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Fighting Brain Cancer with Trojan Horses | Dr. Alfredo Quinones-Hinojosa | TEDxZumbroRiver


my son says to me one day he was about

my son says to me one day he was about 10 years old David is his name dead how

10 years old David is his name dead how

10 years old David is his name dead how come you’re not like mom and I’m like

come you’re not like mom and I’m like

come you’re not like mom and I’m like son mom is amazing she is but but what

son mom is amazing she is but but what

son mom is amazing she is but but what do you mean by that

do you mean by that

do you mean by that you know mom you know she’s got like all

you know mom you know she’s got like all

you know mom you know she’s got like all these tools she works with her hands she

these tools she works with her hands she

these tools she works with her hands she decided to carpentry she knows how to do

decided to carpentry she knows how to do

decided to carpentry she knows how to do plumbing I mean everything around the

plumbing I mean everything around the

plumbing I mean everything around the house you fix us and what do you do you

house you fix us and what do you do you

house you fix us and what do you do you just like you’re always talking about

just like you’re always talking about

just like you’re always talking about some sort of fat sales and Trojan horses

some sort of fat sales and Trojan horses

some sort of fat sales and Trojan horses and some sort of brain surgery what what

and some sort of brain surgery what what

and some sort of brain surgery what what is this all about

is this all about

is this all about fast forward like six months later I get

fast forward like six months later I get

fast forward like six months later I get some letter dr. Q you’ve been awarded

some letter dr. Q you’ve been awarded

some letter dr. Q you’ve been awarded some sort of major award you got to come

some sort of major award you got to come

some sort of major award you got to come to Washington DC we’re gonna send a limo

to Washington DC we’re gonna send a limo

to Washington DC we’re gonna send a limo with you and your family can come with

with you and your family can come with

with you and your family can come with you

you

you no one wanted to go I finally convinced

no one wanted to go I finally convinced

no one wanted to go I finally convinced David David they can have a limos and a

David David they can have a limos and a

David David they can have a limos and a pick us up she’s already dead

pick us up she’s already dead

pick us up she’s already dead but it’s a school day don’t worry I’m an

but it’s a school day don’t worry I’m an

but it’s a school day don’t worry I’m an ass for permission he was thrilled he

ass for permission he was thrilled he

ass for permission he was thrilled he was impressed wearing this limo we get

was impressed wearing this limo we get

was impressed wearing this limo we get to this place and here he is sitting in

to this place and here he is sitting in

to this place and here he is sitting in a table with some very famous important

a table with some very famous important

a table with some very famous important people in Washington DC I get an award I

people in Washington DC I get an award I

people in Washington DC I get an award I come up and I show a small video like

come up and I show a small video like

come up and I show a small video like what I’m gonna show soon I may be doing

what I’m gonna show soon I may be doing

what I’m gonna show soon I may be doing brain surgery and his eyes just dilated

brain surgery and his eyes just dilated

brain surgery and his eyes just dilated his pupils dilated and I’m thinking to

his pupils dilated and I’m thinking to

his pupils dilated and I’m thinking to myself oh my gosh my son knows that I am

myself oh my gosh my son knows that I am

myself oh my gosh my son knows that I am the man I finish in my word come back

the man I finish in my word come back

the man I finish in my word come back sit down with him says David what do you

sit down with him says David what do you

sit down with him says David what do you think he goes dead I had no idea that

think he goes dead I had no idea that

think he goes dead I had no idea that you knew how do you say drill because he

you knew how do you say drill because he

you knew how do you say drill because he saw me using a drill a crane your tongue

saw me using a drill a crane your tongue

saw me using a drill a crane your tongue for doing brain surgery I hope over the

for doing brain surgery I hope over the

for doing brain surgery I hope over the next few minutes I’ll tell you a little

next few minutes I’ll tell you a little

next few minutes I’ll tell you a little bit about the work that we do not just

bit about the work that we do not just

bit about the work that we do not just myself but a team of people working in

myself but a team of people working in

myself but a team of people working in our laboratory I’ll tell you a little

our laboratory I’ll tell you a little

our laboratory I’ll tell you a little bit about Trojan horses fat cells cancer

bit about Trojan horses fat cells cancer

bit about Trojan horses fat cells cancer and some of the things that our team has

