of animals
dies in
experiments with
testing new
medicines for one year
for example vangi
raise your hands those who
I think that this figure
is 40,000
there are no next 400
thousand well, and read who
then the figure
is 4 million
right on
statistics
royal
protection society
animals annually in
England is dying
testing new
medicines 4 million
animals and
imagine it
only on official
data
only for one year and
in only one
little england and
Imagine
such figures are achieved
these values throughout
the world over the years
tests for what
generally need animals
when developing new
drugs and where
such
huge quantities
My name is Sergey
evteev I’m a student
faculty
a fundamental
of mu and
doing
development of medicines
and today, together with
we’ll figure it out
this topic
the first question is
worth highlighting is that
but how much at all
time is spent on
developing a new
drugs on the very
about ten
years and what is spent
all this time order
one year is spent on
Search
active compounds
Imagine that we
analyzed
great amount
literature conducted
a number of chemical
experiments and
found that ten
thousands of connections
have the
biological
activity that
we need but we
Do not know whether these
less effective
will they
are safe and not alone
a man of sound mind
will not dare to experience
all these
connection therefore
further held
preclinical
studies on
animals they occupy
about three years and here
we select those
connections that
showed
effectiveness and
security
another question
thing is
human organism
animal organism
has a number
certain differences
and so on
it is necessary to
clinical
research ie
human trial
they occupy about
five years but in the end we
select somewhere 5
compounds that
will already arrive at
consideration
regulatory
bodies there will check
how much
benign
all
past stage and one
the drug will fall on
pharmacy counter from
ten thousand original
molecule appears
question and
all these
stage can
abandon
any one of them and
the answer lies in
history if we
back to the middle
of the last century
see what’s on the market
the drug came out
thalidomide he
was positioned as
remedy for treatment
insomnia in
pregnant women and
manufacturers
stated and
guaranteed
quality and
security
product but how
result to light
there were 10 thousand
children with congenital
anomalies with
defects in the hands of the feet and
found that communication
was precisely with
with thalidomide
It was banned launched
serving a and included in
list of dangerous
connections and a monument
victims of this tragedy
but we have to
in london but now we
with you we understand that
each result
clinical
studies he
is extremely important as
clinically there that
there is in this case
made silent
about one of the side
effects
detected in step
preclinical
research and what
on this pedagogical
research we
we study firstly
we understand that
medicine
really treat
secondly, we can
find out what she is
does it safely
that is, the drug is not
is toxic and
we can choose a dose
which will be
most optimal
for the treatment of
another disease but
Do not you think that
this approach
use of other
organisms it
somewhat outdated
such a bad habit
which entered in
routine
pharmaceutical
practice and whether there is
our century development
technologies of some kind
other approaches
which would allow
abandon these
methods in fact
the scientist asks himself
these issues and
there is so
called the principle and
3r they are based on three
whales
the first of which is
saw for or
decrease it
implies that we
should include in
experiment
least
number of animals
which are necessary
for getting
reliable
result
imagine
we have a new
medicine
we try it
if we try
treat them this
model animals
there and after seeing something
do not recover
or continue
be sick and imagine
imagine that you
experiment we
included two
of animals
one recovered
another is not to him
can say heals
our preparation or not
but if we take
sampling for example
blue animals and
we will see that six of
they recovered
one only is not present that we
we can say yes our
the drug is likely
treat the following
The principle is rafael and
improve it
implies that we
should contain in
laboratory
animals
comfortable conditions and
minimally
subject them to stress
maximally
to alleviate that pain
which they thus
experience
but my favorite
principle this principle
replace or replace in
in this case he
implies that we
should use
some
alternative
methods that do not
involve in
animal experiment
and such techniques for
in fact there is
one of them is
testing new
preparations per cell
or on tissues in our
century development
biotechnology
process of obtaining
new cloth to few
more difficult than
gardening
what do we need for this
you need to take something
that we will
grow their own
kind seeds yes we
take the cells further
We need something where we’ll be
grow their own
kind of ground yes yes this
used cups
petrie special 3d
matrix and and we need
some nutritious
substances for top dressing and
here its role
carry out
nutrient media and
growth factors
which provide
growth and development of our
cell cultures in
transplantation
this method on data
and using for
development of
artificial leather
but we can
use it for
to check
effectiveness and
toxicity
preparations for
certain types of
cells but here
there is a
The problem is that our
the body consists of
a huge number
cells and tissues is
very complex system
let’s look at
Amsterdam which
he is a huge match
number of channels
rivulets
roughly like ours
the whole body
permeated with the blood
system
that is,
which flows blood and
it would seem
the system
simulate
it is impossible but for us
help comes
computer methods
we can imagine
imagine a vessel like a pipe
on which flows
blood and blood will be
provide some
wall pressure
blood vessels is the pressure
will depend on
how often
beats our heart and with
what strength
how narrow the blood vessels are
and various
chemical substances
will change this
pressure in a large
or a smaller side and
computer- based approaches
allows for this
moment to predict
that administration for at
a certain dose
norepinephrine will be
increase pressure a
visions of the Sakhalin
lower it is
one can imagine
by example
garden hose from
which water will come
the forum is flowing with water
as soon as we strengthen
this pressure and
narrow down so to speak
this vessel is the head
water becomes stronger and
this example he
the only one far in
use of
computer
technologies have everything
the so-called approach
ratio
structure of activity
each chemical
the substance possesses
some structure
which determines
its properties
biological
effects and similar
substance in its
structure will be
resemble
properties such
using
this principle scientists
created computer
connectivity libraries
her and comparing
structure of the new
substances with
known
biological
activity
a computer
predicts which
effects will be
our new
A molecule and will not
she is
about the danger
imagine on
cubes of lego if u
We have some kind of
new detail
which before we do not
saw that we can
compare to what
details in our
set new item
it seems yes and we can
predict
representative to
we get settled and
what function does it
but can perform
the problem is
in that all these
approaches they are satisfied
new and
only gaining its
force is only gaining
turnovers only
develop and therefore
currently not
It allows us to
completely refuse
from
preclinical
research on
animals and only
only
We also need to accompany
somehow support
but I certainly think
that the rejection of
you use animals
similar purposes is
a sign of healthy
society and I believe that
sometime we will learn
develop
drugs in 1 click
but animals that
rescued laboratory
experiments will disappear in
and we will be
remind only
similar monuments
how is Novosibirsk?
thank you for attention
[applause]
”
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