[Music] [Applause]
before we reimagine the future of
before we reimagine the future of longevity we’re through a quick pop quiz
longevity we’re through a quick pop quiz
longevity we’re through a quick pop quiz on something you learned earlier I’d
on something you learned earlier I’d
on something you learned earlier I’d like to ask you to count that number of
like to ask you to count that number of
like to ask you to count that number of times the letter F appears in this
times the letter F appears in this
times the letter F appears in this single sentence not a trick question
single sentence not a trick question
single sentence not a trick question just read the number read the sentence
just read the number read the sentence
just read the number read the sentence count the number of times the letter F
count the number of times the letter F
count the number of times the letter F up here’s in the sense okay I know you
up here’s in the sense okay I know you
up here’s in the sense okay I know you guys are fast readers how many people
guys are fast readers how many people
guys are fast readers how many people saw all three most of you anybody see
saw all three most of you anybody see
saw all three most of you anybody see for some of you anybody see five okay so
for some of you anybody see five okay so
for some of you anybody see five okay so the real answer is six and so now that
the real answer is six and so now that
the real answer is six and so now that you know the answers you can count the
you know the answers you can count the
you know the answers you can count the six FS I’m gonna help you out five flies
six FS I’m gonna help you out five flies
six FS I’m gonna help you out five flies of of scientific of hiding plain sight
of of scientific of hiding plain sight
of of scientific of hiding plain sight as Robert said earlier now young kids
as Robert said earlier now young kids
as Robert said earlier now young kids can see these things two older we get
can see these things two older we get
can see these things two older we get the harder it is for us to see these FS
the harder it is for us to see these FS
the harder it is for us to see these FS that’s another depressing future of
that’s another depressing future of
that’s another depressing future of aging except I’m here to tell you it’s
aging except I’m here to tell you it’s
aging except I’m here to tell you it’s good news you know why because that F
good news you know why because that F
good news you know why because that F could represent the future of longevity
could represent the future of longevity
could represent the future of longevity in fact that F represents functional
in fact that F represents functional
in fact that F represents functional longevity that’s what’s coming now
longevity that’s what’s coming now
longevity that’s what’s coming now what’s current longevity current
what’s current longevity current
what’s current longevity current longevity is we’re living longer and
longevity is we’re living longer and
longevity is we’re living longer and stronger lives or we’re not solving your
stronger lives or we’re not solving your
stronger lives or we’re not solving your online problem aging so we’ll create an
online problem aging so we’ll create an
online problem aging so we’ll create an older population that needs to consume
older population that needs to consume
older population that needs to consume more health care that’s a vicious cycle
more health care that’s a vicious cycle
more health care that’s a vicious cycle when you do something radically
when you do something radically
when you do something radically different than that this is whack Amole
different than that this is whack Amole
different than that this is whack Amole the current system right so let’s build
the current system right so let’s build
the current system right so let’s build it ground up from first principles
it ground up from first principles
it ground up from first principles living systems the first principle is
living systems the first principle is
living systems the first principle is selection favors increasing homeostatic
selection favors increasing homeostatic
selection favors increasing homeostatic capacity now what’s what we said a
capacity now what’s what we said a
capacity now what’s what we said a capacity well here are some definitions
capacity well here are some definitions
capacity well here are some definitions resilience for a bus test you can read
resilience for a bus test you can read
resilience for a bus test you can read the rest of the list but it’s it’s
the rest of the list but it’s it’s
the rest of the list but it’s it’s easier if I show you
easier if I show you
easier if I show you you remember homeostasis which is a
you remember homeostasis which is a
you remember homeostasis which is a state of equilibrium when we set a
state of equilibrium when we set a
state of equilibrium when we set a capacity is your ability to get to
capacity is your ability to get to
capacity is your ability to get to homeostasis which is think about it like
homeostasis which is think about it like
homeostasis which is think about it like a weeble wobble that’s my other favorite
a weeble wobble that’s my other favorite
a weeble wobble that’s my other favorite toy you push it and it self centers
toy you push it and it self centers
toy you push it and it self centers that’s such a when nature gave us and
that’s such a when nature gave us and
that’s such a when nature gave us and it’s so successful that we don’t realize
it’s so successful that we don’t realize
it’s so successful that we don’t realize we have it until we start losing it
we have it until we start losing it
we have it until we start losing it right around my age so here are the
right around my age so here are the
right around my age so here are the things I lost I’m gonna catalog for you
things I lost I’m gonna catalog for you
things I lost I’m gonna catalog for you I turned 40 and all of a sudden I
I turned 40 and all of a sudden I
I turned 40 and all of a sudden I couldn’t ride a roller coaster or do a
couldn’t ride a roller coaster or do a
couldn’t ride a roller coaster or do a cartwheel
cartwheel
cartwheel to a somersault because now I come out
to a somersault because now I come out
to a somersault because now I come out of it wobbly my weeble doesn’t
of it wobbly my weeble doesn’t
of it wobbly my weeble doesn’t self-centered and I say I don’t want to
self-centered and I say I don’t want to
self-centered and I say I don’t want to do it anymore my kids have no idea what
do it anymore my kids have no idea what
