[Music] ad as Imus disease each time I give this
ad as Imus disease each time I give this
ad as Imus disease each time I give this diagnosis to one of my patients I feel
diagnosis to one of my patients I feel
diagnosis to one of my patients I feel like I’m giving them a death sentence
like I’m giving them a death sentence
like I’m giving them a death sentence I’m sorry sir you will progressively
I’m sorry sir you will progressively
I’m sorry sir you will progressively forget everything everything you do
forget everything everything you do
forget everything everything you do everything you’ve done all the ones
everything you’ve done all the ones
everything you’ve done all the ones you’ve loved and this is horrible but
you’ve loved and this is horrible but
you’ve loved and this is horrible but what is Alzheimer’s disease exactly how
what is Alzheimer’s disease exactly how
what is Alzheimer’s disease exactly how does this start by forgetting your keys
does this start by forgetting your keys
does this start by forgetting your keys by not remembering the name of the
by not remembering the name of the
by not remembering the name of the previous speaker or not knowing tomorrow
previous speaker or not knowing tomorrow
previous speaker or not knowing tomorrow that you’ve come here today to this
that you’ve come here today to this
that you’ve come here today to this wonderful TEDx event as a doctor I would
wonderful TEDx event as a doctor I would
wonderful TEDx event as a doctor I would say this is the most serious Simas
say this is the most serious Simas
say this is the most serious Simas disease is characterized by an episodic
disease is characterized by an episodic
disease is characterized by an episodic memory loss forgetting the episodes of
memory loss forgetting the episodes of
memory loss forgetting the episodes of your life the recent events you just
your life the recent events you just
your life the recent events you just left but you can forget for many other
left but you can forget for many other
left but you can forget for many other reasons than as I MERS so it’s not only
reasons than as I MERS so it’s not only
reasons than as I MERS so it’s not only a memory loss as Eimer
a memory loss as Eimer
a memory loss as Eimer is a brain disease but the thing is that
is a brain disease but the thing is that
is a brain disease but the thing is that until very recently we could not see
until very recently we could not see
until very recently we could not see this disease in the brain during life
this disease in the brain during life
this disease in the brain during life and new imaging techniques now allow
and new imaging techniques now allow
and new imaging techniques now allow seeing Al’s Imus regions in vivo and
seeing Al’s Imus regions in vivo and
seeing Al’s Imus regions in vivo and this brings a lot of hope to find a cure
this brings a lot of hope to find a cure
this brings a lot of hope to find a cure for this terrible infection so hoping to
for this terrible infection so hoping to
for this terrible infection so hoping to find a cure three years ago I quit my
find a cure three years ago I quit my
find a cure three years ago I quit my doctor’s job and I went to Harvard
doctor’s job and I went to Harvard
doctor’s job and I went to Harvard University to do research
University to do research
University to do research so instead of giving diagnoses like a
so instead of giving diagnoses like a
so instead of giving diagnoses like a judge give sentences I became a
judge give sentences I became a
judge give sentences I became a scientist looking for answers kind of a
scientist looking for answers kind of a
scientist looking for answers kind of a detective and that is the adventure I’d
detective and that is the adventure I’d
detective and that is the adventure I’d like to take you on today because now is
like to take you on today because now is
like to take you on today because now is the time for even more research but let
the time for even more research but let
the time for even more research but let me start by giving you some background
me start by giving you some background
me start by giving you some background about Alzheimer’s disease here is the
about Alzheimer’s disease here is the
about Alzheimer’s disease here is the very first patient diagnosed by dr. Hans
very first patient diagnosed by dr. Hans
very first patient diagnosed by dr. Hans Zimmer with what I call to the time the
Zimmer with what I call to the time the
Zimmer with what I call to the time the dementia of forgetfulness dementia comes
dementia of forgetfulness dementia comes
dementia of forgetfulness dementia comes from latin d mention literally losing
from latin d mention literally losing
from latin d mention literally losing your mind losing what makes you human
your mind losing what makes you human
your mind losing what makes you human a lot of diseases can cause dementia a
a lot of diseases can cause dementia a
a lot of diseases can cause dementia a brain tumor
