cancer it’s everywhere literally if I could ask all of the women in this room
could ask all of the women in this room
could ask all of the women in this room to take a look to your right take a look
to take a look to your right take a look
to take a look to your right take a look to your left one of the three of you
to your left one of the three of you
to your left one of the three of you will have cancer in your lifetime now if
will have cancer in your lifetime now if
will have cancer in your lifetime now if I could get the men to take a look to
I could get the men to take a look to
I could get the men to take a look to your right and that’s all you need to do
your right and that’s all you need to do
your right and that’s all you need to do one of the two of you will have cancer
one of the two of you will have cancer
one of the two of you will have cancer in your lifetime now let’s try it this
in your lifetime now let’s try it this
in your lifetime now let’s try it this way if you know someone who has cancer
way if you know someone who has cancer
way if you know someone who has cancer raise your hand and keep it up please if
raise your hand and keep it up please if
raise your hand and keep it up please if you know someone who has had cancer
you know someone who has had cancer
you know someone who has had cancer raise your hand keep all your hands up
look around the room and while the
look around the room and while the statistics showed that there is an
statistics showed that there is an
statistics showed that there is an increase in the number of people who
increase in the number of people who
increase in the number of people who have cancer we also know that nobody
have cancer we also know that nobody
have cancer we also know that nobody touched by this disease is simply a
touched by this disease is simply a
touched by this disease is simply a statistic I like most of you has have
statistic I like most of you has have
statistic I like most of you has have had my own touch points with cancer and
had my own touch points with cancer and
had my own touch points with cancer and that’s one of the reasons why I’m
that’s one of the reasons why I’m
that’s one of the reasons why I’m standing here with you today now I have
standing here with you today now I have
standing here with you today now I have to be honest on paper it might look a
to be honest on paper it might look a
to be honest on paper it might look a little strange that this liberal arts
little strange that this liberal arts
little strange that this liberal arts graduate who learned Russian when I was
graduate who learned Russian when I was
graduate who learned Russian when I was in middle school high school in college
in middle school high school in college
in middle school high school in college because I wanted to be a CIA agent
because I wanted to be a CIA agent
because I wanted to be a CIA agent turning to stay-at-home mom who became
turning to stay-at-home mom who became
turning to stay-at-home mom who became an entrepreneur who got into politics a
an entrepreneur who got into politics a
an entrepreneur who got into politics a little bit and then went back to my
little bit and then went back to my
little bit and then went back to my entrepreneurial roots seems strange I
entrepreneurial roots seems strange I
entrepreneurial roots seems strange I suppose that I would be standing here
suppose that I would be standing here
suppose that I would be standing here running a biotech today I found my way
running a biotech today I found my way
running a biotech today I found my way into running a biotech because I wanted
into running a biotech because I wanted
into running a biotech because I wanted to use my unique skill sets to advance a
to use my unique skill sets to advance a
to use my unique skill sets to advance a technology that can bend the curve on
technology that can bend the curve on
technology that can bend the curve on cancer the hidden link in everything
cancer the hidden link in everything
cancer the hidden link in everything that I’ve done in my career comes down
that I’ve done in my career comes down
that I’ve done in my career comes down to three P’s people possibility and
to three P’s people possibility and
to three P’s people possibility and promise and while the first questions I
promise and while the first questions I
promise and while the first questions I asked you highlighted a dire set of
asked you highlighted a dire set of
asked you highlighted a dire set of statistics my talk today I hope is not
statistics my talk today I hope is not
statistics my talk today I hope is not as depressing as that might have sounded
as depressing as that might have sounded
as depressing as that might have sounded the fact is is that even though cancer
the fact is is that even though cancer
the fact is is that even though cancer rates are increasing the number of
rates are increasing the number of
rates are increasing the number of cancer survivors are also increasing as
cancer survivors are also increasing as
cancer survivors are also increasing as the cancer death rate is going down
the cancer death rate is going down
the cancer death rate is going down we are finally turning the corner on
we are finally turning the corner on
we are finally turning the corner on cancer and the trends show that progress
cancer and the trends show that progress
cancer and the trends show that progress is being made but there is a lot left to
is being made but there is a lot left to
is being made but there is a lot left to do today I want to share a message about
do today I want to share a message about
do today I want to share a message about in ultra small technology that can have
in ultra small technology that can have
in ultra small technology that can have a huge impact a message of hope not hope
a huge impact a message of hope not hope
a huge impact a message of hope not hope that is a faraway dream for the next
that is a faraway dream for the next
that is a faraway dream for the next generation but hope that is here now and
generation but hope that is here now and
generation but hope that is here now and delivered in a way that used to be the
delivered in a way that used to be the
delivered in a way that used to be the stuff of science fiction some of you may
stuff of science fiction some of you may
stuff of science fiction some of you may remember a movie called the Fantastic
remember a movie called the Fantastic
remember a movie called the Fantastic Voyage from the late 1960s I have to
Voyage from the late 1960s I have to
Voyage from the late 1960s I have to admit I wasn’t born then but as the
admit I wasn’t born then but as the
admit I wasn’t born then but as the youngest of eight was six older brothers
youngest of eight was six older brothers
youngest of eight was six older brothers I often saw movies that many girls my
