a time to be born this is a familiar phrase
phrase
phrase most people it’s an ancient phrase comes
most people it’s an ancient phrase comes
most people it’s an ancient phrase comes from the recognition by the ancients
from the recognition by the ancients
from the recognition by the ancients that nature is psychical that animals
that nature is psychical that animals
that nature is psychical that animals sheep horses other species of
sheep horses other species of
sheep horses other species of domestication were born at certain times
domestication were born at certain times
domestication were born at certain times of year so this recognition that time
of year so this recognition that time
of year so this recognition that time plays a role in our lives from the
plays a role in our lives from the
plays a role in our lives from the beginning is an ancient one but there
beginning is an ancient one but there
beginning is an ancient one but there are other dimensions of time that relate
are other dimensions of time that relate
are other dimensions of time that relate to birth especially for the human that
to birth especially for the human that
to birth especially for the human that need to be considered the time course of
need to be considered the time course of
need to be considered the time course of pregnancy being one of them normal
pregnancy being one of them normal
pregnancy being one of them normal pregnancy runs as most people know nine
pregnancy runs as most people know nine
pregnancy runs as most people know nine months more exact 38 to 40 weeks if the
months more exact 38 to 40 weeks if the
months more exact 38 to 40 weeks if the pregnancy is interrupted before that
pregnancy is interrupted before that
pregnancy is interrupted before that problems arise we talk about preterm
problems arise we talk about preterm
problems arise we talk about preterm birth being a pregnancy that ends before
birth being a pregnancy that ends before
birth being a pregnancy that ends before weeks 37 if it ends much earlier than
weeks 37 if it ends much earlier than
weeks 37 if it ends much earlier than that the chances of the baby surviving
that the chances of the baby surviving
that the chances of the baby surviving are very very poor technology has
are very very poor technology has
are very very poor technology has advanced so far that a late preemie
advanced so far that a late preemie
advanced so far that a late preemie after week 30 32 of pregnancy has a good
after week 30 32 of pregnancy has a good
after week 30 32 of pregnancy has a good chance of survival but may still have a
chance of survival but may still have a
chance of survival but may still have a life long series of disabilities from
life long series of disabilities from
life long series of disabilities from neurological immunological and otherwise
neurological immunological and otherwise
neurological immunological and otherwise the causes of preterm labor are diverse
the causes of preterm labor are diverse
the causes of preterm labor are diverse many still unknown and there really
many still unknown and there really
many still unknown and there really hasn’t been much advancement in this
hasn’t been much advancement in this
hasn’t been much advancement in this field in the last 3040 years there are a
field in the last 3040 years there are a
field in the last 3040 years there are a lot of drugs used which extend labor
lot of drugs used which extend labor
lot of drugs used which extend labor from the point of preterm contractions
from the point of preterm contractions
from the point of preterm contractions maybe a week and granted every day is
maybe a week and granted every day is
maybe a week and granted every day is valuable
valuable
valuable the longer the pregnancy lasts the more
the longer the pregnancy lasts the more
the longer the pregnancy lasts the more likely the child will be to survive
likely the child will be to survive
likely the child will be to survive but I’m interested in time as you might
but I’m interested in time as you might
but I’m interested in time as you might have picked up so there’s another
have picked up so there’s another
have picked up so there’s another dimension of time that everyone knows
dimension of time that everyone knows
dimension of time that everyone knows about when it comes to labor you ask any
about when it comes to labor you ask any
about when it comes to labor you ask any OBGYN when her baby’s born and they all
OBGYN when her baby’s born and they all
OBGYN when her baby’s born and they all say well the night that’s why I’ve got
say well the night that’s why I’ve got
say well the night that’s why I’ve got to work nights off but you ask them why
to work nights off but you ask them why
to work nights off but you ask them why why does it happen tonight there’s no
why does it happen tonight there’s no
why does it happen tonight there’s no answer just is well I’m a scientist I
answer just is well I’m a scientist I
answer just is well I’m a scientist I don’t like answers like that so I wanted
don’t like answers like that so I wanted
don’t like answers like that so I wanted to know why does it happen
to know why does it happen
to know why does it happen why does labor typically in an eighty
why does labor typically in an eighty
why does labor typically in an eighty eighty-five percent of the human
eighty-five percent of the human
eighty-five percent of the human population begin at night now you can
population begin at night now you can
population begin at night now you can answer this in different ways you can
