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Sex and gender differences in brain disease | Antonella Santuccione-Chadha | TEDxCarouge


a robot named Sophia recently became a

a robot named Sophia recently became a media sensation because it was the first

media sensation because it was the first

media sensation because it was the first robot being awarded with a citizenship

robot being awarded with a citizenship

robot being awarded with a citizenship it is a development of ansan technology

it is a development of ansan technology

it is a development of ansan technology in Hong Kong and it is officially a

in Hong Kong and it is officially a

in Hong Kong and it is officially a citizen of Saudi Arabia Sophia it is

citizen of Saudi Arabia Sophia it is

citizen of Saudi Arabia Sophia it is capable of answering some open-ended

capable of answering some open-ended

capable of answering some open-ended questions sophia capacity of

questions sophia capacity of

questions sophia capacity of understanding and providing an answer

understanding and providing an answer

understanding and providing an answer it is quite astonishing and it’s a

it is quite astonishing and it’s a

it is quite astonishing and it’s a telling glimpse of what lies around the

telling glimpse of what lies around the

telling glimpse of what lies around the corner in the near future

corner in the near future

corner in the near future Sophie as we heard has been asked

Sophie as we heard has been asked

Sophie as we heard has been asked whether it is agenda and its answer was

whether it is agenda and its answer was

whether it is agenda and its answer was I’m a robot technically I have no agenda

I’m a robot technically I have no agenda

I’m a robot technically I have no agenda but I consider myself as a woman and I

but I consider myself as a woman and I

but I consider myself as a woman and I don’t mind to be perceived as a woman

don’t mind to be perceived as a woman

don’t mind to be perceived as a woman but in fact what does it mean to have a

but in fact what does it mean to have a

but in fact what does it mean to have a female or a male human intelligence

female or a male human intelligence

female or a male human intelligence today other differences between the male

today other differences between the male

today other differences between the male brain and the female brain my

brain and the female brain my

brain and the female brain my grandmother she used to tell me girls

grandmother she used to tell me girls

grandmother she used to tell me girls are smarter than boys so what’d she

are smarter than boys so what’d she

are smarter than boys so what’d she write or as she simply try to train

write or as she simply try to train

write or as she simply try to train force my self-confidence

force my self-confidence

force my self-confidence let’s explore today together this is

let’s explore today together this is

let’s explore today together this is what a brain in a jar looks like the

what a brain in a jar looks like the

what a brain in a jar looks like the brain it is how our command center and

brain it is how our command center and

brain it is how our command center and it contains 100 120 billion neurons

it contains 100 120 billion neurons

it contains 100 120 billion neurons which together with ten times more glial

which together with ten times more glial

which together with ten times more glial cells

cells

cells constitute what we know as gray matter

constitute what we know as gray matter

constitute what we know as gray matter and it is well where our intelligence

and it is well where our intelligence

and it is well where our intelligence lie lies neurons look a bit like that

lie lies neurons look a bit like that

lie lies neurons look a bit like that this is of course a drawing they

this is of course a drawing they

this is of course a drawing they originate actions and actions which get

originate actions and actions which get

originate actions and actions which get myelinated which means covered by other

myelinated which means covered by other

myelinated which means covered by other cells with a kind of fatty substance