and some of the things that our team has

and some of the things that our team has actually learned about how to fight

actually learned about how to fight

actually learned about how to fight cancer let me tell you why cancer it

cancer let me tell you why cancer it

cancer let me tell you why cancer it turns out and most many of you guys

turns out and most many of you guys

turns out and most many of you guys probably know already cancer will be the

probably know already cancer will be the

probably know already cancer will be the leading

leading

leading death in the world by the year 2025

death in the world by the year 2025

death in the world by the year 2025 maybe you’re not aware that us 2012 8

maybe you’re not aware that us 2012 8

maybe you’re not aware that us 2012 8 million people died a year of cancer all

million people died a year of cancer all

million people died a year of cancer all types of cancer by the year 2030 13

types of cancer by the year 2030 13

types of cancer by the year 2030 13 million deaths in the world due to

million deaths in the world due to

million deaths in the world due to cancer in the United States alone when

cancer in the United States alone when

cancer in the United States alone when you look at the curve of heart disease

you look at the curve of heart disease

you look at the curve of heart disease and cancer over the last five decades

and cancer over the last five decades

and cancer over the last five decades cancer has been catching up very

cancer has been catching up very

cancer has been catching up very steadily and very fast in 22 states in

steadily and very fast in 22 states in

steadily and very fast in 22 states in the United States cancer is the number

the United States cancer is the number

the United States cancer is the number one cause of death just think about this

one cause of death just think about this

one cause of death just think about this how ill prepare we are to deal with

how ill prepare we are to deal with

how ill prepare we are to deal with cancer it’s painful it’s a disease that

cancer it’s painful it’s a disease that

cancer it’s painful it’s a disease that has affected most of us I’m sure in this

has affected most of us I’m sure in this

has affected most of us I’m sure in this audience or family members of Logans

audience or family members of Logans

audience or family members of Logans it’s extraordinarily expensive and we’re

it’s extraordinarily expensive and we’re

it’s extraordinarily expensive and we’re not ready to deal with this I have

not ready to deal with this I have

not ready to deal with this I have dedicated my life to study cancer and

dedicated my life to study cancer and

dedicated my life to study cancer and when he comes on two cancers there’s one

when he comes on two cancers there’s one

when he comes on two cancers there’s one cancer that I call it the king of

cancer that I call it the king of

cancer that I call it the king of cancers and I try to explain my son this

cancers and I try to explain my son this

cancers and I try to explain my son this but he wouldn’t have it he saw this

but he wouldn’t have it he saw this

but he wouldn’t have it he saw this picture one day of this human brain

picture one day of this human brain

picture one day of this human brain rotated that was actually one of my

rotated that was actually one of my

rotated that was actually one of my patients she was four years old it’s a

patients she was four years old it’s a

patients she was four years old it’s a beautiful brain and then I showed David

beautiful brain and then I showed David

beautiful brain and then I showed David Olivia and Gabby this picture of cells

Olivia and Gabby this picture of cells

Olivia and Gabby this picture of cells migraine for the first time in our

migraine for the first time in our

migraine for the first time in our laboratory we can actually see human

laboratory we can actually see human

laboratory we can actually see human cancer cells migrating in the human

cancer cells migrating in the human

cancer cells migrating in the human brain and wonder why is it that we can’t

brain and wonder why is it that we can’t

brain and wonder why is it that we can’t cure this disease thing you can see it

cure this disease thing you can see it

cure this disease thing you can see it right there in green they’re fluorescent

right there in green they’re fluorescent

right there in green they’re fluorescent with green fluorescent protein they’re

with green fluorescent protein they’re

with green fluorescent protein they’re invading the brain they’re going along

invading the brain they’re going along

invading the brain they’re going along the blood vessels they are

the blood vessels they are

the blood vessels they are extraordinarily smart this is indeed the

extraordinarily smart this is indeed the

extraordinarily smart this is indeed the most devastating cancer that affects our