do it anymore my kids have no idea what I’m talking about my kids have no idea
I’m talking about my kids have no idea
I’m talking about my kids have no idea what I’m talking about
what I’m talking about
what I’m talking about when I said 8,000 feet I don’t feel well
when I said 8,000 feet I don’t feel well
when I said 8,000 feet I don’t feel well they’re running around they’re sprinting
they’re running around they’re sprinting
they’re running around they’re sprinting at 8,000 feet I’ve lost something my
at 8,000 feet I’ve lost something my
at 8,000 feet I’ve lost something my weeble doesn’t self-center when I go
weeble doesn’t self-center when I go
weeble doesn’t self-center when I go into a restaurant my peoples won’t open
into a restaurant my peoples won’t open
into a restaurant my peoples won’t open up enough so now it’s too dark you know
up enough so now it’s too dark you know
up enough so now it’s too dark you know outside 55 degrees my kids are in
outside 55 degrees my kids are in
outside 55 degrees my kids are in t-shirts and I made two layers
t-shirts and I made two layers
t-shirts and I made two layers I’ve lost my ability to self-center when
I’ve lost my ability to self-center when
I’ve lost my ability to self-center when they get sick they’re sick for two days
they get sick they’re sick for two days
they get sick they’re sick for two days they’re totally fine I get sick I’m
they’re totally fine I get sick I’m
they’re totally fine I get sick I’m coughing for a month you know ice to be
coughing for a month you know ice to be
coughing for a month you know ice to be able to stay up all night in college and
able to stay up all night in college and
able to stay up all night in college and feel fine the next day I want to see
feel fine the next day I want to see
feel fine the next day I want to see Coldplay last Wednesday I was still
Coldplay last Wednesday I was still
Coldplay last Wednesday I was still tired on Saturday there is no recovery
tired on Saturday there is no recovery
tired on Saturday there is no recovery recovering from an injury wound it just
recovering from an injury wound it just
recovering from an injury wound it just takes forever you know I still eat
takes forever you know I still eat
takes forever you know I still eat anything now I want to eat a bad meal I
anything now I want to eat a bad meal I
anything now I want to eat a bad meal I wake up at 1:00 a.m. so is it really bad
wake up at 1:00 a.m. so is it really bad
wake up at 1:00 a.m. so is it really bad diet alone is it also lost when we set a
diet alone is it also lost when we set a
diet alone is it also lost when we set a capacity I’m losing metabolic capacity
capacity I’m losing metabolic capacity
capacity I’m losing metabolic capacity this the reason I think all high-end
this the reason I think all high-end
this the reason I think all high-end athletes are retiring at 40 because all
athletes are retiring at 40 because all
athletes are retiring at 40 because all of a sudden though homey set a capacity
of a sudden though homey set a capacity
of a sudden though homey set a capacity across-the-board Czar’s declining those
across-the-board Czar’s declining those
across-the-board Czar’s declining those are the subjective experiences of
are the subjective experiences of
are the subjective experiences of lawsonia static capacity
lawsonia static capacity
lawsonia static capacity now think about objective things you
now think about objective things you
now think about objective things you can’t feel when we’re young and our
can’t feel when we’re young and our
can’t feel when we’re young and our blood pressure sugar go high or homey
blood pressure sugar go high or homey
blood pressure sugar go high or homey static capacity returns at the
static capacity returns at the
static capacity returns at the homeostasis except after 40 and some of
homeostasis except after 40 and some of
homeostasis except after 40 and some of us they stay high and we give it names
us they stay high and we give it names
us they stay high and we give it names like diabetes and hypertension what if
like diabetes and hypertension what if
like diabetes and hypertension what if all these things are just features of
all these things are just features of
all these things are just features of loss when we set a capacity just one
loss when we set a capacity just one
loss when we set a capacity just one thing we should always look for the most
thing we should always look for the most
thing we should always look for the most parsimonious explanation for this prayer
parsimonious explanation for this prayer
parsimonious explanation for this prayer for Naaman on may be lost when we
for Naaman on may be lost when we
for Naaman on may be lost when we aesthetic capacity is that explanation
aesthetic capacity is that explanation
aesthetic capacity is that explanation and that we just can’t see it because in
and that we just can’t see it because in
and that we just can’t see it because in evolutionary terms were stuck in a
evolutionary terms were stuck in a
evolutionary terms were stuck in a adaptive Valley where it’s an uphill
adaptive Valley where it’s an uphill
adaptive Valley where it’s an uphill battle to see a completely new way of
battle to see a completely new way of
battle to see a completely new way of treating the human body so in order to
treating the human body so in order to
treating the human body so in order to create a new system we created a prize
create a new system we created a prize
create a new system we created a prize with the industry leaders and scientific
with the industry leaders and scientific
with the industry leaders and scientific leaders called the power of the prize my
leaders called the power of the prize my
leaders called the power of the prize my wife and I put a million dollars in to
wife and I put a million dollars in to
wife and I put a million dollars in to create this new system that we want to
create this new system that we want to
create this new system that we want to see and we recently announced a two
see and we recently announced a two
see and we recently announced a two million dollar donation to the National
million dollar donation to the National
million dollar donation to the National Academy of Medicine to foster new
Academy of Medicine to foster new
Academy of Medicine to foster new innovations and the way we think about
innovations and the way we think about
innovations and the way we think about aging now in order to do this we have to
aging now in order to do this we have to
aging now in order to do this we have to fundamentally change the way we think
