was out the hill wins 41 percent
protein was out the hill wins 41 percent
protein was out the hill wins 41 percent faster but even better our synthetic
faster but even better our synthetic
faster but even better our synthetic granule and is able to mate cleanly and
granule and is able to mate cleanly and
granule and is able to mate cleanly and cheaply healed in 4.9 days that’s 43
cheaply healed in 4.9 days that’s 43
cheaply healed in 4.9 days that’s 43 percent better than controls and almost
percent better than controls and almost
percent better than controls and almost 50 percent better than the currently
50 percent better than the currently
50 percent better than the currently available treatment so we think we’re
available treatment so we think we’re
available treatment so we think we’re onto a winner something that can make
onto a winner something that can make
onto a winner something that can make cheaply cleanly and is effective at
cheaply cleanly and is effective at
cheaply cleanly and is effective at wound healing but this isn’t all about
wound healing but this isn’t all about
wound healing but this isn’t all about graphs and figures
graphs and figures
graphs and figures it’s about people imagine going to the
it’s about people imagine going to the
it’s about people imagine going to the doctor and getting diagnosed with a
doctor and getting diagnosed with a
doctor and getting diagnosed with a chronic wound this reach the bone you’re
chronic wound this reach the bone you’re
chronic wound this reach the bone you’re going to need an amputation this isn’t
going to need an amputation this isn’t
going to need an amputation this isn’t just going to change your life it’s
just going to change your life it’s
just going to change your life it’s going to change everyone around you it
going to change everyone around you it
going to change everyone around you it wasn’t anything you did it wasn’t
wasn’t anything you did it wasn’t
wasn’t anything you did it wasn’t anything that could have been prevented
anything that could have been prevented
anything that could have been prevented chronic wounds are just horrible in this
chronic wounds are just horrible in this
chronic wounds are just horrible in this way but what if you could have had a
way but what if you could have had a
way but what if you could have had a cream some kind of treatment that could
cream some kind of treatment that could
cream some kind of treatment that could have supercharged your wound healing
have supercharged your wound healing
have supercharged your wound healing like our worm spit that might have been
like our worm spit that might have been
like our worm spit that might have been able to heal that chronic wound and
able to heal that chronic wound and
able to heal that chronic wound and avoid that amputation and this is a
avoid that amputation and this is a
avoid that amputation and this is a really big deal because diabetics who
really big deal because diabetics who
really big deal because diabetics who get an amputation only half of them will
get an amputation only half of them will
get an amputation only half of them will survive for more than five years due to
survive for more than five years due to
survive for more than five years due to all the horrible complications so it’s a
all the horrible complications so it’s a
all the horrible complications so it’s a really big impact on their lives so
really big impact on their lives so
really big impact on their lives so hopefully with the right funding we’re a
hopefully with the right funding we’re a
hopefully with the right funding we’re a few years away of getting some kind of
few years away of getting some kind of
few years away of getting some kind of treatment that might be able to go into
treatment that might be able to go into
treatment that might be able to go into humans and help the million diabetics
humans and help the million diabetics
humans and help the million diabetics who are on track every single year to
who are on track every single year to
who are on track every single year to lose a limb so remember don’t eat raw
lose a limb so remember don’t eat raw
lose a limb so remember don’t eat raw fish in Thailand where it heals wounds
fish in Thailand where it heals wounds
fish in Thailand where it heals wounds and a new treatment might be just around
and a new treatment might be just around
and a new treatment might be just around the corner to help diabetic chronic
the corner to help diabetic chronic
the corner to help diabetic chronic wounds and avoid these amputations thank
wounds and avoid these amputations thank
wounds and avoid these amputations thank you
”
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