cells with a kind of fatty substance

cells with a kind of fatty substance called myelin do or grams and themself

called myelin do or grams and themself

called myelin do or grams and themself in bundles and are in charge of

in bundles and are in charge of

in bundles and are in charge of transporting the information from our

transporting the information from our

transporting the information from our brain towards the rest of the body and

brain towards the rest of the body and

brain towards the rest of the body and also between neurons constituting the

also between neurons constituting the

also between neurons constituting the white matter now let’s go back to our

white matter now let’s go back to our

white matter now let’s go back to our brain in a jar and let me ask you is

brain in a jar and let me ask you is

brain in a jar and let me ask you is this a female brain or a male brain

anyone has an answer don’t worry you’re

anyone has an answer don’t worry you’re not at medical school with an exam in

not at medical school with an exam in

not at medical school with an exam in your Anatomy it’s not a nightmare and

your Anatomy it’s not a nightmare and

your Anatomy it’s not a nightmare and don’t worry you are not meant to have an

don’t worry you are not meant to have an

don’t worry you are not meant to have an answer because even the best

answer because even the best

answer because even the best neuroanatomist in this planet won’t have

neuroanatomist in this planet won’t have

neuroanatomist in this planet won’t have an answer in fact there are own

an answer in fact there are own

an answer in fact there are own differences between the female and the

differences between the female and the

differences between the female and the male brain morphological difference

male brain morphological difference

male brain morphological difference which can be appreciated by human highs

which can be appreciated by human highs

which can be appreciated by human highs not even with the help of the most

not even with the help of the most

not even with the help of the most powerful microscope in this planet well

powerful microscope in this planet well

powerful microscope in this planet well nevertheless what if I tell you that

nevertheless what if I tell you that

nevertheless what if I tell you that scientist has been always very busy with

scientist has been always very busy with

scientist has been always very busy with these issues now they were always

these issues now they were always

these issues now they were always interested in searching for functional

interested in searching for functional

interested in searching for functional or morphological differences between the

or morphological differences between the

or morphological differences between the two brains even Darwin was busy with

two brains even Darwin was busy with

two brains even Darwin was busy with this topic and in his book The Descent

this topic and in his book The Descent

this topic and in his book The Descent of Man II state that a man can attain to

of Man II state that a man can attain to

of Man II state that a man can attain to the iist hominins

the iist hominins

the iist hominins and intelligence then women can do

and intelligence then women can do

and intelligence then women can do whatever is up to either using is

whatever is up to either using is

whatever is up to either using is intellect intuition reasoning or merely

intellect intuition reasoning or merely

intellect intuition reasoning or merely the use of senses and hands today thanks

the use of senses and hands today thanks

the use of senses and hands today thanks to the revolution that

to the revolution that

to the revolution that the position of women bear in our

the position of women bear in our

the position of women bear in our society we know that Darwin was

society we know that Darwin was

society we know that Darwin was misguided in this regard and this is

misguided in this regard and this is

misguided in this regard and this is also thanks to the advancement of modern

also thanks to the advancement of modern

also thanks to the advancement of modern science nevertheless still the debate is

