so as you just have heard I’m a scientist
scientist
scientist by that motto human being so I will age
by that motto human being so I will age
by that motto human being so I will age and I will die one day
and I will die one day
and I will die one day not today and hopefully not tomorrow but
not today and hopefully not tomorrow but
not today and hopefully not tomorrow but one day I will be dead
one day I will be dead
one day I will be dead and I always told myself if I can live
and I always told myself if I can live
and I always told myself if I can live up to 90 years be healthy happy brain
up to 90 years be healthy happy brain
up to 90 years be healthy happy brain function is alive and I gonna die
function is alive and I gonna die
function is alive and I gonna die on the day after my 90th birthday I’m
on the day after my 90th birthday I’m
on the day after my 90th birthday I’m the happiest person on this planet in
the happiest person on this planet in
the happiest person on this planet in that I start thinking about it you know
that I start thinking about it you know
that I start thinking about it you know if I can stay healthy I’ll 290 and maybe
if I can stay healthy I’ll 290 and maybe
if I can stay healthy I’ll 290 and maybe I could stay until healthy until 100 why
I could stay until healthy until 100 why
I could stay until healthy until 100 why would I want to die you know there’s so
would I want to die you know there’s so
would I want to die you know there’s so much things to do and this is what got
much things to do and this is what got
much things to do and this is what got me thinking I love trains train stations
me thinking I love trains train stations
me thinking I love trains train stations public transportation I really like it
public transportation I really like it
public transportation I really like it and there’s a construction site for a
and there’s a construction site for a
and there’s a construction site for a high-speed train tracks close to where I
high-speed train tracks close to where I
high-speed train tracks close to where I live and now they cover defenses to the
live and now they cover defenses to the
live and now they cover defenses to the construction site with infotainment
construction site with infotainment
construction site with infotainment that’s the new thing you know if you
that’s the new thing you know if you
that’s the new thing you know if you work through and is displayed novel
work through and is displayed novel
work through and is displayed novel train concepts of the future like this
train concepts of the future like this
train concepts of the future like this one that also hyper loops on display and
one that also hyper loops on display and
one that also hyper loops on display and all of that everything futuristic and
all of that everything futuristic and
all of that everything futuristic and then I said ever think my gosh I would
then I said ever think my gosh I would
then I said ever think my gosh I would like to see which one the concepts will
like to see which one the concepts will
like to see which one the concepts will come true in a couple of years maybe in
come true in a couple of years maybe in
come true in a couple of years maybe in 50 years and I would like to see that I
50 years and I would like to see that I
50 years and I would like to see that I would like to stay alive or know which
would like to stay alive or know which
would like to stay alive or know which train I’m gonna ride in 50 years and now
train I’m gonna ride in 50 years and now
train I’m gonna ride in 50 years and now also like I also like Rockets really
also like I also like Rockets really
also like I also like Rockets really Rockets okay
Rockets okay
Rockets okay so I would like to see Rockets flying
so I would like to see Rockets flying
so I would like to see Rockets flying people to Mars I really like see that
people to Mars I really like see that
people to Mars I really like see that okay same and also as you know I’m a
okay same and also as you know I’m a
okay same and also as you know I’m a scientist I really would like to see
scientist I really would like to see
scientist I really would like to see what science brings us in the next
what science brings us in the next
what science brings us in the next couple of years you know still my
couple of years you know still my
couple of years you know still my curiosity and and and be able to
curiosity and and and be able to
curiosity and and and be able to experience that and if I could hold on
experience that and if I could hold on
experience that and if I could hold on to my health
to my health
to my health would I not want to be long around the
would I not want to be long around the
would I not want to be long around the people I really love that I cherish
people I really love that I cherish
people I really love that I cherish maybe even those are the people that
maybe even those are the people that
maybe even those are the people that challenge me
challenge me
challenge me and I think we have all that in common
and I think we have all that in common
and I think we have all that in common there’s something about future in the
there’s something about future in the
there’s something about future in the future that we would like to see
future that we would like to see
future that we would like to see encounter feel or be with that has
encounter feel or be with that has
encounter feel or be with that has meaning to us and that would be worth
meaning to us and that would be worth
