today in this country there are no people who were born in 19th century
people who were born in 19th century
people who were born in 19th century there are no such people already not
there are no such people already not
there are no such people already not only in this country but probably on the
only in this country but probably on the
only in this country but probably on the whole planet the reason for that is
whole planet the reason for that is
whole planet the reason for that is obvious they’re all gone
obvious they’re all gone
obvious they’re all gone those who died from diseases we usually
those who died from diseases we usually
those who died from diseases we usually name as prematurely died that means that
name as prematurely died that means that
name as prematurely died that means that those who died from aging a it died on
those who died from aging a it died on
those who died from aging a it died on time so this here you see the typical
time so this here you see the typical
time so this here you see the typical program of life which consists of two
program of life which consists of two
program of life which consists of two periods while we are developing and
periods while we are developing and
periods while we are developing and reaching reproductive age and then
reaching reproductive age and then
reaching reproductive age and then unavoidably starts declining in all our
unavoidably starts declining in all our
unavoidably starts declining in all our functions acquiring frailty and finally
functions acquiring frailty and finally
functions acquiring frailty and finally dying and this is the best scenario
dying and this is the best scenario
dying and this is the best scenario today so I don’t know how you but I
today so I don’t know how you but I
today so I don’t know how you but I think it’s very depressing to have this
think it’s very depressing to have this
think it’s very depressing to have this best-case scenario so the mystery of
best-case scenario so the mystery of
best-case scenario so the mystery of aging and death from aging and
aging and death from aging and
aging and death from aging and limitation of our longevity has been in
limitation of our longevity has been in
limitation of our longevity has been in people’s mind forever and fairy tales
people’s mind forever and fairy tales
people’s mind forever and fairy tales from the past are filled with recipes
from the past are filled with recipes
from the past are filled with recipes how one can rejuvenate himself so
how one can rejuvenate himself so
how one can rejuvenate himself so illustration is this famous drawing by
illustration is this famous drawing by
illustration is this famous drawing by Lucas Cranach the elder Fountain of
Lucas Cranach the elder Fountain of
Lucas Cranach the elder Fountain of Youth where you see one of these recipes
Youth where you see one of these recipes
Youth where you see one of these recipes what is interesting that this picture
what is interesting that this picture
what is interesting that this picture drawn in 16th century was drawn at the
drawn in 16th century was drawn at the
drawn in 16th century was drawn at the times when vast majority of people never
times when vast majority of people never
times when vast majority of people never reached aging because they were dying
reached aging because they were dying
reached aging because they were dying from infectious diseases cholera plague
from infectious diseases cholera plague
from infectious diseases cholera plague smallpox syphilis so nevertheless aging
smallpox syphilis so nevertheless aging
smallpox syphilis so nevertheless aging was already recognized as a mystery well
was already recognized as a mystery well
was already recognized as a mystery well what we can do today
what we can do today
what we can do today does medicine during last hundred years
does medicine during last hundred years
does medicine during last hundred years which actually found cures to numerous
which actually found cures to numerous
which actually found cures to numerous diseases did something with aging as
diseases did something with aging as
diseases did something with aging as well well clearly at Lucas Cranach
well well clearly at Lucas Cranach
well well clearly at Lucas Cranach times aging and infectious diseases were
times aging and infectious diseases were
times aging and infectious diseases were clearly separated because plague
clearly separated because plague
clearly separated because plague attacked everybody with no difference
attacked everybody with no difference
attacked everybody with no difference whether they were children or senior
whether they were children or senior
whether they were children or senior people however after we dealt with
people however after we dealt with
people however after we dealt with infectious diseases and with antibiotics
infectious diseases and with antibiotics
infectious diseases and with antibiotics we came to the era when people start
we came to the era when people start
we came to the era when people start dying from cancer from cardiovascular
dying from cancer from cardiovascular
dying from cancer from cardiovascular disease the diseases are clearly related
disease the diseases are clearly related
disease the diseases are clearly related to age so one would expect that a
to age so one would expect that a
to age so one would expect that a hundred years ago when we still did not
hundred years ago when we still did not
hundred years ago when we still did not have antibiotics and during this path
have antibiotics and during this path
have antibiotics and during this path from birth to death we are losing lots
from birth to death we are losing lots
from birth to death we are losing lots of people we lost lots of people for
of people we lost lots of people for
of people we lost lots of people for these diseases hundred years later what
these diseases hundred years later what
these diseases hundred years later what situation would change and it does
situation would change and it does
situation would change and it does change we know that the ref huge
change we know that the ref huge
change we know that the ref huge demographic differences in our society
demographic differences in our society
demographic differences in our society versus society at that time so a lot
versus society at that time so a lot