science nevertheless still the debate is

science nevertheless still the debate is going on what we know is that the male

going on what we know is that the male

going on what we know is that the male brain it is roughly 10 percent larger

brain it is roughly 10 percent larger

brain it is roughly 10 percent larger than the female one and that’s normal

than the female one and that’s normal

than the female one and that’s normal man are usually bigger and we know that

man are usually bigger and we know that

man are usually bigger and we know that the brain size it is proportional to

the brain size it is proportional to

the brain size it is proportional to body size in other words the bigger you

body size in other words the bigger you

body size in other words the bigger you are the bigger your brain and the

are the bigger your brain and the

are the bigger your brain and the smaller you are the smaller your brain

smaller you are the smaller your brain

smaller you are the smaller your brain might be there are plenty of small man

might be there are plenty of small man

might be there are plenty of small man with a small brain and plenty of big

with a small brain and plenty of big

with a small brain and plenty of big ladies with a big brain but big doesn’t

ladies with a big brain but big doesn’t

ladies with a big brain but big doesn’t mean necessarily smarter in fact we have

mean necessarily smarter in fact we have

mean necessarily smarter in fact we have lots of evidences from scientific

lots of evidences from scientific

lots of evidences from scientific literature pointing to the fact that

literature pointing to the fact that

literature pointing to the fact that when it goes to IQ both the male brain

when it goes to IQ both the male brain

when it goes to IQ both the male brain and the female one can basically attain

and the female one can basically attain

and the female one can basically attain the same intelligence regardless of

the same intelligence regardless of

the same intelligence regardless of brain size when we start from the same

brain size when we start from the same

brain size when we start from the same condition we can achieve both the same

condition we can achieve both the same

condition we can achieve both the same result

result

result nevertheless some morphological

nevertheless some morphological

nevertheless some morphological difference might still exist and for

difference might still exist and for

difference might still exist and for example here we have some images from a

example here we have some images from a

example here we have some images from a group which in 2015 pointed to the fact

group which in 2015 pointed to the fact

group which in 2015 pointed to the fact that the white matter in the female

that the white matter in the female

that the white matter in the female brain it is slightly larger than the one

brain it is slightly larger than the one

brain it is slightly larger than the one in the male brain and this is a debate

in the male brain and this is a debate

in the male brain and this is a debate which is going on since nearly 20 years

which is going on since nearly 20 years

which is going on since nearly 20 years they also state that in the left

they also state that in the left

they also state that in the left hemisphere of our brain the Broca’s area

hemisphere of our brain the Broca’s area

hemisphere of our brain the Broca’s area it is slightly larger in female versus

it is slightly larger in female versus

it is slightly larger in female versus man they speculate this is the reason

man they speculate this is the reason

man they speculate this is the reason why women can talk more if you ask me

why women can talk more if you ask me

why women can talk more if you ask me the reason is that because men never

the reason is that because men never

the reason is that because men never listen

listen

listen but you know this is just my person

but you know this is just my person

but you know this is just my person opinion and a mother of two boys so yeah

opinion and a mother of two boys so yeah

opinion and a mother of two boys so yeah some other scientists pointed to the

some other scientists pointed to the

some other scientists pointed to the fact of connectivity in our brain so

fact of connectivity in our brain so

fact of connectivity in our brain so they find out that apparently in the

they find out that apparently in the

they find out that apparently in the brain of women which is depicted there

brain of women which is depicted there

brain of women which is depicted there in orange the connections are basically

in orange the connections are basically

in orange the connections are basically more intense within the two hemispheres

more intense within the two hemispheres

more intense within the two hemispheres while in the main brain the connections

while in the main brain the connections

while in the main brain the connections are stronger within one atmosphere and

are stronger within one atmosphere and

are stronger within one atmosphere and they again speculate that this might

they again speculate that this might

they again speculate that this might justify why men are better in

justify why men are better in

justify why men are better in coordination and etheric skills while

coordination and etheric skills while

coordination and etheric skills while women are more into connectivity for

women are more into connectivity for

women are more into connectivity for functioning like intuition and cognition

functioning like intuition and cognition

functioning like intuition and cognition this is just to give you a dimension of

this is just to give you a dimension of

this is just to give you a dimension of the debate which is going on if you has

the debate which is going on if you has

the debate which is going on if you has to Sam your scientists they might tell

to Sam your scientists they might tell

to Sam your scientists they might tell you this is not really true no

you this is not really true no

you this is not really true no difference exists they are not even

difference exists they are not even

difference exists they are not even meaningful this is what is going on in

meaningful this is what is going on in

meaningful this is what is going on in the field but what if I tell you that

the field but what if I tell you that

the field but what if I tell you that there is a big big elephant in the room

there is a big big elephant in the room

