just quickly what does a pathologist do when we cut update animals and we also
when we cut update animals and we also
when we cut update animals and we also take surgical biopsies from animals and
take surgical biopsies from animals and
take surgical biopsies from animals and we read out diagnosis and we read out
we read out diagnosis and we read out
we read out diagnosis and we read out the reasons why animals are you sick or
the reasons why animals are you sick or
the reasons why animals are you sick or ab dermatitis or hepatitis whatever and
ab dermatitis or hepatitis whatever and
ab dermatitis or hepatitis whatever and so long this is my son here and i sat by
so long this is my son here and i sat by
so long this is my son here and i sat by lilly last night so I we had some of
lilly last night so I we had some of
lilly last night so I we had some of those conversations that were just
those conversations that were just
those conversations that were just fantastic and my wife she’s from
fantastic and my wife she’s from
fantastic and my wife she’s from Bellevue and that’s our there so my talk
Bellevue and that’s our there so my talk
Bellevue and that’s our there so my talk today is about animal health and
today is about animal health and
today is about animal health and discovering animal health and it’s
discovering animal health and it’s
discovering animal health and it’s interrelatedness to human disease in
interrelatedness to human disease in
interrelatedness to human disease in global health and I’m going to talk
global health and I’m going to talk
global health and I’m going to talk about domestic animals and exotic
about domestic animals and exotic
about domestic animals and exotic animals somewhat so that’s that’s what
animals somewhat so that’s that’s what
animals somewhat so that’s that’s what I’m going to talk about the health of
I’m going to talk about the health of
I’m going to talk about the health of animals especially our domestic even
animals especially our domestic even
animals especially our domestic even even some of our livestock animals and
even some of our livestock animals and
even some of our livestock animals and how it’s interrelated to human in global
how it’s interrelated to human in global
how it’s interrelated to human in global health and so as a veterinary
health and so as a veterinary
health and so as a veterinary pathologist and a veteran at
pathologist and a veteran at
pathologist and a veteran at veterinarian we’re well positioned to
veterinarian we’re well positioned to
veterinarian we’re well positioned to see this because this we’re seeing
see this because this we’re seeing
see this because this we’re seeing animals that die is apologist other
animals that die is apologist other
animals that die is apologist other veterinarians are diagnosing disease but
veterinarians are diagnosing disease but
veterinarians are diagnosing disease but we’re seeing the lesions histologically
we’re seeing the lesions histologically
we’re seeing the lesions histologically microscopically that’s going on some of
microscopically that’s going on some of
microscopically that’s going on some of these animal tissues that’s very similar
these animal tissues that’s very similar
these animal tissues that’s very similar to what you see in human disease but
to what you see in human disease but
to what you see in human disease but we’re at that point where we’re seeing
we’re at that point where we’re seeing
we’re at that point where we’re seeing some stuff that maybe others don’t see
some stuff that maybe others don’t see
some stuff that maybe others don’t see and there’s plenty of scientists that do
and there’s plenty of scientists that do
and there’s plenty of scientists that do similar things and they have great ideas
similar things and they have great ideas
similar things and they have great ideas also but there’s there’s a core that a
also but there’s there’s a core that a
also but there’s there’s a core that a few core things in these examples that
few core things in these examples that
few core things in these examples that I’ll talk about today and I bet that you
I’ll talk about today and I bet that you
I’ll talk about today and I bet that you know most of these that I’m going to
know most of these that I’m going to
know most of these that I’m going to talk about that anybody know where this
talk about that anybody know where this
talk about that anybody know where this is by the way you probably do its
is by the way you probably do its
is by the way you probably do its Bellevue like a damn number 12 and so
Bellevue like a damn number 12 and so
Bellevue like a damn number 12 and so that’s Charlie fragments flatness he’s
that’s Charlie fragments flatness he’s
that’s Charlie fragments flatness he’s from Mason said he’s a friend of mine
from Mason said he’s a friend of mine
from Mason said he’s a friend of mine and he’s well positioned there to die
and he’s well positioned there to die
and he’s well positioned there to die them to lock and dam number 12
them to lock and dam number 12
them to lock and dam number 12 Mississippi River and that’s that’s my
Mississippi River and that’s that’s my
Mississippi River and that’s that’s my correlate of us being as veterinarians
correlate of us being as veterinarians
correlate of us being as veterinarians be well positioned for diagnosis of
be well positioned for diagnosis of
be well positioned for diagnosis of these diseases anybody know this guy
these diseases anybody know this guy
these diseases anybody know this guy probably not I didn’t and so his name is
probably not I didn’t and so his name is
probably not I didn’t and so his name is dr. Salman and he was from the first
