one in a million what are the odds welcome to watchmojo.com and today we’re
welcome to watchmojo.com and today we’re
welcome to watchmojo.com and today we’re counting down our picks for the top ten
counting down our picks for the top ten
counting down our picks for the top ten rarest conditions and diseases fop is
rarest conditions and diseases fop is
rarest conditions and diseases fop is one of the rarest conditions known to
one of the rarest conditions known to
one of the rarest conditions known to mankind
mankind
mankind before we begin we publish new videos
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more great content for this list we’re
more great content for this list we’re ranking the medical conditions that
ranking the medical conditions that
ranking the medical conditions that occur the least among the human
occur the least among the human
occur the least among the human population these diseases either tend to
population these diseases either tend to
population these diseases either tend to be found in one specific area of the
be found in one specific area of the
be found in one specific area of the world or otherwise rarely present within
world or otherwise rarely present within
world or otherwise rarely present within large groups of people and tend to carry
large groups of people and tend to carry
large groups of people and tend to carry with them some very bizarre symptoms one
with them some very bizarre symptoms one
with them some very bizarre symptoms one leg swollen more than double the size of
leg swollen more than double the size of
leg swollen more than double the size of the other her skin hot and thick number
the other her skin hot and thick number
the other her skin hot and thick number 10 foreign accent syndrome between 1941
10 foreign accent syndrome between 1941
10 foreign accent syndrome between 1941 and 2009 62 cases of the speech
and 2009 62 cases of the speech
and 2009 62 cases of the speech condition known as foreign accent
condition known as foreign accent
condition known as foreign accent syndrome or FAS were reported first
syndrome or FAS were reported first
syndrome or FAS were reported first discovered in 1907 FAS is characterized
discovered in 1907 FAS is characterized
discovered in 1907 FAS is characterized by the subject speaking their native
by the subject speaking their native
by the subject speaking their native language with an accent that is foreign
language with an accent that is foreign
language with an accent that is foreign to them oh you’re visiting we’ll put a
to them oh you’re visiting we’ll put a
to them oh you’re visiting we’ll put a rush on you for all ongoing why are
rush on you for all ongoing why are
rush on you for all ongoing why are people saying this so imagine a born and
people saying this so imagine a born and
people saying this so imagine a born and raised New Yorker suddenly speaking with
raised New Yorker suddenly speaking with
raised New Yorker suddenly speaking with a deep Southern drawl or like a member
a deep Southern drawl or like a member
a deep Southern drawl or like a member of the British aristocracy Simon I can
of the British aristocracy Simon I can
of the British aristocracy Simon I can summation it what does a chances in some
summation it what does a chances in some
summation it what does a chances in some cases rather than an accent
cases rather than an accent
cases rather than an accent a person’s pitch or ability to correctly
a person’s pitch or ability to correctly
a person’s pitch or ability to correctly pronounce syllables may be affected say
pronounce syllables may be affected say
pronounce syllables may be affected say it again bagel
it again bagel
it again bagel SAS can be brought on by a stroke or
SAS can be brought on by a stroke or
SAS can be brought on by a stroke or some form of head trauma with patients
some form of head trauma with patients
some form of head trauma with patients sometimes comparing the symptoms to
sometimes comparing the symptoms to
sometimes comparing the symptoms to those associated with a speech disorder
those associated with a speech disorder
those associated with a speech disorder she turned up after having a nasty head
she turned up after having a nasty head
she turned up after having a nasty head injury eight years ago speaking with a
injury eight years ago speaking with a
injury eight years ago speaking with a French accent
French accent
French accent can’t believe my ears number nine
can’t believe my ears number nine
can’t believe my ears number nine microcephaly the connection between the
microcephaly the connection between the
microcephaly the connection between the Zika virus in pregnant women and
Zika virus in pregnant women and
Zika virus in pregnant women and children’s born with microcephaly
children’s born with microcephaly