answer this in different ways you can
answer this in different ways you can say well there’s an advantage to babies
say well there’s an advantage to babies
say well there’s an advantage to babies being born at night at least there used
being born at night at least there used
being born at night at least there used to be say a million years ago the woman
to be say a million years ago the woman
to be say a million years ago the woman was pregnant and would retreat to her
was pregnant and would retreat to her
was pregnant and would retreat to her clan to her tribe in the caves or in the
clan to her tribe in the caves or in the
clan to her tribe in the caves or in the huts she would be around her peers her
huts she would be around her peers her
huts she would be around her peers her families and be safe likelihood of the
families and be safe likelihood of the
families and be safe likelihood of the child being born in safety and security
child being born in safety and security
child being born in safety and security is much improved interestingly in other
is much improved interestingly in other
is much improved interestingly in other animals rodents that are active at night
animals rodents that are active at night
animals rodents that are active at night are giving birth in the daytime
are giving birth in the daytime
are giving birth in the daytime well those animals in the daytime are in
well those animals in the daytime are in
well those animals in the daytime are in their burrows so it’s the same logic
their burrows so it’s the same logic
their burrows so it’s the same logic that they’re with their mates and
that they’re with their mates and
that they’re with their mates and protected and safe so that’s one answer
protected and safe so that’s one answer
protected and safe so that’s one answer but it’s not the answer I’m looking for
but it’s not the answer I’m looking for
but it’s not the answer I’m looking for when I see a trace like this I think of
when I see a trace like this I think of
when I see a trace like this I think of clocks biological clocks we’re all
clocks biological clocks we’re all
clocks biological clocks we’re all familiar with our sleep/wake cycles this
familiar with our sleep/wake cycles this
familiar with our sleep/wake cycles this is known to be under the control of a
is known to be under the control of a
is known to be under the control of a part of the brain known as our clock and
part of the brain known as our clock and
part of the brain known as our clock and this circadian clock which times 24-hour
this circadian clock which times 24-hour
this circadian clock which times 24-hour rhythms regulates all sorts of things
rhythms regulates all sorts of things
rhythms regulates all sorts of things not just our sleep/wake cycles as you
not just our sleep/wake cycles as you
not just our sleep/wake cycles as you can see on this graph it regulates when
can see on this graph it regulates when
can see on this graph it regulates when our fastest reaction times are late
our fastest reaction times are late
our fastest reaction times are late afternoon when our blood pressure rises
afternoon when our blood pressure rises
afternoon when our blood pressure rises the most when we’re most alert when our
the most when we’re most alert when our
the most when we’re most alert when our body temperature is the minimum
body temperature is the minimum
body temperature is the minimum so on so I’ve over the last 15 years
so on so I’ve over the last 15 years
so on so I’ve over the last 15 years tried to address the possibility that
tried to address the possibility that
tried to address the possibility that the timing of labor shown here in pink
the timing of labor shown here in pink
the timing of labor shown here in pink which is nighttime is somehow associated
which is nighttime is somehow associated
which is nighttime is somehow associated with the brain’s clock via its main
with the brain’s clock via its main
with the brain’s clock via its main hormonal signal melatonin
hormonal signal melatonin
hormonal signal melatonin who here has not heard of melatonin I
who here has not heard of melatonin I
who here has not heard of melatonin I think everyone’s heard of melatonin in
think everyone’s heard of melatonin in
think everyone’s heard of melatonin in the context of sleep right most people
the context of sleep right most people
the context of sleep right most people turns out it’s a major hormonal output
turns out it’s a major hormonal output
turns out it’s a major hormonal output signal of the brain to the rest of the
signal of the brain to the rest of the
signal of the brain to the rest of the body to tell us it’s nighttime certain
body to tell us it’s nighttime certain
body to tell us it’s nighttime certain things should happen other things
things should happen other things
things should happen other things shouldn’t happen a real interesting
shouldn’t happen a real interesting
shouldn’t happen a real interesting feature of melatonin is the fact that it
feature of melatonin is the fact that it
feature of melatonin is the fact that it is secreted by the brain in response to
is secreted by the brain in response to
is secreted by the brain in response to signals from the clock but it also feeds
signals from the clock but it also feeds
signals from the clock but it also feeds back and works on the talk this is why I
back and works on the talk this is why I
back and works on the talk this is why I take it for example for jet lag
take it for example for jet lag