dr. Salman and he was from the first
dr. Salman and he was from the first veterinary class in the United States
veterinary class in the United States
veterinary class in the United States well in the universe
well in the universe
well in the universe canon is the oldest vendor school in our
canon is the oldest vendor school in our
canon is the oldest vendor school in our Comerica but he was from the first met
Comerica but he was from the first met
Comerica but he was from the first met in our class but dr. salman si el mo an
in our class but dr. salman si el mo an
in our class but dr. salman si el mo an ring bell so Salman not the fish but
ring bell so Salman not the fish but
ring bell so Salman not the fish but he’s important for one thing and
he’s important for one thing and
he’s important for one thing and probably many other things too but he
probably many other things too but he
probably many other things too but he was a guy that isolated salmonella and
was a guy that isolated salmonella and
was a guy that isolated salmonella and salmonella is caused typhoid fever and
salmonella is caused typhoid fever and
salmonella is caused typhoid fever and all that so he reckoned he was working
all that so he reckoned he was working
all that so he reckoned he was working in microbiology and we recognize this
in microbiology and we recognize this
in microbiology and we recognize this organism identified it and that organism
organism identified it and that organism
organism identified it and that organism cause disease in a lot of different
cause disease in a lot of different
cause disease in a lot of different species but it also causes disease in
species but it also causes disease in
species but it also causes disease in humans also working in his lab is
humans also working in his lab is
humans also working in his lab is Theobald Smith and Theobald Smith
Theobald Smith and Theobald Smith
Theobald Smith and Theobald Smith identified in cultured brucellosis which
identified in cultured brucellosis which
identified in cultured brucellosis which also causes these and animals that can
also causes these and animals that can
also causes these and animals that can also cause in the cause disease in
also cause in the cause disease in
also cause in the cause disease in humans as well so there’s an example of
humans as well so there’s an example of
humans as well so there’s an example of somebody just kind of porphyrin kind of
somebody just kind of porphyrin kind of
somebody just kind of porphyrin kind of working on things recognizing things
working on things recognizing things
working on things recognizing things putting two and two together and
putting two and two together and
putting two and two together and identified some things this one is Bill
identified some things this one is Bill
identified some things this one is Bill have oh and Bill have Oh kind of looking
have oh and Bill have Oh kind of looking
have oh and Bill have Oh kind of looking what I have there I have up on the
what I have there I have up on the
what I have there I have up on the screen scrapie and kuru and you can see
screen scrapie and kuru and you can see
screen scrapie and kuru and you can see a sheep and then right next to that is a
a sheep and then right next to that is a
a sheep and then right next to that is a brain it’s a section of a brain and I’ve
brain it’s a section of a brain and I’ve
brain it’s a section of a brain and I’ve met bill he’s a veterinarian he’s a
met bill he’s a veterinarian he’s a
met bill he’s a veterinarian he’s a veterinary pathologist he passed away a
veterinary pathologist he passed away a
veterinary pathologist he passed away a couple years ago wonderful humble you a
couple years ago wonderful humble you a
couple years ago wonderful humble you a human being but in the 1950s he was some
human being but in the 1950s he was some
human being but in the 1950s he was some working on scraping and scrape is a
working on scraping and scrape is a
working on scraping and scrape is a disease it’s a CNS disease that’s its
disease it’s a CNS disease that’s its
disease it’s a CNS disease that’s its kind of obscure and he was noticing that
kind of obscure and he was noticing that
kind of obscure and he was noticing that the sheep and even talk eventually went
the sheep and even talk eventually went
the sheep and even talk eventually went to work on mink encephalopathy and
to work on mink encephalopathy and
to work on mink encephalopathy and chronic wasting disease and sheep but he
chronic wasting disease and sheep but he
chronic wasting disease and sheep but he was noticing these things in chief and
was noticing these things in chief and
was noticing these things in chief and he had read about this disease called
he had read about this disease called
he had read about this disease called kuru in Guinea in New Guinea some of the
kuru in Guinea in New Guinea some of the
kuru in Guinea in New Guinea some of the native people that live in New Guinea
native people that live in New Guinea
native people that live in New Guinea and they had a ritual of eating at some
and they had a ritual of eating at some
and they had a ritual of eating at some sort of ritual were they eat brains so
sort of ritual were they eat brains so
sort of ritual were they eat brains so there’s some cannibalism and they
there’s some cannibalism and they
there’s some cannibalism and they developed this deletion and it come to
developed this deletion and it come to
developed this deletion and it come to find out that it was a prion disease
find out that it was a prion disease
find out that it was a prion disease which we now know in these cruel people
