good afternoon everyone so a long long time ago like a long time ago there was
time ago like a long time ago there was
time ago like a long time ago there was no internet and an even longer time ago
no internet and an even longer time ago
no internet and an even longer time ago there was no radio advent radio waves
there was no radio advent radio waves
there was no radio advent radio waves made it possible to communicate
made it possible to communicate
made it possible to communicate instantaneously across the enterprise
instantaneously across the enterprise
instantaneously across the enterprise world war 2 the Germans realized well we
world war 2 the Germans realized well we
world war 2 the Germans realized well we have high tech radio communications we
have high tech radio communications we
have high tech radio communications we need high tech decryption mentis
need high tech decryption mentis
need high tech decryption mentis especially when you’re sending messages
especially when you’re sending messages
especially when you’re sending messages related to the important battles people
related to the important battles people
related to the important battles people consider you don’t want those to be
consider you don’t want those to be
consider you don’t want those to be intercepted well other countries working
intercepted well other countries working
intercepted well other countries working on this the Germans were the first to
on this the Germans were the first to
on this the Germans were the first to actually in there the Germans were the
actually in there the Germans were the
actually in there the Germans were the first to invent this machine called the
first to invent this machine called the
first to invent this machine called the Enigma and this instrument is
Enigma and this instrument is
Enigma and this instrument is essentially looks like typewriter with
essentially looks like typewriter with
essentially looks like typewriter with the keyboard and what you choose input
the keyboard and what you choose input
the keyboard and what you choose input your message and it out for the chipra
your message and it out for the chipra
your message and it out for the chipra SH you can then send your gibberish
SH you can then send your gibberish
SH you can then send your gibberish excellent message over the radio and on
excellent message over the radio and on
excellent message over the radio and on the other end you have another group of
the other end you have another group of
the other end you have another group of people and they input the gibberish and
people and they input the gibberish and
people and they input the gibberish and out comes real message so essentially
out comes real message so essentially
out comes real message so essentially this complicated encoder is able to
this complicated encoder is able to
this complicated encoder is able to ensure that your information is pregnant
ensure that your information is pregnant
ensure that your information is pregnant well more won’t grow more turns over but
well more won’t grow more turns over but
well more won’t grow more turns over but there’s still some encoding that needs
there’s still some encoding that needs
there’s still some encoding that needs to be done but this time it’s a long
to be done but this time it’s a long
to be done but this time it’s a long available and the scientists are the one
available and the scientists are the one
available and the scientists are the one who are at war our body is an
who are at war our body is an
who are at war our body is an increasingly complex system made up of
increasingly complex system made up of
increasingly complex system made up of multiple organs and layered over various
multiple organs and layered over various
multiple organs and layered over various tissues do you have millions of cells
tissues do you have millions of cells
tissues do you have millions of cells that work together to communicate and in
that work together to communicate and in
that work together to communicate and in a in a very complex ecosystem and one of
a in a very complex ecosystem and one of
a in a very complex ecosystem and one of these players
these players
these players in this step this can result in a whole
in this step this can result in a whole
in this step this can result in a whole slew of health problems and disease it
slew of health problems and disease it
slew of health problems and disease it is what we can identify this grow
is what we can identify this grow
is what we can identify this grow through molecules that we can call them
through molecules that we can call them
through molecules that we can call them biomarkers and these are essentially
biomarkers and these are essentially
biomarkers and these are essentially indicators online biological processes
indicators online biological processes
indicators online biological processes when we can identify these markers we
when we can identify these markers we
when we can identify these markers we can prepare and plan for the proper
can prepare and plan for the proper
can prepare and plan for the proper course of action and intervene when it
course of action and intervene when it
course of action and intervene when it is most appropriate and also you’re
is most appropriate and also you’re
is most appropriate and also you’re probably more familiar Booth’s than you
probably more familiar Booth’s than you
probably more familiar Booth’s than you may think when you go to the doctor’s
may think when you go to the doctor’s
may think when you go to the doctor’s office and you have your blood drawn
office and you have your blood drawn