fundamentally change the way we think
fundamentally change the way we think about things again build it bottoms up
about things again build it bottoms up
about things again build it bottoms up our bodies our dynamics
our bodies our dynamics
our bodies our dynamics and yet we’ve been using static models
and yet we’ve been using static models
and yet we’ve been using static models of study at what am I mean by this
of study at what am I mean by this
of study at what am I mean by this physics cut integrated by treating as a
physics cut integrated by treating as a
physics cut integrated by treating as a dynamic system Minkowski added the
dynamic system Minkowski added the
dynamic system Minkowski added the fourth dimension that physics integrated
fourth dimension that physics integrated
fourth dimension that physics integrated space and time and all of a sudden now
space and time and all of a sudden now
space and time and all of a sudden now physics made sense we need to do the
physics made sense we need to do the
physics made sense we need to do the same thing in biology files you right
same thing in biology files you right
same thing in biology files you right now at three Natural Sciences let’s just
now at three Natural Sciences let’s just
now at three Natural Sciences let’s just add one more dimension make it four
add one more dimension make it four
add one more dimension make it four dimensional and it’ll change everything
dimensional and it’ll change everything
dimensional and it’ll change everything let me explain right now when you go to
let me explain right now when you go to
let me explain right now when you go to the annual checkup a doctor will measure
the annual checkup a doctor will measure
the annual checkup a doctor will measure your heart rate blood pressure glucose
your heart rate blood pressure glucose
your heart rate blood pressure glucose cholesterol these are all state
cholesterol these are all state
cholesterol these are all state variables that’s like a seismic
variables that’s like a seismic
variables that’s like a seismic scientist trying to forecast the
scientist trying to forecast the
scientist trying to forecast the collapse risk of a building based on the
collapse risk of a building based on the
collapse risk of a building based on the angle of declination that’s not what
angle of declination that’s not what
angle of declination that’s not what they do they do resilience testing right
they do they do resilience testing right
they do they do resilience testing right that map’s much better collabora so we
that map’s much better collabora so we
that map’s much better collabora so we know that our heart rate doesn’t change
know that our heart rate doesn’t change
know that our heart rate doesn’t change your whole life our heart rate response
your whole life our heart rate response
your whole life our heart rate response to exercise what the clients so why are
to exercise what the clients so why are
to exercise what the clients so why are we using the thing that doesn’t
we using the thing that doesn’t
we using the thing that doesn’t correlate with aging and risk instead of
correlate with aging and risk instead of
correlate with aging and risk instead of using the one that actually does
using the one that actually does
using the one that actually does correlate now imagine doing this to
correlate now imagine doing this to
correlate now imagine doing this to every diagnostic test turning every
every diagnostic test turning every
every diagnostic test turning every diagnostic test into a resilience test
diagnostic test into a resilience test
diagnostic test into a resilience test dynamic diagnostic is a new diagnostic
dynamic diagnostic is a new diagnostic
dynamic diagnostic is a new diagnostic field we got to create on top of the
field we got to create on top of the
field we got to create on top of the current field to bring it up to date to
current field to bring it up to date to
current field to bring it up to date to the 21st century 100 years after physics
the 21st century 100 years after physics
the 21st century 100 years after physics the goal here is to add temporal
the goal here is to add temporal
the goal here is to add temporal resolution to biology we have great
resolution to biology we have great
resolution to biology we have great spatial resolution getting smaller and
spatial resolution getting smaller and
spatial resolution getting smaller and smaller but it’s actually our the time
smaller but it’s actually our the time
smaller but it’s actually our the time domain and that’ll change everything
domain and that’ll change everything
domain and that’ll change everything it’ll also change the way we do drug
it’ll also change the way we do drug
it’ll also change the way we do drug discovery because instead of think about
discovery because instead of think about
discovery because instead of think about longevity as the endpoint we can think
longevity as the endpoint we can think
longevity as the endpoint we can think about homeostatic capacity as endpoint
about homeostatic capacity as endpoint
about homeostatic capacity as endpoint that’s something we can measure right
that’s something we can measure right
that’s something we can measure right now how resilient are you let’s stay
now how resilient are you let’s stay
now how resilient are you let’s stay healthy a whole lot longer and longevity
healthy a whole lot longer and longevity
healthy a whole lot longer and longevity is a free call option okay so when you
is a free call option okay so when you
is a free call option okay so when you think about therapeutics now we’ve got
think about therapeutics now we’ve got
think about therapeutics now we’ve got to think very differently than we have
to think very differently than we have
to think very differently than we have been instead of trying to restore
been instead of trying to restore
been instead of trying to restore homeostasis let’s increase homeostatic
homeostasis let’s increase homeostatic
homeostasis let’s increase homeostatic capacity let’s focus on capacity
capacity let’s focus on capacity
capacity let’s focus on capacity building instead of just trying to solve
building instead of just trying to solve
building instead of just trying to solve the problem the way we treat
the problem the way we treat
the problem the way we treat hypertension right now is we give you a
hypertension right now is we give you a
hypertension right now is we give you a blood pressure lowering medicine your
blood pressure lowering medicine your