most devastating cancer that affects our

most devastating cancer that affects our human body and it happens to affect what

human body and it happens to affect what

human body and it happens to affect what I considered to be the most beautiful

I considered to be the most beautiful

I considered to be the most beautiful organ which is our brain we know that

organ which is our brain we know that

organ which is our brain we know that these tumors can grow this is actually

these tumors can grow this is actually

these tumors can grow this is actually one of the papers that we published in

one of the papers that we published in

one of the papers that we published in our laboratory taking

our laboratory taking

our laboratory taking affect not only your function they can

affect not only your function they can

affect not only your function they can completely destroy your life and many

completely destroy your life and many

completely destroy your life and many times we not only as physicians but as

times we not only as physicians but as

times we not only as physicians but as patients question what is the meaning of

patients question what is the meaning of

patients question what is the meaning of this what is the meaning of living with

this what is the meaning of living with

this what is the meaning of living with this type of cancer I share with you one

this type of cancer I share with you one

this type of cancer I share with you one of the many experiences that I have had

of the many experiences that I have had

of the many experiences that I have had personally dealing and battling cancer

personally dealing and battling cancer

personally dealing and battling cancer with my own patients this is JP John

with my own patients this is JP John

with my own patients this is JP John Petrovic I can tell you his name because

Petrovic I can tell you his name because

Petrovic I can tell you his name because he was actually featuring the news in

he was actually featuring the news in

he was actually featuring the news in Baltimore when I was at Johns Hopkins

Baltimore when I was at Johns Hopkins

Baltimore when I was at Johns Hopkins before I moved to the Mayo Clinic a few

before I moved to the Mayo Clinic a few

before I moved to the Mayo Clinic a few months ago he was in his mid twenties

months ago he was in his mid twenties

months ago he was in his mid twenties full of life about to finish law school

full of life about to finish law school

full of life about to finish law school and he wanted to change the world as he

and he wanted to change the world as he

and he wanted to change the world as he was training for a marathon he’s found

was training for a marathon he’s found

was training for a marathon he’s found on the side of the road seesee he’s

on the side of the road seesee he’s

on the side of the road seesee he’s brought into a hospital he requested to

brought into a hospital he requested to

brought into a hospital he requested to be transferred right around that time

be transferred right around that time

be transferred right around that time there was a show that was had been

there was a show that was had been

there was a show that was had been released what they had featured me doing

released what they had featured me doing

released what they had featured me doing brain surgery he says I want to go with

brain surgery he says I want to go with

brain surgery he says I want to go with that crazy guy that has an accent at

that crazy guy that has an accent at

that crazy guy that has an accent at Hopkins he didn’t know how to pronounce

Hopkins he didn’t know how to pronounce

Hopkins he didn’t know how to pronounce my name he’s not that difficult skinny

my name he’s not that difficult skinny

my name he’s not that difficult skinny honest in a HOSA that’s why they call me

honest in a HOSA that’s why they call me

honest in a HOSA that’s why they call me dr. cute but he says I want to go with

dr. cute but he says I want to go with

dr. cute but he says I want to go with that guy we did the surgery it was

that guy we did the surgery it was

that guy we did the surgery it was unbelievable

unbelievable

unbelievable we kept him awake we actually ended up

we kept him awake we actually ended up

we kept him awake we actually ended up doing this surgery and when he woke up

doing this surgery and when he woke up

doing this surgery and when he woke up he was paralyzed in half of his body

he was paralyzed in half of his body

he was paralyzed in half of his body luckily it was only temporary he went on

luckily it was only temporary he went on

luckily it was only temporary he went on to Train finished his training ended up

to Train finished his training ended up

to Train finished his training ended up running a full marathon and this is the

running a full marathon and this is the

running a full marathon and this is the type of surgery that we did let me see

type of surgery that we did let me see

type of surgery that we did let me see if I can play this for you and bring you

if I can play this for you and bring you