brain tumor
brain tumor for instance Al’s i’ma starts with
for instance Al’s i’ma starts with
for instance Al’s i’ma starts with forgetfulness a memory loss that
forgetfulness a memory loss that
forgetfulness a memory loss that progressively evolved to dementia a
progressively evolved to dementia a
progressively evolved to dementia a stage at which you are no longer able to
stage at which you are no longer able to
stage at which you are no longer able to care for yourself that is the stage
care for yourself that is the stage
care for yourself that is the stage everybody is afraid of and we have very
everybody is afraid of and we have very
everybody is afraid of and we have very good reasons to be afraid no treatment
good reasons to be afraid no treatment
good reasons to be afraid no treatment and it seems unavoidable
and it seems unavoidable
and it seems unavoidable the two main risks for Alzheimer’s our
the two main risks for Alzheimer’s our
the two main risks for Alzheimer’s our age and genetics sorry madam I can’t
age and genetics sorry madam I can’t
age and genetics sorry madam I can’t change your genes and whatever we do we
change your genes and whatever we do we
change your genes and whatever we do we all getting older this just seems
all getting older this just seems
all getting older this just seems hopeless the thing why not trying
hopeless the thing why not trying
hopeless the thing why not trying research maybe if we understand better
research maybe if we understand better
research maybe if we understand better what’s happening in the brain we can fix
what’s happening in the brain we can fix
what’s happening in the brain we can fix it like hair could borrow would
it like hair could borrow would
it like hair could borrow would elucidate a murder in Agoura Christi
elucidate a murder in Agoura Christi
elucidate a murder in Agoura Christi let’s try to understand how why and what
let’s try to understand how why and what
let’s try to understand how why and what an Alzheimer skills or minds but above
an Alzheimer skills or minds but above
an Alzheimer skills or minds but above all what could we do to prevent this
all what could we do to prevent this
all what could we do to prevent this murder doctor Alzheimer’s paved the way
murder doctor Alzheimer’s paved the way
murder doctor Alzheimer’s paved the way by giving a description of the brain
by giving a description of the brain
by giving a description of the brain pathology after his first patient died
pathology after his first patient died
pathology after his first patient died he performed the brain atop C and
he performed the brain atop C and
he performed the brain atop C and identified two lesions which together
identified two lesions which together
identified two lesions which together define Alzheimer’s disease these two
define Alzheimer’s disease these two
define Alzheimer’s disease these two lesions are amyloid plaques and two
lesions are amyloid plaques and two
lesions are amyloid plaques and two tangles
tangles
tangles sounds complicated but this too after
sounds complicated but this too after
sounds complicated but this too after the Greek letter with that name and
the Greek letter with that name and
the Greek letter with that name and amoled are still today a century later
amoled are still today a century later
amoled are still today a century later the two main suspects in alzhiemer’s
the two main suspects in alzhiemer’s
the two main suspects in alzhiemer’s disease but if a doctor can’t see them
disease but if a doctor can’t see them
disease but if a doctor can’t see them he can never be sure
he can never be sure
he can never be sure someone has Alzheimer’s early detection
someone has Alzheimer’s early detection
someone has Alzheimer’s early detection and Prevention I’m possible then however
and Prevention I’m possible then however
and Prevention I’m possible then however we learned a lot from these of top C
we learned a lot from these of top C
we learned a lot from these of top C studies and the most important thing we
studies and the most important thing we
studies and the most important thing we have learned is that amyloid plaques are
have learned is that amyloid plaques are
have learned is that amyloid plaques are not only present in the brain of
not only present in the brain of
not only present in the brain of patients with Alzheimer’s dementia but
patients with Alzheimer’s dementia but
patients with Alzheimer’s dementia but also in normal individuals like you and
also in normal individuals like you and
also in normal individuals like you and me and the older we get the more common
me and the older we get the more common
me and the older we get the more common it becomes at the age of 35 years old a
it becomes at the age of 35 years old a
it becomes at the age of 35 years old a third of us has amyloid pathology in our
third of us has amyloid pathology in our
third of us has amyloid pathology in our brain but wait a minute should we care
brain but wait a minute should we care
