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Stem Cell Research | Dr. Johnny Huard Dr. Johnny Huard | TEDxVail


[Music]

[Music] there is something you know fair in life

there is something you know fair in life

there is something you know fair in life is aging because whether you’re poor or

is aging because whether you’re poor or

is aging because whether you’re poor or you’re rich we all age one day at the

you’re rich we all age one day at the

you’re rich we all age one day at the time and the thing that we all have in

time and the thing that we all have in

time and the thing that we all have in common is nobody wants to age so what

common is nobody wants to age so what

common is nobody wants to age so what I’m going to be presenting today is the

I’m going to be presenting today is the

I’m going to be presenting today is the research that we have been doing to try

research that we have been doing to try

research that we have been doing to try to delay aging so if you want to hear

to delay aging so if you want to hear

to delay aging so if you want to hear about this you have to give me a big yes

about this you have to give me a big yes

about this you have to give me a big yes okay right on so here is what I’m gonna

okay right on so here is what I’m gonna

okay right on so here is what I’m gonna try to show you is you know here we have

try to show you is you know here we have

try to show you is you know here we have a young individuals and a whole

a young individuals and a whole

a young individuals and a whole individuals and what’s happen is you

individuals and what’s happen is you

individuals and what’s happen is you know when we’re young we have a lot of

know when we’re young we have a lot of

know when we’re young we have a lot of stem cells and those stem cells are very

stem cells and those stem cells are very

stem cells and those stem cells are very active there really is a lot of factors

active there really is a lot of factors

active there really is a lot of factors and this is why our kids feel very fast

and this is why our kids feel very fast

and this is why our kids feel very fast when they injure themselves when we get

when they injure themselves when we get

when they injure themselves when we get older we have less stem cells and those

older we have less stem cells and those

older we have less stem cells and those stem cells are not very active so this

stem cells are not very active so this

stem cells are not very active so this is why you know we’re not repairing our

is why you know we’re not repairing our

is why you know we’re not repairing our tissue very well so what we’re trying to

tissue very well so what we’re trying to

tissue very well so what we’re trying to do here is not to take someone order to

do here is not to take someone order to

do here is not to take someone order to make him younger is to take someone

make him younger is to take someone

make him younger is to take someone older and make him hate out here so here

older and make him hate out here so here

older and make him hate out here so here is you know what we have been doing so

is you know what we have been doing so

is you know what we have been doing so you probably have seen you know this on

you probably have seen you know this on

you probably have seen you know this on TV you know those proteinuria patient

TV you know those proteinuria patient

TV you know those proteinuria patient you know they are like 10 years of age

you know they are like 10 years of age

you know they are like 10 years of age and they look like 85 years of age age

and they look like 85 years of age age

and they look like 85 years of age age very fast sure enough we made a

very fast sure enough we made a

very fast sure enough we made a transgenic mice here this mice you know

transgenic mice here this mice you know

transgenic mice here this mice you know as a same mutation gene mutation at the

as a same mutation gene mutation at the

as a same mutation gene mutation at the pro Tyria patient and this mice age very

pro Tyria patient and this mice age very

pro Tyria patient and this mice age very fast as well this mice you know leave

fast as well this mice you know leave

fast as well this mice you know leave only 21 days normal mice will leave two

only 21 days normal mice will leave two

only 21 days normal mice will leave two years so what we ask is we found that

years so what we ask is we found that

years so what we ask is we found that the stem cell from those mice you know

the stem cell from those mice you know

the stem cell from those mice you know get depleted very fast so what we ask is

get depleted very fast so what we ask is

get depleted very fast so what we ask is if we inject young stem cell to those

if we inject young stem cell to those

if we inject young stem cell to those mice can we make them leave with longer

mice can we make them leave with longer

mice can we make them leave with longer than 21 days and here this is what’s

than 21 days and here this is what’s

than 21 days and here this is what’s happened you can see that my the red bar

happened you can see that my the red bar

happened you can see that my the red bar here the mice injected with all stem

here the mice injected with all stem

here the mice injected with all stem cells you can see now they live for up

cells you can see now they live for up

cells you can see now they live for up to 70 days not only do you live longer

to 70 days not only do you live longer

to 70 days not only do you live longer but they look better too so I don’t know

but they look better too so I don’t know

but they look better too so I don’t know if a mice can look better but those

if a mice can look better but those

if a mice can look better but those might look better than a non injected

might look better than a non injected

might look better than a non injected mice so the bottom line here is what we

mice so the bottom line here is what we

mice so the bottom line here is what we found is those protein your minds if you

found is those protein your minds if you

found is those protein your minds if you inject young stem cells you can make

inject young stem cells you can make

inject young stem cells you can make them live longer

them live longer

them live longer and you know they look LT or as well so

and you know they look LT or as well so

and you know they look LT or as well so what doesn’t mean for all of us today so

what doesn’t mean for all of us today so

what doesn’t mean for all of us today so that mean that the best gift we can give

that mean that the best gift we can give

that mean that the best gift we can give to our newborn is to Bhangarh stem cells

to our newborn is to Bhangarh stem cells

to our newborn is to Bhangarh stem cells at Birth from the umbilical cord you can

at Birth from the umbilical cord you can

at Birth from the umbilical cord you can bang their stem cells and after this

bang their stem cells and after this

bang their stem cells and after this those cells you know again we can Orvis

those cells you know again we can Orvis

those cells you know again we can Orvis the stem cells we can grow millions of

the stem cells we can grow millions of

the stem cells we can grow millions of them and what we’re going to do is we’re

them and what we’re going to do is we’re

them and what we’re going to do is we’re gonna Bank them as soon as we put them

gonna Bank them as soon as we put them

gonna Bank them as soon as we put them we freeze them up those cells stop the

we freeze them up those cells stop the

we freeze them up those cells stop the aging 20 years later they come in Vail

aging 20 years later they come in Vail

aging 20 years later they come in Vail and this key and they injure themselves

and this key and they injure themselves

and this key and they injure themselves then we can tow those cells put this in

then we can tow those cells put this in

then we can tow those cells put this in a syringe and basically treat them and

a syringe and basically treat them and

a syringe and basically treat them and again not only after injuries but maybe

again not only after injuries but maybe

again not only after injuries but maybe you know we can if the they look older a

you know we can if the they look older a

you know we can if the they look older a little bit so maybe we can inject their

little bit so maybe we can inject their

little bit so maybe we can inject their stem cells to delay their aging process

stem cells to delay their aging process

stem cells to delay their aging process the same thing is true for all the

the same thing is true for all the

the same thing is true for all the soldiers just think about you know if we

soldiers just think about you know if we

soldiers just think about you know if we were able to do this with all the

were able to do this with all the

were able to do this with all the soldiers we are a vessel stem cell

soldiers we are a vessel stem cell

soldiers we are a vessel stem cell before they go to the battlefield and

before they go to the battlefield and

before they go to the battlefield and what’s happened is you know if they have

what’s happened is you know if they have

what’s happened is you know if they have an injury they come back so we have stem