office and you have your blood drawn your blood is and they tell you well
your blood is and they tell you well
your blood is and they tell you well come back with you days and we’ll call
come back with you days and we’ll call
come back with you days and we’ll call you in a few days results well during
you in a few days results well during
you in a few days results well during that time your blood is sent off in a
that time your blood is sent off in a
that time your blood is sent off in a little package to a lab for they’re able
little package to a lab for they’re able
little package to a lab for they’re able to perform with a wide variety of tests
to perform with a wide variety of tests
to perform with a wide variety of tests and screen for molecules like cluster
and screen for molecules like cluster
and screen for molecules like cluster ala Lucas and these have a good
ala Lucas and these have a good
ala Lucas and these have a good indication of whether your risk for
indication of whether your risk for
indication of whether your risk for heart disease or diabetes but biomarkers
heart disease or diabetes but biomarkers
heart disease or diabetes but biomarkers are not exclusively for the doctor’s
are not exclusively for the doctor’s
are not exclusively for the doctor’s office they are also able for our homies
office they are also able for our homies
office they are also able for our homies the most common example is where a small
the most common example is where a small
the most common example is where a small presence of a hormone in your urine can
presence of a hormone in your urine can
presence of a hormone in your urine can cause an indicator to turn pink and
cause an indicator to turn pink and
cause an indicator to turn pink and indicates that your event your family is
indicates that your event your family is
indicates that your event your family is going to change the commission
going to change the commission
going to change the commission biomarkers the goal of identifying
biomarkers the goal of identifying
biomarkers the goal of identifying biomarkers for s decoding the body is
biomarkers for s decoding the body is
biomarkers for s decoding the body is not even low something finished one such
not even low something finished one such
not even low something finished one such example is a variant cancer one detected
example is a variant cancer one detected
example is a variant cancer one detected early ovarian cancer our patients have
early ovarian cancer our patients have
early ovarian cancer our patients have privately on the first five years pretty
privately on the first five years pretty
privately on the first five years pretty good button but the other remaining
good button but the other remaining
good button but the other remaining people that was incredibly great only
people that was incredibly great only
people that was incredibly great only 20% of cases of ovarian cancer are
20% of cases of ovarian cancer are
20% of cases of ovarian cancer are actually detected earlier and that’s
actually detected earlier and that’s
actually detected earlier and that’s just not good enough and it’s not alone
just not good enough and it’s not alone
just not good enough and it’s not alone this is just one example is just one
this is just one example is just one
this is just one example is just one disease neurological disorders make up
disease neurological disorders make up
disease neurological disorders make up an entire category of disorders or
an entire category of disorders or
an entire category of disorders or biomarkers are currently underserved and
biomarkers are currently underserved and
biomarkers are currently underserved and the strangest this includes diseases
the strangest this includes diseases
the strangest this includes diseases like dementia autism ADHD depression and
like dementia autism ADHD depression and
like dementia autism ADHD depression and addiction in my lab at the University of
addiction in my lab at the University of
addiction in my lab at the University of Georgia we focus on understanding
Georgia we focus on understanding
Georgia we focus on understanding neurological disorders such as addiction
neurological disorders such as addiction
neurological disorders such as addiction which is characterized as a chronic
which is characterized as a chronic
which is characterized as a chronic relapsing disorder given by
relapsing disorder given by
relapsing disorder given by uncontrollable drug seeking despite
uncontrollable drug seeking despite
uncontrollable drug seeking despite promises to yourself or others and with
promises to yourself or others and with
promises to yourself or others and with that we focus on the brain now we study
that we focus on the brain now we study
that we focus on the brain now we study a specific class of molecules colors
a specific class of molecules colors
a specific class of molecules colors which are essentially facts you may use
which are essentially facts you may use
which are essentially facts you may use them as oils in your home cooking or
them as oils in your home cooking or
them as oils in your home cooking or good foods that are high in fats these
good foods that are high in fats these
good foods that are high in fats these facts in brain and in the body have
facts in brain and in the body have
facts in brain and in the body have incredibly important to see a lot of the
incredibly important to see a lot of the
incredibly important to see a lot of the world’s studies have shown that lipids
world’s studies have shown that lipids
world’s studies have shown that lipids played a big role in mediating some
