as a pretty popular high school athlete I always thought I would be fit fine and
I always thought I would be fit fine and
I always thought I would be fit fine and fabulous at the age of 40
fabulous at the age of 40
fabulous at the age of 40 having the exceptional balance between
having the exceptional balance between
having the exceptional balance between healthy eating and living with the
healthy eating and living with the
healthy eating and living with the perfect workout regimen however I got
perfect workout regimen however I got
perfect workout regimen however I got older so did my body and my time to
older so did my body and my time to
older so did my body and my time to workout gotten limited I noticed that my
workout gotten limited I noticed that my
workout gotten limited I noticed that my natural-born athleticism started to
natural-born athleticism started to
natural-born athleticism started to diminish and was noticeable it became
diminish and was noticeable it became
diminish and was noticeable it became extremely noticeable after playing an
extremely noticeable after playing an
extremely noticeable after playing an impromptu game of basketball in my
impromptu game of basketball in my
impromptu game of basketball in my mid-20s with some friends that game was
mid-20s with some friends that game was
mid-20s with some friends that game was the start of a downward spiral of knee
the start of a downward spiral of knee
the start of a downward spiral of knee injuries that resulted in for Denis
injuries that resulted in for Denis
injuries that resulted in for Denis surgeries all those knee surgeries led
surgeries all those knee surgeries led
surgeries all those knee surgeries led me to believe that this knee injury
me to believe that this knee injury
me to believe that this knee injury business is never-ending well the truth
business is never-ending well the truth
business is never-ending well the truth of the matter is happens and it
of the matter is happens and it
of the matter is happens and it happened to me
at this moment I realize that no matter
at this moment I realize that no matter how healthy or athletic I am at some
how healthy or athletic I am at some
how healthy or athletic I am at some point in time via playing sports being
point in time via playing sports being
point in time via playing sports being active or just naturally aging my knees
active or just naturally aging my knees
active or just naturally aging my knees your knees our knees will begin to
your knees our knees will begin to
your knees our knees will begin to slowly deteriorate the unfortunate truth
slowly deteriorate the unfortunate truth
slowly deteriorate the unfortunate truth is that over time we all will be faced
is that over time we all will be faced
is that over time we all will be faced with some knee problems as we age
with some knee problems as we age
with some knee problems as we age according to the National Institutes of
according to the National Institutes of
according to the National Institutes of Health by the year 2030 nearly 65
Health by the year 2030 nearly 65
Health by the year 2030 nearly 65 millions of Americans will suffer from
millions of Americans will suffer from
millions of Americans will suffer from some knee problems affiliated with
some knee problems affiliated with
some knee problems affiliated with osteoarthritis commonly known as oay
osteoarthritis commonly known as oay
osteoarthritis commonly known as oay furthermore every year approximately
furthermore every year approximately
furthermore every year approximately 700,000 Americans undergo knee
700,000 Americans undergo knee
700,000 Americans undergo knee replacement surgeries chances are you or
replacement surgeries chances are you or
replacement surgeries chances are you or someone you know will have to deal with
someone you know will have to deal with
someone you know will have to deal with the chronic pain and inflammation
the chronic pain and inflammation
the chronic pain and inflammation affiliated with the knee injury or knee
affiliated with the knee injury or knee
affiliated with the knee injury or knee surgery and knee surgeries are about so
surgery and knee surgeries are about so
surgery and knee surgeries are about so much more than the actual surgeries
much more than the actual surgeries
much more than the actual surgeries themselves in my case I didn’t realize
themselves in my case I didn’t realize
themselves in my case I didn’t realize the amount of pain and downtime
the amount of pain and downtime
the amount of pain and downtime affiliated with the recovery I also
affiliated with the recovery I also
affiliated with the recovery I also didn’t realize the simple things we take
didn’t realize the simple things we take
didn’t realize the simple things we take for granted by hopping to the bathroom
for granted by hopping to the bathroom
for granted by hopping to the bathroom or asking someone to assist you with
or asking someone to assist you with
or asking someone to assist you with your hopping to the bathroom
eventually my scientific curiosity led
eventually my scientific curiosity led me to question what technologies if any
me to question what technologies if any
me to question what technologies if any were on the market given this curiosity
were on the market given this curiosity