meaning to us and that would be worth living for longer if you could do that
living for longer if you could do that
living for longer if you could do that in good health so mother nature is
in good health so mother nature is
in good health so mother nature is actually pretty cool she starts to
actually pretty cool she starts to
actually pretty cool she starts to fulfill in part these dreams are ready
fulfill in part these dreams are ready
fulfill in part these dreams are ready so the demographic development tells us
so the demographic development tells us
so the demographic development tells us that a lot of people they become more
that a lot of people they become more
that a lot of people they become more than a hundred years old in the next
than a hundred years old in the next
than a hundred years old in the next couple of decades and the new normal
couple of decades and the new normal
couple of decades and the new normal will be that on average people will
will be that on average people will
will be that on average people will become 90 years old and the good thing
become 90 years old and the good thing
become 90 years old and the good thing is you don’t have to do anything about
is you don’t have to do anything about
is you don’t have to do anything about it it just happens that’s how the M
it it just happens that’s how the M
it it just happens that’s how the M demography works mother nature also
demography works mother nature also
demography works mother nature also forgot a small part smart piece in the
forgot a small part smart piece in the
forgot a small part smart piece in the whole equation usually she does not
whole equation usually she does not
whole equation usually she does not allow us to age in good health so you
allow us to age in good health so you
allow us to age in good health so you know all about these diseases that
know all about these diseases that
know all about these diseases that people get when they get older like my
people get when they get older like my
people get when they get older like my grandmother or even recently my mother
grandmother or even recently my mother
grandmother or even recently my mother that’s not good and you all know loved
that’s not good and you all know loved
that’s not good and you all know loved ones yourself that come down with these
ones yourself that come down with these
ones yourself that come down with these diseases and how much pain that is and
diseases and how much pain that is and
diseases and how much pain that is and how much the quality of life is not
how much the quality of life is not
how much the quality of life is not delivered so is then this concept of
delivered so is then this concept of
delivered so is then this concept of becoming old and healthy staying healthy
becoming old and healthy staying healthy
becoming old and healthy staying healthy just a fantasy or is there something
just a fantasy or is there something
just a fantasy or is there something real to it can we do something about it
real to it can we do something about it
real to it can we do something about it so my interest in this research aging
so my interest in this research aging
so my interest in this research aging research anti-aging research started
research anti-aging research started
research anti-aging research started when I was already a student so all
when I was already a student so all
when I was already a student so all living organisms are made out of small
living organisms are made out of small
living organisms are made out of small autonomous units they’re called cells
autonomous units they’re called cells
autonomous units they’re called cells everybody I drove
everybody I drove
everybody I drove might have heard about them and these
might have heard about them and these
might have heard about them and these cells different type of cells form
cells different type of cells form
cells different type of cells form together organs tissues and it er all
together organs tissues and it er all
together organs tissues and it er all human beings and at that time I was
human beings and at that time I was
human beings and at that time I was interested if he could make young cells
interested if he could make young cells
interested if he could make young cells from young people even younger can we
from young people even younger can we
from young people even younger can we build time machines for cells and I
build time machines for cells and I
build time machines for cells and I still remember that very moment sitting
still remember that very moment sitting
still remember that very moment sitting at my desk looking at an auto radiograph
at my desk looking at an auto radiograph
at my desk looking at an auto radiograph with certain bands on it that’s how
with certain bands on it that’s how
with certain bands on it that’s how scientists do that and the certain
scientists do that and the certain
scientists do that and the certain pattern told me yes it is possible it is
pattern told me yes it is possible it is
pattern told me yes it is possible it is possible to make young cells younger and
possible to make young cells younger and
possible to make young cells younger and although at that time again was only
although at that time again was only
although at that time again was only young cells making younger they got me
young cells making younger they got me
young cells making younger they got me hooked on this topic I think we can
hooked on this topic I think we can
hooked on this topic I think we can build time machines for cells so when I
build time machines for cells so when I