versus society at that time so a lot more people live to very senior age and
more people live to very senior age and
more people live to very senior age and because of our success in treatment
because of our success in treatment
because of our success in treatment first infectious and now cardiovascular
first infectious and now cardiovascular
first infectious and now cardiovascular diseases and cancer so now when we
diseases and cancer so now when we
diseases and cancer so now when we celebrate this triumph of medicine can
celebrate this triumph of medicine can
celebrate this triumph of medicine can we also celebrate the triumph of its
we also celebrate the triumph of its
we also celebrate the triumph of its defeating aging because intuitively you
defeating aging because intuitively you
defeating aging because intuitively you think that if average life of population
think that if average life of population
think that if average life of population today in civilized countries during the
today in civilized countries during the
today in civilized countries during the hundred years increased more than 25
hundred years increased more than 25
hundred years increased more than 25 years the length of life of the whole
years the length of life of the whole
years the length of life of the whole generation in the past that you expect
generation in the past that you expect
generation in the past that you expect intuitively that should affect also the
intuitively that should affect also the
intuitively that should affect also the maximum longevity unfortunately the
maximum longevity unfortunately the
maximum longevity unfortunately the answer appeared to be quite different
answer appeared to be quite different
answer appeared to be quite different because if you look what would happen
because if you look what would happen
because if you look what would happen with those people who successfully
with those people who successfully
with those people who successfully reached nineteen hundred years old today
reached nineteen hundred years old today
reached nineteen hundred years old today by 120 there would be none we today
by 120 there would be none we today
by 120 there would be none we today recently the oldest person in this
recently the oldest person in this
recently the oldest person in this country died who was 114 years old and
country died who was 114 years old and
country died who was 114 years old and the oldest ever recorded person on this
the oldest ever recorded person on this
the oldest ever recorded person on this planet was hotter than 20
planet was hotter than 20
planet was hotter than 20 two years old so which means that
two years old so which means that
two years old so which means that something mysterious is happening at
something mysterious is happening at
something mysterious is happening at this last part of our life and
this last part of our life and
this last part of our life and regardless how healthy we are coming to
regardless how healthy we are coming to
regardless how healthy we are coming to this point our destiny is actually
this point our destiny is actually
this point our destiny is actually already predetermined we will die from
already predetermined we will die from
already predetermined we will die from increasing frailty and all achievements
increasing frailty and all achievements
increasing frailty and all achievements of Medicine all our ability to treat
of Medicine all our ability to treat
of Medicine all our ability to treat diseases at the rescue ourselves from
diseases at the rescue ourselves from
diseases at the rescue ourselves from this did not change this at all
this did not change this at all
this did not change this at all this actually means very important thing
this actually means very important thing
this actually means very important thing that this there is a something which I
that this there is a something which I
that this there is a something which I named a cliff of aging so very sharp
named a cliff of aging so very sharp
named a cliff of aging so very sharp decline in our health which is occurring
decline in our health which is occurring
decline in our health which is occurring at the times above 90 years old and
at the times above 90 years old and
at the times above 90 years old and which leads to avoid about death even
which leads to avoid about death even
which leads to avoid about death even the most healthy people with minimal
the most healthy people with minimal
the most healthy people with minimal diseases and so they’re very strict hard
diseases and so they’re very strict hard
diseases and so they’re very strict hard stop in our life which never could be
stop in our life which never could be
stop in our life which never could be more than 120 years and this altogether
more than 120 years and this altogether
more than 120 years and this altogether means that there is some mysterious
means that there is some mysterious
means that there is some mysterious mechanism which is ticking in us which
mechanism which is ticking in us which
mechanism which is ticking in us which you may name clock of life which somehow
you may name clock of life which somehow
you may name clock of life which somehow determines our really ability to live as
determines our really ability to live as
determines our really ability to live as long as we can and it looks like this
long as we can and it looks like this
long as we can and it looks like this mechanism is species-specific
mechanism is species-specific
mechanism is species-specific because as we all know every species
because as we all know every species
because as we all know every species besides humans have very clear life time
besides humans have very clear life time
besides humans have very clear life time which you never can cross mostly we know
which you never can cross mostly we know
which you never can cross mostly we know it of course from our pets so is there
it of course from our pets so is there
it of course from our pets so is there hope at all our common sense tells not
hope at all our common sense tells not
hope at all our common sense tells not because during all our lifetime we
because during all our lifetime we
because during all our lifetime we didn’t see a single example of anybody
didn’t see a single example of anybody
didn’t see a single example of anybody who would avoid aging and and live twice