if I can play this for you and bring you into the afternoon to what I do that’s

into the afternoon to what I do that’s

into the afternoon to what I do that’s me doing brain surgery in a 19 year old

me doing brain surgery in a 19 year old

me doing brain surgery in a 19 year old patient

that little part of the brain as I touch

that little part of the brain as I touch it I was able to stop the patient from

it I was able to stop the patient from

it I was able to stop the patient from reading that’s performed but the patient

reading that’s performed but the patient

reading that’s performed but the patient is noticed when an essential area is

is noticed when an essential area is

is noticed when an essential area is stimulated the function normalizes where

stimulated the function normalizes where

stimulated the function normalizes where the stimulation is stopped that’s just

the stimulation is stopped that’s just

the stimulation is stopped that’s just me gently notice how beautiful the brain

me gently notice how beautiful the brain

me gently notice how beautiful the brain is and I am about to go and invade what

is and I am about to go and invade what

is and I am about to go and invade what I think appears to be one of the most

I think appears to be one of the most

I think appears to be one of the most beautiful things that I get to see very

beautiful things that I get to see very

beautiful things that I get to see very after all here I am making a decision as

after all here I am making a decision as

after all here I am making a decision as to what I’m gonna take and what I’m

to what I’m gonna take and what I’m

to what I’m gonna take and what I’m gonna leave behind this 19 year old

gonna leave behind this 19 year old

gonna leave behind this 19 year old patient who is incidentally a very

patient who is incidentally a very

patient who is incidentally a very well-known poet with Texas here we are

well-known poet with Texas here we are

well-known poet with Texas here we are respecting the tumor keeping the patient

respecting the tumor keeping the patient

respecting the tumor keeping the patient awake and this was exactly the surgery

awake and this was exactly the surgery

awake and this was exactly the surgery that I actually did in John Patrick the

that I actually did in John Patrick the

that I actually did in John Patrick the difference was that he was right in the

difference was that he was right in the

difference was that he was right in the motor cortex time went on John actually

motor cortex time went on John actually

motor cortex time went on John actually did one marathon and how little did I

did one marathon and how little did I

did one marathon and how little did I know how lost I was he invited me to run

know how lost I was he invited me to run

know how lost I was he invited me to run with him and I declined the first time

with him and I declined the first time

with him and I declined the first time the second time he had a second surgery

the second time he had a second surgery

the second time he had a second surgery within a year the second time he was

within a year the second time he was

within a year the second time he was more debilitated secondary to his

more debilitated secondary to his

more debilitated secondary to his surgery and as he was waking up from

surgery and as he was waking up from

surgery and as he was waking up from anesthesia I told him joking I thought

anesthesia I told him joking I thought

anesthesia I told him joking I thought he was under anesthesia

he was under anesthesia

he was under anesthesia I said sure ah but I’m gonna run the

I said sure ah but I’m gonna run the

I said sure ah but I’m gonna run the half marathon with you we were about a

half marathon with you we were about a

half marathon with you we were about a month and a half away from the half

month and a half away from the half

month and a half away from the half marathon and a week and half when he

marathon and a week and half when he

marathon and a week and half when he sees me post a few girls are you ready

sees me post a few girls are you ready

sees me post a few girls are you ready dr. Q and I was like I didn’t think he

dr. Q and I was like I didn’t think he

dr. Q and I was like I didn’t think he was gonna remember so here I am you know

was gonna remember so here I am you know

was gonna remember so here I am you know I start training for like a couple of

I start training for like a couple of

I start training for like a couple of weeks and I finish that half marathon in

weeks and I finish that half marathon in

weeks and I finish that half marathon in two hours and 12 minutes he finished in

two hours and 12 minutes he finished in

two hours and 12 minutes he finished in about an hour and 52 thank you it was an

about an hour and 52 thank you it was an

about an hour and 52 thank you it was an accomplishment for me but I was so proud

accomplishment for me but I was so proud

accomplishment for me but I was so proud of me he flew through this but we’re not