blood pressure lowering medicine your blood pressure – I try to prop up the we
blood pressure – I try to prop up the we
blood pressure – I try to prop up the we bowl with a drug and what happens he was
bowl with a drug and what happens he was
bowl with a drug and what happens he was propping up it causes system atrophy
propping up it causes system atrophy
propping up it causes system atrophy your body actually it gets worse and
your body actually it gets worse and
your body actually it gets worse and eating more and more drug this is like
eating more and more drug this is like
eating more and more drug this is like the coffee model it’s a great pick-me-up
the coffee model it’s a great pick-me-up
the coffee model it’s a great pick-me-up but the more you drink the more tired
but the more you drink the more tired
but the more you drink the more tired your baseline so you can’t solve chronic
your baseline so you can’t solve chronic
your baseline so you can’t solve chronic problems with these acute therapies
problems with these acute therapies
problems with these acute therapies that’s what we’ve been doing for the
that’s what we’ve been doing for the
that’s what we’ve been doing for the last 100 you
last 100 you
last 100 you what’s the best way to treat high blood
what’s the best way to treat high blood
what’s the best way to treat high blood pressure is to exercise and when you’re
pressure is to exercise and when you’re
pressure is to exercise and when you’re exercising you’re raising your heart
exercising you’re raising your heart
exercising you’re raising your heart rate and raising your blood pressure and
rate and raising your blood pressure and
rate and raising your blood pressure and your home is set of capacity acts as a
your home is set of capacity acts as a
your home is set of capacity acts as a drug and restores normal blood pressure
drug and restores normal blood pressure
drug and restores normal blood pressure imagine putting blood pressure raising
imagine putting blood pressure raising
imagine putting blood pressure raising medicines into the body low doses
medicines into the body low doses
medicines into the body low doses intermittently as a way to lower blood
intermittently as a way to lower blood
intermittently as a way to lower blood pressure we’ve never tried this except
pressure we’ve never tried this except
pressure we’ve never tried this except we know it already works in fact we know
we know it already works in fact we know
we know it already works in fact we know it works in exercise the more you make
it works in exercise the more you make
it works in exercise the more you make the body worse the stronger it gets it’s
the body worse the stronger it gets it’s
the body worse the stronger it gets it’s like building a muscle or you can take
like building a muscle or you can take
like building a muscle or you can take about a like bassant vaccination make
about a like bassant vaccination make
about a like bassant vaccination make the body worse it gets stronger
the body worse it gets stronger
the body worse it gets stronger completely counterintuitive building
completely counterintuitive building
completely counterintuitive building capacity instead of solving the problem
capacity instead of solving the problem
capacity instead of solving the problem is the future of therapeutics now
is the future of therapeutics now
is the future of therapeutics now there’s something I’m even more excited
there’s something I’m even more excited
there’s something I’m even more excited about there’s an old idea in evolution
about there’s an old idea in evolution
about there’s an old idea in evolution called Wiseman’s hypothesis which is the
called Wiseman’s hypothesis which is the
called Wiseman’s hypothesis which is the idea that maybe senescence was actually
idea that maybe senescence was actually
idea that maybe senescence was actually a trait this idea wasn’t biology for
a trait this idea wasn’t biology for
a trait this idea wasn’t biology for many decades until 1953 when Nobel
many decades until 1953 when Nobel
many decades until 1953 when Nobel laureate Peter Medawar said you know
laureate Peter Medawar said you know
laureate Peter Medawar said you know senescence is unlikely to be a trade
senescence is unlikely to be a trade
senescence is unlikely to be a trade because it occurs after you finished
because it occurs after you finished
because it occurs after you finished reproducing that’s known as Mathers
reproducing that’s known as Mathers
reproducing that’s known as Mathers argument and people stop thinking about
argument and people stop thinking about
argument and people stop thinking about senescence as a trait that you could do
senescence as a trait that you could do
senescence as a trait that you could do something about so now the assumption is
something about so now the assumption is
something about so now the assumption is aging is something that happens now
aging is something that happens now
aging is something that happens now here’s the counter-argument to metamours
here’s the counter-argument to metamours
here’s the counter-argument to metamours argument we just lost miss Amanda aging
argument we just lost miss Amanda aging
argument we just lost miss Amanda aging now he was reproducing long after he
now he was reproducing long after he
now he was reproducing long after he started aging so maybe man where’s
started aging so maybe man where’s
started aging so maybe man where’s argument applies to females it doesn’t
argument applies to females it doesn’t
argument applies to females it doesn’t apply to males and I would argue even in
apply to males and I would argue even in
apply to males and I would argue even in females menopause happens during
females menopause happens during
females menopause happens during reproductive age there should have been
reproductive age there should have been
reproductive age there should have been runaway selection to defer menopause it
runaway selection to defer menopause it
runaway selection to defer menopause it didn’t happen so I don’t think MANOWAR’s
didn’t happen so I don’t think MANOWAR’s
didn’t happen so I don’t think MANOWAR’s argument holds fact if you look across
argument holds fact if you look across
argument holds fact if you look across nature they’re species that have no
nature they’re species that have no
nature they’re species that have no evidence of senescence solving
evidence of senescence solving
evidence of senescence solving senescence doesn’t violate the laws of
senescence doesn’t violate the laws of
senescence doesn’t violate the laws of physics right because we are not a