which we now know in these cruel people
which we now know in these cruel people or in this disease called kuru that is
or in this disease called kuru that is
or in this disease called kuru that is actually similar to scrapie and sheep
actually similar to scrapie and sheep
actually similar to scrapie and sheep and so he put that together and that
and so he put that together and that
and so he put that together and that what I have out there that text up there
what I have out there that text up there
what I have out there that text up there is a letter he sent to the
is a letter he sent to the
is a letter he sent to the lancet the journal Lancet and he
lancet the journal Lancet and he
lancet the journal Lancet and he connected these two things and
connected these two things and
connected these two things and eventually people went on and said aha
eventually people went on and said aha
eventually people went on and said aha yes they are connected and then then
yes they are connected and then then
yes they are connected and then then further on then staniel prisoner he
further on then staniel prisoner he
further on then staniel prisoner he identified prion ceased being the cause
identified prion ceased being the cause
identified prion ceased being the cause of these and so unfortunately he didn’t
of these and so unfortunately he didn’t
of these and so unfortunately he didn’t get the Nobel Prize everybody that
get the Nobel Prize everybody that
get the Nobel Prize everybody that worked on that around him ended up
worked on that around him ended up
worked on that around him ended up getting the Nobel Prize but he was the
getting the Nobel Prize but he was the
getting the Nobel Prize but he was the one that connected it and came that
one that connected it and came that
one that connected it and came that close to the Nobel Prize but don’t put
close to the Nobel Prize but don’t put
close to the Nobel Prize but don’t put that connection get really interesting
that connection get really interesting
that connection get really interesting story and humble is just our most humble
story and humble is just our most humble
story and humble is just our most humble guy and so accomplished so then this one
guy and so accomplished so then this one
guy and so accomplished so then this one this is dr. John clue be an island in
this is dr. John clue be an island in
this is dr. John clue be an island in another veterinary pathologist and
another veterinary pathologist and
another veterinary pathologist and you’ll see there’s some sections there
you’ll see there’s some sections there
you’ll see there’s some sections there there’s a brain and then there’s another
there’s a brain and then there’s another
there’s a brain and then there’s another brain on the right and then there’s a
brain on the right and then there’s a
brain on the right and then there’s a cow that’s kind of stumbling around well
cow that’s kind of stumbling around well
cow that’s kind of stumbling around well John Kluge was working about he was a
John Kluge was working about he was a
John Kluge was working about he was a veteran pathologist in my part with my
veteran pathologist in my part with my
veteran pathologist in my part with my current department and when he retired
current department and when he retired
current department and when he retired he worked for an vsl national veterinary
he worked for an vsl national veterinary
he worked for an vsl national veterinary services lab and their job is to look at
services lab and their job is to look at
services lab and their job is to look at brains of cattle letter down to make
brains of cattle letter down to make
brains of cattle letter down to make sure that we’re not getting bovine
sure that we’re not getting bovine
sure that we’re not getting bovine spongiform encephalopathy in the united
spongiform encephalopathy in the united
spongiform encephalopathy in the united states which is mad cow disease and mad
states which is mad cow disease and mad
states which is mad cow disease and mad cow disease is a prion disease similar
cow disease is a prion disease similar
cow disease is a prion disease similar bill had holes that just rape improve
bill had holes that just rape improve
bill had holes that just rape improve thing that i was just talking about but
thing that i was just talking about but
thing that i was just talking about but one Saturday John was looking in the
one Saturday John was looking in the
one Saturday John was looking in the slides and we had never had BF c in the
slides and we had never had BF c in the
slides and we had never had BF c in the United States and John was looking at
United States and John was looking at
United States and John was looking at his slides 20 slides and number 18 was
his slides 20 slides and number 18 was
his slides 20 slides and number 18 was red and he’s not that’s really odd you
red and he’s not that’s really odd you
red and he’s not that’s really odd you know why is that red well he went
know why is that red well he went
know why is that red well he went through one by one by one by one
through one by one by one by one
through one by one by one by one negative negative deadly that red one he
negative negative deadly that red one he
negative negative deadly that red one he thought he was an artifact no it was mad
thought he was an artifact no it was mad
thought he was an artifact no it was mad cow so he called that the billion-dollar
cow so he called that the billion-dollar
cow so he called that the billion-dollar diagnosis which has potentially funny
diagnosis which has potentially funny
diagnosis which has potentially funny and real because then during that