of me he flew through this but we’re not

of me he flew through this but we’re not done with his story yet he was so

done with his story yet he was so

done with his story yet he was so passionate about what we were doing in

passionate about what we were doing in

passionate about what we were doing in the laboratory he passionately believed

the laboratory he passionately believed

the laboratory he passionately believed that we needed to think of new paradigms

that we needed to think of new paradigms

that we needed to think of new paradigms to treat cancer he went on to raise

to treat cancer he went on to raise

to treat cancer he went on to raise funds he believed that the fat cells

funds he believed that the fat cells

funds he believed that the fat cells that we were isolating from our own

that we were isolating from our own

that we were isolating from our own patient

patient

patient from the belly from our own patients and

from the belly from our own patients and

from the belly from our own patients and establishing stem cells were gonna help

establishing stem cells were gonna help

establishing stem cells were gonna help us to finally cure against cancer this

us to finally cure against cancer this

us to finally cure against cancer this is actually a Trojan horse that sits in

is actually a Trojan horse that sits in

is actually a Trojan horse that sits in my office in the laboratory actually at

my office in the laboratory actually at

my office in the laboratory actually at the Mayo Clinic in which you can

the Mayo Clinic in which you can

the Mayo Clinic in which you can actually see a tremendous amount of

actually see a tremendous amount of

actually see a tremendous amount of detail he asked me to think outside the

detail he asked me to think outside the

detail he asked me to think outside the box

box

box to help him find a cure for this disease

to help him find a cure for this disease

to help him find a cure for this disease and to give many others hope because

and to give many others hope because

and to give many others hope because they have so little we went on to

they have so little we went on to

they have so little we went on to publish some major landmark since the

publish some major landmark since the

publish some major landmark since the paper actually when you see those red

paper actually when you see those red

paper actually when you see those red cells surrounding a brain tumor and all

cells surrounding a brain tumor and all

cells surrounding a brain tumor and all we did is we trained these cells we

we did is we trained these cells we

we did is we trained these cells we genetically engineered these cells it’s

genetically engineered these cells it’s

genetically engineered these cells it’s fat cells from patients to be able to

fat cells from patients to be able to

fat cells from patients to be able to attack tumors and this actually made the

attack tumors and this actually made the

attack tumors and this actually made the cover of one journal this is another

cover of one journal this is another

cover of one journal this is another cover in which all we did we gave

cover in which all we did we gave

cover in which all we did we gave soluble factors liquid basically from

soluble factors liquid basically from

soluble factors liquid basically from our own body from our own brain to the

our own body from our own brain to the

our own body from our own brain to the cells so they can actually smell it they

cells so they can actually smell it they

cells so they can actually smell it they can sense it and then we put it back on

can sense it and then we put it back on

can sense it and then we put it back on animal models that we use as avatars

animal models that we use as avatars

animal models that we use as avatars they have the human cancer and they were

they have the human cancer and they were

they have the human cancer and they were able to cure cancer and rodents and this