brain but wait a minute should we care about this is that Alzheimer’s disease
about this is that Alzheimer’s disease
about this is that Alzheimer’s disease having amyloid in the brain but a normal
having amyloid in the brain but a normal
having amyloid in the brain but a normal memory I think we should care about this
memory I think we should care about this
memory I think we should care about this because if we look at the risk for exam
because if we look at the risk for exam
because if we look at the risk for exam as dementia we see a similar curve 15
as dementia we see a similar curve 15
as dementia we see a similar curve 15 years later at the age of 90 years old
years later at the age of 90 years old
years later at the age of 90 years old it is a third of us who will suffer from
it is a third of us who will suffer from
it is a third of us who will suffer from Alzheimer’s dementia we should try to do
Alzheimer’s dementia we should try to do
Alzheimer’s dementia we should try to do something about this and I think these
something about this and I think these
something about this and I think these 15 years during which pathology slowly
15 years during which pathology slowly
15 years during which pathology slowly builds up but memory symptoms are not
builds up but memory symptoms are not
builds up but memory symptoms are not present yet our wonderful opportunity
present yet our wonderful opportunity
present yet our wonderful opportunity for who wants to prevent the disease
for who wants to prevent the disease
for who wants to prevent the disease from occurring catching the killer
from occurring catching the killer
from occurring catching the killer before murder is committed
brain uh Topsy that’s quite a late stage
brain uh Topsy that’s quite a late stage for doing this so the first breakthrough
for doing this so the first breakthrough
for doing this so the first breakthrough I’d like to mention to you is amulet
I’d like to mention to you is amulet
I’d like to mention to you is amulet imaging for the past ten years now we’ve
imaging for the past ten years now we’ve
imaging for the past ten years now we’ve been able to perform a scan and
been able to perform a scan and
been able to perform a scan and visualize amyloid in the brain – in life
visualize amyloid in the brain – in life
visualize amyloid in the brain – in life hidden red on the scan and we could
hidden red on the scan and we could
hidden red on the scan and we could confirm that at the age of 75 a third of
confirm that at the age of 75 a third of
confirm that at the age of 75 a third of us have a positive scan for amulet the
us have a positive scan for amulet the
us have a positive scan for amulet the big lesson here is that this complicated
big lesson here is that this complicated
big lesson here is that this complicated thing named amulet is not important for
thing named amulet is not important for
thing named amulet is not important for memory right now but it has a drastic
memory right now but it has a drastic
memory right now but it has a drastic impact on how memory will evolve in the
impact on how memory will evolve in the
impact on how memory will evolve in the future so what’s happening
future so what’s happening
future so what’s happening how can someone have a head full of
how can someone have a head full of
how can someone have a head full of amyloid his memories working fine and
amyloid his memories working fine and
amyloid his memories working fine and then suddenly he becomes demented what’s
then suddenly he becomes demented what’s
then suddenly he becomes demented what’s new I think that the second lesion in as
new I think that the second lesion in as
new I think that the second lesion in as Amos has now come into play now
Amos has now come into play now
Amos has now come into play now pathology so the pathology is strongly
pathology so the pathology is strongly
pathology so the pathology is strongly correlated with memory in individuals
correlated with memory in individuals
correlated with memory in individuals who had a normal memory during life only
who had a normal memory during life only
who had a normal memory during life only future pathology is observed at the top
future pathology is observed at the top
future pathology is observed at the top see what you can see here on the left in
see what you can see here on the left in
see what you can see here on the left in brown but for individuals who had mild
brown but for individuals who had mild
brown but for individuals who had mild cognitive impairment at the end of their
cognitive impairment at the end of their
cognitive impairment at the end of their life
life
life we observed motor pathology and an
we observed motor pathology and an
we observed motor pathology and an expanded to pathology all over the brain
expanded to pathology all over the brain
expanded to pathology all over the brain is almost always associated with
is almost always associated with