take it for example for jet lag I can reset my clock so that when I land
I can reset my clock so that when I land
I can reset my clock so that when I land in Paris I’m no longer in American time
in Paris I’m no longer in American time
in Paris I’m no longer in American time zone I’m in European time so it’s a nice
zone I’m in European time so it’s a nice
zone I’m in European time so it’s a nice little trick I learned along the way now
little trick I learned along the way now
little trick I learned along the way now this is a study from over 20 years ago
this is a study from over 20 years ago
this is a study from over 20 years ago showing the pattern of sleep and wake in
showing the pattern of sleep and wake in
showing the pattern of sleep and wake in a blind child now blind people generally
a blind child now blind people generally
a blind child now blind people generally have a lot of issues with keeping their
have a lot of issues with keeping their
have a lot of issues with keeping their sleep wake cycles and sync with the
sleep wake cycles and sync with the
sleep wake cycles and sync with the outside world on the left you can see
outside world on the left you can see
outside world on the left you can see the red trace tracks the onset of sleep
the red trace tracks the onset of sleep
the red trace tracks the onset of sleep those dark horizontal bars each row is a
those dark horizontal bars each row is a
those dark horizontal bars each row is a different day and this child is doing
different day and this child is doing
different day and this child is doing what we say freerunning that is to say
what we say freerunning that is to say
what we say freerunning that is to say the clock doesn’t have a sense of winds
the clock doesn’t have a sense of winds
the clock doesn’t have a sense of winds the right time to sleep and when’s the
the right time to sleep and when’s the
the right time to sleep and when’s the right time to wake up and this is of
right time to wake up and this is of
right time to wake up and this is of course very challenging for the child to
course very challenging for the child to
course very challenging for the child to stay awake in the daytime for example
stay awake in the daytime for example
stay awake in the daytime for example and for the parents quite obviously in
and for the parents quite obviously in
and for the parents quite obviously in this study one of the earlier studies
this study one of the earlier studies
this study one of the earlier studies it’s been replicated a million times
it’s been replicated a million times
it’s been replicated a million times they gave melatonin at those green
they gave melatonin at those green
they gave melatonin at those green points in the right graph and I think
points in the right graph and I think
points in the right graph and I think everyone immediately senses what’s going
everyone immediately senses what’s going
everyone immediately senses what’s going on the clock is now locked into that so
on the clock is now locked into that so
on the clock is now locked into that so this melatonin signal serves as a
this melatonin signal serves as a
this melatonin signal serves as a feedback signal to our clocks to
feedback signal to our clocks to
feedback signal to our clocks to establish the proper day/night rhythms
establish the proper day/night rhythms
establish the proper day/night rhythms so this was very tantalizing
so this was very tantalizing
so this was very tantalizing to me in the context of the timing of
to me in the context of the timing of
to me in the context of the timing of birth now as I mentioned a moment ago
birth now as I mentioned a moment ago
birth now as I mentioned a moment ago rats
rats
rats since their night active they tend to
since their night active they tend to
since their night active they tend to give birth in the daytime in the study
give birth in the daytime in the study
give birth in the daytime in the study by Takayama many years ago they showed
by Takayama many years ago they showed
by Takayama many years ago they showed that in the normal case the blue little
that in the normal case the blue little
that in the normal case the blue little mice there are rats will normally be
mice there are rats will normally be
mice there are rats will normally be born during the daytime when melatonin
born during the daytime when melatonin
born during the daytime when melatonin is low that blue arrow however if you
is low that blue arrow however if you
is low that blue arrow however if you remove the source of melatonin which is
remove the source of melatonin which is
remove the source of melatonin which is the brains pineal gland that rhythm is
the brains pineal gland that rhythm is
the brains pineal gland that rhythm is lost
lost
lost these animals are giving birth across 24
these animals are giving birth across 24
these animals are giving birth across 24 hours pretty randomly however if you
hours pretty randomly however if you
hours pretty randomly however if you restore melatonin to the mother rat in a
restore melatonin to the mother rat in a
restore melatonin to the mother rat in a manner that replicates the normal
manner that replicates the normal
manner that replicates the normal nighttime pattern you get back to the
nighttime pattern you get back to the
nighttime pattern you get back to the normal timing of births so this was very
normal timing of births so this was very
normal timing of births so this was very strong evidence for me that there is a
strong evidence for me that there is a
strong evidence for me that there is a connection between melatonin and the