played a big role in mediating some
played a big role in mediating some responses to addiction these include
responses to addiction these include
responses to addiction these include terms like synaptic plasticity in their
terms like synaptic plasticity in their
terms like synaptic plasticity in their modulation and our research has the
modulation and our research has the
modulation and our research has the hypothesis that in the brain within a
hypothesis that in the brain within a
hypothesis that in the brain within a region within specific regions such as
region within specific regions such as
region within specific regions such as in the campus a region involved in
in the campus a region involved in
in the campus a region involved in learning and memory that lipids play a
learning and memory that lipids play a
learning and memory that lipids play a role in regulating some of the responses
role in regulating some of the responses
role in regulating some of the responses to drug use and then we can exploit
to drug use and then we can exploit
to drug use and then we can exploit understand
understand
understand these and five markers for addictions
these and five markers for addictions
these and five markers for addictions this is going to include it some
this is going to include it some
this is going to include it some questions like is someone multiples
questions like is someone multiples
questions like is someone multiples addiction for the first place are they
addiction for the first place are they
addiction for the first place are they likely to relapse these lipids are
likely to relapse these lipids are
likely to relapse these lipids are differentially expressed throughout the
differentially expressed throughout the
differentially expressed throughout the region like a mentor for campus learning
region like a mentor for campus learning
region like a mentor for campus learning and memory we think about we learn new
and memory we think about we learn new
and memory we think about we learn new things in school but learning and memory
things in school but learning and memory
things in school but learning and memory are really important to drug seeking in
are really important to drug seeking in
are really important to drug seeking in the first place you learn to associate
the first place you learn to associate
the first place you learn to associate drug reward behaviors and memories and
drug reward behaviors and memories and
drug reward behaviors and memories and those become reinforcing in your brain
those become reinforcing in your brain
those become reinforcing in your brain the bigger goal of this is cancel it so
the bigger goal of this is cancel it so
the bigger goal of this is cancel it so we identified the brain can be Neeson’s
we identified the brain can be Neeson’s
we identified the brain can be Neeson’s biomarkers most people are not going to
biomarkers most people are not going to
biomarkers most people are not going to want their brains being isolated
want their brains being isolated
want their brains being isolated instructors so he screamed for these
instructors so he screamed for these
instructors so he screamed for these Olympics in the bottoms up and see that
Olympics in the bottoms up and see that
Olympics in the bottoms up and see that it so we walk you through scenario let’s
it so we walk you through scenario let’s
it so we walk you through scenario let’s say we have an X and we want to see how
say we have an X and we want to see how
say we have an X and we want to see how does regulate it we have three possible
does regulate it we have three possible
does regulate it we have three possible hours if we were to compare an addictive
hours if we were to compare an addictive
hours if we were to compare an addictive individuals lipids to non-addictive
individuals lipids to non-addictive
individuals lipids to non-addictive visuals the first outcome is that in the
visuals the first outcome is that in the
visuals the first outcome is that in the addicted individual these with levels
addicted individual these with levels
addicted individual these with levels increase another scenario it would stay
increase another scenario it would stay
increase another scenario it would stay exactly the same which would sort of
exactly the same which would sort of
exactly the same which would sort of imply that is exactly the same uniject
imply that is exactly the same uniject
imply that is exactly the same uniject is not addictive
is not addictive
is not addictive that is probably not being affected by
that is probably not being affected by
that is probably not being affected by the addictive state the third outcome is
the addictive state the third outcome is
the addictive state the third outcome is that it decreases and regardless of
that it decreases and regardless of
that it decreases and regardless of whether it increases or decreases both
whether it increases or decreases both
whether it increases or decreases both either way we’re interested in that
either way we’re interested in that
either way we’re interested in that because it’s a change change from the
because it’s a change change from the
because it’s a change change from the normal free stuff all right I’m plugging
normal free stuff all right I’m plugging
normal free stuff all right I’m plugging things love it
things love it
things love it next two years they look at X is just
next two years they look at X is just
next two years they look at X is just one of hundreds of thousands of lipids
one of hundreds of thousands of lipids
one of hundreds of thousands of lipids throughout your body in your tissues so