an injury they come back so we have stem

an injury they come back so we have stem cell to treat them think about those

cell to treat them think about those

cell to treat them think about those astronauts they go on the moon they face

astronauts they go on the moon they face

astronauts they go on the moon they face radiation so our vesting our stem so

radiation so our vesting our stem so

radiation so our vesting our stem so before they go in a shuttle they come

before they go in a shuttle they come

before they go in a shuttle they come back then we have their stem cell to

back then we have their stem cell to

back then we have their stem cell to treat them so this is really preventive

treat them so this is really preventive

treat them so this is really preventive medicine I know what you’re thinking

medicine I know what you’re thinking

medicine I know what you’re thinking though you’re probably thinking we’re –

though you’re probably thinking we’re –

though you’re probably thinking we’re – were to hold for this because you know

were to hold for this because you know

were to hold for this because you know we’re not taking at birth here so what

we’re not taking at birth here so what

we’re not taking at birth here so what we did is you know we has a question you

we did is you know we has a question you

we did is you know we has a question you know many people tell me you know I am

know many people tell me you know I am

know many people tell me you know I am way to hold to get my stem cells Bank

way to hold to get my stem cells Bank

way to hold to get my stem cells Bank you’re never to hold for that because

you’re never to hold for that because

you’re never to hold for that because let me give you an example if at Birth

let me give you an example if at Birth

let me give you an example if at Birth you know let’s say that all your stem

you know let’s say that all your stem

you know let’s say that all your stem cells are good at 50 years of age let’s

cells are good at 50 years of age let’s

cells are good at 50 years of age let’s say that 50% of them are very good at 75

say that 50% of them are very good at 75

say that 50% of them are very good at 75 maybe 25% of them are very good so what

maybe 25% of them are very good so what

maybe 25% of them are very good so what when we do the banking we can identify

when we do the banking we can identify

when we do the banking we can identify the good stem cells and this is the one

the good stem cells and this is the one

the good stem cells and this is the one that we grow millions of them but you

that we grow millions of them but you

that we grow millions of them but you will tell me you know what’s happen

will tell me you know what’s happen

will tell me you know what’s happen what’s happened with the one that are

what’s happened with the one that are

what’s happened with the one that are not so good so we did a lot of research

not so good so we did a lot of research

not so good so we did a lot of research recently and we found that you know we

recently and we found that you know we

recently and we found that you know we find a way to take a whole stem cells to

find a way to take a whole stem cells to

find a way to take a whole stem cells to make them young again and I’m gonna go

make them young again and I’m gonna go

make them young again and I’m gonna go in details a little bit here you know in

in details a little bit here you know in

in details a little bit here you know in in genetics but the bottom line here we

in genetics but the bottom line here we

in genetics but the bottom line here we found that when a young stem cells get

found that when a young stem cells get

found that when a young stem cells get old we have a protein complex they’re

old we have a protein complex they’re

old we have a protein complex they’re called mTOR and this protein complex

called mTOR and this protein complex

called mTOR and this protein complex sticker yarns themselves and make them

sticker yarns themselves and make them

sticker yarns themselves and make them hold why is that important for us

hold why is that important for us

hold why is that important for us because we find draw

because we find draw

because we find draw we were looking for drug that can block

we were looking for drug that can block

we were looking for drug that can block dissent or pathways and it turns out

dissent or pathways and it turns out

dissent or pathways and it turns out that one of the drug here is rapamycin

that one of the drug here is rapamycin

that one of the drug here is rapamycin rapamycin is an FDA approved drug it’s

rapamycin is an FDA approved drug it’s

rapamycin is an FDA approved drug it’s an immunosuppressive Asian and rapamycin

an immunosuppressive Asian and rapamycin

an immunosuppressive Asian and rapamycin is able to block the enter and proven