there is a big big elephant in the room that scientist drug developers and high

that scientist drug developers and high

that scientist drug developers and high professional don’t see the big elephant

professional don’t see the big elephant

professional don’t see the big elephant it is the differences in the number of

it is the differences in the number of

it is the differences in the number of disease affecting the female brain

disease affecting the female brain

disease affecting the female brain versus the main one did you know for

versus the main one did you know for

versus the main one did you know for example the depression it is affecting

example the depression it is affecting

example the depression it is affecting women is twice as much as men and this

women is twice as much as men and this

women is twice as much as men and this is true for migraine this is true for

is true for migraine this is true for

is true for migraine this is true for post-traumatic stress disorder this is

post-traumatic stress disorder this is

post-traumatic stress disorder this is true for multiple sclerosis this is true

true for multiple sclerosis this is true

true for multiple sclerosis this is true for what have I forgotten anxiety

for what have I forgotten anxiety

for what have I forgotten anxiety disorder even certain brain tumor seems

disorder even certain brain tumor seems

disorder even certain brain tumor seems to have preference for the female brain

to have preference for the female brain

to have preference for the female brain like for example meningioma versus

like for example meningioma versus

like for example meningioma versus others which prefer the male brain like

others which prefer the male brain like

others which prefer the male brain like glioblastomas already notice things look

glioblastomas already notice things look

glioblastomas already notice things look the

the

the current anencephaly ax it is a defect of

current anencephaly ax it is a defect of

current anencephaly ax it is a defect of the brain development within the first

the brain development within the first

the brain development within the first weeks of our embryonic life and it seems

weeks of our embryonic life and it seems

weeks of our embryonic life and it seems to affect more female embryos versus the

to affect more female embryos versus the

to affect more female embryos versus the male ones vice versa otice which is also

male ones vice versa otice which is also

male ones vice versa otice which is also another neurodevelopmental disorder most

another neurodevelopmental disorder most

another neurodevelopmental disorder most likely linked to the epsilon chromosome

likely linked to the epsilon chromosome

likely linked to the epsilon chromosome effects more boys than girls I am sure

effects more boys than girls I am sure

effects more boys than girls I am sure that you’ve heard about Alzheimer

that you’ve heard about Alzheimer

that you’ve heard about Alzheimer disease unfortunately as summer’ disease

disease unfortunately as summer’ disease

disease unfortunately as summer’ disease it is a neurodegenerative disorder which

it is a neurodegenerative disorder which

it is a neurodegenerative disorder which is starting to shrink our brain already

is starting to shrink our brain already

is starting to shrink our brain already decades before the symptoms become

decades before the symptoms become

decades before the symptoms become manifested and they will be so severe

manifested and they will be so severe

manifested and they will be so severe that a person with Alzheimer disease at

that a person with Alzheimer disease at

that a person with Alzheimer disease at the end won’t be able to recognize even

the end won’t be able to recognize even

the end won’t be able to recognize even is or her family members but what if I

is or her family members but what if I

is or her family members but what if I tell you that I’ll summarize ‘yes it is

tell you that I’ll summarize ‘yes it is

tell you that I’ll summarize ‘yes it is affecting women as twice as much as men

affecting women as twice as much as men

affecting women as twice as much as men and what if I tell you that in mental

and what if I tell you that in mental

and what if I tell you that in mental diseases even symptoms might differ when

diseases even symptoms might differ when

diseases even symptoms might differ when I was a doctor working in a ward for

I was a doctor working in a ward for

I was a doctor working in a ward for psychiatry I have certainly met more

psychiatry I have certainly met more

psychiatry I have certainly met more female patients than male one my female

female patients than male one my female

female patients than male one my female patients used to experience together

patients used to experience together

patients used to experience together with their cognitive deficit also

with their cognitive deficit also

with their cognitive deficit also symptoms like delusion they felt that

symptoms like delusion they felt that

symptoms like delusion they felt that they were persecuted spired

they were persecuted spired

they were persecuted spired that someone wanted to poison them and

that someone wanted to poison them and

that someone wanted to poison them and they ended up in a treatment which was

they ended up in a treatment which was

they ended up in a treatment which was with antidepressant and anxiolytic on

with antidepressant and anxiolytic on

with antidepressant and anxiolytic on the contrary my male patients there

the contrary my male patients there

the contrary my male patients there would have been much more aggressive

would have been much more aggressive

would have been much more aggressive being dangerous to themselves and to the

being dangerous to themselves and to the

being dangerous to themselves and to the others needing a treatment with

others needing a treatment with

others needing a treatment with antipsychotics drugs with a strong

antipsychotics drugs with a strong

antipsychotics drugs with a strong sedative effect this is true also for

sedative effect this is true also for

sedative effect this is true also for depression my depressive female patients

depression my depressive female patients

depression my depressive female patients they used to fix their thoughts on their

they used to fix their thoughts on their

they used to fix their thoughts on their negative events in life and they used to