throughout your body in your tissues so
throughout your body in your tissues so how do we know which one that we must be
how do we know which one that we must be
how do we know which one that we must be how do we know which one they go after
how do we know which one they go after
how do we know which one they go after it specific disease dates well the
it specific disease dates well the
it specific disease dates well the approach that we use in our line is a
approach that we use in our line is a
approach that we use in our line is a quick and dirty method called a shotgun
quick and dirty method called a shotgun
quick and dirty method called a shotgun approach and essentially it is the
approach and essentially it is the
approach and essentially it is the analytical analysis of thousands of
analytical analysis of thousands of
analytical analysis of thousands of little species simultaneously you
little species simultaneously you
little species simultaneously you analyze all the same time and you hope
analyze all the same time and you hope
analyze all the same time and you hope that one will stick and have a
that one will stick and have a
that one will stick and have a meaningful relationship within your sea
meaningful relationship within your sea
meaningful relationship within your sea state using this approach we have
state using this approach we have
state using this approach we have identified if you look at candidates
identified if you look at candidates
identified if you look at candidates does any pop promise within the context
does any pop promise within the context
does any pop promise within the context of addiction shown here is just one of
of addiction shown here is just one of
of addiction shown here is just one of them now before we focus on this we’re
them now before we focus on this we’re
them now before we focus on this we’re studying the brain I’m not the point
studying the brain I’m not the point
studying the brain I’m not the point Ryan isolating human brains but I am
Ryan isolating human brains but I am
Ryan isolating human brains but I am working with growth models rats are
working with growth models rats are
working with growth models rats are gonna behavioral model for addiction so
gonna behavioral model for addiction so
gonna behavioral model for addiction so we try to mimic the condition that was
we try to mimic the condition that was
we try to mimic the condition that was seeing people for me model things about
seeing people for me model things about
seeing people for me model things about what relapse and accidents and so once
what relapse and accidents and so once
what relapse and accidents and so once we were able to establish that
we were able to establish that
we were able to establish that behavioral paradigm we can then this
behavioral paradigm we can then this
behavioral paradigm we can then this assessor break and see how the addicted
assessor break and see how the addicted
assessor break and see how the addicted brain has changed so shown here is just
brain has changed so shown here is just
brain has changed so shown here is just a section with a little cut of the brain
and this limit species is called
and this limit species is called hospital 38:56 that’s just a fancy name
hospital 38:56 that’s just a fancy name
hospital 38:56 that’s just a fancy name for the one cooler structure if you look
for the one cooler structure if you look
for the one cooler structure if you look at this image you’ll see that there it
at this image you’ll see that there it
at this image you’ll see that there it is on color gradient now the bluer
is on color gradient now the bluer
is on color gradient now the bluer colours indicate lower levels of slippin
colours indicate lower levels of slippin
colours indicate lower levels of slippin where the red Pink’s indicate higher
where the red Pink’s indicate higher
where the red Pink’s indicate higher levels within and throughout the entire
levels within and throughout the entire
levels within and throughout the entire brain section in the drug user we have a
brain section in the drug user we have a
brain section in the drug user we have a complete obliteration of that and that’s
complete obliteration of that and that’s
complete obliteration of that and that’s really interesting because that I think
really interesting because that I think
really interesting because that I think I should be clear clear there this is
I should be clear clear there this is
I should be clear clear there this is not whether you use the drug or not this
not whether you use the drug or not this
not whether you use the drug or not this is a persistent change that has
is a persistent change that has
is a persistent change that has permanently changed in the brain five
permanently changed in the brain five
permanently changed in the brain five markers truly have the potential to
markers truly have the potential to
markers truly have the potential to transform the field of healthcare by
transform the field of healthcare by
transform the field of healthcare by making it more personalized to patients
making it more personalized to patients
making it more personalized to patients by using your body as a metric for
by using your body as a metric for
by using your body as a metric for today’s progression and agreeable to
today’s progression and agreeable to
today’s progression and agreeable to decode the human body we can be there to
decode the human body we can be there to
decode the human body we can be there to make better change in the future
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