is able to block the enter and proven

is able to block the enter and proven your stem cells to get old and sure

your stem cells to get old and sure

your stem cells to get old and sure enough now people are using rapamycin

enough now people are using rapamycin

enough now people are using rapamycin here we have done some studies in rat in

here we have done some studies in rat in

here we have done some studies in rat in mice when you give them rapamycin they

mice when you give them rapamycin they

mice when you give them rapamycin they live longer they live out here and now

live longer they live out here and now

live longer they live out here and now you have people that take Reformation

you have people that take Reformation

you have people that take Reformation because an FDA approved drug already

because an FDA approved drug already

because an FDA approved drug already they have side effects associated with

they have side effects associated with

they have side effects associated with it but you know your doctor can decide

it but you know your doctor can decide

it but you know your doctor can decide not only that but another drug year this

not only that but another drug year this

not only that but another drug year this drug here you know it’s a diabetic drug

drug here you know it’s a diabetic drug

drug here you know it’s a diabetic drug metformin metformin has been used to

metformin metformin has been used to

metformin metformin has been used to delay aging for many years now this is a

delay aging for many years now this is a

delay aging for many years now this is a drug the cause of it is almost nothing

drug the cause of it is almost nothing

drug the cause of it is almost nothing and these drugs appear to be very good

and these drugs appear to be very good

and these drugs appear to be very good to delay aging as well so now I’m going

to delay aging as well so now I’m going

to delay aging as well so now I’m going to move to the next point we have done a

to move to the next point we have done a

to move to the next point we have done a lot of science to try to understand

lot of science to try to understand

lot of science to try to understand where the stem cell comes from because

where the stem cell comes from because

where the stem cell comes from because you have stem cells in your liver you

you have stem cells in your liver you

you have stem cells in your liver you have stem cells a new fat in your bone

have stem cells a new fat in your bone

have stem cells a new fat in your bone marrow in your muscle so it turns out

marrow in your muscle so it turns out

marrow in your muscle so it turns out that we found that stem cells come from

that we found that stem cells come from

that we found that stem cells come from the blood vessels all the micro vessel

the blood vessels all the micro vessel

the blood vessels all the micro vessel that you have in your tissues the

that you have in your tissues the

that you have in your tissues the systems that come from and why is that

systems that come from and why is that

systems that come from and why is that important because if I can increase the

important because if I can increase the

important because if I can increase the number of blood vessel I should be able

number of blood vessel I should be able

number of blood vessel I should be able to increase the number of stem cells and

to increase the number of stem cells and

to increase the number of stem cells and the best way to increase the number of

the best way to increase the number of

the best way to increase the number of blood vessels folks is exercise because

blood vessels folks is exercise because

blood vessels folks is exercise because when you do exercise you increase the

when you do exercise you increase the

when you do exercise you increase the number but vessels in your brain in your

number but vessels in your brain in your

number but vessels in your brain in your heart in your muscle and sure enough we

heart in your muscle and sure enough we

heart in your muscle and sure enough we wanted to prove it right

wanted to prove it right

wanted to prove it right we put my son treadmill mice are very

we put my son treadmill mice are very

we put my son treadmill mice are very lazy in nature mice they hit the drink

lazy in nature mice they hit the drink

lazy in nature mice they hit the drink they sleep those won’t do not those

they sleep those won’t do not those

they sleep those won’t do not those won’t run but sure enough you know when

won’t run but sure enough you know when

won’t run but sure enough you know when we run them and after this if we enjoyed

we run them and after this if we enjoyed

we run them and after this if we enjoyed our muscle their body heal significantly

our muscle their body heal significantly

our muscle their body heal significantly faster than the mice that are sitting in