who would avoid aging and and live twice
who would avoid aging and and live twice longer at least twice longer than what
longer at least twice longer than what
longer at least twice longer than what others do we don’t see it not only in US
others do we don’t see it not only in US
others do we don’t see it not only in US but also in pets we do see it in non
but also in pets we do see it in non
but also in pets we do see it in non mammals but in mammals it looks like you
mammals but in mammals it looks like you
mammals but in mammals it looks like you know well the hope is there and the
know well the hope is there and the
know well the hope is there and the hopes come with these interesting
hopes come with these interesting
hopes come with these interesting creatures so you don’t see them every
creatures so you don’t see them every
creatures so you don’t see them every day because they live in warm countries
day because they live in warm countries
day because they live in warm countries underground but and they are typical
underground but and they are typical
underground but and they are typical rodents they are a size of a mouse or
rodents they are a size of a mouse or
rodents they are a size of a mouse or rat and they have very similar genetics
rat and they have very similar genetics
rat and they have very similar genetics but the Cardinal difference is that they
but the Cardinal difference is that they
but the Cardinal difference is that they live up to 10 times longer than their
live up to 10 times longer than their
live up to 10 times longer than their neighbors in their genus for example
neighbors in their genus for example
neighbors in their genus for example this creature on the top leaves 10 times
this creature on the top leaves 10 times
this creature on the top leaves 10 times longer than the mouse and dies without
longer than the mouse and dies without
longer than the mouse and dies without frailty and also these creatures never
frailty and also these creatures never
frailty and also these creatures never develop cancer so dream animals very
develop cancer so dream animals very
develop cancer so dream animals very frequently hear remarks well if I need
frequently hear remarks well if I need
frequently hear remarks well if I need to pay for longevity beings with such an
to pay for longevity beings with such an
to pay for longevity beings with such an ugly appearance I’m not sure how much I
ugly appearance I’m not sure how much I
ugly appearance I’m not sure how much I want that
want that
want that well I’m usually thinking well if you
well I’m usually thinking well if you
well I’m usually thinking well if you are undressed you may not be looking
are undressed you may not be looking
are undressed you may not be looking that attractive to so well but what is
that attractive to so well but what is
that attractive to so well but what is important about these creatures they
important about these creatures they
important about these creatures they give us inspirational example that
give us inspirational example that
give us inspirational example that technically mammals can live much longer
technically mammals can live much longer
technically mammals can live much longer and live without frailty which means
and live without frailty which means
and live without frailty which means that they give us the evening
that they give us the evening
that they give us the evening inspiration to think that aging is not
inspiration to think that aging is not
inspiration to think that aging is not law of nature which is unbreakable and
law of nature which is unbreakable and
law of nature which is unbreakable and it’s not there another example of
it’s not there another example of
it’s not there another example of perpetuum mobile’ a which as we all know
perpetuum mobile’ a which as we all know
perpetuum mobile’ a which as we all know is impossible to build because these two
is impossible to build because these two
is impossible to build because these two creatures they are to a certain degree
creatures they are to a certain degree
creatures they are to a certain degree prepare to Moberly so what does science
prepare to Moberly so what does science
prepare to Moberly so what does science tell us about this period of declining
tell us about this period of declining
tell us about this period of declining of aging what do we know today about
of aging what do we know today about
of aging what do we know today about this process and what can we do from
this process and what can we do from
this process and what can we do from this knowledge so about hundred years
this knowledge so about hundred years
this knowledge so about hundred years ago one of the first Nobel Prize winners
ago one of the first Nobel Prize winners
ago one of the first Nobel Prize winners Elia Mexico in 1903 came up with the
Elia Mexico in 1903 came up with the
Elia Mexico in 1903 came up with the idea that aging resembles poisoning I
idea that aging resembles poisoning I
idea that aging resembles poisoning I think we all intuitively can easily
think we all intuitively can easily
think we all intuitively can easily accept that because we all have
accept that because we all have
accept that because we all have depressing examples of people who are
depressing examples of people who are
depressing examples of people who are prematurely aging and dying who are drug
prematurely aging and dying who are drug
prematurely aging and dying who are drug addicts or who are poisoning themselves
addicts or who are poisoning themselves
addicts or who are poisoning themselves with alcohol so and he was thinking that
with alcohol so and he was thinking that
with alcohol so and he was thinking that about the possible source of this
about the possible source of this
about the possible source of this poisoning and he came up with the idea
poisoning and he came up with the idea
poisoning and he came up with the idea that this poisoning is coming from the
that this poisoning is coming from the
that this poisoning is coming from the natural microflora which with age
natural microflora which with age
natural microflora which with age changes and takes some toxic
changes and takes some toxic
changes and takes some toxic microorganism which start poisoning us
microorganism which start poisoning us