and real because then during that
and real because then during that weekend I think he diagnosed it on a
weekend I think he diagnosed it on a
weekend I think he diagnosed it on a Saturday and then the stocks changed
Saturday and then the stocks changed
Saturday and then the stocks changed immensely by monday and it probably
immensely by monday and it probably
immensely by monday and it probably changed mcdonough stocks or whatever bye
changed mcdonough stocks or whatever bye
changed mcdonough stocks or whatever bye dollars and since then we’ve had mad cow
dollars and since then we’ve had mad cow
dollars and since then we’ve had mad cow we’ve had a few cattle that have had it
we’ve had a few cattle that have had it
we’ve had a few cattle that have had it but you know we’re living with it were
but you know we’re living with it were
but you know we’re living with it were understanding and diagnosing it better
understanding and diagnosing it better
understanding and diagnosing it better it’s just not United States much anymore
it’s just not United States much anymore
it’s just not United States much anymore but just another example of a person
but just another example of a person
but just another example of a person putting a couple things together and the
putting a couple things together and the
putting a couple things together and the effects that it has on on animal and
effects that it has on on animal and
effects that it has on on animal and human in global health Tracy McNamara
human in global health Tracy McNamara
human in global health Tracy McNamara she’s a veterinary pathologist I met
she’s a veterinary pathologist I met
she’s a veterinary pathologist I met Tracy when she we were training at a
Tracy when she we were training at a
Tracy when she we were training at a similar training session years ago and
similar training session years ago and
similar training session years ago and then I want my way she went her way and
then I want my way she went her way and
then I want my way she went her way and she was working at the Bronx Zoo in New
she was working at the Bronx Zoo in New
she was working at the Bronx Zoo in New York and she noticed in 1999 some
York and she noticed in 1999 some
York and she noticed in 1999 some there’s reports of horses dying and then
there’s reports of horses dying and then
there’s reports of horses dying and then in New York City there are reports of
in New York City there are reports of
in New York City there are reports of people dying and then a reports of crows
people dying and then a reports of crows
people dying and then a reports of crows dying so I think this might be sounded
dying so I think this might be sounded
dying so I think this might be sounded familiar to you and but she was at the
familiar to you and but she was at the
familiar to you and but she was at the zoo and the cormorants are dying I can
zoo and the cormorants are dying I can
zoo and the cormorants are dying I can hardly say that word but it’s a bird she
hardly say that word but it’s a bird she
hardly say that word but it’s a bird she noticed the cormorants are dying and
noticed the cormorants are dying and
noticed the cormorants are dying and Tracy was thinking could there be
Tracy was thinking could there be
Tracy was thinking could there be something connected between the humans
something connected between the humans
something connected between the humans the horse the crows the cormorants and
the horse the crows the cormorants and
the horse the crows the cormorants and so she did a whole bunch of
so she did a whole bunch of
so she did a whole bunch of investigation and a whole bunch of work
investigation and a whole bunch of work
investigation and a whole bunch of work ends up West Nile virus that’s what it
ends up West Nile virus that’s what it
ends up West Nile virus that’s what it was and she had that virus isolated from
was and she had that virus isolated from
was and she had that virus isolated from the car- it was a flavivirus is what it
the car- it was a flavivirus is what it
the car- it was a flavivirus is what it is had it isolated here at NV SL in Ames
is had it isolated here at NV SL in Ames
is had it isolated here at NV SL in Ames Iowa and the CDC wouldn’t believe it
Iowa and the CDC wouldn’t believe it
Iowa and the CDC wouldn’t believe it because lots of the bedroom lab we don’t
because lots of the bedroom lab we don’t
because lots of the bedroom lab we don’t quite believe that it’s not quite
quite believe that it’s not quite
quite believe that it’s not quite accurate and then she it’s fun to cook
accurate and then she it’s fun to cook
accurate and then she it’s fun to cook listen to her talk but she ended up you
listen to her talk but she ended up you
listen to her talk but she ended up you know cracking the case and that’s what
know cracking the case and that’s what
know cracking the case and that’s what it ended up being small world I know her
it ended up being small world I know her
it ended up being small world I know her and ends up that she’s going to talk to
and ends up that she’s going to talk to
and ends up that she’s going to talk to our student pathology group on tuesday
our student pathology group on tuesday
our student pathology group on tuesday she’s going to zoom in and do a zoom
she’s going to zoom in and do a zoom
she’s going to zoom in and do a zoom with our student group so another
with our student group so another
with our student group so another connection big impact West Nile still
connection big impact West Nile still
connection big impact West Nile still around about 2010 where there’s a little
around about 2010 where there’s a little