faster than the mice that are sitting in

faster than the mice that are sitting in their cage doing nothing and I just

their cage doing nothing and I just

their cage doing nothing and I just would like to say that some experiment

would like to say that some experiment

would like to say that some experiment has been done recently

has been done recently

has been done recently instead of engineering those mice that

instead of engineering those mice that

instead of engineering those mice that were running the inject cancer cells to

were running the inject cancer cells to

were running the inject cancer cells to those mice all the mice that were

those mice all the mice that were

those mice all the mice that were sitting in their box not running you

sitting in their box not running you

sitting in their box not running you know they all died from that tumor which

know they all died from that tumor which

know they all died from that tumor which is expected 50% of the mice that were

is expected 50% of the mice that were

is expected 50% of the mice that were running survived that term so again

running survived that term so again

running survived that term so again folks exercise is very good for you so

folks exercise is very good for you so

folks exercise is very good for you so now you know and again you know timing

now you know and again you know timing

now you know and again you know timing is everything you know this issue of

is everything you know this issue of

is everything you know this issue of time

time

time you know that was published last year

you know that was published last year

you know that was published last year you need to get that issue but it is

you need to get that issue but it is

you need to get that issue but it is very important they assured that you

very important they assured that you

very important they assured that you know research link to exercise to less

know research link to exercise to less

know research link to exercise to less depression better memory quicker

depression better memory quicker

depression better memory quicker learning you know if you took the other

learning you know if you took the other

learning you know if you took the other side you can keep yourself younger and

side you can keep yourself younger and

side you can keep yourself younger and sure enough exercise has been shown to

sure enough exercise has been shown to

sure enough exercise has been shown to extend lifespan you know by as much as

extend lifespan you know by as much as

extend lifespan you know by as much as five years

five years

five years so again exercise is very important so

so again exercise is very important so

so again exercise is very important so now I just would like to finish by

now I just would like to finish by

now I just would like to finish by saying that not only your stem cells get

saying that not only your stem cells get

saying that not only your stem cells get hold when you get holder your blood get

hold when you get holder your blood get

hold when you get holder your blood get hold as well and what we have done here

hold as well and what we have done here

hold as well and what we have done here you’re gonna find this a little bit

you’re gonna find this a little bit

you’re gonna find this a little bit funny but what we take we take a two

funny but what we take we take a two

funny but what we take we take a two mice and we stitch them together

mice and we stitch them together

mice and we stitch them together stitchers

stitchers

stitchers their skin together and what we found if

their skin together and what we found if

their skin together and what we found if you stitch a young mice to a whole

you stitch a young mice to a whole

you stitch a young mice to a whole night’s ok you can rejuvenate the whole

night’s ok you can rejuvenate the whole

night’s ok you can rejuvenate the whole minds the whole mice with the young

minds the whole mice with the young

minds the whole mice with the young blood from the young mice now the young

blood from the young mice now the young

blood from the young mice now the young the whole my snout can repair our muscle

the whole my snout can repair our muscle

the whole my snout can repair our muscle there are bone they’re hard better

there are bone they’re hard better

there are bone they’re hard better showing clearly that the young blood can

showing clearly that the young blood can

showing clearly that the young blood can rejuvenate the whole minds so maybe

rejuvenate the whole minds so maybe

rejuvenate the whole minds so maybe after all you know not only we need to

after all you know not only we need to

after all you know not only we need to bank your stem cells we may need to Bank

bank your stem cells we may need to Bank

bank your stem cells we may need to Bank your blood as well because your blood is

