
pain it’s something we go through our whole lives trying to avoid from the
whole lives trying to avoid from the
whole lives trying to avoid from the acute pain of a burn or cut its the
acute pain of a burn or cut its the
acute pain of a burn or cut its the chronic pain of cancer to the psychic
chronic pain of cancer to the psychic
chronic pain of cancer to the psychic pain of depression but perhaps the pain
pain of depression but perhaps the pain
pain of depression but perhaps the pain that hurts the worst is a social pain
that hurts the worst is a social pain
that hurts the worst is a social pain it’s the pain of isolation of being
it’s the pain of isolation of being
it’s the pain of isolation of being excluded of being an outsider now I’ve
excluded of being an outsider now I’ve
excluded of being an outsider now I’ve been an outsider many times in my life
been an outsider many times in my life
been an outsider many times in my life I am a black Jewish woman psychiatrist
I am a black Jewish woman psychiatrist
I am a black Jewish woman psychiatrist neuroscientist immunologist I’ve never
neuroscientist immunologist I’ve never
neuroscientist immunologist I’ve never really fit in but I’m here to tell you
really fit in but I’m here to tell you
really fit in but I’m here to tell you that there’s a power and coming in from
that there’s a power and coming in from
that there’s a power and coming in from the outside it can help you to make
the outside it can help you to make
the outside it can help you to make connections and to generate insight and
connections and to generate insight and
connections and to generate insight and I want to tell you a story about how I
I want to tell you a story about how I
I want to tell you a story about how I came into the outside to science and
came into the outside to science and
came into the outside to science and made connections between pain and the
made connections between pain and the
made connections between pain and the immune system and why that’s important
immune system and why that’s important
immune system and why that’s important for women so one day when I was in
for women so one day when I was in
for women so one day when I was in graduate school my best friend called me
graduate school my best friend called me
graduate school my best friend called me and told me that she had lupus and my
and told me that she had lupus and my
and told me that she had lupus and my heart sank because I knew what that
heart sank because I knew what that
heart sank because I knew what that meant
meant
meant lupus is an autoimmune disorder that’s a
lupus is an autoimmune disorder that’s a
lupus is an autoimmune disorder that’s a disease where the immune system instead
disease where the immune system instead
disease where the immune system instead of doing its job fighting off infection
of doing its job fighting off infection
of doing its job fighting off infection instead attacks the body and it causes
instead attacks the body and it causes
instead attacks the body and it causes all sorts of problems the only
all sorts of problems the only
all sorts of problems the only treatments we have are these powerful
treatments we have are these powerful
treatments we have are these powerful immunosuppressants that sometimes can be
immunosuppressants that sometimes can be
immunosuppressants that sometimes can be worse than the actual disease and over
worse than the actual disease and over
worse than the actual disease and over the years I’ve watched my friend lose
the years I’ve watched my friend lose
the years I’ve watched my friend lose her hair get skin problems breathing
her hair get skin problems breathing
her hair get skin problems breathing problems and sometimes have pain so bad
problems and sometimes have pain so bad
problems and sometimes have pain so bad she couldn’t get out of bed and yet
she couldn’t get out of bed and yet
she couldn’t get out of bed and yet throughout this all she has had the most
throughout this all she has had the most
throughout this all she has had the most wonderful positive attitude she’s
wonderful positive attitude she’s
wonderful positive attitude she’s incredibly resilient she goes out and
incredibly resilient she goes out and
incredibly resilient she goes out and has adventures I on the other hand felt
has adventures I on the other hand felt
has adventures I on the other hand felt helpless and almost guilty because Here
helpless and almost guilty because Here
helpless and almost guilty because Here I am I’m a physician and I’m an
I am I’m a physician and I’m an
I am I’m a physician and I’m an immunologist and I can’t give her any
immunologist and I can’t give her any
immunologist and I can’t give her any better treatment options
better treatment options
better treatment options so my friends story is not unusual lupus
so my friends story is not unusual lupus
so my friends story is not unusual lupus is a disease that affects 9 times more
is a disease that affects 9 times more
is a disease that affects 9 times more women than men for every 9 women that
women than men for every 9 women that
women than men for every 9 women that get it one man gets it and indeed over
get it one man gets it and indeed over
get it one man gets it and indeed over 80% of all autoimmune disease occurs in
80% of all autoimmune disease occurs in
80% of all autoimmune disease occurs in women our immunity isn’t the only
women our immunity isn’t the only
women our immunity isn’t the only disorder that happens more to women
disorder that happens more to women
disorder that happens more to women depression and anxiety and pain also
depression and anxiety and pain also
depression and anxiety and pain also happen more in women now the pain might
happen more in women now the pain might
happen more in women now the pain might be counterintuitive because women go
be counterintuitive because women go
be counterintuitive because women go through the pain of childbirth so aren’t
through the pain of childbirth so aren’t
through the pain of childbirth so aren’t they more pain tolerant that’s actually
they more pain tolerant that’s actually
they more pain tolerant that’s actually not the case women report pain more and