around about 2010 where there’s a little more higher incidence of it but now it’s
more higher incidence of it but now it’s
more higher incidence of it but now it’s a little bit thin the backwater but it’s
a little bit thin the backwater but it’s
a little bit thin the backwater but it’s just a neat thing and it shows the
just a neat thing and it shows the
just a neat thing and it shows the interdependence again of some of these
interdependence again of some of these
interdependence again of some of these diseases in our domestic
diseases in our domestic
diseases in our domestic animals that affect global human health
animals that affect global human health
animals that affect global human health but this is Nancy Jax and her husband
but this is Nancy Jax and her husband
but this is Nancy Jax and her husband Jerry jacks they’re in the military and
Jerry jacks they’re in the military and
Jerry jacks they’re in the military and so one picture of them is in the uniform
so one picture of them is in the uniform
so one picture of them is in the uniform their Kansas State University Nancy’s a
their Kansas State University Nancy’s a
their Kansas State University Nancy’s a veterinary pathologist Jerry is not a
veterinary pathologist Jerry is not a
veterinary pathologist Jerry is not a veterinary pathologist into the
veterinary pathologist into the
veterinary pathologist into the veterinarian but I just talked about
veterinarian but I just talked about
veterinarian but I just talked about this one because in Reston Virginia a
this one because in Reston Virginia a
this one because in Reston Virginia a fair number of years ago they are the
fair number of years ago they are the
fair number of years ago they are the ones that there was an outbreak of Ebola
ones that there was an outbreak of Ebola
ones that there was an outbreak of Ebola virus in Reston Virginia was in a
virus in Reston Virginia was in a
virus in Reston Virginia was in a research lab and they’re in their suits
research lab and they’re in their suits
research lab and they’re in their suits there they had to go in they did all
there they had to go in they did all
there they had to go in they did all this brave work and then off an offshoot
this brave work and then off an offshoot
this brave work and then off an offshoot was that was the book called outbreak
was that was the book called outbreak
was that was the book called outbreak and then the movie was hot so on then
and then the movie was hot so on then
and then the movie was hot so on then the hot zone came out so they work with
the hot zone came out so they work with
the hot zone came out so they work with Ebola virus and then as you know a few
Ebola virus and then as you know a few
Ebola virus and then as you know a few years ago that’s been out in in Africa
years ago that’s been out in in Africa
years ago that’s been out in in Africa and it’s been spreading and now that’s
and it’s been spreading and now that’s
and it’s been spreading and now that’s dad down a little bit too but anyway
dad down a little bit too but anyway
dad down a little bit too but anyway those are two again veterinary
those are two again veterinary
those are two again veterinary pathologist right on the cutting edge
pathologist right on the cutting edge
pathologist right on the cutting edge veterinarians that see this and put well
veterinarians that see this and put well
veterinarians that see this and put well that wasn’t putting two to do two
that wasn’t putting two to do two
that wasn’t putting two to do two together that was working with the virus
together that was working with the virus
together that was working with the virus itself and it was really neat they have
itself and it was really neat they have
itself and it was really neat they have really need stories about what they did
really need stories about what they did
really need stories about what they did the only thing I would add to that story
the only thing I would add to that story
the only thing I would add to that story is that their veterinarians outbreak
is that their veterinarians outbreak
is that their veterinarians outbreak came out but when the movie came out on
came out but when the movie came out on
came out but when the movie came out on the hot zone they ended up changing him
the hot zone they ended up changing him
the hot zone they ended up changing him from veterinarians to physicians I don’t
from veterinarians to physicians I don’t
from veterinarians to physicians I don’t know why exactly but it’s just probably
know why exactly but it’s just probably
know why exactly but it’s just probably something better they made a better
something better they made a better
something better they made a better story I don’t know so I got a couple
story I don’t know so I got a couple
story I don’t know so I got a couple more examples and this is a friend of
more examples and this is a friend of
more examples and this is a friend of mine mark williamson and so he’s not an
mine mark williamson and so he’s not an
mine mark williamson and so he’s not an eye when he’s an Australian actually but
eye when he’s an Australian actually but
eye when he’s an Australian actually but he worked at Iowa State University
he worked at Iowa State University
he worked at Iowa State University veterinary pathologist and he’s the one
veterinary pathologist and he’s the one
veterinary pathologist and he’s the one on the low broad one and he’s with his
on the low broad one and he’s with his
on the low broad one and he’s with his friend they did a swim meet in Australia
friend they did a swim meet in Australia
friend they did a swim meet in Australia and they just got done and so on that’s
and they just got done and so on that’s