build time machines for cells so when I became an independent researcher I then
became an independent researcher I then
became an independent researcher I then started to dream about the ultimate time
started to dream about the ultimate time
started to dream about the ultimate time machine can we made eight cells younger
machine can we made eight cells younger
machine can we made eight cells younger can we really achieve that can we build
can we really achieve that can we build
can we really achieve that can we build time machines that are able to do so and
time machines that are able to do so and
time machines that are able to do so and I decided to focus on a very specific
I decided to focus on a very specific
I decided to focus on a very specific type of cell which is called stem cell
type of cell which is called stem cell
type of cell which is called stem cell somatic stem cell why’s that so specific
somatic stem cell why’s that so specific
somatic stem cell why’s that so specific or so special a stem cell our body
or so special a stem cell our body
or so special a stem cell our body consists out of 30 trillion cells that’s
consists out of 30 trillion cells that’s
consists out of 30 trillion cells that’s a 10 with 13 zeros there’s a lot of
a 10 with 13 zeros there’s a lot of
a 10 with 13 zeros there’s a lot of cells and every day you me you me lose
cells and every day you me you me lose
cells and every day you me you me lose 200 billions of these cells due to
200 billions of these cells due to
200 billions of these cells due to attrition it’s primarily blood cells
attrition it’s primarily blood cells
attrition it’s primarily blood cells skin cells and skin cells in your
skin cells and skin cells in your
skin cells and skin cells in your intestine get just one hour we don’t
intestine get just one hour we don’t
intestine get just one hour we don’t need them anymore and it’s dangerous to
need them anymore and it’s dangerous to
need them anymore and it’s dangerous to keep them longer in the body and they
keep them longer in the body and they
keep them longer in the body and they need to be replaced
need to be replaced
need to be replaced 200 billion it’s a 10 with 11 zeros how
200 billion it’s a 10 with 11 zeros how
200 billion it’s a 10 with 11 zeros how do we actually do that so nature
do we actually do that so nature
do we actually do that so nature invented also very clever system it’s
invented also very clever system it’s
invented also very clever system it’s called the stem cell that allows us to
called the stem cell that allows us to
called the stem cell that allows us to do that healthy happy
do that healthy happy
do that healthy happy not Victor dangers come usually from
not Victor dangers come usually from
not Victor dangers come usually from other systems to do so stem cells to
other systems to do so stem cells to
other systems to do so stem cells to only bear the information to make all of
only bear the information to make all of
only bear the information to make all of these cells that were gonna lose his
these cells that were gonna lose his
these cells that were gonna lose his blood cells or this immune type of cells
blood cells or this immune type of cells
blood cells or this immune type of cells and they pass on his information and
and they pass on his information and
and they pass on his information and give the duty to daughters and sons of
give the duty to daughters and sons of
give the duty to daughters and sons of them that then multiply very rapidly and
them that then multiply very rapidly and
them that then multiply very rapidly and replace all of the cells gone but these
replace all of the cells gone but these
replace all of the cells gone but these other daughters they also have a finite
other daughters they also have a finite
other daughters they also have a finite lifespan because making this replication
lifespan because making this replication
lifespan because making this replication very often can be dangerous you can get
very often can be dangerous you can get
very often can be dangerous you can get cancer at the end so the stem cell keeps
cancer at the end so the stem cell keeps
cancer at the end so the stem cell keeps to information and manages the system
to information and manages the system
to information and manages the system it’s the manager of the tissue the work
it’s the manager of the tissue the work
it’s the manager of the tissue the work is done by others but keeps a manager
is done by others but keeps a manager
is done by others but keeps a manager happy and healthy for a very long time
happy and healthy for a very long time
happy and healthy for a very long time and initially people thought that mean
and initially people thought that mean
and initially people thought that mean pristine for forever
pristine for forever
pristine for forever that would mean although year 60 or 50
that would mean although year 60 or 50
that would mean although year 60 or 50 you stem cells are still 20 and 30 and
you stem cells are still 20 and 30 and
you stem cells are still 20 and 30 and that was wrong cause us stem cells start
that was wrong cause us stem cells start
that was wrong cause us stem cells start to age they changed a function over time
to age they changed a function over time
to age they changed a function over time and they cannot manage the system
and they cannot manage the system
and they cannot manage the system anymore so for these blood-forming stem
anymore so for these blood-forming stem