children’s born with microcephaly brought significant attention to this
brought significant attention to this
brought significant attention to this disorder microcephaly generally presents
disorder microcephaly generally presents
disorder microcephaly generally presents at birth or early in a child’s
at birth or early in a child’s
at birth or early in a child’s development children born with the
development children born with the
development children born with the condition exhibit a lack of brain
condition exhibit a lack of brain
condition exhibit a lack of brain development and a
development and a
development and a head much smaller than normal side
head much smaller than normal side
head much smaller than normal side effects include intellectual
effects include intellectual
effects include intellectual disabilities and low motor function as
disabilities and low motor function as
disabilities and low motor function as well as a propensity for seizures and
well as a propensity for seizures and
well as a propensity for seizures and dwarfism the lifespan is also typically
dwarfism the lifespan is also typically
dwarfism the lifespan is also typically affected although there have been cases
affected although there have been cases
affected although there have been cases where those suffering from this
where those suffering from this
where those suffering from this condition went on to lead a normal life
condition went on to lead a normal life
condition went on to lead a normal life usually the impaired brain function has
usually the impaired brain function has
usually the impaired brain function has a significant negative impact but it’s
a significant negative impact but it’s
a significant negative impact but it’s not the end of solutions because you
not the end of solutions because you
not the end of solutions because you have these kids they would teach them so
have these kids they would teach them so
have these kids they would teach them so much number eight
much number eight
much number eight epidermal dysplasia bruise the form of
epidermal dysplasia bruise the form of
epidermal dysplasia bruise the form of the human body is a strange and
the human body is a strange and
the human body is a strange and mysterious thing that can fall victim to
mysterious thing that can fall victim to
mysterious thing that can fall victim to a number of equally strange diseases
a number of equally strange diseases
a number of equally strange diseases case in point the hereditary skin
case in point the hereditary skin
case in point the hereditary skin disease epidermidis plays abruzzo formas
disease epidermidis plays abruzzo formas
disease epidermidis plays abruzzo formas also known as the tree man illness the
also known as the tree man illness the
also known as the tree man illness the disease which is often abbreviated to
disease which is often abbreviated to
disease which is often abbreviated to evey occurs as a result of a pH mutation
evey occurs as a result of a pH mutation
evey occurs as a result of a pH mutation within the genes evey affects the body’s
within the genes evey affects the body’s
within the genes evey affects the body’s resilience to human papillomaviruses on
resilience to human papillomaviruses on
resilience to human papillomaviruses on the skin often infecting the patient
the skin often infecting the patient
the skin often infecting the patient with uncontrolled scale-like growth
with uncontrolled scale-like growth
with uncontrolled scale-like growth these growths often take on the
these growths often take on the
these growths often take on the appearance of tree-like appendages
appearance of tree-like appendages
appearance of tree-like appendages growing from the hands or feet
growing from the hands or feet
growing from the hands or feet remarkably resistant to both medication
remarkably resistant to both medication
remarkably resistant to both medication and surgery evey patients have been
and surgery evey patients have been
and surgery evey patients have been treated with some success but they
treated with some success but they
treated with some success but they usually require repeated treatment
usually require repeated treatment
usually require repeated treatment number seven fibro dysplasia ossificans
number seven fibro dysplasia ossificans
number seven fibro dysplasia ossificans progressiva
progressiva
progressiva our bodies can be incredibly efficient
our bodies can be incredibly efficient
our bodies can be incredibly efficient healing machines but what happens when
healing machines but what happens when
healing machines but what happens when that natural repair process goes wrong
that natural repair process goes wrong
that natural repair process goes wrong this is the situation with fibro
this is the situation with fibro