is almost always associated with dementia so emulate might be the first
dementia so emulate might be the first
dementia so emulate might be the first culprit in Alzheimer’s disease but do
culprit in Alzheimer’s disease but do
culprit in Alzheimer’s disease but do seems closer to the symptoms the Opeth
seems closer to the symptoms the Opeth
seems closer to the symptoms the Opeth ology starts accumulating in the brain
ology starts accumulating in the brain
ology starts accumulating in the brain region that is the most important for
region that is the most important for
region that is the most important for memory and the morte accumulates the
memory and the morte accumulates the
memory and the morte accumulates the more memory declines so let me share to
more memory declines so let me share to
more memory declines so let me share to you my current understanding of
you my current understanding of
you my current understanding of Alzheimer’s disease and compare this to
Alzheimer’s disease and compare this to
Alzheimer’s disease and compare this to the three steps of a
the three steps of a
the three steps of a murder first someone wishes you’d that
murder first someone wishes you’d that
murder first someone wishes you’d that and actually that might happen more
and actually that might happen more
and actually that might happen more often than you think but it doesn’t
often than you think but it doesn’t
often than you think but it doesn’t necessarily mean you will die this is a
necessarily mean you will die this is a
necessarily mean you will die this is a me looat building up in the brain that
me looat building up in the brain that
me looat building up in the brain that is actually quite frequent with age it
is actually quite frequent with age it
is actually quite frequent with age it doesn’t necessarily mean you will have
doesn’t necessarily mean you will have
doesn’t necessarily mean you will have dementia but for sure that increases the
dementia but for sure that increases the
dementia but for sure that increases the risk if you have no amulet no Alzheimer
risk if you have no amulet no Alzheimer
risk if you have no amulet no Alzheimer if no one wishes you dead you won’t die
if no one wishes you dead you won’t die
if no one wishes you dead you won’t die from a murder but in the second step the
from a murder but in the second step the
from a murder but in the second step the one who wishes you dad actually contacts
one who wishes you dad actually contacts
one who wishes you dad actually contacts a killer and that’s what becomes more
a killer and that’s what becomes more
a killer and that’s what becomes more serious because he asked him to prepare
serious because he asked him to prepare
serious because he asked him to prepare the murder and that is a merit
the murder and that is a merit
the murder and that is a merit increasing to pathology no memory
increasing to pathology no memory
increasing to pathology no memory symptoms yet but soon the patient will
symptoms yet but soon the patient will
symptoms yet but soon the patient will come and see his doctor because he has
come and see his doctor because he has
come and see his doctor because he has noticed some memory loss and bam he
noticed some memory loss and bam he
noticed some memory loss and bam he receives a death sentence he learns he
receives a death sentence he learns he
receives a death sentence he learns he has Alzheimer’s disease and very little
has Alzheimer’s disease and very little
has Alzheimer’s disease and very little can be done to save him many brain
can be done to save him many brain
can be done to save him many brain regions have been destroyed by a
regions have been destroyed by a
regions have been destroyed by a militant to and repairing the brain
militant to and repairing the brain
militant to and repairing the brain would be as difficult as resuscitating
would be as difficult as resuscitating
would be as difficult as resuscitating someone after murder what we should do
someone after murder what we should do
someone after murder what we should do is prevention preventing a melittin –
is prevention preventing a melittin –
is prevention preventing a melittin – from destroying the brain but that was
from destroying the brain but that was
from destroying the brain but that was not quite possible if we could not see
not quite possible if we could not see
not quite possible if we could not see these lesions during life and it is only
these lesions during life and it is only
these lesions during life and it is only three years ago then two scans we
three years ago then two scans we
three years ago then two scans we developed in Harvard University and this
developed in Harvard University and this
developed in Harvard University and this invention two scans is probably a
invention two scans is probably a
invention two scans is probably a turning point in Alzheimer’s research
turning point in Alzheimer’s research
turning point in Alzheimer’s research because now we have the technical