negative events in life and they used to

negative events in life and they used to grounded about it and the treatment was

grounded about it and the treatment was

grounded about it and the treatment was taking really long my male

taking really long my male

taking really long my male patients will they rather be very

patients will they rather be very

patients will they rather be very irritable and we’ll look for consolation

irritable and we’ll look for consolation

irritable and we’ll look for consolation into alcohol consumption now what if I

into alcohol consumption now what if I

into alcohol consumption now what if I tell you that even drugs may act

tell you that even drugs may act

tell you that even drugs may act differently in the female brain versus

differently in the female brain versus

differently in the female brain versus the male one

the male one

the male one in 2013 the FDA had to implement a

in 2013 the FDA had to implement a

in 2013 the FDA had to implement a change in the labeling of zolpidem this

change in the labeling of zolpidem this

change in the labeling of zolpidem this is a drug which is commonly used for

is a drug which is commonly used for

is a drug which is commonly used for treating sleeping disorders in humans

treating sleeping disorders in humans

treating sleeping disorders in humans and the dosage of this drug had to be

and the dosage of this drug had to be

and the dosage of this drug had to be alpha for women only versus men simply

alpha for women only versus men simply

alpha for women only versus men simply because women would have experienced

because women would have experienced

because women would have experienced much more severe side effects the next

much more severe side effects the next

much more severe side effects the next morning and ending up in the emergency

morning and ending up in the emergency

morning and ending up in the emergency room with symptoms like Angola aspirin

room with symptoms like Angola aspirin

room with symptoms like Angola aspirin if we prescribe aspirin to her woman her

if we prescribe aspirin to her woman her

if we prescribe aspirin to her woman her chances of developing stroke how much

chances of developing stroke how much

chances of developing stroke how much less which is not true for men aspirin

less which is not true for men aspirin

less which is not true for men aspirin if prescribed to men vice versa will

if prescribed to men vice versa will

if prescribed to men vice versa will decrease the risk of developing

decrease the risk of developing

decrease the risk of developing cardiovascular diseases let’s look at

cardiovascular diseases let’s look at

cardiovascular diseases let’s look at antipsychotic and side effects

antipsychotic and side effects

antipsychotic and side effects tardive dyskinesia it is quite a bad

tardive dyskinesia it is quite a bad

tardive dyskinesia it is quite a bad side effects of Antibes psychotic it is

side effects of Antibes psychotic it is

side effects of Antibes psychotic it is a disturbance in your body movement

a disturbance in your body movement

a disturbance in your body movement difficult to treat and difficult to cope

difficult to treat and difficult to cope

difficult to treat and difficult to cope with what if I tell you that again we

with what if I tell you that again we

with what if I tell you that again we have evidence is pointing to the fact

have evidence is pointing to the fact

have evidence is pointing to the fact that it’s more a side effect occurring

that it’s more a side effect occurring

that it’s more a side effect occurring in women versus men above all air the

in women versus men above all air the

in women versus men above all air the related so said that I’ve pointed to the

related so said that I’ve pointed to the

related so said that I’ve pointed to the fact that you know differences exist in

fact that you know differences exist in

fact that you know differences exist in symptoms of diseases treatment numbers

symptoms of diseases treatment numbers

symptoms of diseases treatment numbers of diseases affecting men and women

of diseases affecting men and women

of diseases affecting men and women differently but what if I tell you that

differently but what if I tell you that

differently but what if I tell you that we still don’t know the underlying cause

we still don’t know the underlying cause

we still don’t know the underlying cause we just don’t know if it is because of

we just don’t know if it is because of

we just don’t know if it is because of our DNA which is encrypted in our it’s

our DNA which is encrypted in our it’s

our DNA which is encrypted in our it’s it’s Epsilon chromosome meaning sex or

it’s Epsilon chromosome meaning sex or

it’s Epsilon chromosome meaning sex or if it is just gender meaning the way

if it is just gender meaning the way

if it is just gender meaning the way man or a woman it is perceived within a

man or a woman it is perceived within a

man or a woman it is perceived within a society with all of the social crohn’s

society with all of the social crohn’s

society with all of the social crohn’s threat around it and with all the

threat around it and with all the

threat around it and with all the stereotypes around it maybe it’s a

stereotypes around it maybe it’s a

stereotypes around it maybe it’s a combination of both we still don’t know

combination of both we still don’t know

combination of both we still don’t know and the reason might be that we are

and the reason might be that we are

and the reason might be that we are doing things not really the right way

doing things not really the right way

doing things not really the right way what if I tell you that in neuroscience

what if I tell you that in neuroscience

what if I tell you that in neuroscience most of the experiments which are

most of the experiments which are

most of the experiments which are performed in laboratories are done using

performed in laboratories are done using

performed in laboratories are done using mice which are male only female ones are