this is the situation with fibro dysplasia ossificans progressiva
dysplasia ossificans progressiva
dysplasia ossificans progressiva or FOP this disease of the connective
or FOP this disease of the connective
or FOP this disease of the connective tissue affects the body’s ability to
tissue affects the body’s ability to
tissue affects the body’s ability to naturally heal supply of fibrous tissue
naturally heal supply of fibrous tissue
naturally heal supply of fibrous tissue like muscles joints and ligaments
like muscles joints and ligaments
like muscles joints and ligaments translation when someone uplifted with
translation when someone uplifted with
translation when someone uplifted with FOP is injured their body repairs itself
FOP is injured their body repairs itself
FOP is injured their body repairs itself not by growing healthy new tissue but by
not by growing healthy new tissue but by
not by growing healthy new tissue but by growing foam sometimes this results in
growing foam sometimes this results in
growing foam sometimes this results in joints that are literally frozen by the
joints that are literally frozen by the
joints that are literally frozen by the process of ossification and it causes my
process of ossification and it causes my
process of ossification and it causes my muscles and connective tissues to turn
muscles and connective tissues to turn
muscles and connective tissues to turn to bone number six hutchinson-gilford
to bone number six hutchinson-gilford
to bone number six hutchinson-gilford progeria syndrome all those a Curious
progeria syndrome all those a Curious
progeria syndrome all those a Curious Case of Benjamin Button is this who have
Case of Benjamin Button is this who have
Case of Benjamin Button is this who have been inspired by hutchinson-gilford
been inspired by hutchinson-gilford
been inspired by hutchinson-gilford progeria syndrome the condition in real
progeria syndrome the condition in real
progeria syndrome the condition in real life is quite different however body
life is quite different however body
life is quite different however body else was aging
else was aging
else was aging was kidding element babies born with
was kidding element babies born with
was kidding element babies born with this extremely rare genetic disorder
this extremely rare genetic disorder
this extremely rare genetic disorder often simply called progeria aim to age
often simply called progeria aim to age
often simply called progeria aim to age at a vastly accelerated rate few live
at a vastly accelerated rate few live
at a vastly accelerated rate few live beyond their early 20s and most exhibit
beyond their early 20s and most exhibit
beyond their early 20s and most exhibit symptoms of the disease shortly after
symptoms of the disease shortly after
symptoms of the disease shortly after birth these symptoms start with a
birth these symptoms start with a
birth these symptoms start with a failure to fly those other babies do
failure to fly those other babies do
failure to fly those other babies do along with a hardening of the skin other
along with a hardening of the skin other
along with a hardening of the skin other symptoms include brittle bones hair loss
symptoms include brittle bones hair loss
symptoms include brittle bones hair loss reduced eyesight wrinkled skin and
reduced eyesight wrinkled skin and
reduced eyesight wrinkled skin and excessive weight loss essentially the
excessive weight loss essentially the
excessive weight loss essentially the young child seems to be aging way faster
young child seems to be aging way faster
young child seems to be aging way faster than they should be and sadly there is
than they should be and sadly there is
than they should be and sadly there is no cure number 5 Harlequin type Dixie
no cure number 5 Harlequin type Dixie
no cure number 5 Harlequin type Dixie OSIS remarkable advances in the area of
OSIS remarkable advances in the area of
OSIS remarkable advances in the area of neonatal care have proven to be a
neonatal care have proven to be a
neonatal care have proven to be a godsend for those suffering from the
godsend for those suffering from the
godsend for those suffering from the extremely rare skin condition known as
extremely rare skin condition known as
extremely rare skin condition known as Harlequin type exposes this disease is
Harlequin type exposes this disease is
Harlequin type exposes this disease is distinguished by the presence of a thick
distinguished by the presence of a thick
distinguished by the presence of a thick hard armor-like plate of dry skin all
hard armor-like plate of dry skin all
hard armor-like plate of dry skin all over the body dehydration and
over the body dehydration and
over the body dehydration and respiratory issues are common as is
respiratory issues are common as is