because now we have the technical
because now we have the technical capability of observing both amulet and
capability of observing both amulet and
capability of observing both amulet and – because now we have the two main
– because now we have the two main
– because now we have the two main suspects in custody
suspects in custody
suspects in custody and we can question
and we can question
and we can question so I went to Harvard to learn more about
so I went to Harvard to learn more about
so I went to Harvard to learn more about it and the first two scans confirmed
it and the first two scans confirmed
it and the first two scans confirmed what we knew from a Topsy – is really
what we knew from a Topsy – is really
what we knew from a Topsy – is really bad for your memory if you have a lot of
bad for your memory if you have a lot of
bad for your memory if you have a lot of – pathology in your brain you’re
– pathology in your brain you’re
– pathology in your brain you’re probably going to be demented
probably going to be demented
probably going to be demented in contrast emulate increase very early
in contrast emulate increase very early
in contrast emulate increase very early at a time when memory is still normal
at a time when memory is still normal
at a time when memory is still normal and it can stay normal for many years
and it can stay normal for many years
and it can stay normal for many years despite a meal of it and that is the
despite a meal of it and that is the
despite a meal of it and that is the point we should try to prevent
point we should try to prevent
point we should try to prevent Alzheimer’s over the past 20 years
Alzheimer’s over the past 20 years
Alzheimer’s over the past 20 years 95% of clinical trials in Alzheimer’s
95% of clinical trials in Alzheimer’s
95% of clinical trials in Alzheimer’s disease have failed but we were looking
disease have failed but we were looking
disease have failed but we were looking in the dark we could not verify newman’s
in the dark we could not verify newman’s
in the dark we could not verify newman’s if a drug was effective or not
if a drug was effective or not
if a drug was effective or not except in a very long trial we were
except in a very long trial we were
except in a very long trial we were waiting for cognitive decline basically
waiting for cognitive decline basically
waiting for cognitive decline basically we needed the murder to happen to
we needed the murder to happen to
we needed the murder to happen to identify the murderer no prevention was
identify the murderer no prevention was
identify the murderer no prevention was possible but now that both amulet and
possible but now that both amulet and
possible but now that both amulet and tool scans have been developed we can
tool scans have been developed we can
tool scans have been developed we can start thinking of prevention therapies
start thinking of prevention therapies
start thinking of prevention therapies so now that we understand a little bit
so now that we understand a little bit
so now that we understand a little bit better how this plot is built now that
better how this plot is built now that
better how this plot is built now that we understand better Alzheimer’s disease
we understand better Alzheimer’s disease
we understand better Alzheimer’s disease let’s imagine strategies to fix it
let’s imagine strategies to fix it
let’s imagine strategies to fix it who do you want to see in jail the one
who do you want to see in jail the one
who do you want to see in jail the one who wished you that or the killer I
who wished you that or the killer I
who wished you that or the killer I would say both of them but actually
would say both of them but actually
would say both of them but actually stopping one might be enough to prevent
stopping one might be enough to prevent
stopping one might be enough to prevent the murder so far many clinical trials
the murder so far many clinical trials
the murder so far many clinical trials have intended to remove amyloid from the
have intended to remove amyloid from the
have intended to remove amyloid from the brain and they were not quite successful
brain and they were not quite successful
brain and they were not quite successful but one of the potential reasons is that
but one of the potential reasons is that
but one of the potential reasons is that this trial included patients with
this trial included patients with
this trial included patients with dementia a stage that might be too late
dementia a stage that might be too late
dementia a stage that might be too late to be effective
to be effective
to be effective so currently a very large American trial
so currently a very large American trial
so currently a very large American trial is giving anti-amyloid drug to normal
is giving anti-amyloid drug to normal
is giving anti-amyloid drug to normal individuals who are older than 65 and F
individuals who are older than 65 and F
individuals who are older than 65 and F evidence of Pama late on a scan and we