connection between melatonin and the
connection between melatonin and the timing of birth at least in the rat now
timing of birth at least in the rat now
timing of birth at least in the rat now I can’t go taking the pineal gland out
I can’t go taking the pineal gland out
I can’t go taking the pineal gland out of women who are pregnant to study this
of women who are pregnant to study this
of women who are pregnant to study this right so I had to approach this whole
right so I had to approach this whole
right so I had to approach this whole question in a different manner
question in a different manner
question in a different manner my hypothesis graphically shown here is
my hypothesis graphically shown here is
my hypothesis graphically shown here is that labor leading to birth is occurring
that labor leading to birth is occurring
that labor leading to birth is occurring during the night time and as I’ve
during the night time and as I’ve
during the night time and as I’ve indicated the largest majority of women
indicated the largest majority of women
indicated the largest majority of women do enter labor at nighttime these
do enter labor at nighttime these
do enter labor at nighttime these contractions here shown in pink get
contractions here shown in pink get
contractions here shown in pink get higher and higher during the course of
higher and higher during the course of
higher and higher during the course of night correlated with that is this rise
night correlated with that is this rise
night correlated with that is this rise of melatonin in the bloodstream so the
of melatonin in the bloodstream so the
of melatonin in the bloodstream so the hypothesis I developed about 10 years
hypothesis I developed about 10 years
hypothesis I developed about 10 years ago is that the timing of human labor is
ago is that the timing of human labor is
ago is that the timing of human labor is a circadian event a 24-hour pattern that
a circadian event a 24-hour pattern that
a circadian event a 24-hour pattern that is mediated by the action of melatonin
is mediated by the action of melatonin
is mediated by the action of melatonin melatonin in pregnancy was not very well
melatonin in pregnancy was not very well
melatonin in pregnancy was not very well studied I was one of the fearless
studied I was one of the fearless
studied I was one of the fearless scientists who would attack this
scientists who would attack this
scientists who would attack this question we know what signals night
question we know what signals night
question we know what signals night phase we were the first group to show
phase we were the first group to show
phase we were the first group to show that the receptors the the antenna for
that the receptors the the antenna for
that the receptors the the antenna for melatonin proteins in the uterus are
melatonin proteins in the uterus are
melatonin proteins in the uterus are present we showed in a series of studies
present we showed in a series of studies
present we showed in a series of studies that these
that these
that these chapters when melatonin is present
chapters when melatonin is present
chapters when melatonin is present causes contractions of the uterus this
causes contractions of the uterus this
causes contractions of the uterus this is very similar to oxytocin many people
is very similar to oxytocin many people
is very similar to oxytocin many people know oxytocin as a labor inducing drug
know oxytocin as a labor inducing drug
know oxytocin as a labor inducing drug interesting and very important for our
interesting and very important for our
interesting and very important for our thinking is that the receptors in the
thinking is that the receptors in the
thinking is that the receptors in the uterus are not there throughout most of
uterus are not there throughout most of
uterus are not there throughout most of pregnancy but appear at the end of
pregnancy but appear at the end of
pregnancy but appear at the end of pregnancy when labor begins very
pregnancy when labor begins very
pregnancy when labor begins very analogous to the oxytocin receptors so
analogous to the oxytocin receptors so
analogous to the oxytocin receptors so there rose the question well if you’re
there rose the question well if you’re
there rose the question well if you’re saying it might be linked to preterm but
saying it might be linked to preterm but
saying it might be linked to preterm but there’s no receptors in the uterus
there’s no receptors in the uterus
there’s no receptors in the uterus during most of pregnancy how can that be
during most of pregnancy how can that be
during most of pregnancy how can that be so we had to make a very Herculean
so we had to make a very Herculean
so we had to make a very Herculean effort to find women who would give us
effort to find women who would give us
effort to find women who would give us biopsy material when they went into
biopsy material when they went into
biopsy material when they went into preterm labor this was not easy but we
preterm labor this was not easy but we
preterm labor this was not easy but we managed to get five samples and all five
managed to get five samples and all five
managed to get five samples and all five of these women have melatonin receptors
of these women have melatonin receptors
of these women have melatonin receptors so this really excited us that the
so this really excited us that the
so this really excited us that the hypothesis could be true our working
hypothesis could be true our working