mice which are male only female ones are

mice which are male only female ones are not very often included into the

not very often included into the

not very often included into the experimental plan reasons are several

experimental plan reasons are several

experimental plan reasons are several and I won’t touch on that maybe the

and I won’t touch on that maybe the

and I won’t touch on that maybe the reason is also because we have never

reason is also because we have never

reason is also because we have never looked at risk factors of possibly

looked at risk factors of possibly

looked at risk factors of possibly developing mental diseases considering

developing mental diseases considering

developing mental diseases considering the gender and the sex effect what if I

the gender and the sex effect what if I

the gender and the sex effect what if I tell you for example that the only

tell you for example that the only

tell you for example that the only identified preventive factor for not

identified preventive factor for not

identified preventive factor for not developing Alzheimer’s it is education

developing Alzheimer’s it is education

developing Alzheimer’s it is education so the higher you are educated the less

so the higher you are educated the less

so the higher you are educated the less chances you’ll have to develop Alzheimer

chances you’ll have to develop Alzheimer

chances you’ll have to develop Alzheimer but we know that women worldwide

but we know that women worldwide

but we know that women worldwide received a lower education in general

received a lower education in general

received a lower education in general than men right so what if the reason

than men right so what if the reason

than men right so what if the reason might be just that another possible

might be just that another possible

might be just that another possible reason why we don’t know it could be

reason why we don’t know it could be

reason why we don’t know it could be that we have never looked carefully to

that we have never looked carefully to

that we have never looked carefully to differences in symptoms of diseases

differences in symptoms of diseases

differences in symptoms of diseases between men and women finally women are

between men and women finally women are

between men and women finally women are very often underrepresented in clinical

very often underrepresented in clinical

very often underrepresented in clinical trials above all in the initial phases

trials above all in the initial phases

trials above all in the initial phases of when a drug has to be developed to

of when a drug has to be developed to

of when a drug has to be developed to understand how it works in our body so

understand how it works in our body so

understand how it works in our body so set all this back to Sophia I’m not sure

set all this back to Sophia I’m not sure

set all this back to Sophia I’m not sure that once Sophia will learn all this she

that once Sophia will learn all this she

that once Sophia will learn all this she might still want to consider herself as

might still want to consider herself as

might still want to consider herself as a woman and being perceived yourself as

a woman and being perceived yourself as

a woman and being perceived yourself as a woman

a woman

a woman I hope nevertheless that Sophia will

I hope nevertheless that Sophia will

I hope nevertheless that Sophia will join in forces with us humans in trying

join in forces with us humans in trying

join in forces with us humans in trying to understand

to understand

to understand why this is happening and trying to find

why this is happening and trying to find

why this is happening and trying to find a cure we were recently you might have

a cure we were recently you might have

a cure we were recently you might have read it on the press it was everywhere

read it on the press it was everywhere

read it on the press it was everywhere that artificial intelligence is capable

that artificial intelligence is capable

that artificial intelligence is capable of predicting the onset of Alzheimer

of predicting the onset of Alzheimer

of predicting the onset of Alzheimer disease several years before we doctors

disease several years before we doctors

disease several years before we doctors can do so I hope that once the human

can do so I hope that once the human

can do so I hope that once the human limits are reached then the superpower

limits are reached then the superpower

limits are reached then the superpower of artificial intelligence will just

of artificial intelligence will just

of artificial intelligence will just join in and take over thank you

join in and take over thank you

join in and take over thank you [Applause]

”

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