physics right because we are not a
physics right because we are not a closed system we can always acquire more
closed system we can always acquire more
closed system we can always acquire more energy to fight entropy but I’m not here
energy to fight entropy but I’m not here
energy to fight entropy but I’m not here to debate whether or not senescence is a
to debate whether or not senescence is a
to debate whether or not senescence is a trait or not I’m just gonna take the
trait or not I’m just gonna take the
trait or not I’m just gonna take the road less traveled because the idea that
road less traveled because the idea that
road less traveled because the idea that senescence might be a trade has not been
senescence might be a trade has not been
senescence might be a trade has not been looked at in decades and yet this is
looked at in decades and yet this is
looked at in decades and yet this is exactly what might be possible when you
exactly what might be possible when you
exactly what might be possible when you think about this possibility I think
think about this possibility I think
think about this possibility I think it’s actually quite like it we’re gonna
it’s actually quite like it we’re gonna
it’s actually quite like it we’re gonna be able to find these and be able to
be able to find these and be able to
be able to find these and be able to edit it out because it’s happening
edit it out because it’s happening
edit it out because it’s happening already
already
already there was an old idea biology that cells
there was an old idea biology that cells
there was an old idea biology that cells have programmed into them
have programmed into them
have programmed into them death and aging that was a heretic alai
death and aging that was a heretic alai
death and aging that was a heretic alai dia until now it’s accepted well what
dia until now it’s accepted well what
dia until now it’s accepted well what are cells that are programmed to age and
are cells that are programmed to age and
are cells that are programmed to age and die who edit out their own genes today
die who edit out their own genes today
die who edit out their own genes today they’re called cancers it is happening
they’re called cancers it is happening
they’re called cancers it is happening all over the place now cancers the
all over the place now cancers the
all over the place now cancers the scourge of humanity but why don’t we
scourge of humanity but why don’t we
scourge of humanity but why don’t we focus on not only what they’re doing
focus on not only what they’re doing
focus on not only what they’re doing wrong what are they doing right how are
wrong what are they doing right how are
wrong what are they doing right how are they able to edit out their senescence
they able to edit out their senescence
they able to edit out their senescence pathways sometimes your greatest enemy
pathways sometimes your greatest enemy
pathways sometimes your greatest enemy is your greatest friend as Bob Marley
is your greatest friend as Bob Marley
is your greatest friend as Bob Marley said now I think that there are
said now I think that there are
said now I think that there are interesting things that we already know
interesting things that we already know
interesting things that we already know that are destroying that are genetic
that are destroying that are genetic
that are destroying that are genetic traits that are destroying our body
traits that are destroying our body
traits that are destroying our body after 40 Clarke’s control systems repair
after 40 Clarke’s control systems repair
after 40 Clarke’s control systems repair mechanisms and power these other things
mechanisms and power these other things
mechanisms and power these other things are all in decline every cell under
are all in decline every cell under
are all in decline every cell under performs a little bit after 40 and the
performs a little bit after 40 and the
performs a little bit after 40 and the cumulative effects of that are probably
cumulative effects of that are probably
cumulative effects of that are probably the features of aging so let’s go find
the features of aging so let’s go find
the features of aging so let’s go find those genes edit the amount they could
those genes edit the amount they could
those genes edit the amount they could be the end of senescence as we know it
be the end of senescence as we know it
be the end of senescence as we know it relatively soon which is crazy now it’s
relatively soon which is crazy now it’s
relatively soon which is crazy now it’s only 1953 that we discovered the code of
only 1953 that we discovered the code of
only 1953 that we discovered the code of life this is James Watson who
life this is James Watson who
life this is James Watson who co-discovered the double helix
co-discovered the double helix
co-discovered the double helix ironically the year we discovered the
ironically the year we discovered the
ironically the year we discovered the code of life is a year we stop thinking
code of life is a year we stop thinking
code of life is a year we stop thinking about the code for aging and death so
about the code for aging and death so
about the code for aging and death so it’s time to put it all back together on
it’s time to put it all back together on
it’s time to put it all back together on the table right use all the molecular
the table right use all the molecular
the table right use all the molecular biology and the tools we know to go hunt
biology and the tools we know to go hunt
biology and the tools we know to go hunt for the cure for aging all this is not
for the cure for aging all this is not
for the cure for aging all this is not going to slow down evolution it’s not
going to slow down evolution it’s not
going to slow down evolution it’s not you’re going to increase evolutionary
you’re going to increase evolutionary
you’re going to increase evolutionary speed right cuz the olden days we needed
speed right cuz the olden days we needed
speed right cuz the olden days we needed hardware to be able to select
hardware to be able to select
hardware to be able to select preferences for blue flu or red pill
preferences for blue flu or red pill
preferences for blue flu or red pill because everything was hardwired but now
because everything was hardwired but now
because everything was hardwired but now that we have a brain and we can use
that we have a brain and we can use
that we have a brain and we can use memes and ideas as a way to acquire
memes and ideas as a way to acquire