and they just got done and so on that’s him there but mark worked on hendra
him there but mark worked on hendra
him there but mark worked on hendra virus and in Australia there were some
virus and in Australia there were some
virus and in Australia there were some horses dying again and people were
horses dying again and people were
horses dying again and people were wondering why and it ends up that there
wondering why and it ends up that there
wondering why and it ends up that there was these some flying foxes the bat
was these some flying foxes the bat
was these some flying foxes the bat that’s shown there and the flying foxes
that’s shown there and the flying foxes
that’s shown there and the flying foxes would rest on trees and then they’re
would rest on trees and then they’re
would rest on trees and then they’re dropped they eat the fruit droppings had
dropped they eat the fruit droppings had
dropped they eat the fruit droppings had come down the horses would eat through
come down the horses would eat through
come down the horses would eat through the horse of the die but hendra virus is
the horse of the die but hendra virus is
the horse of the die but hendra virus is a paramyxovirus and people were dying
a paramyxovirus and people were dying
a paramyxovirus and people were dying too so they also worked with these
too so they also worked with these
too so they also worked with these infectious agents they ended up stopping
infectious agents they ended up stopping
infectious agents they ended up stopping it it didn’t
it it didn’t
it it didn’t bread watch out of Australia and
bread watch out of Australia and
bread watch out of Australia and probably never will because the flying
probably never will because the flying
probably never will because the flying foxes are the kind of a unique niche but
foxes are the kind of a unique niche but
foxes are the kind of a unique niche but it is one of those small connections
it is one of those small connections
it is one of those small connections connections of a disease that affects
connections of a disease that affects
connections of a disease that affects our domestic animals in some spread to
our domestic animals in some spread to
our domestic animals in some spread to humans as well just kind of interesting
humans as well just kind of interesting
humans as well just kind of interesting as well so now this is I’m gonna give an
as well so now this is I’m gonna give an
as well so now this is I’m gonna give an example here I just have two more
example here I just have two more
example here I just have two more examples and I’ll be doing but this is
examples and I’ll be doing but this is
examples and I’ll be doing but this is not really an outbreak of things this is
not really an outbreak of things this is
not really an outbreak of things this is cystic fibrosis people familiar with
cystic fibrosis people familiar with
cystic fibrosis people familiar with cystic fibrosis it’s a devastating
cystic fibrosis it’s a devastating
cystic fibrosis it’s a devastating disease of infants that’s being treated
disease of infants that’s being treated
disease of infants that’s being treated better and better with time now the
better and better with time now the
better and better with time now the infant song live a lot longer than they
infant song live a lot longer than they
infant song live a lot longer than they used to but it’s a genetic defects and
used to but it’s a genetic defects and
used to but it’s a genetic defects and they’re cftr receptor gene so they don’t
they’re cftr receptor gene so they don’t
they’re cftr receptor gene so they don’t secrete chloride into the lungs and they
secrete chloride into the lungs and they
secrete chloride into the lungs and they get a lot of ammonia is pretty easily
get a lot of ammonia is pretty easily
get a lot of ammonia is pretty easily they also have some pancreatic
they also have some pancreatic
they also have some pancreatic deficiencies there was a mouse model
deficiencies there was a mouse model
deficiencies there was a mouse model this they knocked out that gene in mice
this they knocked out that gene in mice
this they knocked out that gene in mice but the mice never had the respiratory
but the mice never had the respiratory
but the mice never had the respiratory problem and that’s a big problem because
problem and that’s a big problem because
problem and that’s a big problem because most individuals if they die they die of
most individuals if they die they die of
most individuals if they die they die of the respiratory component more so than
the respiratory component more so than
the respiratory component more so than pancreatic calls for operations and so
pancreatic calls for operations and so
pancreatic calls for operations and so in the top I guess your top right is
in the top I guess your top right is
in the top I guess your top right is Mike Welsch she’s an Iowan Paul McRae’s
Mike Welsch she’s an Iowan Paul McRae’s
Mike Welsch she’s an Iowan Paul McRae’s from Davenport I when they’re both
from Davenport I when they’re both
from Davenport I when they’re both physicians and in the middle center is
physicians and in the middle center is
physicians and in the middle center is Dave Meyer Holtz and he’s a veterinary
Dave Meyer Holtz and he’s a veterinary
Dave Meyer Holtz and he’s a veterinary pathologist from wapello he worked at
pathologist from wapello he worked at
pathologist from wapello he worked at I’ve State University and those three
I’ve State University and those three
I’ve State University and those three got together and they decided they were
got together and they decided they were