microorganism which start poisoning us with the products of their secretion
with the products of their secretion
with the products of their secretion unfortunately he was not right but
unfortunately he was not right but
unfortunately he was not right but today’s science did not go that far
today’s science did not go that far
today’s science did not go that far conceptually because today our hopes in
conceptually because today our hopes in
conceptually because today our hopes in this poisoning theory it is with these
this poisoning theory it is with these
this poisoning theory it is with these cells which are appear here on the
cells which are appear here on the
cells which are appear here on the background of other cells as blue will
background of other cells as blue will
background of other cells as blue will name them senescence cells this cells do
name them senescence cells this cells do
name them senescence cells this cells do not exist in the body of of us and
not exist in the body of of us and
not exist in the body of of us and animals when we are young but they
animals when we are young but they
animals when we are young but they accumulate in large numbers in tissues
accumulate in large numbers in tissues
accumulate in large numbers in tissues when we become older and older this
when we become older and older this
when we become older and older this senescence cells they have a number of
senescence cells they have a number of
senescence cells they have a number of differences from normal cells they
differences from normal cells they
differences from normal cells they differ look differently under microscope
differ look differently under microscope
differ look differently under microscope but most importantly they secrete a
but most importantly they secrete a
but most importantly they secrete a series of bioactive factors which create
series of bioactive factors which create
series of bioactive factors which create local inflammation around each of them
local inflammation around each of them
local inflammation around each of them since aging at the physiological level
since aging at the physiological level
since aging at the physiological level is associated with acquisition of
is associated with acquisition of
is associated with acquisition of systemic inflammation of unknown origin
systemic inflammation of unknown origin
systemic inflammation of unknown origin there was a idea that maybe we should
there was a idea that maybe we should
there was a idea that maybe we should link acquisition and accumulation of
link acquisition and accumulation of
link acquisition and accumulation of these cells with poisoning but the
these cells with poisoning but the
these cells with poisoning but the factors of their secretion so this idea
factors of their secretion so this idea
factors of their secretion so this idea was supported by a number of works and
was supported by a number of works and
was supported by a number of works and recently became the most popular theory
recently became the most popular theory
recently became the most popular theory of aging today and there are multiple
of aging today and there are multiple
of aging today and there are multiple laboratories in the world which are
laboratories in the world which are
laboratories in the world which are trying to make drugs which could
trying to make drugs which could
trying to make drugs which could selectively kill only senescence cells
selectively kill only senescence cells
selectively kill only senescence cells without touching others and through that
without touching others and through that
without touching others and through that reach stopping the process of frailty
reach stopping the process of frailty
reach stopping the process of frailty and rejuvenation and you know good
and rejuvenation and you know good
and rejuvenation and you know good perspective of life well I can tell you
perspective of life well I can tell you
perspective of life well I can tell you that there are already several papers
that there are already several papers
that there are already several papers which came out in top visibility
which came out in top visibility
which came out in top visibility journals describing the exploration of
journals describing the exploration of
journals describing the exploration of different senility compounds and they
different senility compounds and they
different senility compounds and they leave mixed impression on one hand we
leave mixed impression on one hand we
leave mixed impression on one hand we clearly see that these animals which
clearly see that these animals which
clearly see that these animals which were treated against us themselves they
were treated against us themselves they
were treated against us themselves they have quality of life somewhat improved
have quality of life somewhat improved
have quality of life somewhat improved however their longevity did not extend
however their longevity did not extend
however their longevity did not extend that much not more about 20
that much not more about 20
that much not more about 20 to set not a revolution although so the
to set not a revolution although so the
to set not a revolution although so the smell is that we’re on the right track
smell is that we’re on the right track
smell is that we’re on the right track but something is not exactly right here
but something is not exactly right here
but something is not exactly right here so and indeed the suspicion is that at
so and indeed the suspicion is that at
so and indeed the suspicion is that at the moment we stopped treatment
the moment we stopped treatment
the moment we stopped treatment senescence cells will come back and
senescence cells will come back and
senescence cells will come back and after they come back they will continue
after they come back they will continue
after they come back they will continue their bad work and you know we’re
their bad work and you know we’re
their bad work and you know we’re returning us back to the tractors that’s
returning us back to the tractors that’s
returning us back to the tractors that’s the gray so well what can be done if
the gray so well what can be done if
the gray so well what can be done if indeed are on the right track and we
indeed are on the right track and we
indeed are on the right track and we already have some good intermediate as a
already have some good intermediate as a