memes and ideas as a way to acquire traits it’s more important to live so
traits it’s more important to live so
traits it’s more important to live so historically Darwinian evolution relied
historically Darwinian evolution relied
historically Darwinian evolution relied on the death of individuals as a way to
on the death of individuals as a way to
on the death of individuals as a way to innovate for hardware innovation we need
innovate for hardware innovation we need
innovate for hardware innovation we need to die for software innovation we have
to die for software innovation we have
to die for software innovation we have to live right now we’re accumulating all
to live right now we’re accumulating all
to live right now we’re accumulating all these memes and yet we’re dying
these memes and yet we’re dying
these memes and yet we’re dying so we’re shoveling all this knowledge to
so we’re shoveling all this knowledge to
so we’re shoveling all this knowledge to the next generation through school and
the next generation through school and
the next generation through school and books no it’s actually much better if
books no it’s actually much better if
books no it’s actually much better if you just continue living and living
you just continue living and living
you just continue living and living healthier lives stuff so the end of
healthier lives stuff so the end of
healthier lives stuff so the end of senescence is actually the human destiny
senescence is actually the human destiny
senescence is actually the human destiny it’s the evolutionary destiny okay
it’s the evolutionary destiny okay
it’s the evolutionary destiny okay so what are the things that you can do
so what are the things that you can do
so what are the things that you can do right now while we’re waiting for
right now while we’re waiting for
right now while we’re waiting for scientists to figure all this stuff out
scientists to figure all this stuff out
scientists to figure all this stuff out you guys ready for this this is your
you guys ready for this this is your
you guys ready for this this is your prescription for a functional longevity
prescription for a functional longevity
prescription for a functional longevity you can
you can
you can are doing today okay how many people
are doing today okay how many people
are doing today okay how many people here have spent a day surfing or being
here have spent a day surfing or being
here have spent a day surfing or being out of the beach and they get tired at
out of the beach and they get tired at
out of the beach and they get tired at night how many people to experience that
night how many people to experience that
night how many people to experience that okay seriously here’s the ball do you
okay seriously here’s the ball do you
okay seriously here’s the ball do you need to know
need to know
need to know sunlight suppresses melatonin and you
sunlight suppresses melatonin and you
sunlight suppresses melatonin and you get the return of melatonin a night
get the return of melatonin a night
get the return of melatonin a night every species in nature history lived in
every species in nature history lived in
every species in nature history lived in ambient light day night variation were
ambient light day night variation were
ambient light day night variation were the first species to cover ourselves
the first species to cover ourselves
the first species to cover ourselves during the day with indoor jobs sunblock
during the day with indoor jobs sunblock
during the day with indoor jobs sunblock sunglasses clothes and at night instead
sunglasses clothes and at night instead
sunglasses clothes and at night instead of enjoying the darkness we put on all
of enjoying the darkness we put on all
of enjoying the darkness we put on all the lights
the lights
the lights we’re losing the dynamic range we’re
we’re losing the dynamic range we’re
we’re losing the dynamic range we’re actually losing functional capacity
actually losing functional capacity
actually losing functional capacity let’s actually do the other thing let’s
let’s actually do the other thing let’s
let’s actually do the other thing let’s increase our dynamic range you know
increase our dynamic range you know
increase our dynamic range you know right now if you stay away from the Sun
right now if you stay away from the Sun
right now if you stay away from the Sun you actually D buffer your capacity to
you actually D buffer your capacity to
you actually D buffer your capacity to be able to helm them so we always have
be able to helm them so we always have
be able to helm them so we always have the perfect amount of melanin in our
the perfect amount of melanin in our
the perfect amount of melanin in our skin and now that we’re staying away
skin and now that we’re staying away
skin and now that we’re staying away from it is why we get some burns and
from it is why we get some burns and
from it is why we get some burns and other types of skin diseases where the
other types of skin diseases where the
other types of skin diseases where the first pieces did not live in ambient
first pieces did not live in ambient
first pieces did not live in ambient temperature every species out there
temperature every species out there
temperature every species out there lived in 40 degrees 100 degrees they’re
lived in 40 degrees 100 degrees they’re
lived in 40 degrees 100 degrees they’re brown fat to heat them up their cooling
brown fat to heat them up their cooling
brown fat to heat them up their cooling mechanisms were the first species that’s
mechanisms were the first species that’s
mechanisms were the first species that’s trying to stay 70 degrees all the time
trying to stay 70 degrees all the time
trying to stay 70 degrees all the time we’re trying to narrow our dynamic range
we’re trying to narrow our dynamic range
we’re trying to narrow our dynamic range right we put on clothes we have HVAC
right we put on clothes we have HVAC
right we put on clothes we have HVAC systems we moved to California
systems we moved to California
systems we moved to California your Bloods not fitting when you move to
your Bloods not fitting when you move to
your Bloods not fitting when you move to California losing dynamic range one of
California losing dynamic range one of
California losing dynamic range one of my clients said you know my wife can
my clients said you know my wife can
my clients said you know my wife can tell the difference between 69 and 71
tell the difference between 69 and 71
tell the difference between 69 and 71 that’s a disaster but you’re supposed to
that’s a disaster but you’re supposed to