respiratory issues are common as is serious infection due to the skins
serious infection due to the skins
serious infection due to the skins cracked arid nature this disease was
cracked arid nature this disease was
cracked arid nature this disease was almost always fatal to infants when it
almost always fatal to infants when it
almost always fatal to infants when it was first seen during the mid 1700s
was first seen during the mid 1700s
was first seen during the mid 1700s today however early care and treatment
today however early care and treatment
today however early care and treatment means that babies born with Harlequin
means that babies born with Harlequin
means that babies born with Harlequin type XP osis now have a fighting chance
type XP osis now have a fighting chance
type XP osis now have a fighting chance for survival when I get such ignorant
for survival when I get such ignorant
for survival when I get such ignorant sand things it does chip away and I just
sand things it does chip away and I just
sand things it does chip away and I just hope it doesn’t completely take take my
hope it doesn’t completely take take my
hope it doesn’t completely take take my confidence away number four congenital
confidence away number four congenital
confidence away number four congenital analgesia we’ve all day dreamed about
analgesia we’ve all day dreamed about
analgesia we’ve all day dreamed about being a superhero and being able to
being a superhero and being able to
being a superhero and being able to withstand an enormous amount of pain or
withstand an enormous amount of pain or
withstand an enormous amount of pain or damage without batting an eye could you
damage without batting an eye could you
damage without batting an eye could you do this harder what would happen if we
do this harder what would happen if we
do this harder what would happen if we actually couldn’t feel any pain
actually couldn’t feel any pain
actually couldn’t feel any pain whatsoever what this really be a good
whatsoever what this really be a good
whatsoever what this really be a good thing not according to those who suffer
thing not according to those who suffer
thing not according to those who suffer from congenital analgesia a rare and
from congenital analgesia a rare and
from congenital analgesia a rare and dangerous disorder which does just that
dangerous disorder which does just that
dangerous disorder which does just that it affects the body’s ability to feel
it affects the body’s ability to feel
it affects the body’s ability to feel pain doctors believe an excessive amount
pain doctors believe an excessive amount
pain doctors believe an excessive amount of endorphins produced in the brain
of endorphins produced in the brain
of endorphins produced in the brain caused this condition unfortunately this
caused this condition unfortunately this
caused this condition unfortunately this exacerbates damage to the body rather
exacerbates damage to the body rather
exacerbates damage to the body rather than diminishing it many of those
than diminishing it many of those
than diminishing it many of those afflicted by CA have reported biting off
afflicted by CA have reported biting off
afflicted by CA have reported biting off their own tongue breaking bones or
their own tongue breaking bones or
their own tongue breaking bones or suffering severe in
suffering severe in
suffering severe in action number three ahlstrom syndrome
action number three ahlstrom syndrome
action number three ahlstrom syndrome Ostrom syndrome or ahlstrom halgren
Ostrom syndrome or ahlstrom halgren
Ostrom syndrome or ahlstrom halgren syndrome as it’s sometimes known is one
syndrome as it’s sometimes known is one
syndrome as it’s sometimes known is one of the most recently discovered
of the most recently discovered
of the most recently discovered conditions on our list first reported in
conditions on our list first reported in
conditions on our list first reported in 1959 by Swedish psychiatrist Carl Henry
1959 by Swedish psychiatrist Carl Henry
1959 by Swedish psychiatrist Carl Henry Ostrom it’s also one of the rarest
Ostrom it’s also one of the rarest
Ostrom it’s also one of the rarest conditions with just over 500 cases
conditions with just over 500 cases
conditions with just over 500 cases having been reported all over the world
having been reported all over the world
having been reported all over the world ahlstrom syndrome can usually be seen in
ahlstrom syndrome can usually be seen in
ahlstrom syndrome can usually be seen in infancy characterized by a wide array of
infancy characterized by a wide array of
infancy characterized by a wide array of severe organ issues obesity blindness
severe organ issues obesity blindness
severe organ issues obesity blindness loss of hearing and diabetes are just a