already have some good intermediate as a potential target for a therapeutic
potential target for a therapeutic
potential target for a therapeutic intervention maybe we just need to think
intervention maybe we just need to think
intervention maybe we just need to think little deeper and when you are dealing
little deeper and when you are dealing
little deeper and when you are dealing with for example international terrorism
with for example international terrorism
with for example international terrorism what you can do you can prevent
what you can do you can prevent
what you can do you can prevent terrorists from exploding their bells
terrorists from exploding their bells
terrorists from exploding their bells for example but would that stop terror
for example but would that stop terror
for example but would that stop terror is no you need to deal with the system
is no you need to deal with the system
is no you need to deal with the system which creates them which train them
which creates them which train them
which creates them which train them which recruit them which equip them so
which recruit them which equip them so
which recruit them which equip them so senescence cells appear from something
senescence cells appear from something
senescence cells appear from something and the hope is that when we find this
and the hope is that when we find this
and the hope is that when we find this something which creates an essence cells
something which creates an essence cells
something which creates an essence cells in our body that would give us knowledge
in our body that would give us knowledge
in our body that would give us knowledge how to deal with them so and this is the
how to deal with them so and this is the
how to deal with them so and this is the not black but blue box which till
not black but blue box which till
not black but blue box which till recently was a mystery for me and now I
recently was a mystery for me and now I
recently was a mystery for me and now I will share with you what we found in it
will share with you what we found in it
will share with you what we found in it and I hope that by finding it we now can
and I hope that by finding it we now can
and I hope that by finding it we now can become much closer to the resolution
become much closer to the resolution
become much closer to the resolution because senescence cells as we learn
because senescence cells as we learn
because senescence cells as we learn from our studies is probably just tip of
from our studies is probably just tip of
from our studies is probably just tip of the iceberg just only one of the types
the iceberg just only one of the types
the iceberg just only one of the types of cells which are damaged during our
of cells which are damaged during our
of cells which are damaged during our life and which accumulate and start
life and which accumulate and start
life and which accumulate and start poisoning us and we they better be seen
poisoning us and we they better be seen
poisoning us and we they better be seen as biomarkers of aging rather than being
as biomarkers of aging rather than being
as biomarkers of aging rather than being ultimate however targets which means
ultimate however targets which means
ultimate however targets which means that we need to find this garbage
that we need to find this garbage
that we need to find this garbage producing mechanism and stop it from
producing mechanism and stop it from
producing mechanism and stop it from doing that so what do we know about this
doing that so what do we know about this
doing that so what do we know about this mechanism so hope is that we find this
mechanism so hope is that we find this
mechanism so hope is that we find this mechanism will decipher the source of
mechanism will decipher the source of
mechanism will decipher the source of this
this
this live of Aging and we’ll be able to do
live of Aging and we’ll be able to do
live of Aging and we’ll be able to do something with that so we believe that
something with that so we believe that
something with that so we believe that clock may be hidden in this box so how
clock may be hidden in this box so how
clock may be hidden in this box so how to approach this clock well you may ask
to approach this clock well you may ask
to approach this clock well you may ask the question what turns cell into
the question what turns cell into
the question what turns cell into senescence and we know today that what
senescence and we know today that what
senescence and we know today that what turns cell into senescence is damage to
turns cell into senescence is damage to
turns cell into senescence is damage to their DNA when we know that we say aha
their DNA when we know that we say aha
their DNA when we know that we say aha it’s very simple DNA is damaged by what
it’s very simple DNA is damaged by what
it’s very simple DNA is damaged by what by ultraviolet light by gamma radiation
by ultraviolet light by gamma radiation
by ultraviolet light by gamma radiation by smoking carcinogens by alcohol
by smoking carcinogens by alcohol
by smoking carcinogens by alcohol because it creates reactive oxygen
because it creates reactive oxygen
because it creates reactive oxygen species and so on so let’s just change
species and so on so let’s just change
species and so on so let’s just change habits and we will be safe but we all
habits and we will be safe but we all
habits and we will be safe but we all know that whatever you do with your
know that whatever you do with your
know that whatever you do with your habits you may only increase your chance
habits you may only increase your chance
habits you may only increase your chance to reach this cliff relatively healthy
to reach this cliff relatively healthy
to reach this cliff relatively healthy but you will not be able to move it and
but you will not be able to move it and
but you will not be able to move it and we have the proofs of that in mice as
we have the proofs of that in mice as
we have the proofs of that in mice as well today mice in this country live in
well today mice in this country live in
well today mice in this country live in conditions which are much more healthy
conditions which are much more healthy
conditions which are much more healthy than what we live in because we are
than what we live in because we are