able to cure cancer and rodents and this

able to cure cancer and rodents and this is actually how we train the cells we

is actually how we train the cells we

is actually how we train the cells we put them in these nano groups biomedical

put them in these nano groups biomedical

put them in these nano groups biomedical engineering we have a tremendous amount

engineering we have a tremendous amount

engineering we have a tremendous amount of collaborative efforts with some

of collaborative efforts with some

of collaborative efforts with some really smart people I tell you we put

really smart people I tell you we put

really smart people I tell you we put them right there they race we train them

them right there they race we train them

them right there they race we train them and I always tell people this is almost

and I always tell people this is almost

and I always tell people this is almost like the movie I put a Creed the last

like the movie I put a Creed the last

like the movie I put a Creed the last one remember when the guy is running

one remember when the guy is running

one remember when the guy is running he’s got that mark that mask that allows

he’s got that mark that mask that allows

he’s got that mark that mask that allows you to deprive from oxygen this sucker

you to deprive from oxygen this sucker

you to deprive from oxygen this sucker what we’re doing right here and we put

what we’re doing right here and we put

what we’re doing right here and we put them in this stretch right here and then

them in this stretch right here and then

them in this stretch right here and then we give them the soluble factors and we

we give them the soluble factors and we

we give them the soluble factors and we can actually put them in this amazingly

can actually put them in this amazingly

can actually put them in this amazingly fast highways and these are the red

fast highways and these are the red

fast highways and these are the red cells and underneath are cancer cells

cells and underneath are cancer cells

cells and underneath are cancer cells human cancer cells so we train these

human cancer cells so we train these

human cancer cells so we train these cells to be able to be super fast super

cells to be able to be super fast super

cells to be able to be super fast super powerful cells that can actually go back

powerful cells that can actually go back

powerful cells that can actually go back and fight cancer and that is the work

and fight cancer and that is the work

and fight cancer and that is the work that we’ve been doing in our laboratory

that we’ve been doing in our laboratory

that we’ve been doing in our laboratory most recently we went on to not only

most recently we went on to not only

most recently we went on to not only engineer these cells with viruses but we

engineer these cells with viruses but we

engineer these cells with viruses but we actually engineered them with

actually engineered them with

actually engineered them with nanoparticles so now suddenly these

nanoparticles so now suddenly these

nanoparticles so now suddenly these cells are becoming the true

cells are becoming the true

cells are becoming the true and horses that we envisioned years ago

and horses that we envisioned years ago

and horses that we envisioned years ago when John was so diligently working to

when John was so diligently working to

when John was so diligently working to help us find a cure for cancer this is

help us find a cure for cancer this is

help us find a cure for cancer this is one of the most recent papers that we

one of the most recent papers that we

one of the most recent papers that we published you can actually see the tumor

published you can actually see the tumor

published you can actually see the tumor and that little mouse is decreasing in

and that little mouse is decreasing in

and that little mouse is decreasing in size this is a human tumor and an animal

size this is a human tumor and an animal

size this is a human tumor and an animal model that we use as an avatar with the

model that we use as an avatar with the

model that we use as an avatar with the goal of using these cells in the human

goal of using these cells in the human

goal of using these cells in the human body and the not-too-distant future to

body and the not-too-distant future to

body and the not-too-distant future to be able to cure not only brain cancer

be able to cure not only brain cancer

be able to cure not only brain cancer but cancer in general

but cancer in general

but cancer in general Jaypee unfortunately left this world

Jaypee unfortunately left this world

Jaypee unfortunately left this world physically but he left an amazing story

physically but he left an amazing story

physically but he left an amazing story an amazing passion for life he has

an amazing passion for life he has

an amazing passion for life he has inspired so many of us and for me he

inspired so many of us and for me he

inspired so many of us and for me he symbolizes so many of my patients that

symbolizes so many of my patients that

symbolizes so many of my patients that daily inspire me not only with the

daily inspire me not only with the

daily inspire me not only with the passion they have their life but the way

passion they have their life but the way

passion they have their life but the way they fight diseases for which we have no

they fight diseases for which we have no

they fight diseases for which we have no cure this is actually how he wrote his

cure this is actually how he wrote his

cure this is actually how he wrote his own eulogy I don’t know who’s here

own eulogy I don’t know who’s here

own eulogy I don’t know who’s here obviously but I hope that whoever is

obviously but I hope that whoever is

obviously but I hope that whoever is here and who ever wanted to be as here

here and who ever wanted to be as here

here and who ever wanted to be as here is what I imagined I left behind and

is what I imagined I left behind and

is what I imagined I left behind and that is an army of people who knew that

that is an army of people who knew that

that is an army of people who knew that I love them as much as I could

I love them as much as I could

I love them as much as I could who will always remember me as I hope

who will always remember me as I hope

who will always remember me as I hope they would and not whatever I became as

they would and not whatever I became as

they would and not whatever I became as my mind wilted away or as my strength

my mind wilted away or as my strength

my mind wilted away or as my strength disappear that is how does the cease

disappear that is how does the cease

disappear that is how does the cease begins to take our patients and to me

begins to take our patients and to me

begins to take our patients and to me there’s nothing more challenging more

there’s nothing more challenging more

there’s nothing more challenging more difficult he’s not the surgery that I do

difficult he’s not the surgery that I do

difficult he’s not the surgery that I do it’s not the science that I do is having