that’s a disaster but you’re supposed to handle everything so spend more time in
handle everything so spend more time in
handle everything so spend more time in cold weather and spent time in altitude
cold weather and spent time in altitude
cold weather and spent time in altitude spend time in depths stretch your range
spend time in depths stretch your range
spend time in depths stretch your range spend time in the desert this is my son
spend time in the desert this is my son
spend time in the desert this is my son and his friends at Burning Man and okay
and his friends at Burning Man and okay
and his friends at Burning Man and okay it’s not exercise all the lifestyle
it’s not exercise all the lifestyle
it’s not exercise all the lifestyle recommendations out there are half right
recommendations out there are half right
recommendations out there are half right they got half of a right exercise is
they got half of a right exercise is
they got half of a right exercise is good but it’s about variation and
good but it’s about variation and
good but it’s about variation and exercise different routines therefore
exercise different routines therefore
exercise different routines therefore time of day different muscle groups
time of day different muscle groups
time of day different muscle groups different pace I mean running a marathon
different pace I mean running a marathon
different pace I mean running a marathon is fine but what happened to the first
is fine but what happened to the first
is fine but what happened to the first guy that ran 26.2 miles he died right so
guy that ran 26.2 miles he died right so
guy that ran 26.2 miles he died right so think about variations of exercise
think about variations of exercise
think about variations of exercise rather than static exercise but now that
rather than static exercise but now that
rather than static exercise but now that you think about increasing homeostatic
you think about increasing homeostatic
you think about increasing homeostatic capacity increase your dynamic range
capacity increase your dynamic range
capacity increase your dynamic range there’s now a new idea you can think
there’s now a new idea you can think
there’s now a new idea you can think about which is that you can get above
about which is that you can get above
about which is that you can get above normal healthy because right now
normal healthy because right now
normal healthy because right now everything about health is getting back
everything about health is getting back
everything about health is getting back to healthy no what do you think about
to healthy no what do you think about
to healthy no what do you think about homeostatic capacity you can have
homeostatic capacity you can have
homeostatic capacity you can have above baseline you can have more health
above baseline you can have more health
above baseline you can have more health than you were born with this is gonna
than you were born with this is gonna
than you were born with this is gonna transform the way we think about help
transform the way we think about help
transform the way we think about help athletes already doing it again
athletes already doing it again
athletes already doing it again ergonomic and neutral that’s reducing
ergonomic and neutral that’s reducing
ergonomic and neutral that’s reducing dynamic range right we know what happens
dynamic range right we know what happens
dynamic range right we know what happens if you put your leg in a cast you
if you put your leg in a cast you
if you put your leg in a cast you actually lose muscle what you should do
actually lose muscle what you should do
actually lose muscle what you should do is the opposite instead of ergonomic and
is the opposite instead of ergonomic and
is the opposite instead of ergonomic and neutral you should be stretching your
neutral you should be stretching your
neutral you should be stretching your dynamic range flexion and extension
dynamic range flexion and extension
dynamic range flexion and extension again it our eyes have the ability to
again it our eyes have the ability to
again it our eyes have the ability to see things that are six inches away and
see things that are six inches away and
see things that are six inches away and 30 miles away right you can see it you
30 miles away right you can see it you
30 miles away right you can see it you have incredible dynamic range how we use
have incredible dynamic range how we use
have incredible dynamic range how we use in those eyes 18 inches in front of us
in those eyes 18 inches in front of us
in those eyes 18 inches in front of us all day long
all day long
all day long we’re losing dynamic great stretch that
we’re losing dynamic great stretch that
we’re losing dynamic great stretch that dynamic range okay so that last lady
dynamic range okay so that last lady
dynamic range okay so that last lady look a little stress but chronic stress
look a little stress but chronic stress
look a little stress but chronic stress is what’s bad well I accept that but the
is what’s bad well I accept that but the
is what’s bad well I accept that but the answer to that isn’t meditation or
answer to that isn’t meditation or
answer to that isn’t meditation or sleeping which is what we’re told sleep
sleeping which is what we’re told sleep
sleeping which is what we’re told sleep and meditate more that’s all good stuff
and meditate more that’s all good stuff
and meditate more that’s all good stuff but what I’m here to tell you is it’s
but what I’m here to tell you is it’s
but what I’m here to tell you is it’s actually that and alternating with
actually that and alternating with
actually that and alternating with something exhilarating right don’t just
something exhilarating right don’t just
something exhilarating right don’t just meditate do something exciting
meditate do something exciting
meditate do something exciting it’s the variation that matters it’s not
it’s the variation that matters it’s not
it’s the variation that matters it’s not meditation or asleep it’s the change
meditation or asleep it’s the change
meditation or asleep it’s the change increase your dynamic range again
increase your dynamic range again
increase your dynamic range again there’s so much news out there and
there’s so much news out there and
there’s so much news out there and recommendations about food eat this eat
recommendations about food eat this eat
recommendations about food eat this eat that eat that I’m here to tell you the
that eat that I’m here to tell you the
that eat that I’m here to tell you the exact opposite I’m here to tell you to