were on the market given this curiosity I decided to ask my resident orthopedic
I decided to ask my resident orthopedic
I decided to ask my resident orthopedic surgeon if he would allow me to watch
surgeon if he would allow me to watch
surgeon if he would allow me to watch him perform a knee replacement
him perform a knee replacement
him perform a knee replacement surgery well as you can imagine my
surgery well as you can imagine my
surgery well as you can imagine my perception on how knee surgeries were
perception on how knee surgeries were
perception on how knee surgeries were perform
perform
perform changed drastically after viewing the
changed drastically after viewing the
changed drastically after viewing the surgery I realized two things one the
surgery I realized two things one the
surgery I realized two things one the human body is physically indispensable
human body is physically indispensable
human body is physically indispensable in to knee replacements are one size
in to knee replacements are one size
in to knee replacements are one size fits all and the current technology sure
fits all and the current technology sure
fits all and the current technology sure treats them like they are I noticed it
treats them like they are I noticed it
treats them like they are I noticed it didn’t matter if you had a small medium
didn’t matter if you had a small medium
didn’t matter if you had a small medium or large knee it was simply about what
or large knee it was simply about what
or large knee it was simply about what is available and making it fit no matter
is available and making it fit no matter
is available and making it fit no matter what I began investigating the current
what I began investigating the current
what I began investigating the current technologies to see how they worked I
technologies to see how they worked I
technologies to see how they worked I learnt the first component in the
learnt the first component in the
learnt the first component in the technology is something called a
technology is something called a
technology is something called a synthetic scaffold that is used as a
synthetic scaffold that is used as a
synthetic scaffold that is used as a mold to help tissue grow a tissue
mold to help tissue grow a tissue
mold to help tissue grow a tissue scaffold is comparable to the metal
scaffold is comparable to the metal
scaffold is comparable to the metal building scaffold you see while walking
building scaffold you see while walking
building scaffold you see while walking in a busy downtown area the scaffold is
in a busy downtown area the scaffold is
in a busy downtown area the scaffold is there to hold the building up while new
there to hold the building up while new
there to hold the building up while new materials are added to help repair the
materials are added to help repair the
materials are added to help repair the building after all the components are
building after all the components are
building after all the components are added the scaffold is then removed and
added the scaffold is then removed and
added the scaffold is then removed and the building is complete scaffolds are
the building is complete scaffolds are
the building is complete scaffolds are used in tissue engineering as well and
used in tissue engineering as well and
used in tissue engineering as well and they consist of things such as hydrogels
they consist of things such as hydrogels
they consist of things such as hydrogels and three-dimensional fibres but instead
and three-dimensional fibres but instead
and three-dimensional fibres but instead of using metal and drywall like in
of using metal and drywall like in
of using metal and drywall like in building scaffolds we use cells and
building scaffolds we use cells and
building scaffolds we use cells and biological entities such as proteins and
biological entities such as proteins and
biological entities such as proteins and growth factors this process helps helps
growth factors this process helps helps
growth factors this process helps helps expedite tissue growth and formation
expedite tissue growth and formation
expedite tissue growth and formation resulting in newly formed tissue such as
resulting in newly formed tissue such as
resulting in newly formed tissue such as bone and cartilage see cartilage it
bone and cartilage see cartilage it
bone and cartilage see cartilage it doesn’t regenerate itself
doesn’t regenerate itself
doesn’t regenerate itself once it’s injured it is irreplaceable
once it’s injured it is irreplaceable
once it’s injured it is irreplaceable cartilage is a dense material that
cartilage is a dense material that
cartilage is a dense material that doesn’t have blood vessels flowing
doesn’t have blood vessels flowing
doesn’t have blood vessels flowing through it making it a little more
through it making it a little more
through it making it a little more problematic to work with for knee
problematic to work with for knee
problematic to work with for knee injuries the current treatments include
injuries the current treatments include
injuries the current treatments include scaffolds such as injectable gels that
scaffolds such as injectable gels that
scaffolds such as injectable gels that are used to stabilize and support the
are used to stabilize and support the
are used to stabilize and support the knee these commercially available