hypothesis could be true our working hypothesis then out of all this data was
hypothesis then out of all this data was
hypothesis then out of all this data was that melatonin underlies contractions
that melatonin underlies contractions
that melatonin underlies contractions leading to labor well if we impede if we
leading to labor well if we impede if we
leading to labor well if we impede if we somehow interfere with that signal we
somehow interfere with that signal we
somehow interfere with that signal we should be able to lower contractions
should be able to lower contractions
should be able to lower contractions well how does one do that like I say I’m
well how does one do that like I say I’m
well how does one do that like I say I’m not going to take the pineal gland out
not going to take the pineal gland out
not going to take the pineal gland out at these women there are drugs which we
at these women there are drugs which we
at these women there are drugs which we use in the laboratory can block the
use in the laboratory can block the
use in the laboratory can block the receptors they’ve never been clinically
receptors they’ve never been clinically
receptors they’ve never been clinically tested there are drugs which can block
tested there are drugs which can block
tested there are drugs which can block the synthesis in the brain again too
the synthesis in the brain again too
the synthesis in the brain again too many side effects so we landed upon a
many side effects so we landed upon a
many side effects so we landed upon a unique approach and yet one that’s not
unique approach and yet one that’s not
unique approach and yet one that’s not unfamiliar you’ve probably heard or read
unfamiliar you’ve probably heard or read
unfamiliar you’ve probably heard or read somewhere along the way about photo
somewhere along the way about photo
somewhere along the way about photo therapy yeah photo therapy is used to
therapy yeah photo therapy is used to
therapy yeah photo therapy is used to treat seasonal affective disorder which
treat seasonal affective disorder which
treat seasonal affective disorder which is a circadian disorder by the way
is a circadian disorder by the way
is a circadian disorder by the way winter depression right and it involves
winter depression right and it involves
winter depression right and it involves using a lamp a photo therapy monitor
using a lamp a photo therapy monitor
using a lamp a photo therapy monitor that the person looks at in the morning
that the person looks at in the morning
that the person looks at in the morning to lower their depressive state well I
to lower their depressive state well I
to lower their depressive state well I have friends in this field as you might
have friends in this field as you might
have friends in this field as you might imagine
imagine
imagine and so I said hey can I borrow your
and so I said hey can I borrow your
and so I said hey can I borrow your phototherapy lab for a few years it’s in
phototherapy lab for a few years it’s in
phototherapy lab for a few years it’s in a few years maybe a few months but I
a few years maybe a few months but I
a few years maybe a few months but I managed to compromise on a year and we
managed to compromise on a year and we
managed to compromise on a year and we set up a study involving pregnant women
set up a study involving pregnant women
set up a study involving pregnant women undergoing contractions now these
undergoing contractions now these
undergoing contractions now these weren’t preterm contractions cuz there’s
weren’t preterm contractions cuz there’s
weren’t preterm contractions cuz there’s no way to know are you gonna go preterm
no way to know are you gonna go preterm
no way to know are you gonna go preterm next week
next week
next week we can’t know this right so we had to go
we can’t know this right so we had to go
we can’t know this right so we had to go with women late in pregnancy who were
with women late in pregnancy who were
with women late in pregnancy who were starting to contract needless to say
starting to contract needless to say
starting to contract needless to say this was somewhat risky because in a few
this was somewhat risky because in a few
this was somewhat risky because in a few cases they had their babies before they
cases they had their babies before they
cases they had their babies before they came to the study we had to wait till
came to the study we had to wait till
came to the study we had to wait till the very end of pregnancy to see those
the very end of pregnancy to see those
the very end of pregnancy to see those contractions appearing the hypothesis
contractions appearing the hypothesis
contractions appearing the hypothesis the prediction shown here is that that
the prediction shown here is that that
the prediction shown here is that that melatonin rise the blue line here which
melatonin rise the blue line here which
melatonin rise the blue line here which is the normal pattern by inhibiting it
is the normal pattern by inhibiting it
is the normal pattern by inhibiting it with light which is known to work should
with light which is known to work should
with light which is known to work should suppress contractions right
suppress contractions right
suppress contractions right if melatonin underlies those
if melatonin underlies those
if melatonin underlies those contractions if we suppress not don’t
contractions if we suppress not don’t
contractions if we suppress not don’t should suppress the contractions people
should suppress the contractions people
