to figure it out
issue
I started hungry
I suggest you play
in a small game
let’s check your
30 this photo I
I will do in one of
Moscow pharmacies
here actually
drugs against
virus infections and
what do you think at all
how many of these
drugs
online proven
efficiency
make a wish for yourself
there 10 20 50 percent
can be so
drum roll those
which are marked
red this medicine
which in general is not
was sufficient
evidence base
to judge their
effectiveness and
hence the
such a question really
everything is so bad can
this is some kind of private
case in one of the
some in one
just a pharmacy and can
these drugs are not
so much for that
that the viewer on this
question let’s
look at
sales statistics
preparations for
Russian pharma market
for 2016 this is 120
drugs by volume
sales
here in general you are
can see all of us
familiar to the known
medicine
but of these 20 somewhere 9
they are not
have sufficient
evidence base
in order to judge
the air
effectiveness and
the amount of sales
of these drugs
is approximately 30
billions of rubles
there is one drug
actually
account for 3
billion rubles if
take for example the amount
if you take the price 1
packaging of such
drug and share
in total sales
at this price, then in general
somewhere
from each of these
is sold
10 million forgings in
year, that is, in general
of these figures, you can
suggest that
everyone sitting in this
the audience
at least once in my life I
I think I ran into
what he bought
spell and did not know on
really effective
he or not well why
actually we
buy such
drugs seem to me
one of the reasons why
so this is what happens
what do we assume
by default when
go to the pharmacy what
a drug that we
advised the doctor or
slugger
it is effective
works and we do not
put it at all under
doubt but on the other
parties when we go
watch the movie we
go to the cinema search
watch reviews
critics for example
evaluation of who
was shot in the film and
so on, that is, we
trying to figure out what
we are dealing with a for
there are not even
resources for
fact where everyone
a person can stop by
see find out in
Kevin preparations are not present
now i’m working
researcher
laboratory
medical chemistry in
informatics insulin and
doing
computer
modeling in
area of development
new drugs but
In addition, we
we are engaged one by one
project under the working
title
admonter with my
colleagues from
laboratory
actually we
develop such
application in which
any person can
come and see
how effective
this or that drug
but for starters, let’s
in general, then you are with him that
such medicine but
if anyone does not know
what do you have in general
association with the word
medication occurs in
head but also think
what pills yes
probably you think
or syringe and powders
possible at the very
Well, of course it’s
relates to
new medicines
medications still
these molecules are large
or small
which when hit
our body they
act on proteins
or to others by
its reduction due to
this has
certain effect
here’s an example for him
on a banal example
can see there is
two consonants
drug teraflu and
tamiflu
but this two
completely different
medicines
because in teraflu
main active
the substance is simple
mol of time Flew
this is the node to me where that
there are two different
molecules and act
they are different
prostomol without
cyclooxygenase
in the human body
and due to this
reduces symptoms
flu interview
actually acts
on
the term even at the very
influenza and protect it
acts on the source
the disease itself
what do you generally
know more of the drug
against influenza well
call somewhere
as
but still well Frol rex
koldrex
in fact also become
leaders are still
any louder
well, in general, yes, you were
all approximately
correctly called
so I took with me
some of them
drugs
so one of the most
perhaps popular
Here for example arbidol
active substance
he has to go upstairs
the molecule was
developed in the 1970s
the mechanism
actions
Interestingly
find out its only
recently published an article
in 2017 that he
can communicate with
proteins on
the surface of the virus
flu is what’s most
interesting here
usually do
on the contrary first
remove the actions a
then release
drug on the market and
clinical
research itself
those who
now the data from
clinical
studies of their
not enough to
merge
objectivity of this
preparation
Here means went too
called when whole
copolymer with
current
with the gossypol substance
the whole table yes
natural polyphenols
which by the way
enough
it was toxic
show in
some
studies that
may cause
decline
reproductive
functions in men
manufacturer
states that in
general in the bound
is safe and
again the data
clinical
research
rather scanty
and it is difficult to judge by
logic for all of this
drug that’s
perhaps the last of
the most
popular it
ingavirin
also a mechanism
action
substance valis
masses is doubtful and
until 2008 this
carrier drug
substance for
the name de carbonyl
and was sold in
as a means
which stimulate
hematopoiesis
but in 2008 directly
before the epidemic
This swine flu
drug fast
released on the market with
minimum say
so necessary
documents here
none of the
of the named drugs
he is not
registered in either
USA and in Europe and not
recognized there in
quality
effective
medicinal
facilities
but I do not know
the last two
probably worth
mention and on
coronation
Well, these are still
drugs that
people like to buy in
in general, it is not even
medicine is
drugs that
belong to the class
homeopathy and in them
even molecules
actually
there are no
so no
greater effect
except for placebo and
they should not be expected
well, in general, how
know how
the drug is effective
to the most important
the question of which
criteria
appreciate this
there is so
called
so -called level
evidence-based
medicine is the lowest
level is an opinion
individual experts
or doctors about
is effective
drug or not
evidence-based
medicine are
clinical
tests and than
large quantity
people who
tested the drug and
the better the design
research
the higher the level
evidence
reference
necessary medicine
are double
blind
placebo-controlled
research in
who moved
compared with placebo
and not the patient is not a doctor
do not know which guy
such
take the patient
placebo
or examined
drug at the expense of
this we can
get objective
data on that works
drug or not, but
even this is not the most
high level
evidence-based
general medicine
highest level
it is systematically
analyzes and
systematic
reviews and meta-analysis and
who blame
data from several
clinical
research and
the basis of this data
make and reception
content is such an opinion
let’s say so in ken
drug or not for
We reduce this account
actual errors
which can be
committed in separate
clinical
tests and where
look
actual output
these thematic
reviews and mid- analyzes
exist
organizations that
they are conducted
and their sites can be
see the findings and
conclusions
regarding those or
other drugs
own and from
[music]
together with colleagues
from my lab
We analyzed
as a molecule on
Russian market their
order
1600 and of them for only
for the thousand we found
information
here such base bases
of data
and for the remaining 600
molecules unfortunately
until such information
no
and in general for
common man
which is not
is confronted with science
do not deal with
science it is quite
difficult to find at all
necessary information
then how much
is effective and
a drug is safe
actually for this
we are doing our
Project dredge enter
developed by
application in which
we have all this information
from the database
we collected say so
sorry for this
short and you
you can then
application type
name
of interest to you
drug and
view by
results
systematic
reviews are not
analyzes for which
can generally be
which can be
sure that while
Unfortunately application
it is being developed
Not yet came out but I
I think in two
months already
the first version and so
I think my report
generally wore such
pessimistic
character as
seem seem
everything is bad and everything
horrible preparations
Ineffective and us
cheat there
conspiracies are rare in
her and so on but I
generally call you
somewhat different
point of view namely
to the fact that each of the
he carries us
responsibility for
and then what drugs
accept such
drugs are bought in
pharmacy and what
the drugs he gives
to their children and relatives
and
that is, there is no
it seems everyone needs
think about
that it takes and
raise one’s level
awareness in this
question no more
responsibly to this
suit
and our task is
provide for
this is all necessary
resources and sources
information
Thank you
”
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