got together and they decided they were going to make a cystic fibrosis pig and
going to make a cystic fibrosis pig and
going to make a cystic fibrosis pig and they did and the pig has a respiratory
they did and the pig has a respiratory
they did and the pig has a respiratory relations and the respiratory lesions
relations and the respiratory lesions
relations and the respiratory lesions mimic that Memphis very well and so it’s
mimic that Memphis very well and so it’s
mimic that Memphis very well and so it’s a huge breakthrough it’s a neat model
a huge breakthrough it’s a neat model
a huge breakthrough it’s a neat model and now it’s used it so I think one of
and now it’s used it so I think one of
and now it’s used it so I think one of the leading models for studying cystic
the leading models for studying cystic
the leading models for studying cystic fibrosis and infants in this model and
fibrosis and infants in this model and
fibrosis and infants in this model and things and so all islands here at the
things and so all islands here at the
things and so all islands here at the University of Iowa a domestic animal
University of Iowa a domestic animal
University of Iowa a domestic animal that we know really well and it’s it’s
that we know really well and it’s it’s
that we know really well and it’s it’s important to our economy but they’ve
important to our economy but they’ve
important to our economy but they’ve used that need to see a pig and it’s
used that need to see a pig and it’s
used that need to see a pig and it’s just fantastic model and now they can
just fantastic model and now they can
just fantastic model and now they can use it for therapies and valuable seen
use it for therapies and valuable seen
use it for therapies and valuable seen on different disease conditions of
on different disease conditions of
on different disease conditions of cystic fibrosis symptoms so now i’m near
cystic fibrosis symptoms so now i’m near
cystic fibrosis symptoms so now i’m near to the end of my talk in this is me so
to the end of my talk in this is me so
to the end of my talk in this is me so this is i’m up on that picnic table my
this is i’m up on that picnic table my
this is i’m up on that picnic table my grandma and spray Pope took that picture
grandma and spray Pope took that picture
grandma and spray Pope took that picture I don’t know how I didn’t fall off I had
I don’t know how I didn’t fall off I had
I don’t know how I didn’t fall off I had these slick shoes on and I’m feeding
these slick shoes on and I’m feeding
these slick shoes on and I’m feeding that little lamb but I work with lambs
that little lamb but I work with lambs
that little lamb but I work with lambs now and i work with respiratory
now and i work with respiratory
now and i work with respiratory syncytial virus people familiar with
syncytial virus people familiar with
syncytial virus people familiar with that you’ve probably all had it and it
that you’ve probably all had it and it
that you’ve probably all had it and it causes the common cold but in infants it
causes the common cold but in infants it
causes the common cold but in infants it causes severe pneumonia and it causes
causes severe pneumonia and it causes
causes severe pneumonia and it causes bronchiolitis and here again rsd doesn’t
bronchiolitis and here again rsd doesn’t
bronchiolitis and here again rsd doesn’t have a great model oops cotton rat model
have a great model oops cotton rat model
have a great model oops cotton rat model there’s a mouse model and it doesn’t
there’s a mouse model and it doesn’t
there’s a mouse model and it doesn’t have it’s missing a lot of stuff and so
have it’s missing a lot of stuff and so
have it’s missing a lot of stuff and so some of my work I’ve worked on
some of my work I’ve worked on
some of my work I’ve worked on respiratory syncytial virus and lambs
respiratory syncytial virus and lambs
respiratory syncytial virus and lambs which seems kind of odd but the neat
which seems kind of odd but the neat
which seems kind of odd but the neat thing is this virus in human replicates
thing is this virus in human replicates
thing is this virus in human replicates well in lands and I wasn’t the first to
well in lands and I wasn’t the first to
well in lands and I wasn’t the first to start this land model some others
start this land model some others
start this land model some others Randall couplet and hard lehmkuhl at the
Randall couplet and hard lehmkuhl at the
Randall couplet and hard lehmkuhl at the national anthem of the sea center first
national anthem of the sea center first
national anthem of the sea center first started working with bovine respiratory
started working with bovine respiratory
started working with bovine respiratory syncytial virus and lambs and started
syncytial virus and lambs and started
syncytial virus and lambs and started working on it and then marks Williamson
working on it and then marks Williamson
working on it and then marks Williamson a guy from Australia came up to me one
a guy from Australia came up to me one
a guy from Australia came up to me one time and said hey mark jammer I think
time and said hey mark jammer I think
time and said hey mark jammer I think about working on RSV and putting that
about working on RSV and putting that
about working on RSV and putting that human virus into lambs and said no and
human virus into lambs and said no and
human virus into lambs and said no and so I did and now we’ve developed this
so I did and now we’ve developed this
so I did and now we’ve developed this model a lot of work number of years but
model a lot of work number of years but
model a lot of work number of years but now we’re using this model to test human