it’s not the science that I do is having

it’s not the science that I do is having to see my patients surrendering as

to see my patients surrendering as

to see my patients surrendering as slowly but steadily many times to do the

slowly but steadily many times to do the

slowly but steadily many times to do the disease and try to keep hope and many

disease and try to keep hope and many

disease and try to keep hope and many times life will put you down in your

times life will put you down in your

times life will put you down in your knees and the greatest challenge that we

knees and the greatest challenge that we

knees and the greatest challenge that we have in what I saw from John is getting

have in what I saw from John is getting

have in what I saw from John is getting up in trying again over and over without

up in trying again over and over without

up in trying again over and over without giving that I asked Gaby she’s my oldest

giving that I asked Gaby she’s my oldest

giving that I asked Gaby she’s my oldest she say Tina I said Gaby I need a

she say Tina I said Gaby I need a

she say Tina I said Gaby I need a butterfly say dad why I tell you the

butterfly say dad why I tell you the

butterfly say dad why I tell you the story about the butterfly after JP

story about the butterfly after JP

story about the butterfly after JP passed away there was one more

passed away there was one more

passed away there was one more half-marathon that I wanted to do in my

half-marathon that I wanted to do in my

half-marathon that I wanted to do in my objective was

objective was

objective was just to go to a distance I wanted to

just to go to a distance I wanted to

just to go to a distance I wanted to finish and I said something has to be in

finish and I said something has to be in

finish and I said something has to be in jail well yellow was his favorite color

jail well yellow was his favorite color

jail well yellow was his favorite color and that’s why you see the yellow right

and that’s why you see the yellow right

and that’s why you see the yellow right in the middle he loved monarch

in the middle he loved monarch

in the middle he loved monarch butterflies and I said one day after I

butterflies and I said one day after I

butterflies and I said one day after I did the third merit the third half

did the third merit the third half

did the third merit the third half marathon and he wasn’t there with me

marathon and he wasn’t there with me

marathon and he wasn’t there with me anymore all I wanted to feel is that he

anymore all I wanted to feel is that he

anymore all I wanted to feel is that he was right next to me and I finished that

was right next to me and I finished that

was right next to me and I finished that one in an hour and 32 minutes he was

one in an hour and 32 minutes he was

one in an hour and 32 minutes he was amazing

amazing

amazing that’s the fastest I ever been I felt

that’s the fastest I ever been I felt

that’s the fastest I ever been I felt that he was right there with me I tell

that he was right there with me I tell

that he was right there with me I tell you he’s really inspired me he gave me

you he’s really inspired me he gave me

you he’s really inspired me he gave me strength and I just I couldn’t get tired

strength and I just I couldn’t get tired

strength and I just I couldn’t get tired the next day in the morning this was on

the next day in the morning this was on

the next day in the morning this was on a Saturday this was the Baltimore half

a Saturday this was the Baltimore half

a Saturday this was the Baltimore half marathon

marathon

marathon the next day on a Sunday I got up and I

the next day on a Sunday I got up and I

the next day on a Sunday I got up and I just I get something I just had this

just I get something I just had this

just I get something I just had this itch and I went for a run and I am going

itch and I went for a run and I am going

itch and I went for a run and I am going right through the woods you know up in

right through the woods you know up in

right through the woods you know up in Maryland through behind the house and

Maryland through behind the house and

Maryland through behind the house and sound I see this butterfly that is in

sound I see this butterfly that is in

sound I see this butterfly that is in front of me and suddenly the butterfly

front of me and suddenly the butterfly

front of me and suddenly the butterfly takes off and as he takes off I see this

takes off and as he takes off I see this

takes off and as he takes off I see this beautiful tree and this memory hunts me

beautiful tree and this memory hunts me

beautiful tree and this memory hunts me right away

right away

right away and I remember just about three years

and I remember just about three years

and I remember just about three years prior an amazing blizzard around 2010

prior an amazing blizzard around 2010

prior an amazing blizzard around 2010 2011 and we had planted in the summer a

2011 and we had planted in the summer a

2011 and we had planted in the summer a small little tree and this this actual

small little tree and this this actual

small little tree and this this actual tree was just getting absolutely

tree was just getting absolutely

tree was just getting absolutely destroyed by the blizzard so I remember

destroyed by the blizzard so I remember

destroyed by the blizzard so I remember it was on a weekend and I got up and I

it was on a weekend and I got up and I

it was on a weekend and I got up and I dis memories in my brain as I’m Ronnie

dis memories in my brain as I’m Ronnie

dis memories in my brain as I’m Ronnie and I go out there with my gloves really

and I go out there with my gloves really

and I go out there with my gloves really cold the sticks and rope in a hammer and