knee these commercially available
knee these commercially available injectable gels are used to replace the
injectable gels are used to replace the
injectable gels are used to replace the naturally occurring lubricant found in
naturally occurring lubricant found in
naturally occurring lubricant found in the knee acting as a shock absorber to
the knee acting as a shock absorber to
the knee acting as a shock absorber to prevent bone-on-bone contact
unfortunately these materials act as a
unfortunately these materials act as a band-aid
after three to six months and another
after three to six months and another injection is needed because of this
injection is needed because of this
injection is needed because of this band-aid however during this time your
band-aid however during this time your
band-aid however during this time your cartilage is not being regenerated nor
cartilage is not being regenerated nor
cartilage is not being regenerated nor is any healing occurring contrary to
is any healing occurring contrary to
is any healing occurring contrary to knee injuries for knee replacement
knee injuries for knee replacement
knee injuries for knee replacement surgeries there’s a shelf life of around
surgeries there’s a shelf life of around
surgeries there’s a shelf life of around 18 years but again still no healing
18 years but again still no healing
18 years but again still no healing occurs or cartilage is being regenerated
to date there is nothing available to
to date there is nothing available to regenerate cartilage but what if there
regenerate cartilage but what if there
regenerate cartilage but what if there could be a product that would improve
could be a product that would improve
could be a product that would improve the current technology begin to
the current technology begin to
the current technology begin to regenerate your cartilage and start to
regenerate your cartilage and start to
regenerate your cartilage and start to heal your knee from the inside out
heal your knee from the inside out
heal your knee from the inside out before the damage escalates after all
before the damage escalates after all
before the damage escalates after all everyone wants to be healthy forever so
everyone wants to be healthy forever so
everyone wants to be healthy forever so what if I could what if I could even
what if I could what if I could even
what if I could what if I could even invent a preventative therapy to help
invent a preventative therapy to help
invent a preventative therapy to help those of us at the cusp of getting older
those of us at the cusp of getting older
those of us at the cusp of getting older this challenge intrigued me and forced
this challenge intrigued me and forced
this challenge intrigued me and forced me to make this my life’s mission to
me to make this my life’s mission to
me to make this my life’s mission to solve this daunting task what my
solve this daunting task what my
solve this daunting task what my research lab
research lab
research lab développé is an innovative injectable
développé is an innovative injectable
développé is an innovative injectable gel that shows promise in providing a
gel that shows promise in providing a
gel that shows promise in providing a non-invasive way to regenerate knee
non-invasive way to regenerate knee
non-invasive way to regenerate knee cartilage more importantly this product
cartilage more importantly this product
cartilage more importantly this product will provide millions of Americans with
will provide millions of Americans with
will provide millions of Americans with relief an improvement of knee pain as
relief an improvement of knee pain as
relief an improvement of knee pain as they continue to age especially for
they continue to age especially for
they continue to age especially for those athletes runners and my adrenaline
those athletes runners and my adrenaline
those athletes runners and my adrenaline junkies so how does it how did I come up
junkies so how does it how did I come up
junkies so how does it how did I come up with this idea by simply taking a look
with this idea by simply taking a look
with this idea by simply taking a look from a different lens I was able to come
from a different lens I was able to come
from a different lens I was able to come up with a clever approach to help people
up with a clever approach to help people
up with a clever approach to help people with the knee injuries I wanted to blow
with the knee injuries I wanted to blow
with the knee injuries I wanted to blow the roof off that the traditional
the roof off that the traditional
the roof off that the traditional therapies but more importantly I wanted
therapies but more importantly I wanted
therapies but more importantly I wanted to break into this field but something
to break into this field but something
to break into this field but something different and unique on how we go about
different and unique on how we go about
different and unique on how we go about treating knee injuries one thing that
treating knee injuries one thing that
treating knee injuries one thing that stood out to me was how the current
stood out to me was how the current
stood out to me was how the current treatments for new therapies are
treatments for new therapies are
treatments for new therapies are performed and how they differ from
