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thank you for frankenstein but constant
who adapted to 2015
ladies and gentlemen the medicine of
immediate future ie tomorrow
since the future is not and will not be
the one of yesterday nor even less of the past
because the medicine of the past is
based on is based until today
on the use of drugs
the drugs made are there only
to correct quotes I’m talking about
serious illness huh what’s called the
treatments but there is no cure
total in a lot a lot a lot
of patients and therefore medicine
we are riding here today between
both in medicine of the future the
medicine of tomorrow you medicine
restorative regenerative
generative I mean by that a
replacement medicine we replace
parts these two mechanics who
wanted a shortcut that failure of
dynamos I have no soul alternator of a
starter we remove and set up his
current medicine that is in the process of
to develop and medicine
Regenerative regenerative one can
even go further regenerate
organs make from
cells what are called cells
strains
they are at the origin of everything from
all the cells of the body
it’s the strains are topical
forgiveness in this slide does not have
was enlarged but it does not matter any
recent she represents it’s a
slide that fed who is to be
of antiquity that nourished
the imaginary of generations in
generations
since this is a transplant of a
leg a black leg taken from a
black colored individual reflected a
white patient it’s just to show
the genetic difference the difference
genetic
it’s like in the mice
lab on ebook on a war etc
these are two brothers holy doctor
como and saint damien
they are Christian Arab doctors
which operated at the wholesale level at the
of current city current act so
this leg
you imagine until today
it’s difficult because the problem
to roger was not only black and
even white between us between blacks between
Chinese blonde all you want
you grafted it must be
compatible so-called listo
compatibility ie tissues
for them to be compatible which not
to roger that earned a nobel prize
I’m going to Paris in 1958 to
determine it’s tissue groups
which make it possible to determine if
someone can be grafted or not
especially an organ donor we have a
catcher who are waiting for a kidney a heart
a lung
once all you want there
should seek by giving for them
may be incompatible you have beautiful
give it as a gift an organ is not
not compatible rejected that’s the law
of immunology
ago that twins iron situations
no one at all has not
twins or found in nature
someone who is compatible with you and
who has the same dna as you right now
there you have the chance to regret it
without there being any roger
this slide this table he fed
the imaginary as early as Thursday researchers
and doctors
it’s an interesting journey
a journey the year strewn with pitfalls but
exciting because what tells us
not this table so it’s very beautiful
we see that even when its date and we
sees people who are interested in
try to graft and heal and
to take organs is the challenge
of today to be able to graft all the
world that has no shortage of organs
that’s the drama we can not because
that even if we find donors this
is not possible because of this
famous biological law that is tail
the genetics of recognition
of choosing the name either because your
system that accept or rejects
in most cases this is the
immune system the system
immune works according to a concept
who is there the difference the
self and name recognition be it
makes the difference to vodafone organ
did not go to you so they attack the
recognizes he gets to do in ten
other care and Anglo Saxon the
self or not safe
I come back this table I placed a little
I planted the immunological decor
for you are imbued with this
culture it’s a little complex but what
will be easier for afterwards
this slide does not tell us if his leg
was accepted or rejected but between
we
gently had to be rejected what the
challenge right now that’s it
it is an image that can perhaps
shock sensitive souls this graft
of face
it’s about the face guard
this gentleman is doing very well
know big diseases of cancer
of the face of the deformations of
genetic diseases you have people
that you can not even look at that
was possible
we would not have done it if we
know baasist should not see by
the rim
it would have been rejected we can
can graft a heart a yield
whatever you want it will be rejected
we’re not going to go that complicated
things
with the grace of a face if it’s
reject but it’s no longer
possible
that is to say there I can say the stock market
the strike is possible without them having
to roger what is now called
which is still the subject of
search the shield starts to be
applied in the first transplants
of the face is the induction of
tolerance is possible so if we
had grafted classically as the
leg of just now in three months
and it will be the chips but here the trick
the secret is no sugar and in science
a way of speaking
it is beforehand before transplant and
this face it could have been a heart
arms to be something else is to have
prepared to receive him at home what
sir there who is lying before
face transplant
we took from the patient who
gave this face of stem cells
it’s the stem cells are
cells that
I find in the bone marrow
at the water level and which allow
make all the cells of
the body and especially the one that
flows in the direction of the white blood cells
red blood cells