loss of hearing and diabetes are just a
loss of hearing and diabetes are just a few of the symptoms associated with AF
few of the symptoms associated with AF
few of the symptoms associated with AF if you live past age 50 due largely to
if you live past age 50 due largely to
if you live past age 50 due largely to the fact that there’s currently no cure
the fact that there’s currently no cure
the fact that there’s currently no cure for the disease only therapy and
for the disease only therapy and
for the disease only therapy and treatment number two fields disease no
treatment number two fields disease no
treatment number two fields disease no medical condition is rarer than the
medical condition is rarer than the
medical condition is rarer than the neuromuscular condition known as Fields
neuromuscular condition known as Fields
neuromuscular condition known as Fields disease only two cases have been
disease only two cases have been
disease only two cases have been reported to date the twin sisters
reported to date the twin sisters
reported to date the twin sisters Catherine and Kirsty fields for whom the
Catherine and Kirsty fields for whom the
Catherine and Kirsty fields for whom the disease is named in 1998 their parents
disease is named in 1998 their parents
disease is named in 1998 their parents noticed some initial problems within
noticed some initial problems within
noticed some initial problems within five years the girls were suffering from
five years the girls were suffering from
five years the girls were suffering from severe muscular degeneration eventually
severe muscular degeneration eventually
severe muscular degeneration eventually losing their ability to speak and
losing their ability to speak and
losing their ability to speak and requiring Walker’s to assist in mobility
requiring Walker’s to assist in mobility
requiring Walker’s to assist in mobility meanwhile neurological issues caused
meanwhile neurological issues caused
meanwhile neurological issues caused severe shaking and trembling hands so
severe shaking and trembling hands so
severe shaking and trembling hands so difficult to manage a 2012 update from
difficult to manage a 2012 update from
difficult to manage a 2012 update from Britain’s Daily Mirror showed the girls
Britain’s Daily Mirror showed the girls
Britain’s Daily Mirror showed the girls in good spirits after they were given
in good spirits after they were given
in good spirits after they were given speech devices similar to those used by
speech devices similar to those used by
speech devices similar to those used by Stephen Hawking before we named our
Stephen Hawking before we named our
Stephen Hawking before we named our rarest medical conditions here are some
rarest medical conditions here are some
rarest medical conditions here are some honorable mentions
honorable mentions
honorable mentions [Music]
number one aquagenic urticaria some
number one aquagenic urticaria some people can’t swim some folks just hate
people can’t swim some folks just hate
people can’t swim some folks just hate the water water never touch the stuff
the water water never touch the stuff
the water water never touch the stuff fish in it but what if exposure to h2o
fish in it but what if exposure to h2o
fish in it but what if exposure to h2o actually caused you intense physical
actually caused you intense physical
actually caused you intense physical pain
pain
pain those who suffer from aquagenic
those who suffer from aquagenic
those who suffer from aquagenic urticaria an intense skin reaction to
urticaria an intense skin reaction to
urticaria an intense skin reaction to water contend with this problem on a
water contend with this problem on a
water contend with this problem on a daily basis red itchy hives can emerge
daily basis red itchy hives can emerge
daily basis red itchy hives can emerge on the skin only minutes after exposure
on the skin only minutes after exposure
on the skin only minutes after exposure what’s more there’s no cure for
what’s more there’s no cure for
what’s more there’s no cure for aquagenic urticaria which is more likely
aquagenic urticaria which is more likely
aquagenic urticaria which is more likely to occur in women than men only
to occur in women than men only
to occur in women than men only antihistamine steroids radiation or
antihistamine steroids radiation or
antihistamine steroids radiation or medication offer limited comfort to
medication offer limited comfort to
medication offer limited comfort to those for whom every shower or hand
those for whom every shower or hand
those for whom every shower or hand washing session is a challenge do you
washing session is a challenge do you
washing session is a challenge do you agree with our pics check out these
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