Regenerative medicine is a subject that
is fashionable in 1902 expectation of
pathway in Colombia was 32 years at
end the 20th century
it was 74 and 78 years old and 1,900 in 2017
We are around 80 and 76 years old
so most of the people in
this auditorium will go 100 years
want it or do not want it 100 years and
if there were 100 people in this
auditorium a good number of the
people present here today are going to
achieve to see the birth of the 22nd century
this is so true of the director of the
international monetary fund exclaimed
at a fund meeting last year
that the elderly live too much and this
it is a risk to the global economy and
It urges governments to do something and this
lapidary phrase was to take many
shapes
one of them could be good as in
the book ‘a happy world’ written in
1930
we have people be happy you
We fulfill all your needs and
60 years
chau a new generation
this is probably not going to happen
so we have to do something because
this elderly over population goes to
present a challenge to governments and
economies
in fact I want to show you what
is happening in the world
here they have the evolution of the
population of Spain from 1960 to
the ept a progressive aging a
Japan’s most dramatic example is
where you already see an investment of the
population pyramid then in another
in colombia we could say more
we are saved not so much as
you see we had a population with
excess of children in 1950 and now already
we have an aging population and
we will be in the same place that is
japan within 23 years within 23
years the Colombian population will begin
to decrease in absolute numbers but
the proportion of elderly people
it will be very high
so much so that in some countries a
single daughter person
at age 28 he manages to go to the market of
work and you have to contribute
his taxes to support his two
retired parents to their four grandparents
retired and 12 my retired grandparents
the problem is not that they are retired
the problem is that they are hanging
health services like all
we know they have an increase
progressive throughout the world not only
in Colombia and threatens to break the
economies of all countries
this is not because it presents us with a challenge that
we have to face
the idea is not to prolong life anymore
because it is already being extended
naturally and even that year it
speaks of the possibility that
humans can live between 200 and 400
years like whales do or
400 year old greenland sharks
brother to live so long but
to live it well then the idea of what
we have been working is to look
therapeutic alternatives that we
let live not prolong life live
all right
until the day in which we die
cost well the penultimate day and
dawn ready to be buried
This involves designing strategies for
repair or replacement feedback
of cells and tissues by using
bioengineering engineering
genetics and technology
stem cells which is precisely what
that we’re going to talk here but before
continue
I want to refresh a concept that
the everyday we consider it natural that
is the identification by the code of
bars before moving on to the methodology
the description of the methodology of
kim eriz tissue and organ action
to replace them damaged all
we know the bar code
this has evolved in such a way that
just by passing a reader we can
know without opening it and so that the
quantity the quality of which is stated when
It was done when it’s over
features price everything
you want
this is a sign of identification and
are incorporated in both
identity of all countries you
can see on the card in the part of
behind the barcode
incredibly you can think
that only has the name and date of
birth has much more data than
that you can think and you think
incorporate up to the clinical history
the cells of all Serbs
especially mammals have
characteristics that are worth looking at
this is a cell of a mammal
he called attention to being the
reddish structure that is called
mitochondria are three-dimensional
there is no empty space and they are
surrounded by a membrane like
shell of an orange
but that shell is not so simple is
an incredibly complex structure
where proteins are expressed from all
the types that are receiving channels are
tra and one of those proteins is
precisely the bar code of
identification is present in all
the cells of your body and it’s unique
like your fingerprints
that allows your immune system
recognize each and every one of the
cells and the one that does not present its
Identity document is immediately
isolated and destroyed
this can happen because it is an element
I miss a strange tissue or because
simply changed the identity by
example a cancer cell or a virus
or a bacterium that is unable to
present the document and science
then the chimeric action the
definition that we
is the method that allows
achieve the coexistence of material
genetic of different individuals in a
organism tissue or organ using I know
the mothers of the person who is going to
receive that tissue by making unnecessary
the use of drugs that prevents rejection of
that tissue and this what we work
we take an organ we process it what
we grow and later we add
stem cells for a given time
before transplanting we are doing
that starting from a principle that all
the Serbs communicates and this is a