anymore so for these blood-forming stem cells that has real consequences when
cells that has real consequences when
cells that has real consequences when they become older they also make all the
they become older they also make all the
they become older they also make all the immune cells that means when you get
immune cells that means when you get
immune cells that means when you get older you’d get more infections you’re
older you’d get more infections you’re
older you’d get more infections you’re getting more likely to flu and it’s much
getting more likely to flu and it’s much
getting more likely to flu and it’s much more difficult to get rid of the flu and
more difficult to get rid of the flu and
more difficult to get rid of the flu and there’s still a lot of elderly people
there’s still a lot of elderly people
there’s still a lot of elderly people just die from flu and complications on
just die from flu and complications on
just die from flu and complications on top of it he also will more likely get
top of it he also will more likely get
top of it he also will more likely get cancer blood that cancers when you get
cancer blood that cancers when you get
cancer blood that cancers when you get aged do you do stem cells or not working
aged do you do stem cells or not working
aged do you do stem cells or not working properly anymore and there’s even new
properly anymore and there’s even new
properly anymore and there’s even new research it’s just very exciting that
research it’s just very exciting that
research it’s just very exciting that would imply that problems if too hard
would imply that problems if too hard
would imply that problems if too hard when you get older are – – problems –
when you get older are – – problems –
when you get older are – – problems – your stem cells in the blood that form
your stem cells in the blood that form
your stem cells in the blood that form the blood so there are real consequences
the blood so there are real consequences
the blood so there are real consequences and it looks like that aging of stem
and it looks like that aging of stem
and it looks like that aging of stem cells seems to be in the way of healthy
cells seems to be in the way of healthy
cells seems to be in the way of healthy aging
so why do stem cells say is how we can
so why do stem cells say is how we can explain that they age cells consists of
explain that they age cells consists of
explain that they age cells consists of a lot of units parts they are very
a lot of units parts they are very
a lot of units parts they are very complicated entities within a cell we
complicated entities within a cell we
complicated entities within a cell we have probably a hundred thousand
have probably a hundred thousand
have probably a hundred thousand different units DNA RNA proteins lipids
different units DNA RNA proteins lipids
different units DNA RNA proteins lipids are they called and they usually come in
are they called and they usually come in
are they called and they usually come in multiple copies that means a cell has
multiple copies that means a cell has
multiple copies that means a cell has probably 1 million parts in itself 1
probably 1 million parts in itself 1
probably 1 million parts in itself 1 million a car for example is only 30,000
million a car for example is only 30,000
million a car for example is only 30,000 parts and these parts in the cell form
parts and these parts in the cell form
parts and these parts in the cell form larger units machines that are very
larger units machines that are very
larger units machines that are very critical to for example generate energy
critical to for example generate energy
critical to for example generate energy for a cell or make new machines that
for a cell or make new machines that
for a cell or make new machines that make proteins for a cell or help you to
make proteins for a cell or help you to
make proteins for a cell or help you to protect your genetic information or make
protect your genetic information or make
protect your genetic information or make its genetic information accessible so
its genetic information accessible so
its genetic information accessible so the structure and order of these
the structure and order of these
the structure and order of these machines and other parts in a Cell
machines and other parts in a Cell
machines and other parts in a Cell working together is very critical
working together is very critical
working together is very critical pivotal for a stem cell to function
pivotal for a stem cell to function
pivotal for a stem cell to function correctly like shown here this is a stem
correctly like shown here this is a stem
correctly like shown here this is a stem cell that’s real life data from the
cell that’s real life data from the
cell that’s real life data from the laboratory the red one is one piece of a
laboratory the red one is one piece of a
laboratory the red one is one piece of a machine the green one is one piece of a
machine the green one is one piece of a
machine the green one is one piece of a machine they have order and structure
machine they have order and structure
machine they have order and structure it’s like real life correct should be at
it’s like real life correct should be at
it’s like real life correct should be at least sometimes ok
now over time what happens to the stem
now over time what happens to the stem cell why it’s becoming aged why is not
cell why it’s becoming aged why is not
cell why it’s becoming aged why is not functional non-management anymore and
functional non-management anymore and