cold the sticks and rope in a hammer and

cold the sticks and rope in a hammer and I put a stick and I put that tree

I put a stick and I put that tree

I put a stick and I put that tree straight right in the middle of this no

straight right in the middle of this no

straight right in the middle of this no and I forgot about it and Here I am

and I forgot about it and Here I am

and I forgot about it and Here I am suddenly the butterfly shows me this

suddenly the butterfly shows me this

suddenly the butterfly shows me this tree and I remember I was that tree

tree and I remember I was that tree

tree and I remember I was that tree about three years ago when I was

about three years ago when I was

about three years ago when I was completely lost when I couldn’t

completely lost when I couldn’t

completely lost when I couldn’t understand when I thought I was going to

understand when I thought I was going to

understand when I thought I was going to find a cure for brain cancer by myself

find a cure for brain cancer by myself

find a cure for brain cancer by myself with my laboratory and how little did I

with my laboratory and how little did I

with my laboratory and how little did I know that the people that I was trying

know that the people that I was trying

know that the people that I was trying to help were going to be the people who

to help were going to be the people who

to help were going to be the people who inspire us the most and this butterfly

inspire us the most and this butterfly

inspire us the most and this butterfly incidentally is the type of cancer that

incidentally is the type of cancer that

incidentally is the type of cancer that killed John he’s called the butterfly

killed John he’s called the butterfly

killed John he’s called the butterfly glioma is so powerful that both sides of

glioma is so powerful that both sides of

glioma is so powerful that both sides of the brain get invaded by this cancer and

the brain get invaded by this cancer and

the brain get invaded by this cancer and that’s what that butterfly is so

that’s what that butterfly is so

that’s what that butterfly is so symbolic and Gavi through

symbolic and Gavi through

symbolic and Gavi through for me a couple of days ago and I also

for me a couple of days ago and I also

for me a couple of days ago and I also asked you he says in his eulogy that

asked you he says in his eulogy that

asked you he says in his eulogy that when you shed tears when you get angry

when you shed tears when you get angry

when you shed tears when you get angry or feel agony when you want to look at

or feel agony when you want to look at

or feel agony when you want to look at the sky with anger and want to shout

the sky with anger and want to shout

the sky with anger and want to shout that instead you use that energy to make

that instead you use that energy to make

that instead you use that energy to make a difference in a way that aligns with

a difference in a way that aligns with

a difference in a way that aligns with the goals I have had all along that goal

the goals I have had all along that goal

the goals I have had all along that goal was to have people I met think they were

was to have people I met think they were

was to have people I met think they were a little better for having known me and

a little better for having known me and

a little better for having known me and I can tell you John not only made me a

I can tell you John not only made me a

I can tell you John not only made me a better surgeon a better physician but he

better surgeon a better physician but he

better surgeon a better physician but he made me a better person over the last

made me a better person over the last

made me a better person over the last few years we created a foundation that

few years we created a foundation that

few years we created a foundation that has allow us to go all over the world to

has allow us to go all over the world to

has allow us to go all over the world to provide some of the most complex brain

provide some of the most complex brain

provide some of the most complex brain surgical care for patients that have

surgical care for patients that have

surgical care for patients that have very little we also started two

very little we also started two

very little we also started two companies last year to be to serve as

companies last year to be to serve as

companies last year to be to serve as they be Co that others can actually use

they be Co that others can actually use

they be Co that others can actually use to find cures for brain cancer so John

to find cures for brain cancer so John

to find cures for brain cancer so John this one is for you thank you

”

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