should suppress the contractions people thought I was crazy
thought I was crazy
thought I was crazy said what you’re gonna show a light
said what you’re gonna show a light
said what you’re gonna show a light pregnant women and stop the contractions
pregnant women and stop the contractions
pregnant women and stop the contractions that’s nuts nuts but it worked it worked
that’s nuts nuts but it worked it worked
that’s nuts nuts but it worked it worked every woman responded to light we gave
every woman responded to light we gave
every woman responded to light we gave them one hour of light exposure shown
them one hour of light exposure shown
them one hour of light exposure shown here the white bar at 11 p.m. at night
here the white bar at 11 p.m. at night
here the white bar at 11 p.m. at night you see the contractions earlier rising
you see the contractions earlier rising
you see the contractions earlier rising as night precedes that one hour of light
as night precedes that one hour of light
as night precedes that one hour of light suppressed every woman not entirely some
suppressed every woman not entirely some
suppressed every woman not entirely some were suppressed by 50% others by 60% now
were suppressed by 50% others by 60% now
were suppressed by 50% others by 60% now there’s a hundred percent remarkably
there’s a hundred percent remarkably
there’s a hundred percent remarkably when we turned the light off they
when we turned the light off they
when we turned the light off they remained suppressed in most cases for
remained suppressed in most cases for
remained suppressed in most cases for many hours so there was a bit of a lag
many hours so there was a bit of a lag
many hours so there was a bit of a lag phase thereafter suppression and then
phase thereafter suppression and then
phase thereafter suppression and then there is a bit of a rebound here are
there is a bit of a rebound here are
there is a bit of a rebound here are four examples and you see there’s some
four examples and you see there’s some
four examples and you see there’s some variability you know people aren’t rats
variability you know people aren’t rats
variability you know people aren’t rats they very divergent in the responses to
they very divergent in the responses to
they very divergent in the responses to things but in every case we lowered
things but in every case we lowered
things but in every case we lowered contractions and generally suppress them
contractions and generally suppress them
contractions and generally suppress them for hours when I told the office of
for hours when I told the office of
for hours when I told the office of intellectual property about this they
intellectual property about this they
intellectual property about this they said get a patent
said get a patent
said get a patent you got to get a patent so we did and
you got to get a patent so we did and
you got to get a patent so we did and that led to kinderman
that led to kinderman
that led to kinderman we formed this company three years ago
we formed this company three years ago
we formed this company three years ago with the goal of using lights as a drug
with the goal of using lights as a drug
with the goal of using lights as a drug if you will light to suppress
if you will light to suppress
if you will light to suppress contractions now you can’t really
contractions now you can’t really
contractions now you can’t really envision a woman at risk of preterm
envision a woman at risk of preterm
envision a woman at risk of preterm labor using a photo therapy lamp every
labor using a photo therapy lamp every
labor using a photo therapy lamp every night to blast her partner you know
night to blast her partner you know
night to blast her partner you know that’s not gonna work right so we
that’s not gonna work right so we
that’s not gonna work right so we decided we needed to develop a an
decided we needed to develop a an
decided we needed to develop a an individual light emitting device better
individual light emitting device better
individual light emitting device better known as a mask and more importantly we
known as a mask and more importantly we
known as a mask and more importantly we wanted to fine-tune it turns out that
wanted to fine-tune it turns out that
wanted to fine-tune it turns out that the suppression of melatonin by white
the suppression of melatonin by white
the suppression of melatonin by white light is entirely due to one wavelength
light is entirely due to one wavelength
light is entirely due to one wavelength and that’s blue light now isn’t that
and that’s blue light now isn’t that
and that’s blue light now isn’t that interesting
interesting
interesting blue light where do we normally see a
blue light where do we normally see a
blue light where do we normally see a lot of blue light in our world the sky
lot of blue light in our world the sky
lot of blue light in our world the sky hey don’t tell me iPhones the sky the
hey don’t tell me iPhones the sky the
hey don’t tell me iPhones the sky the sky is blue we evolved under this world
sky is blue we evolved under this world
sky is blue we evolved under this world with blue light was daytime and so our
with blue light was daytime and so our
with blue light was daytime and so our eyes have developed a specific sensor
eyes have developed a specific sensor
eyes have developed a specific sensor for blue light and it’s that wavelength
for blue light and it’s that wavelength
for blue light and it’s that wavelength of light that is the most effective at
of light that is the most effective at