now we’re using this model to test human
now we’re using this model to test human pharmaceuticals and I was at the
pharmaceuticals and I was at the
pharmaceuticals and I was at the International RSV meeting in Argentina
International RSV meeting in Argentina
International RSV meeting in Argentina last September and it’s looking like
last September and it’s looking like
last September and it’s looking like there could be a drug for RSV and
there could be a drug for RSV and
there could be a drug for RSV and probably the next five to ten years and
probably the next five to ten years and
probably the next five to ten years and a couple of the drugs were working with
a couple of the drugs were working with
a couple of the drugs were working with one is already in infants or adults and
one is already in infants or adults and
one is already in infants or adults and going in infants and another one is in
going in infants and another one is in
going in infants and another one is in humans and working well in humans and so
humans and working well in humans and so
humans and working well in humans and so that’s a really heat operate or outcome
that’s a really heat operate or outcome
that’s a really heat operate or outcome and it’s just working with this virus
and it’s just working with this virus
and it’s just working with this virus strain again using one of our animal
strain again using one of our animal
strain again using one of our animal models to study a human disease that has
models to study a human disease that has
models to study a human disease that has a global impact because RSV is it’s not
a global impact because RSV is it’s not
a global impact because RSV is it’s not only affects house here in the United
only affects house here in the United
only affects house here in the United States but it could be devastated in
States but it could be devastated in
States but it could be devastated in certain countries so then lastly there
certain countries so then lastly there
certain countries so then lastly there like I said there’s many many other
like I said there’s many many other
like I said there’s many many other people working on a lot of these
people working on a lot of these
people working on a lot of these diseases that have global
diseases that have global
diseases that have global pack I have this as the door of my
pack I have this as the door of my
pack I have this as the door of my office in science magazines one of the I
office in science magazines one of the I
office in science magazines one of the I guess highest-quality scientific
guess highest-quality scientific
guess highest-quality scientific journals that there is science and
journals that there is science and
journals that there is science and nature they’re very important you can
nature they’re very important you can
nature they’re very important you can publish in science you’re doing really
publish in science you’re doing really
publish in science you’re doing really well well I I collect those that have a
well well I I collect those that have a
well well I I collect those that have a bomb some of our animals domestic
bomb some of our animals domestic
bomb some of our animals domestic animals are wild animals here and they
animals are wild animals here and they
animals are wild animals here and they don’t they’re cute most of them are cute
don’t they’re cute most of them are cute
don’t they’re cute most of them are cute but that’s not why they’re on the cover
but that’s not why they’re on the cover
but that’s not why they’re on the cover they’re on the cover because they have
they’re on the cover because they have
they’re on the cover because they have some sort of paradigm shift or very very
some sort of paradigm shift or very very
some sort of paradigm shift or very very significant impact on disease or basic
significant impact on disease or basic
significant impact on disease or basic biology or basic medicine and I have
biology or basic medicine and I have
biology or basic medicine and I have that there because it’s just another
that there because it’s just another
that there because it’s just another indication of a global impact of some of
indication of a global impact of some of
indication of a global impact of some of our animal models that affects health in
our animal models that affects health in
our animal models that affects health in life of our biodiversity in India in the
life of our biodiversity in India in the
life of our biodiversity in India in the world and also the health of humans in
world and also the health of humans in
world and also the health of humans in the health of our animals in the
the health of our animals in the
the health of our animals in the domestic and wild animals there’s a
domestic and wild animals there’s a
domestic and wild animals there’s a number of offshoots from those and there
number of offshoots from those and there
number of offshoots from those and there always will continue to be and we have
always will continue to be and we have
always will continue to be and we have one planet and I think you have to keep
one planet and I think you have to keep
one planet and I think you have to keep the help with this planet com safe and
the help with this planet com safe and
the help with this planet com safe and secure and we need to just continually
secure and we need to just continually
secure and we need to just continually learn about all these diseases in the
learn about all these diseases in the
learn about all these diseases in the wide biodiversity yeah and that’s all I
wide biodiversity yeah and that’s all I
wide biodiversity yeah and that’s all I got thank you
”
Be First to Comment