than what we live in because we are forcing them to do that by even though
forcing them to do that by even though
forcing them to do that by even though they probably would not do it themselves
they probably would not do it themselves
they probably would not do it themselves and do you think they live longer not
and do you think they live longer not
and do you think they live longer not really of course they don’t die from
really of course they don’t die from
really of course they don’t die from infectious diseases but they still
infectious diseases but they still
infectious diseases but they still undergo the same process which means
undergo the same process which means
undergo the same process which means that by living healthy life it’s a good
that by living healthy life it’s a good
that by living healthy life it’s a good thing to do but don’t think that it will
thing to do but don’t think that it will
thing to do but don’t think that it will make you long living it makes you
make you long living it makes you
make you long living it makes you healthier dying
so what is this source of this
so what is this source of this mysterious clock what is the nature of
mysterious clock what is the nature of
mysterious clock what is the nature of that you remember that mechnikov came up
that you remember that mechnikov came up
that you remember that mechnikov came up with the idea that parasites do it
with the idea that parasites do it
with the idea that parasites do it brilliant idea I would say that he was
brilliant idea I would say that he was
brilliant idea I would say that he was absolutely right the problem was that at
absolutely right the problem was that at
absolutely right the problem was that at that time he knew only one source of
that time he knew only one source of
that time he knew only one source of parasites bacteria now gas but he didn’t
parasites bacteria now gas but he didn’t
parasites bacteria now gas but he didn’t know that parasites are much more
know that parasites are much more
know that parasites are much more abundant and much more intimately
abundant and much more intimately
abundant and much more intimately involved in our structure and our life
involved in our structure and our life
involved in our structure and our life because they are part of our own DNA we
because they are part of our own DNA we
because they are part of our own DNA we know this for the last 50 years but only
know this for the last 50 years but only
know this for the last 50 years but only today we start realizing what these
today we start realizing what these
today we start realizing what these parasites do the the problem is that
parasites do the the problem is that
parasites do the the problem is that about between 65 and hundred million
about between 65 and hundred million
about between 65 and hundred million years ago the time when dinosaurs
years ago the time when dinosaurs
years ago the time when dinosaurs suddenly died extinct and the era of
suddenly died extinct and the era of
suddenly died extinct and the era of dinosaurs was switched to the era of
dinosaurs was switched to the era of
dinosaurs was switched to the era of mammals of us well it was the period
mammals of us well it was the period
mammals of us well it was the period when viruses appeared of certain kind
when viruses appeared of certain kind
when viruses appeared of certain kind which were not recorded before which
which were not recorded before which
which were not recorded before which actually represented pieces of DNA which
actually represented pieces of DNA which
actually represented pieces of DNA which started invading into our DNA of our
started invading into our DNA of our
started invading into our DNA of our ancestors and multiplying in it creating
ancestors and multiplying in it creating
ancestors and multiplying in it creating numerous new copies and disrupting genes
numerous new copies and disrupting genes
numerous new copies and disrupting genes changing their level of activity and
changing their level of activity and
changing their level of activity and killing lots of lots of individuals
killing lots of lots of individuals
killing lots of lots of individuals probably leading to massive extinctions
probably leading to massive extinctions
probably leading to massive extinctions I wouldn’t be surprised that eventually
I wouldn’t be surprised that eventually
I wouldn’t be surprised that eventually will prove the dinosaurs died from this
will prove the dinosaurs died from this
will prove the dinosaurs died from this particular disease the reason we know
particular disease the reason we know
particular disease the reason we know about that because think about that
about that because think about that
about that because think about that nearly 50 percent of length of our DNA
nearly 50 percent of length of our DNA
nearly 50 percent of length of our DNA consists of these viruses most of them
consists of these viruses most of them
consists of these viruses most of them are dead most of them are without any
are dead most of them are without any
are dead most of them are without any such a long time that they acquired
such a long time that they acquired
such a long time that they acquired mutations which kill them until recently
mutations which kill them until recently
mutations which kill them until recently we thought that our genome is a cemetery
we thought that our genome is a cemetery
we thought that our genome is a cemetery is a graveyard of viruses which about 65
is a graveyard of viruses which about 65
is a graveyard of viruses which about 65 million years ago were the major source
million years ago were the major source
million years ago were the major source of extinction of mammals and vertebrates
of extinction of mammals and vertebrates
of extinction of mammals and vertebrates on this planet so and we have those
on this planet so and we have those
on this planet so and we have those lucky survivors who happen to keep these
lucky survivors who happen to keep these
lucky survivors who happen to keep these viruses in the safe place
viruses in the safe place
viruses in the safe place in their genome where they luckily did
in their genome where they luckily did
in their genome where they luckily did not do any bad well recently it will
not do any bad well recently it will
not do any bad well recently it will appear to be wrong it will find that not