process that started three thousand 500
to three billion years with the
beginning of life on earth and the
only way life could have
place was because the living beings of that
then in that primordial soup they could
communicate the cells that processed
energy but at the same time with the cells
that process products and in a moment
given one of these cells the one
produced energy was introduced into the
another and life began as we know it
now evolving the cells never
they have stopped communicating and this is
he suspected was part of the teaching in
medicine 40 years ago when
he began to notice that the bacteria
they communicated with each other and passed
genetic material formulas that
allowed to become resistant to
new antibiotics that we carry
developing the whole cell not
only the bacteria communicates
also the cells of the organism
when they are together they establish channels
of communication and through these channels
they communicate small molecules with
signals that allow exchange
of information but more extraordinary
is that they not only communicate molecules
information but
we believe and we start from that basis that
they share organelles like the neighbors that
the pounds of sugar are shared
they share organelles that
allow progress together this
it was the suspicion we had and what
We confirmed last month when he left
published the work of this doctor
doctor james mccully in the hospital
cardiac for children in Boston who
I had noticed that after a
heart transplant to the child the
heart that gave as stunned and in
some cases he died he thought that
they probably lacked energy and the
energy is supplied by those
organized that I pointed out to you in the
Slide back called
mitochondria
then he decided to try a strategy
and that is just before surgery
I took muscle from the child’s abdomen
operate and while he was doing the
heart replacement in a team at
adjacent they pulled out the mitochondria
by molecular biology methods
and at the end of the surgery with a
insulin syringe injected the
mitochondria of the patient within the
donor’s heart beating in his
chest
the surprise was to corroborate the heart
beat with more energy
but the surprise was even greater when
when checking heart biopsies
they found that mitochondria
they migrated into the cells
heart transplantation
this practically confirms us the
theory that we had been working on and what
We are applying in other trials to
make compatible other organs such as
pancreas
the lung the liver to be
transplanted to sick patients their
first first moss the pancreas and
then we get the cells that
they produce more insulin and we implant them
on a device that has been
previously placed inside the
patient’s body as you see the
medicine to science progresses not by
head of a single person but through
the course of the multiple contest
human knowledge disciplines
I want to present an example of a few
procedures
we are making at this time in the
university is the extraction without nose
action of a lung transplant
pig in this that is perhaps a pig
female in a male pig then two
days before transplant
we take patient’s stem cells that
will receive the lung
the day before the lung is removed
is going to be transplanted and is grown by
about 24 hours and day
zero is the graph the crop and the
zero day is transplanted in the chest
the surprise for us initially
was noticing how after transplanted
that lung looked perfectly
years and here I want to show you the
piglet the piglet transplanted
we put to squirt because it was operated
just the day that came to the pope
and today not today, yesterday, he turned 49 days
receive even one aspirin 0 in one
politics suppression is noted
the scar that was left on his side
the tail moves it is not that we have
accelerated to the movie they measure the
speed but it shows the comfort
of service and the absence of pain
the next is the next little pig to
that we named healthy everything because it was made
the day of san tom three days later
of the transplant and you can see it
eating perfectly and next to him
is the first little pig
and to finish this was already a
experiment not so experienced a case
fact of transplanting a tragedy
that chimerical did and was placed in a
young woman of 28 who had a
trache carcinoma that already completes eight
years four months operated and eight years
with absolute absence of any kind
of drug in a suppressor not even
aspirin
then the creation of bank of
tissues opens the future of medicine
regenerative
I want to emphasize one thing on
progress of humanity is no longer a
steps but to strides and probably
the people who are here are going to be
the first ones that are going to be are going to
witness the evolution of their own
species
in your life time I could not say
the dinosaurs evolved during
165 years 765 million years but
none of them thought different
his father if they thought differently from
your son
instead in this generation we are going
probably to witness the evolution
of the human species make a hybrid
with the help of nanotechnologies
biomedicine and biotechnology and
who knows what other science series
for which we still do not suspect that
there are many thanks
[Applause]
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