functional non-management anymore and the most obvious happens it will start
the most obvious happens it will start
the most obvious happens it will start to put disorder into the system ok so
to put disorder into the system ok so
to put disorder into the system ok so it’s not that parts are damaged it’s
it’s not that parts are damaged it’s
it’s not that parts are damaged it’s just that they don’t find a place
just that they don’t find a place
just that they don’t find a place anymore where they belong to again it’s
anymore where they belong to again it’s
anymore where they belong to again it’s like real life correct
like real life correct
like real life correct okay I can tell you it’s not then the
okay I can tell you it’s not then the
okay I can tell you it’s not then the sale the parts are all over that’s also
sale the parts are all over that’s also
sale the parts are all over that’s also real-life data okay you see green is
real-life data okay you see green is
real-life data okay you see green is everywhere red is everywhere okay
everywhere red is everywhere okay
everywhere red is everywhere okay disorder and that sometimes like my
disorder and that sometimes like my
disorder and that sometimes like my office and you mean overtime precisely
office and you mean overtime precisely
office and you mean overtime precisely that happens you’ve started your books
that happens you’ve started your books
that happens you’ve started your books everywhere
everywhere
everywhere you cannot organize anything anymore if
you cannot organize anything anymore if
you cannot organize anything anymore if somebody comes in and asks you where is
somebody comes in and asks you where is
somebody comes in and asks you where is the math book
the math book
the math book you don’t know anymore correct so while
you don’t know anymore correct so while
you don’t know anymore correct so while you’re still able to do the managing
you’re still able to do the managing
you’re still able to do the managing function probably in part like stem
function probably in part like stem
function probably in part like stem cells will do when they age you will
cells will do when they age you will
cells will do when they age you will take a lot of more energy to get the
take a lot of more energy to get the
take a lot of more energy to get the system going and you definitely will
system going and you definitely will
system going and you definitely will make more mistakes like H stem cells do
now you also learned them in a messy
now you also learned them in a messy correct that just told you that so and
correct that just told you that so and
correct that just told you that so and in that I would not be able to manage my
in that I would not be able to manage my
in that I would not be able to manage my laboratory very well anymore okay and it
laboratory very well anymore okay and it
laboratory very well anymore okay and it turned out within H stem cells there’s
turned out within H stem cells there’s
turned out within H stem cells there’s also the messy person it’s called a
also the messy person it’s called a
also the messy person it’s called a protein a messy protein and we gave it a
protein a messy protein and we gave it a
protein a messy protein and we gave it a name cdc42 you don’t have ever to
name cdc42 you don’t have ever to
name cdc42 you don’t have ever to remember that but the important part is
remember that but the important part is
remember that but the important part is it turned out that’s not becoming lazy
it turned out that’s not becoming lazy
it turned out that’s not becoming lazy when the stem cell gets age not lazy and
when the stem cell gets age not lazy and
when the stem cell gets age not lazy and not disorganized
not disorganized
not disorganized it’s become hyperactive that’s the
it’s become hyperactive that’s the
it’s become hyperactive that’s the interesting but hyperactive upon aging
interesting but hyperactive upon aging
interesting but hyperactive upon aging okay
okay
okay it cannot focus on stuff anymore it’s
it cannot focus on stuff anymore it’s
it cannot focus on stuff anymore it’s doing this just using this and that’s
doing this just using this and that’s
doing this just using this and that’s also like real life correct so we have
also like real life correct so we have
also like real life correct so we have people running around doing a lot of
people running around doing a lot of
people running around doing a lot of things at the end of the day nothing is
things at the end of the day nothing is
things at the end of the day nothing is done luckily collaborators developed a
done luckily collaborators developed a
done luckily collaborators developed a drug a compound that is able to tame the
drug a compound that is able to tame the
drug a compound that is able to tame the hyperactivity of this protein it’s like
hyperactivity of this protein it’s like
hyperactivity of this protein it’s like yoga for stem cells and then and then
yoga for stem cells and then and then
yoga for stem cells and then and then really it settles down to the level of a
really it settles down to the level of a
really it settles down to the level of a normal active protein and then the real
normal active protein and then the real
normal active protein and then the real magic happens
magic happens
magic happens it’s
it’s
it’s yeah so this is the magic part okay when
yeah so this is the magic part okay when
yeah so this is the magic part okay when the protein had settled in again even if
the protein had settled in again even if