performed and how they differ from
performed and how they differ from cancer treatments sadly enough cancer is
cancer treatments sadly enough cancer is
cancer treatments sadly enough cancer is a disease that’s constantly changing and
a disease that’s constantly changing and
a disease that’s constantly changing and evolving always masking itself causing
evolving always masking itself causing
evolving always masking itself causing researchers to always figure out a way
researchers to always figure out a way
researchers to always figure out a way to demolish cancer cancer treatments
to demolish cancer cancer treatments
to demolish cancer cancer treatments unlike knee treatments have started
unlike knee treatments have started
unlike knee treatments have started moving into a more personalized area
moving into a more personalized area
moving into a more personalized area where they can focus on one specific
where they can focus on one specific
where they can focus on one specific tumor and demolish it from the inside
tumor and demolish it from the inside
tumor and demolish it from the inside out providing a localized targeted
out providing a localized targeted
out providing a localized targeted therapy
unfortunately the field of orthopaedics
unfortunately the field of orthopaedics has not moved into the area of
has not moved into the area of
has not moved into the area of personalized knee or joint but prepare
personalized knee or joint but prepare
personalized knee or joint but prepare but what if we can start to take a look
but what if we can start to take a look
but what if we can start to take a look at each specific need effect and
at each specific need effect and
at each specific need effect and determining the severity of it is there
determining the severity of it is there
determining the severity of it is there a way to go about looking at each
a way to go about looking at each
a way to go about looking at each specific need of it defense
specific need of it defense
specific need of it defense and determine how long a patient has
and determine how long a patient has
and determine how long a patient has until their knee completely fails what
until their knee completely fails what
until their knee completely fails what my research lab has developed is an
my research lab has developed is an
my research lab has developed is an innovative way to solve this problem by
innovative way to solve this problem by
innovative way to solve this problem by creating a scaffold that is an
creating a scaffold that is an
creating a scaffold that is an injectable gel and contains the natural
injectable gel and contains the natural
injectable gel and contains the natural lubricant found in the knee
lubricant found in the knee
lubricant found in the knee in addition to adding therapeutic
in addition to adding therapeutic
in addition to adding therapeutic molecules these therapeutic molecules in
molecules these therapeutic molecules in
molecules these therapeutic molecules in conjunction with our gel provide a way
conjunction with our gel provide a way
conjunction with our gel provide a way that we can look at each specific need
that we can look at each specific need
that we can look at each specific need affect and treat it by controlling the
affect and treat it by controlling the
affect and treat it by controlling the cell health and viability ensuring that
cell health and viability ensuring that
cell health and viability ensuring that we can recreate those intricate
we can recreate those intricate
we can recreate those intricate structures in cartilage now I’m not
structures in cartilage now I’m not
structures in cartilage now I’m not talking about rocket science but
talking about rocket science but
talking about rocket science but biomedical engineering which is even
biomedical engineering which is even
biomedical engineering which is even cooler and it allows us to do things
cooler and it allows us to do things
cooler and it allows us to do things like 3d printing 3d printing has become
like 3d printing 3d printing has become
like 3d printing 3d printing has become a hot commodity that allows us to make
a hot commodity that allows us to make
a hot commodity that allows us to make anything we want using plastics but more
anything we want using plastics but more
anything we want using plastics but more recently we’ve started using selves and
recently we’ve started using selves and
recently we’ve started using selves and hydrogels to make new tissue using
hydrogels to make new tissue using
hydrogels to make new tissue using chemical design synthesis analysis and
chemical design synthesis analysis and
chemical design synthesis analysis and 3d bioprinting where we can 3d print
3d bioprinting where we can 3d print
3d bioprinting where we can 3d print cells inside of gels to make intricate
cells inside of gels to make intricate
cells inside of gels to make intricate structures that mirror cartilage but
structures that mirror cartilage but
structures that mirror cartilage but also placing these 3d printed gels and
also placing these 3d printed gels and
also placing these 3d printed gels and cells into a low oxygen or hypoxic
cells into a low oxygen or hypoxic
cells into a low oxygen or hypoxic chamber that simulate these knee issues
chamber that simulate these knee issues