of light that is the most effective at suppressing melatonin now it is present
suppressing melatonin now it is present
suppressing melatonin now it is present in iPhones and TV screens and all these
in iPhones and TV screens and all these
in iPhones and TV screens and all these other things and that’s why you should
other things and that’s why you should
other things and that’s why you should use the filter evenings to prevent that
use the filter evenings to prevent that
use the filter evenings to prevent that interference with your clock more
interference with your clock more
interference with your clock more importantly blue light goes through the
importantly blue light goes through the
importantly blue light goes through the skin which means in a mask if the
skin which means in a mask if the
skin which means in a mask if the woman’s eyes are closed it’ll go through
woman’s eyes are closed it’ll go through
woman’s eyes are closed it’ll go through the closed eyelids
the closed eyelids
the closed eyelids she doesn’t have to stand there staring
she doesn’t have to stand there staring
she doesn’t have to stand there staring at this light
at this light
at this light all night long right so we thought that
all night long right so we thought that
all night long right so we thought that was a clear advantage so kinder med has
was a clear advantage so kinder med has
was a clear advantage so kinder med has developed a mask which I actually
developed a mask which I actually
developed a mask which I actually happened to have on me yeah
happened to have on me yeah
happened to have on me yeah now with the bright lights on the stage
now with the bright lights on the stage
now with the bright lights on the stage you probably can’t see this but this
you probably can’t see this but this
you probably can’t see this but this shines well as always it doesn’t work
shines well as always it doesn’t work
shines well as always it doesn’t work when I want it to this is the mask small
when I want it to this is the mask small
when I want it to this is the mask small blue lights behind it they come on
blue lights behind it they come on
blue lights behind it they come on automatically suppress melatonin the
automatically suppress melatonin the
automatically suppress melatonin the woman doesn’t have to worry about
woman doesn’t have to worry about
woman doesn’t have to worry about anything other than sleeping there are
anything other than sleeping there are
anything other than sleeping there are very few side effects
very few side effects
very few side effects certainly fewer than drugs it’s
certainly fewer than drugs it’s
certainly fewer than drugs it’s comfortable it’s convenient and it’s
comfortable it’s convenient and it’s
comfortable it’s convenient and it’s very inexpensive drug therapy for
very inexpensive drug therapy for
very inexpensive drug therapy for preterm labor can run into the tens
preterm labor can run into the tens
preterm labor can run into the tens fifty thousand dollars per treatment so
fifty thousand dollars per treatment so
fifty thousand dollars per treatment so this is definitely an advance we think
this is definitely an advance we think
this is definitely an advance we think our goal ultimately of course is to
our goal ultimately of course is to
our goal ultimately of course is to treat preterm labor this is a huge
treat preterm labor this is a huge
treat preterm labor this is a huge problem as I said it hasn’t changed in
problem as I said it hasn’t changed in
problem as I said it hasn’t changed in the world in 30 years still about 10% of
the world in 30 years still about 10% of
the world in 30 years still about 10% of all pregnancies end in preterm labor
all pregnancies end in preterm labor
all pregnancies end in preterm labor the emotional costs the family costs the
the emotional costs the family costs the
the emotional costs the family costs the healthcare costs are huge talking thirty
healthcare costs are huge talking thirty
healthcare costs are huge talking thirty forty billion dollars in this country
forty billion dollars in this country
forty billion dollars in this country alone annually in the world fifteen
alone annually in the world fifteen
alone annually in the world fifteen million babies are born preterm and many
million babies are born preterm and many
million babies are born preterm and many of them don’t survive it’s time to try
of them don’t survive it’s time to try
of them don’t survive it’s time to try something new even if it appears science
something new even if it appears science
something new even if it appears science fiction we think our blue light mask
fiction we think our blue light mask
fiction we think our blue light mask will make great strides in reducing
will make great strides in reducing
will make great strides in reducing preterm labor and we’re working with
preterm labor and we’re working with
preterm labor and we’re working with Harvard right now on some testing of the
Harvard right now on some testing of the
Harvard right now on some testing of the masks and other groups around the
masks and other groups around the
masks and other groups around the country my hope is that within a year we
country my hope is that within a year we
country my hope is that within a year we can start saving millions of babies
can start saving millions of babies
can start saving millions of babies lives around the world thank you very
lives around the world thank you very
lives around the world thank you very much
much
much [Applause]
”
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