Finding a Cancer Killer | Breakthrough

working out of the University of

working out of the University of Pennsylvania dr. June has been

Pennsylvania dr. June has been

Pennsylvania dr. June has been developing a new technology to leverage

developing a new technology to leverage

developing a new technology to leverage the immune systems t-cells to fight and

the immune systems t-cells to fight and

the immune systems t-cells to fight and kill leukemia in mice I’ve been through

kill leukemia in mice I’ve been through

kill leukemia in mice I’ve been through a long journey so I was a physician and

a long journey so I was a physician and

a long journey so I was a physician and then gradually I came a conclusion that

then gradually I came a conclusion that

then gradually I came a conclusion that could probably help more people through

could probably help more people through

could probably help more people through my scientific laboratory efforts than

my scientific laboratory efforts than

my scientific laboratory efforts than actually seeing people one at a time in

actually seeing people one at a time in

actually seeing people one at a time in a clinic I tell my family now that my MD

a clinic I tell my family now that my MD

a clinic I tell my family now that my MD stands for Mouse doctor

stands for Mouse doctor

stands for Mouse doctor the immune system protects you from

the immune system protects you from

the immune system protects you from outside invasion if a virus bacteria or

outside invasion if a virus bacteria or

outside invasion if a virus bacteria or fungus slips into your body the immune

fungus slips into your body the immune

fungus slips into your body the immune system responds with a coordinated

system responds with a coordinated

system responds with a coordinated attack that killed the invader and only

attack that killed the invader and only

attack that killed the invader and only the invader leaving your body intact

the invader leaving your body intact

the invader leaving your body intact this is a t-cell this immune cells job

this is a t-cell this immune cells job

this is a t-cell this immune cells job is to kill infected cells before they

is to kill infected cells before they

is to kill infected cells before they cause more damage in theory t-cells can

cause more damage in theory t-cells can

cause more damage in theory t-cells can be extraordinarily potent against

be extraordinarily potent against

be extraordinarily potent against leukemia but there’s one problem

leukemia but there’s one problem

leukemia but there’s one problem since cancer is effectively part of your

since cancer is effectively part of your

since cancer is effectively part of your own body the immune system sometimes

own body the immune system sometimes

own body the immune system sometimes ignores these rogue cells allowing the

ignores these rogue cells allowing the

ignores these rogue cells allowing the cancer to spread unchecked jun and his

cancer to spread unchecked jun and his

cancer to spread unchecked jun and his team have worked tirelessly to find a

team have worked tirelessly to find a

team have worked tirelessly to find a way to get the immune system to

way to get the immune system to

way to get the immune system to recognize and destroy all of the

recognize and destroy all of the

recognize and destroy all of the cancerous cells in the body the therapy

cancerous cells in the body the therapy

cancerous cells in the body the therapy word developing is multidisciplinary it

word developing is multidisciplinary it

word developing is multidisciplinary it involves leukemia specialists David

involves leukemia specialists David

involves leukemia specialists David Porter is known around the world for his

Porter is known around the world for his

Porter is known around the world for his treating various kinds of leukemia it

treating various kinds of leukemia it

treating various kinds of leukemia it involves immunology expertise viral

involves immunology expertise viral

involves immunology expertise viral vector design expertise and then the

vector design expertise and then the

vector design expertise and then the cell culturing expertise the Bruce Avena

cell culturing expertise the Bruce Avena

cell culturing expertise the Bruce Avena knows more about than anyone in the

knows more about than anyone in the

knows more about than anyone in the world

world

world I’m quite sure okay I’m a professor in

I’m quite sure okay I’m a professor in

I’m quite sure okay I’m a professor in cancer gene therapy and I direct the

cancer gene therapy and I direct the

cancer gene therapy and I direct the clinical cell and vaccine production

clinical cell and vaccine production

clinical cell and vaccine production facility and what we do is to develop

facility and what we do is to develop

facility and what we do is to develop manufacture and test cell and gene

manufacture and test cell and gene

manufacture and test cell and gene therapies to fight cancer using the

therapies to fight cancer using the

therapies to fight cancer using the patient’s own immune cells that have

patient’s own immune cells that have

patient’s own immune cells that have been genetically targeted to cancer a

been genetically targeted to cancer a

been genetically targeted to cancer a car t-cell is a t-cell that is

car t-cell is a t-cell that is

car t-cell is a t-cell that is genetically modified in a way that

genetically modified in a way that

genetically modified in a way that allows it to see and recognize a cancer

allows it to see and recognize a cancer

allows it to see and recognize a cancer cell a car stands for chimeric antigen

cell a car stands for chimeric antigen

cell a car stands for chimeric antigen receptor it’s a molecule that is

receptor it’s a molecule that is

receptor it’s a molecule that is synthetic we can put it into an immune

synthetic we can put it into an immune

synthetic we can put it into an immune cell genetically change the immune cell

cell genetically change the immune cell

cell genetically change the immune cell to express the car molecule that

to express the car molecule that

to express the car molecule that function of binding activates the T cell

function of binding activates the T cell

function of binding activates the T cell and it allows it to become active to

and it allows it to become active to

and it allows it to become active to become a killer cell and to kill the

become a killer cell and to kill the

become a killer cell and to kill the leukemia

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you [Music]