evidence of Pama late on a scan and we
evidence of Pama late on a scan and we should have the results of this very
should have the results of this very
should have the results of this very first preventive trial in three years
first preventive trial in three years
first preventive trial in three years from now but we should probably also
from now but we should probably also
from now but we should probably also follow other tracks like drugs against
follow other tracks like drugs against
follow other tracks like drugs against to pathology stopping the killer might
to pathology stopping the killer might
to pathology stopping the killer might be the most effective way to stay alive
be the most effective way to stay alive
be the most effective way to stay alive and to share a personal conviction I
and to share a personal conviction I
and to share a personal conviction I think we’re still missing a very
think we’re still missing a very
think we’re still missing a very important piece in Alzheimer’s disease
important piece in Alzheimer’s disease
important piece in Alzheimer’s disease who is the messenger how do you amyl it
who is the messenger how do you amyl it
who is the messenger how do you amyl it until interact actually no one really
until interact actually no one really
until interact actually no one really knows but now we have the tools to
knows but now we have the tools to
knows but now we have the tools to investigate these questions we can look
investigate these questions we can look
investigate these questions we can look for answers and that is a game changer
for answers and that is a game changer
for answers and that is a game changer the research we will conduct today will
the research we will conduct today will
the research we will conduct today will help us not only to live longer but also
help us not only to live longer but also
help us not only to live longer but also in a better mental health however we
in a better mental health however we
in a better mental health however we need to hurry if you want to catch these
need to hurry if you want to catch these
need to hurry if you want to catch these criminals if you want to avoid the
criminals if you want to avoid the
criminals if you want to avoid the serial killing predicted by global aging
serial killing predicted by global aging
serial killing predicted by global aging if we do nothing we all gotta have
if we do nothing we all gotta have
if we do nothing we all gotta have Alzheimer’s once we have been cured from
Alzheimer’s once we have been cured from
Alzheimer’s once we have been cured from cardiovascular disease and cancer so
cardiovascular disease and cancer so
cardiovascular disease and cancer so let’s take together in this fight and
let’s take together in this fight and
let’s take together in this fight and make aging fun again this detective
make aging fun again this detective
make aging fun again this detective story can have a happy ending over the
story can have a happy ending over the
story can have a happy ending over the past few months I resumed the memory
past few months I resumed the memory
past few months I resumed the memory clinics every Wednesday in Brussels and
clinics every Wednesday in Brussels and
clinics every Wednesday in Brussels and I’m still doing research but now with
I’m still doing research but now with
I’m still doing research but now with this increased knowledge I can reassure
this increased knowledge I can reassure
this increased knowledge I can reassure my patients and their families they’re
my patients and their families they’re
my patients and their families they’re not crazy their memory symptoms have a
not crazy their memory symptoms have a
not crazy their memory symptoms have a biological explanation and you also know
biological explanation and you also know
biological explanation and you also know why now
why now
why now and we can do more research to
and we can do more research to
and we can do more research to understand this better and try to fix it
understand this better and try to fix it
understand this better and try to fix it and this hope is really important for
and this hope is really important for
and this hope is really important for the patients with the disease but also
the patients with the disease but also
the patients with the disease but also for you and me who might have the
for you and me who might have the
for you and me who might have the disease in the future my deepest wish is
disease in the future my deepest wish is
disease in the future my deepest wish is to see a prevention for Alzheimer’s
to see a prevention for Alzheimer’s
to see a prevention for Alzheimer’s disease as soon as possible and if we
disease as soon as possible and if we
disease as soon as possible and if we all fight for this I am sure we can do
all fight for this I am sure we can do
all fight for this I am sure we can do it
it
it thank you for supporting research
”
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