exact opposite I’m here to tell you to
exact opposite I’m here to tell you to eat a dynamic range of diet it’s okay to
eat a dynamic range of diet it’s okay to
eat a dynamic range of diet it’s okay to eat healthy but if you keep doing that
eat healthy but if you keep doing that
eat healthy but if you keep doing that you’re gonna lose metabolic capacity so
you’re gonna lose metabolic capacity so
you’re gonna lose metabolic capacity so fine if you eat healthy but have at
fine if you eat healthy but have at
fine if you eat healthy but have at least one bag of the reader per month
otherwise you’re gonna lose metabolic
otherwise you’re gonna lose metabolic capacity okay
capacity okay
capacity okay we’re supposed to have a wide range of
we’re supposed to have a wide range of
we’re supposed to have a wide range of human experiences and we’re putting
human experiences and we’re putting
human experiences and we’re putting everybody on Prozac we’re losing this
everybody on Prozac we’re losing this
everybody on Prozac we’re losing this dynamic range stretch it out right we’re
dynamic range stretch it out right we’re
dynamic range stretch it out right we’re supposed to be happy and sad that’s holy
supposed to be happy and sad that’s holy
supposed to be happy and sad that’s holy okay in fact if you think about the
okay in fact if you think about the
okay in fact if you think about the things that really resonate whether it’s
things that really resonate whether it’s
things that really resonate whether it’s music or the arts this is Shakespeare
music or the arts this is Shakespeare
music or the arts this is Shakespeare and I basically do a graphical line
and I basically do a graphical line
and I basically do a graphical line around the plot of Shakespeare
it basically is a dynamic range right
it basically is a dynamic range right these are the things that really
these are the things that really
these are the things that really resonate inside of us okay then if this
resonate inside of us okay then if this
resonate inside of us okay then if this means you should change the way you
means you should change the way you
means you should change the way you think about the world by having new
think about the world by having new
think about the world by having new experiences go travel go do amazing
experiences go travel go do amazing
experiences go travel go do amazing things go listen to interesting talks
things go listen to interesting talks
things go listen to interesting talks now hang out with new people try on a
now hang out with new people try on a
now hang out with new people try on a different way to look at things look at
different way to look at things look at
different way to look at things look at the world upside down try on the
the world upside down try on the
the world upside down try on the opposing point of view keep stretching
opposing point of view keep stretching
opposing point of view keep stretching your mental dynamic range as well you
your mental dynamic range as well you
your mental dynamic range as well you know go to Burning Man which will
know go to Burning Man which will
know go to Burning Man which will totally throw you for a loop
totally throw you for a loop
totally throw you for a loop I started doing improv on stage which
I started doing improv on stage which
I started doing improv on stage which complete changed my perspective on on
complete changed my perspective on on
complete changed my perspective on on humor I couldn’t find any pictures on
humor I couldn’t find any pictures on
humor I couldn’t find any pictures on the internet and this one
and your thing that really helps is
and your thing that really helps is laughter laughter dramatically increases
laughter laughter dramatically increases
laughter laughter dramatically increases their pulmonary dynamic range and that’s
their pulmonary dynamic range and that’s
their pulmonary dynamic range and that’s a gateway to health as well so this is a
a gateway to health as well so this is a
a gateway to health as well so this is a really an amazing thing right I mean I
really an amazing thing right I mean I
really an amazing thing right I mean I think we’re on the front end of a
think we’re on the front end of a
think we’re on the front end of a revolution in longevity Sciences if
revolution in longevity Sciences if
revolution in longevity Sciences if we’re able to successfully increase
we’re able to successfully increase
we’re able to successfully increase homeostatic capacity we’re gonna unleash
homeostatic capacity we’re gonna unleash
homeostatic capacity we’re gonna unleash human capacity but while we’re waiting
human capacity but while we’re waiting
human capacity but while we’re waiting for all that the good news is that the
for all that the good news is that the
for all that the good news is that the Gateway to your personal longevity the
Gateway to your personal longevity the
Gateway to your personal longevity the Gateway to increasing your functional
Gateway to increasing your functional
Gateway to increasing your functional longevity isn’t eating more broccoli
longevity isn’t eating more broccoli
longevity isn’t eating more broccoli like we were told when we’re young it’s
like we were told when we’re young it’s
like we were told when we’re young it’s actually doing more the things you
actually doing more the things you
actually doing more the things you already love doing more time in the Sun
already love doing more time in the Sun
already love doing more time in the Sun more time sleeping more time meditating
more time sleeping more time meditating
more time sleeping more time meditating more time riding roller coasters more
more time riding roller coasters more
more time riding roller coasters more time skiing spending time in that desert
time skiing spending time in that desert
time skiing spending time in that desert meeting with interesting people eating
meeting with interesting people eating
meeting with interesting people eating different kinds of food trying on new
different kinds of food trying on new
different kinds of food trying on new ideas learning more having more sex
ideas learning more having more sex
ideas learning more having more sex laughing more these are all things we
laughing more these are all things we
laughing more these are all things we love doing and that actually is the best
love doing and that actually is the best
love doing and that actually is the best news of all thank you so much
news of all thank you so much
news of all thank you so much [Applause]
”
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