your blood as well because your blood is

your blood as well because your blood is maybe something we can use on the road

maybe something we can use on the road

maybe something we can use on the road down the road and finally this is my

down the road and finally this is my

down the road and finally this is my best part here do you know that women

best part here do you know that women

best part here do you know that women live longer than men yeah I know the

live longer than men yeah I know the

live longer than men yeah I know the woman or laughing the man or like are

woman or laughing the man or like are

woman or laughing the man or like are you crazy or what woman live longer than

you crazy or what woman live longer than

you crazy or what woman live longer than men in the on average in United States

men in the on average in United States

men in the on average in United States woman live on average 80 years old

woman live on average 80 years old

woman live on average 80 years old the man is 74 why woman live longer than

the man is 74 why woman live longer than

the man is 74 why woman live longer than men people will tell you well men were

men people will tell you well men were

men people will tell you well men were crazy okay we secrete testosterone we

crazy okay we secrete testosterone we

crazy okay we secrete testosterone we take risk taking I went skiing this

take risk taking I went skiing this

take risk taking I went skiing this morning I went downhill but this is not

morning I went downhill but this is not

morning I went downhill but this is not the reason why women live longer than

the reason why women live longer than

the reason why women live longer than men folks you know why because if you

men folks you know why because if you

men folks you know why because if you take mice if you take rat if you take

take mice if you take rat if you take

take mice if you take rat if you take rabbits the female always ought leave

rabbits the female always ought leave

rabbits the female always ought leave the male and they don’t ski and they

the male and they don’t ski and they

the male and they don’t ski and they don’t bite they don’t do any of that so

don’t bite they don’t do any of that so

don’t bite they don’t do any of that so clearly there is something more biologic

clearly there is something more biologic

clearly there is something more biologic about that about why women live longer

about that about why women live longer

about that about why women live longer than men and we think that this is you

than men and we think that this is you

than men and we think that this is you know when the mud when the woman is

know when the mud when the woman is

know when the mud when the woman is pregnant she’s connected to her fetus

pregnant she’s connected to her fetus

pregnant she’s connected to her fetus and the fetus is the young and the woman

and the fetus is the young and the woman

and the fetus is the young and the woman is hold older so the bottom line is you

is hold older so the bottom line is you

is hold older so the bottom line is you have factor coming from the fetters that

have factor coming from the fetters that

have factor coming from the fetters that held the model and again you know we

held the model and again you know we

held the model and again you know we have done a study on this and we we we

have done a study on this and we we we

have done a study on this and we we we as a question we said well if woman that

as a question we said well if woman that

as a question we said well if woman that has never been pregnant on average

has never been pregnant on average

has never been pregnant on average doesn’t live longer than men suggesting

doesn’t live longer than men suggesting

doesn’t live longer than men suggesting that maybe pregnancy play a role here’s

that maybe pregnancy play a role here’s

that maybe pregnancy play a role here’s a paper showing that woman who has been

a paper showing that woman who has been

a paper showing that woman who has been pregnant between the age of 40 to 50

pregnant between the age of 40 to 50

pregnant between the age of 40 to 50 years of age have extremely low Nativity

years of age have extremely low Nativity

years of age have extremely low Nativity is in this paper the woman that they

is in this paper the woman that they

is in this paper the woman that they were pulling in this paper you know

were pulling in this paper you know

were pulling in this paper you know we’re living over 100 year old so again

we’re living over 100 year old so again

we’re living over 100 year old so again you know maybe during pregnancy you

you know maybe during pregnancy you

you know maybe during pregnancy you suffer but you’re getting a lot of

suffer but you’re getting a lot of

suffer but you’re getting a lot of payback from the Vettes so I just would

payback from the Vettes so I just would

payback from the Vettes so I just would like to say that you know even if we do

like to say that you know even if we do

like to say that you know even if we do you know even if I discover a pills for