not the case women report pain more and
not the case women report pain more and their pain neurons are more sensitive I
their pain neurons are more sensitive I
their pain neurons are more sensitive I started to get really interested in this
started to get really interested in this
started to get really interested in this problem of pain as a psychiatrist and
problem of pain as a psychiatrist and
problem of pain as a psychiatrist and seeing so many women come sent to me
seeing so many women come sent to me
seeing so many women come sent to me from physicians because they couldn’t
from physicians because they couldn’t
from physicians because they couldn’t find a cause for the pain and I got
find a cause for the pain and I got
find a cause for the pain and I got interested in the molecular basis and I
interested in the molecular basis and I
interested in the molecular basis and I was surprised to find that pain in the
was surprised to find that pain in the
was surprised to find that pain in the immune system are tightly linked so our
immune system are tightly linked so our
immune system are tightly linked so our neurons and our immune cells talk to
neurons and our immune cells talk to
neurons and our immune cells talk to each other in almost every single organ
each other in almost every single organ
each other in almost every single organ of the body and when that communication
of the body and when that communication
of the body and when that communication goes well we fight off infection and we
goes well we fight off infection and we
goes well we fight off infection and we keep homeostasis or balance in the body
keep homeostasis or balance in the body
keep homeostasis or balance in the body but when that communication doesn’t work
but when that communication doesn’t work
but when that communication doesn’t work when it’s dysfunctional we get these
when it’s dysfunctional we get these
when it’s dysfunctional we get these disorders of autoimmunity and of pain
disorders of autoimmunity and of pain
disorders of autoimmunity and of pain we’ve been studying this for such a long
we’ve been studying this for such a long
we’ve been studying this for such a long time I started to wonder why don’t we
time I started to wonder why don’t we
time I started to wonder why don’t we understand these disorders better and
understand these disorders better and
understand these disorders better and why don’t we understand why they happen
why don’t we understand why they happen
why don’t we understand why they happen more in women so once again I got to
more in women so once again I got to
more in women so once again I got to come in from the outside I went from
come in from the outside I went from
come in from the outside I went from being an immunologist and I went into a
being an immunologist and I went into a
being an immunologist and I went into a neuroscience lab and that’s when I got a
neuroscience lab and that’s when I got a
neuroscience lab and that’s when I got a clue so the first observation I made was
clue so the first observation I made was
clue so the first observation I made was that neuroscientists tend to study males
that neuroscientists tend to study males
that neuroscientists tend to study males men and male organisms like male mice
men and male organisms like male mice
men and male organisms like male mice and a study that came out just a few
and a study that came out just a few
and a study that came out just a few years ago did a survey of the sexes
years ago did a survey of the sexes
years ago did a survey of the sexes studied by different disciplines in
studied by different disciplines in
studied by different disciplines in science and found there was an
science and found there was an
science and found there was an overwhelming male based bias and the
overwhelming male based bias and the
overwhelming male based bias and the bias was worst in neuroscience with
bias was worst in neuroscience with
bias was worst in neuroscience with five-and-a-half experiment studying
five-and-a-half experiment studying
five-and-a-half experiment studying males – one experiment
males – one experiment
males – one experiment studying females it was second worst in
studying females it was second worst in
studying females it was second worst in pharmacology and that’s kind of scary
pharmacology and that’s kind of scary
pharmacology and that’s kind of scary because that’s the science that studies
because that’s the science that studies
because that’s the science that studies and tests drugs and 80% of all the drugs
and tests drugs and 80% of all the drugs
and tests drugs and 80% of all the drugs we made as a venn were tested at males
we made as a venn were tested at males
we made as a venn were tested at males only this was shocking to me because as
only this was shocking to me because as
only this was shocking to me because as an immunologist I study predominantly
an immunologist I study predominantly
an immunologist I study predominantly females and so the first observation is
females and so the first observation is
females and so the first observation is there is a male bias in neuroscience the
there is a male bias in neuroscience the
there is a male bias in neuroscience the second observation is that the
second observation is that the
second observation is that the neuroscientist in the immunologists
neuroscientist in the immunologists
neuroscientist in the immunologists don’t really talk to each other and it’s
don’t really talk to each other and it’s
don’t really talk to each other and it’s not because we don’t like each other
not because we don’t like each other
not because we don’t like each other it’s because the language and the focus
it’s because the language and the focus
it’s because the language and the focus and the techniques are different and so
and the techniques are different and so
and the techniques are different and so sometimes it’s hard for neuroscientists
sometimes it’s hard for neuroscientists
sometimes it’s hard for neuroscientists to really hear what the mean ologists
to really hear what the mean ologists
to really hear what the mean ologists are saying and vice-versa and so there’s
are saying and vice-versa and so there’s