chamber that simulate these knee issues or conditions and diseases of the knee
or conditions and diseases of the knee
or conditions and diseases of the knee so how does it work
at the onset of a knee injury low oxygen
at the onset of a knee injury low oxygen levels occur in the knee this low oxygen
levels occur in the knee this low oxygen
levels occur in the knee this low oxygen environment doesn’t allow the cells to
environment doesn’t allow the cells to
environment doesn’t allow the cells to create the molecules that are essential
create the molecules that are essential
create the molecules that are essential the mechanical stability decreases Wow
the mechanical stability decreases Wow
the mechanical stability decreases Wow the inflammation and pain
the inflammation and pain
the inflammation and pain probe the proteins affiliated with
probe the proteins affiliated with
probe the proteins affiliated with information and playing increase this
information and playing increase this
information and playing increase this low oxygen or hypoxic environment also
low oxygen or hypoxic environment also
low oxygen or hypoxic environment also cultivates toxic free radicals I’ve
cultivates toxic free radicals I’ve
cultivates toxic free radicals I’ve demonstrated in my research lab that we
demonstrated in my research lab that we
demonstrated in my research lab that we can increase the amounts of collagen
can increase the amounts of collagen
can increase the amounts of collagen glucosamine and DA DNA using our gels
glucosamine and DA DNA using our gels
glucosamine and DA DNA using our gels but to improve this technology we begun
but to improve this technology we begun
but to improve this technology we begun incorporating therapeutic molecules to
incorporating therapeutic molecules to
incorporating therapeutic molecules to provide a cell protective scaffold the
provide a cell protective scaffold the
provide a cell protective scaffold the mechanism for how our therapeutic
mechanism for how our therapeutic
mechanism for how our therapeutic molecules work are essentially by
molecules work are essentially by
molecules work are essentially by exploiting the chemical properties of
exploiting the chemical properties of
exploiting the chemical properties of the therapeutic molecules that allow us
the therapeutic molecules that allow us
the therapeutic molecules that allow us to capture those toxic free radicals the
to capture those toxic free radicals the
to capture those toxic free radicals the results show us that we increase the
results show us that we increase the
results show us that we increase the number of collagen glucosamine and DNA
number of collagen glucosamine and DNA
number of collagen glucosamine and DNA but ultimately we decrease the amounts
but ultimately we decrease the amounts
but ultimately we decrease the amounts of inflammatory proteins this
of inflammatory proteins this
of inflammatory proteins this cutting-edge therapeutic technology has
cutting-edge therapeutic technology has
cutting-edge therapeutic technology has allowed me to create a predictive
allowed me to create a predictive
allowed me to create a predictive analytic model that now can focus on one
analytic model that now can focus on one
analytic model that now can focus on one specific knee injury and begin
specific knee injury and begin
specific knee injury and begin incorporating yourselves that later will
incorporating yourselves that later will
incorporating yourselves that later will successfully regenerate my cartilage
successfully regenerate my cartilage
successfully regenerate my cartilage your cartilage our cartilage the future
your cartilage our cartilage the future
your cartilage our cartilage the future of knee repair is moving towards a
of knee repair is moving towards a
of knee repair is moving towards a personalized regenerative approach and I
personalized regenerative approach and I
personalized regenerative approach and I personally want to help Americans have a
personally want to help Americans have a
personally want to help Americans have a better quality of life with knee
better quality of life with knee
better quality of life with knee problems and osteoarthritis because
problems and osteoarthritis because
problems and osteoarthritis because wouldn’t it be awesome if you could go
wouldn’t it be awesome if you could go
wouldn’t it be awesome if you could go into the doctor and discuss a
into the doctor and discuss a
into the doctor and discuss a personalized plan regarding improving
personalized plan regarding improving
personalized plan regarding improving your knee pain and eliminating you
your knee pain and eliminating you
your knee pain and eliminating you from having surgery thanks to this
from having surgery thanks to this
from having surgery thanks to this preventative technology a well balanced
preventative technology a well balanced
preventative technology a well balanced life and a new knee will help me you and
life and a new knee will help me you and
life and a new knee will help me you and others feel fit fine and fabulous at the
others feel fit fine and fabulous at the
others feel fit fine and fabulous at the age of 41 thank you
age of 41 thank you
age of 41 thank you [Applause]
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[Music] you
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