appear to be wrong it will find that not
appear to be wrong it will find that not that many but few of them and if you
that many but few of them and if you
that many but few of them and if you think about copy numbers the copy
think about copy numbers the copy
think about copy numbers the copy numbers of these viruses reaches
numbers of these viruses reaches
numbers of these viruses reaches millions millions copies in our DNA some
millions millions copies in our DNA some
millions millions copies in our DNA some of them several dick several dozens are
of them several dick several dozens are
of them several dick several dozens are actually alive and just deeply asleep
actually alive and just deeply asleep
actually alive and just deeply asleep but they can be awake and their
but they can be awake and their
but they can be awake and their probability of them waking up and start
probability of them waking up and start
probability of them waking up and start multiplying seems to be determined by
multiplying seems to be determined by
multiplying seems to be determined by specious specific mechanism in mice
specious specific mechanism in mice
specious specific mechanism in mice they’re sleeping much less deeply than
they’re sleeping much less deeply than
they’re sleeping much less deeply than in humans that’s why my sleeve two and a
in humans that’s why my sleeve two and a
in humans that’s why my sleeve two and a half years and humans about 90 today
half years and humans about 90 today
half years and humans about 90 today which means that these viruses which are
which means that these viruses which are
which means that these viruses which are sleeping in us but in principle capable
sleeping in us but in principle capable
sleeping in us but in principle capable of repeating what they have done long
of repeating what they have done long
of repeating what they have done long ago
ago
ago maybe that mysterious clock because by
maybe that mysterious clock because by
maybe that mysterious clock because by multiplying our genome they put a poison
multiplying our genome they put a poison
multiplying our genome they put a poison DNA they break it they create senescence
DNA they break it they create senescence
DNA they break it they create senescence cells and other types of damage which
cells and other types of damage which
cells and other types of damage which later on leave to this flood of events
later on leave to this flood of events
later on leave to this flood of events or leading to poisoning and death
or leading to poisoning and death
or leading to poisoning and death well let’s repeat what I just said about
well let’s repeat what I just said about
well let’s repeat what I just said about 65 million years ago there were no
65 million years ago there were no
65 million years ago there were no diversity of mammals there were just
diversity of mammals there were just
diversity of mammals there were just very few of them they were very universe
very few of them they were very universe
very few of them they were very universe and they were not visible among tons of
and they were not visible among tons of
and they were not visible among tons of dinosaurs around then this virus has
dinosaurs around then this virus has
dinosaurs around then this virus has appeared God knows from where and they
appeared God knows from where and they
appeared God knows from where and they start invading massively in the genomes
start invading massively in the genomes
start invading massively in the genomes of these poor ancestors creating
of these poor ancestors creating
of these poor ancestors creating diversity not only between those who
diversity not only between those who
diversity not only between those who died and survived but also affecting
died and survived but also affecting
died and survived but also affecting their appearance and that was the time
their appearance and that was the time
their appearance and that was the time when the all origin of this enormous
when the all origin of this enormous
when the all origin of this enormous diversity of mammals goes back to so
diversity of mammals goes back to so
diversity of mammals goes back to so those who survived and this was a very
those who survived and this was a very
those who survived and this was a very very rough turbulent period in our
very rough turbulent period in our
very rough turbulent period in our evolution during which all these air Chi
evolution during which all these air Chi
evolution during which all these air Chi types of mammals appeared and after that
types of mammals appeared and after that
types of mammals appeared and after that you see no much happen only
you see no much happen only
you see no much happen only microevolution so those who survived
microevolution so those who survived
microevolution so those who survived they not only managed to stop the
they not only managed to stop the
they not only managed to stop the mummification of these viruses but they
mummification of these viruses but they
mummification of these viruses but they acquired them as a big part of the Agena
acquired them as a big part of the Agena
acquired them as a big part of the Agena and the conditions of certain depth of
and the conditions of certain depth of
and the conditions of certain depth of putting asleep of silencing in some of
putting asleep of silencing in some of
putting asleep of silencing in some of you they’re silent completely or near
you they’re silent completely or near
you they’re silent completely or near completion and this comes with the
completion and this comes with the
completion and this comes with the expectation how long we they can do this
expectation how long we they can do this
expectation how long we they can do this without killing us
without killing us
without killing us probably forming this species-specific
probably forming this species-specific
probably forming this species-specific clock with determine length of our life
clock with determine length of our life
clock with determine length of our life what is very important that this process
what is very important that this process
what is very important that this process is ongoing in every single cell in our
is ongoing in every single cell in our
is ongoing in every single cell in our body so which means that ours this
body so which means that ours this