you know even if I discover a pills for

you know even if I discover a pills for anti-aging or Bank your stem cells there

anti-aging or Bank your stem cells there

anti-aging or Bank your stem cells there is a lot of thing is that only one shot

is a lot of thing is that only one shot

is a lot of thing is that only one shot and we’re going to cure everything so we

and we’re going to cure everything so we

and we’re going to cure everything so we believe that down the road we can become

believe that down the road we can become

believe that down the road we can become your personal trainer for aging so we

your personal trainer for aging so we

your personal trainer for aging so we can stem

can stem

can stem Bank your stem cells we can also Bank

Bank your stem cells we can also Bank

Bank your stem cells we can also Bank your blood we can give you on teaching

your blood we can give you on teaching

your blood we can give you on teaching drugs we can exercise it’s very

drugs we can exercise it’s very

drugs we can exercise it’s very important but too much is not good so

important but too much is not good so

important but too much is not good so you have to exercise the right way

you have to exercise the right way

you have to exercise the right way nutrition is very important folks but

nutrition is very important folks but

nutrition is very important folks but also you know like I said to people you

also you know like I said to people you

also you know like I said to people you have to work with us if I give you the

have to work with us if I give you the

have to work with us if I give you the best drug to delay aging but you’re

best drug to delay aging but you’re

best drug to delay aging but you’re dressing like you know 20 year older and

dressing like you know 20 year older and

dressing like you know 20 year older and you are then you’re gonna look older so

you are then you’re gonna look older so

you are then you’re gonna look older so I think you know all those thing

I think you know all those thing

I think you know all those thing mediation yoga you know all player all

mediation yoga you know all player all

mediation yoga you know all player all here too so I just would like to say

here too so I just would like to say

here too so I just would like to say that maybe down the road we’re going to

that maybe down the road we’re going to

that maybe down the road we’re going to become your personal trainer for LT

become your personal trainer for LT

become your personal trainer for LT aging and I just would like to finish by

aging and I just would like to finish by

aging and I just would like to finish by saying that science and heart can come

saying that science and heart can come

saying that science and heart can come together at one point

together at one point

together at one point so we know the word that down the road

so we know the word that down the road

so we know the word that down the road maybe when you Bank your stem cells we

maybe when you Bank your stem cells we

maybe when you Bank your stem cells we can make a very nice frame with your

can make a very nice frame with your

can make a very nice frame with your home stem cells on it that you can

home stem cells on it that you can

home stem cells on it that you can display in your house and when you’re

display in your house and when you’re

display in your house and when you’re going to show this to your friend you

going to show this to your friend you

going to show this to your friend you can say this is my stem cells here so

can say this is my stem cells here so

can say this is my stem cells here so again you know I just would like to

again you know I just would like to

again you know I just would like to finish by saying that you know you’re

finish by saying that you know you’re

finish by saying that you know you’re probably noticed you know I’m Canadian

probably noticed you know I’m Canadian

probably noticed you know I’m Canadian and everything that we do in Canada

and everything that we do in Canada

and everything that we do in Canada relate to our tea so here is it good

relate to our tea so here is it good

relate to our tea so here is it good occupy a place where the park is a great

occupy a place where the park is a great

occupy a place where the park is a great occupier play where the park is

occupier play where the park is

occupier play where the park is going to be so as scientists I can tell

going to be so as scientists I can tell

going to be so as scientists I can tell you five five years from now seven year

you five five years from now seven year

you five five years from now seven year from now you are going to have your stem

from now you are going to have your stem

from now you are going to have your stem cells bank because that’s the right

cells bank because that’s the right

cells bank because that’s the right thing to do so thank you very much for

thing to do so thank you very much for

thing to do so thank you very much for your attention

[Applause]

[Applause] [Music]

”

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