the protein had settled in again even if the stem cell is aged it starts to
the stem cell is aged it starts to
the stem cell is aged it starts to restructure itself again all the books
restructure itself again all the books
restructure itself again all the books put on shelves again all the machines
put on shelves again all the machines
put on shelves again all the machines seem to reassemble and work together
seem to reassemble and work together
seem to reassemble and work together again in a very proper function so you
again in a very proper function so you
again in a very proper function so you can switch from this disorder to order
can switch from this disorder to order
can switch from this disorder to order just by using this drug and you regain
just by using this drug and you regain
just by using this drug and you regain also the useful function of this stem
also the useful function of this stem
also the useful function of this stem cell so for example it will now produce
cell so for example it will now produce
cell so for example it will now produce better immune cells again although it’s
better immune cells again although it’s
better immune cells again although it’s old and will allow you to fight
old and will allow you to fight
old and will allow you to fight infections better and this is per the
infections better and this is per the
infections better and this is per the first way that biology can support
first way that biology can support
first way that biology can support healthy aging now this finding it’s a
healthy aging now this finding it’s a
healthy aging now this finding it’s a small one I think in research but has
small one I think in research but has
small one I think in research but has broad implications for whole biology and
broad implications for whole biology and
broad implications for whole biology and that would mean aging is a very simple
that would mean aging is a very simple
that would mean aging is a very simple process initially it’s like organization
process initially it’s like organization
process initially it’s like organization this organization and you can put that
this organization and you can put that
this organization and you can put that back it’s not irreversible what happens
back it’s not irreversible what happens
back it’s not irreversible what happens upon aging and you can target it by
upon aging and you can target it by
upon aging and you can target it by certain biological mechanisms in this
certain biological mechanisms in this
certain biological mechanisms in this way a drug and it’s not only lifestyle
way a drug and it’s not only lifestyle
way a drug and it’s not only lifestyle or exercise that you can help help you
or exercise that you can help help you
or exercise that you can help help you to become this healthy aging person that
to become this healthy aging person that
to become this healthy aging person that mean it’s not a one-way road and we can
mean it’s not a one-way road and we can
mean it’s not a one-way road and we can profit from that so healthy aging is
profit from that so healthy aging is
profit from that so healthy aging is worth pursuing it’s not a fantasy in the
worth pursuing it’s not a fantasy in the
worth pursuing it’s not a fantasy in the head of a couple of people mother nature
head of a couple of people mother nature
head of a couple of people mother nature biology would allow us to do that and
biology would allow us to do that and
biology would allow us to do that and data I’ve shown you is from the mouse
data I’ve shown you is from the mouse
data I’ve shown you is from the mouse but is also clear that as might work for
but is also clear that as might work for
but is also clear that as might work for human beings at the end allow healthy
human beings at the end allow healthy
human beings at the end allow healthy aging for human beings and that might
aging for human beings and that might
aging for human beings and that might mean that maybe our children or our
mean that maybe our children or our
mean that maybe our children or our grandchildren will be able to see self
grandchildren will be able to see self
grandchildren will be able to see self flying cars
flying cars
flying cars or people taking extended vacation on
or people taking extended vacation on
or people taking extended vacation on Mars because they can hold on to their
Mars because they can hold on to their
Mars because they can hold on to their health and see all of that in their
health and see all of that in their
health and see all of that in their lifetime in the meantime though I will
lifetime in the meantime though I will
lifetime in the meantime though I will keep dreaming about fancy trains hanging
keep dreaming about fancy trains hanging
keep dreaming about fancy trains hanging out with my great-grandchildren and will
out with my great-grandchildren and will
out with my great-grandchildren and will not stop though to work on finding ways
not stop though to work on finding ways
not stop though to work on finding ways to reorganize stem cells that at the end
to reorganize stem cells that at the end
to reorganize stem cells that at the end will based on research today allow us to
will based on research today allow us to
will based on research today allow us to have healthy aging for our children our
have healthy aging for our children our
have healthy aging for our children our grandchildren
grandchildren
grandchildren thank you
thank you
thank you [Applause]
[Applause]
[Applause] [Music]
[Music]
[Music] [Applause]
”
Be First to Comment