body so which means that ours this mechanism is implemented in every single
mechanism is implemented in every single
mechanism is implemented in every single cell in our body as a probability of
cell in our body as a probability of
cell in our body as a probability of awakening of endogenous viruses which
awakening of endogenous viruses which
awakening of endogenous viruses which can create DNA damage in somatic cell
can create DNA damage in somatic cell
can create DNA damage in somatic cell population in our body thereby creating
population in our body thereby creating
population in our body thereby creating that garbage which eventually will kill
that garbage which eventually will kill
that garbage which eventually will kill us from from frailty and aging so does
us from from frailty and aging so does
us from from frailty and aging so does this picture allow you anything to do
this picture allow you anything to do
this picture allow you anything to do what does this knowledge mean to us it
what does this knowledge mean to us it
what does this knowledge mean to us it looks depressing it looks scary it looks
looks depressing it looks scary it looks
looks depressing it looks scary it looks like every cell in our body has a little
like every cell in our body has a little
like every cell in our body has a little piece of uranium which is kind of a kind
piece of uranium which is kind of a kind
piece of uranium which is kind of a kind of making holes in DNA and finally kills
of making holes in DNA and finally kills
of making holes in DNA and finally kills us well either surprisingly there is
us well either surprisingly there is
us well either surprisingly there is because knowing that mechanism of how
because knowing that mechanism of how
because knowing that mechanism of how this virus is amplified we found that in
this virus is amplified we found that in
this virus is amplified we found that in our medical history we dealt with
our medical history we dealt with
our medical history we dealt with viruses of remotely similar kind and
viruses of remotely similar kind and
viruses of remotely similar kind and some of the antiviral drugs which we
some of the antiviral drugs which we
some of the antiviral drugs which we developed not very efficiently but
developed not very efficiently but
developed not very efficiently but sufficiently well working against
sufficiently well working against
sufficiently well working against mechanisms of replication of these
mechanisms of replication of these
mechanisms of replication of these viruses good enough to allow us to take
viruses good enough to allow us to take
viruses good enough to allow us to take some of the drugs which today being used
some of the drugs which today being used
some of the drugs which today being used to treat AIDS HIV could be used by us as
to treat AIDS HIV could be used by us as
to treat AIDS HIV could be used by us as a proof of principle to extend life of
a proof of principle to extend life of
a proof of principle to extend life of mice in which this process is ongoing
mice in which this process is ongoing
mice in which this process is ongoing today can tell you that with some of the
today can tell you that with some of the
today can tell you that with some of the antiviral drugs we can stop this process
antiviral drugs we can stop this process
antiviral drugs we can stop this process of amplification of these viruses and we
of amplification of these viruses and we
of amplification of these viruses and we hope that it will have a dramatic
hope that it will have a dramatic
hope that it will have a dramatic positive impact on our ability to
positive impact on our ability to
positive impact on our ability to cardinally extend our longevity stop
cardinally extend our longevity stop
cardinally extend our longevity stop acquisition frailty and so on so it’s a
acquisition frailty and so on so it’s a
acquisition frailty and so on so it’s a targeted drug it hits what we believe
targeted drug it hits what we believe
targeted drug it hits what we believe today is that mysterious cloak of life
today is that mysterious cloak of life
today is that mysterious cloak of life which is the content of our DNA which we
which is the content of our DNA which we
which is the content of our DNA which we acquired as parasite 65 – 100 million
acquired as parasite 65 – 100 million
acquired as parasite 65 – 100 million years ago and this content is killing us
years ago and this content is killing us
years ago and this content is killing us by being insufficiently well repressed
by being insufficiently well repressed
by being insufficiently well repressed so as a result the clock can be broken
so as a result the clock can be broken
so as a result the clock can be broken and the flood of senescence cells which
and the flood of senescence cells which
and the flood of senescence cells which this cloak creates while it’s working
this cloak creates while it’s working
this cloak creates while it’s working now will be drained and will dry out and
now will be drained and will dry out and
now will be drained and will dry out and no longer poisonous and today we have it
no longer poisonous and today we have it
no longer poisonous and today we have it in real hope for the first time we hope
in real hope for the first time we hope
in real hope for the first time we hope that this road to this cliff which all
that this road to this cliff which all
that this road to this cliff which all of us at different stages at we have a
of us at different stages at we have a
of us at different stages at we have a chance to avoid and we can build the
chance to avoid and we can build the
chance to avoid and we can build the bridge with the help of these drugs
bridge with the help of these drugs
bridge with the help of these drugs which we are working on right now to
which we are working on right now to
which we are working on right now to avoid this cliff and go forward to the
avoid this cliff and go forward to the
avoid this cliff and go forward to the next disease which tell Kela stop
next disease which tell Kela stop
next disease which tell Kela stop killing us after we deal with angel
killing us after we deal with angel
killing us after we deal with angel thank
thank
thank [Applause]
[Applause]
[Applause] [Music]
”
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