are saying and vice-versa and so there’s a separation in the sexes and there’s a
a separation in the sexes and there’s a
a separation in the sexes and there’s a separation in the sciences and in the
separation in the sciences and in the
separation in the sciences and in the sexes that they study here’s the irony
sexes that they study here’s the irony
sexes that they study here’s the irony the body has made the connection the
the body has made the connection the
the body has made the connection the nervous system and the immune system
nervous system and the immune system
nervous system and the immune system talked to each other all the time in the
talked to each other all the time in the
talked to each other all the time in the body but the scientists who study these
body but the scientists who study these
body but the scientists who study these two fields don’t and this reminded me of
two fields don’t and this reminded me of
two fields don’t and this reminded me of a parable of blind people who are
a parable of blind people who are
a parable of blind people who are encountering an elephant for the first
encountering an elephant for the first
encountering an elephant for the first time so they want to figure out what is
time so they want to figure out what is
time so they want to figure out what is this elephant thing and one goes and
this elephant thing and one goes and
this elephant thing and one goes and grabs onto the leg and says Oh an
grabs onto the leg and says Oh an
grabs onto the leg and says Oh an elephant is like a pillar and the other
elephant is like a pillar and the other
elephant is like a pillar and the other goes and starts pulling on the thao and
goes and starts pulling on the thao and
goes and starts pulling on the thao and said oh no an elephant is clearly like a
said oh no an elephant is clearly like a
said oh no an elephant is clearly like a rope you are wrong but the reality is an
rope you are wrong but the reality is an
rope you are wrong but the reality is an elephant is like both of those things
elephant is like both of those things
elephant is like both of those things and even more so how do we fix this
and even more so how do we fix this
and even more so how do we fix this problem how do we tell the true nature
problem how do we tell the true nature
problem how do we tell the true nature of the elephant part of the answer lies
of the elephant part of the answer lies
of the elephant part of the answer lies in coming in from the outside and I’m
in coming in from the outside and I’m
in coming in from the outside and I’m starting to get comfortable with this
starting to get comfortable with this
starting to get comfortable with this pain of being an outsider I was able to
pain of being an outsider I was able to
pain of being an outsider I was able to make these observations precisely
make these observations precisely
make these observations precisely because I came in as a neurosis as an
because I came in as a neurosis as an
because I came in as a neurosis as an immunologist into neuroscience and
immunologist into neuroscience and
immunologist into neuroscience and moreover because I was a black woman
moreover because I was a black woman
moreover because I was a black woman that was more likely to suffer from
that was more likely to suffer from
that was more likely to suffer from these disorders so more and more of us
these disorders so more and more of us
these disorders so more and more of us are starting to connect we’re starting
are starting to connect we’re starting
are starting to connect we’re starting to talk and this connection is actually
to talk and this connection is actually
to talk and this connection is actually generating
generating
generating in sight we’re using words like neuro
in sight we’re using words like neuro
in sight we’re using words like neuro immune system and as we talk more and
immune system and as we talk more and
immune system and as we talk more and more we’re generating more insight into
more we’re generating more insight into
more we’re generating more insight into the nature of pain and I believe this is
the nature of pain and I believe this is
the nature of pain and I believe this is going to help us find treatments for
going to help us find treatments for
going to help us find treatments for both men and women so this story of
both men and women so this story of
both men and women so this story of neuroscience and immunology is just an
neuroscience and immunology is just an
neuroscience and immunology is just an example there are many many many
example there are many many many
example there are many many many elephants out there some of you may be
elephants out there some of you may be
elephants out there some of you may be dealing with elephants in your own lives
dealing with elephants in your own lives
dealing with elephants in your own lives so I would say be fearless cross
so I would say be fearless cross
so I would say be fearless cross boundaries jump into an eel fit new
boundaries jump into an eel fit new
boundaries jump into an eel fit new field try something you’ve never tried
field try something you’ve never tried
field try something you’ve never tried before
before
before be curious about another perspective and
be curious about another perspective and
be curious about another perspective and welcome those in who are of different
welcome those in who are of different
welcome those in who are of different backgrounds that is how we’re going to
backgrounds that is how we’re going to
backgrounds that is how we’re going to address these elephants of pain
address these elephants of pain
address these elephants of pain depression autoimmunity and that’s how
depression autoimmunity and that’s how
depression autoimmunity and that’s how we’re gonna give hope I have hope for
we’re gonna give hope I have hope for
we’re gonna give hope I have hope for those who are suffering from these
those who are suffering from these
those who are suffering from these disorders who are living with these
disorders who are living with these
disorders who are living with these disorders including my friend
”
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