the liver the heart the lungs and that’s
whatever you want start at
from stem cells
so if we had grafted the face of
classic faso like the leg of everything
at the time it was rejected but there
we have prepared their flavor in him
injecting the cells
strains taken from one who has
given the face then went into
the face in the graft on do it on
the receiver at that moment that’s all
quite different
this face this grafted organ is going to
find in a non-aggressive context
that is stem cells
taken from the organ donor
have helped protect this face so
on parrot throw so that’s it that goes
defend him
the face the graft will end up in
face of a system he knows if he has
was grafted from the outset without a
solution behind they found themselves
in a hostile environment
in a receiver he does not know
the receiver will react duval rejected
therefore, it is necessary to wear the
stem cells
I repeat and then graft the face
so this integrated face seen by the
following but there was the face the arms
and most recently a uterus
I have a woman following this uterus to
function
this amount has started a pregnancy
and she gives birth to a child that is
so the arms is not nothing
taken from someone’s arms to
take the bone marrow before
that is, stem cells and
it’s to camp the face for
the uterus is the same before taking
the grounds are to take the marrow
stem cells
after we prepare the receiver then we
puts the uterus
and then and then it works
quite perfectly so the
first transplant before this face a
unimpressive that I have you
showed the first transplant
just before the complete face it was
just about the three the three cases
a face
this is her first lady that we
have grafted to lyon so she was
so see a little diagram l1 can
give a correction to his dog
had a shrinkage the air that has it
assaulted who snatched him by his
beauty of the face in all this has been
a little bit the situation and he the
here is today
this lady had an early face that
is M
in maastricht since grafting a face
face be expressive that goes up
emotions around so and that was
possible if not a mask
it’s rejecting that of course
technically there are the connections that
were made behind nerves and
essential vessels then the rest
did it afterwards
so we ‘ve seen this lady evolve
see today
and that’s just a few players had
sounded right after his operation
his face was frozen that lady I
know personally since we
next in the service and so looks
this is what was redone you have
all that did not move she was going
always with a scarf she hide
her face is today look at her
smile and it’s a face that works
and everything is in place
so I’m coming back to tell you that
the essential is in the cells
strains and it’s sir who are in
waters and that make it possible to manufacture
liver muscle skin all that
you want can be made by the
stem cells these are the ones actually
which is the secret of history
these stem cells we can
take in the lab at the level of
some places in the fetus at
normal class level are going to them
isolate puts them into culture
then put some ingredients on
growth factors
then it depends on the factor of
growth we do not know them all
but some growth factors
when we ‘re adding him we ‘re driving
we help each other cells has evolved
to if we want to make heart have
added and gardians and it’s okay
give cells when you
look at microscope here in this
box of kneaded cells they
will beat like a heart for m if we
puts the ingredients that allowed
to make liver you will have a fabric
hepatic 6 2 for the lungs for everything
what you want you can the
generated but we must identify all
the factors and these factors are not
all known
we can make skin that can not
to make of heart not being able to make
lung a little bit but not
but not all but not all organs
so and so it was possible so
to take cells
strains in a patient who had a
serious heart failure this has been
put in cultivation while waiting for him
find a heart of course that was
put in clean culture with the factors
growth that generates
cardiac tissue of the myocardium
Then it was injected at
from the heart and that built the heart that
was failing and who in which he
was going to be a hole so we can
even graft human cells from
human fetus in the mouse
that’s to make models
two laboratories that allow
treat rare diseases as
example when we developed
the system for trapping the virus from
AIDS since the AIDS virus did not
that human cells and you do not
can not work expectancy face
infected a man with hiv aids
so you have to build a
model that makes a system
immune function in mice
then you can work at
easily mouse this slide which
may be shocking to you but she is
very beautiful
I will tell you why we have
grafted what’s called hands feet and
a built-in hand on a foot at
someone who did not have he was born
without arms
there are no arms at the same level at
level of the shoulder joints he
will have to have a donor tomorrow he goes to
was taken the bone marrow is
the darling of course with that for this
not be rejected because otherwise
is useless then it allows
someone who does not have high arms
level so at the top level
it will allow him to take the
objects she’s stuck between
hollow of 2 so the ankle and the
arm so so without arms his hand is going
to be able to take and manipulate everything
that he wants so here is a little bit I
exceeded my time I want to you
thank for your attention
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