I often saw movies that many girls my
I often saw movies that many girls my age never imagined they would see take a
age never imagined they would see take a
age never imagined they would see take a look
but now a film called Fantastic Voyage
but now a film called Fantastic Voyage has broken through in an unexpected
has broken through in an unexpected
has broken through in an unexpected direction to create an adventure of
direction to create an adventure of
direction to create an adventure of astonishing suspense and beauty one of
astonishing suspense and beauty one of
astonishing suspense and beauty one of the miracles of the universe for men and
the miracles of the universe for men and
the miracles of the universe for men and a beautiful girl off on a fantastic
a beautiful girl off on a fantastic
a beautiful girl off on a fantastic voyage actually entering inside the
voyage actually entering inside the
voyage actually entering inside the human body exploring an unknown universe
human body exploring an unknown universe
human body exploring an unknown universe unknown dangerous anyone remember that
unknown dangerous anyone remember that
unknown dangerous anyone remember that movie four men and a beautiful girl so
movie four men and a beautiful girl so
movie four men and a beautiful girl so the movie is about the crew of a
the movie is about the crew of a
the movie is about the crew of a miniature submarine and they shrink to
miniature submarine and they shrink to
miniature submarine and they shrink to microscopic size and they are sent into
microscopic size and they are sent into
microscopic size and they are sent into the body of an injured scientist to fix
the body of an injured scientist to fix
the body of an injured scientist to fix a clot in his brain the submarine is
a clot in his brain the submarine is
a clot in his brain the submarine is literally injected into the scientist
literally injected into the scientist
literally injected into the scientist and they have one hour to fix the glued
and they have one hour to fix the glued
and they have one hour to fix the glued clot and if they don’t fix the blood
clot and if they don’t fix the blood
clot and if they don’t fix the blood clot they’ll revert back to the regular
clot they’ll revert back to the regular
clot they’ll revert back to the regular size and is it you can imagine that
size and is it you can imagine that
size and is it you can imagine that would not have turned out well so now
would not have turned out well so now
would not have turned out well so now add that this movie at the time was
add that this movie at the time was
add that this movie at the time was absolutely fantastical in terms of what
absolutely fantastical in terms of what
absolutely fantastical in terms of what it was trying to communicate
it was trying to communicate
it was trying to communicate putting aside the bad special effects
putting aside the bad special effects
putting aside the bad special effects just for a moment I ask you to not
just for a moment I ask you to not
just for a moment I ask you to not dismiss the idea completely the good
dismiss the idea completely the good
dismiss the idea completely the good news is is that we don’t have to shrink
news is is that we don’t have to shrink
news is is that we don’t have to shrink anybody we do need however smart vessels
anybody we do need however smart vessels
anybody we do need however smart vessels that have the ability to deliver drugs
that have the ability to deliver drugs
that have the ability to deliver drugs directly to a certain spot in the body
directly to a certain spot in the body
directly to a certain spot in the body as if the doctor was right they’re just
as if the doctor was right they’re just
as if the doctor was right they’re just like the Fantastic Voyage surmised so
like the Fantastic Voyage surmised so
like the Fantastic Voyage surmised so the concept of ultra small solutions
the concept of ultra small solutions
the concept of ultra small solutions like those found in nanotechnology are
like those found in nanotechnology are
like those found in nanotechnology are not tomorrow’s science they’re here
not tomorrow’s science they’re here
not tomorrow’s science they’re here today it’s not science fiction in labs
today it’s not science fiction in labs
today it’s not science fiction in labs in Minnesota and well beyond these
in Minnesota and well beyond these
in Minnesota and well beyond these technologies are being developed and
technologies are being developed and
technologies are being developed and nanotechnology can provide solutions
nanotechnology can provide solutions
nanotechnology can provide solutions that were only previously just dreamed
that were only previously just dreamed
that were only previously just dreamed about in the potential for
about in the potential for
about in the potential for nanotechnology in
nanotechnology in
nanotechnology in health care is extremely exciting so you
health care is extremely exciting so you
health care is extremely exciting so you might ask why why with all of the money
might ask why why with all of the money
might ask why why with all of the money being spent on research and development
being spent on research and development
being spent on research and development why are the disease’s continuing to
why are the disease’s continuing to
why are the disease’s continuing to outpace the solutions to be sure there’s
outpace the solutions to be sure there’s
outpace the solutions to be sure there’s progress being made but the body is a
progress being made but the body is a
progress being made but the body is a worthy adversary and fundamentally
worthy adversary and fundamentally
worthy adversary and fundamentally improving treatments for challenging
improving treatments for challenging
improving treatments for challenging diseases such as cancer have had a rough
diseases such as cancer have had a rough
diseases such as cancer have had a rough pathway so it should be no surprise
pathway so it should be no surprise
pathway so it should be no surprise because the body is a complex place the
because the body is a complex place the
because the body is a complex place the body has tremendous ability to fight off
body has tremendous ability to fight off
body has tremendous ability to fight off diseases and cures but diseases are
diseases and cures but diseases are
diseases and cures but diseases are smart they find ways around the body’s
smart they find ways around the body’s
smart they find ways around the body’s defenses by either impacting genes over
defenses by either impacting genes over
defenses by either impacting genes over time or manipulating the body’s defenses
time or manipulating the body’s defenses
time or manipulating the body’s defenses or finding ways to get past them and it
or finding ways to get past them and it
or finding ways to get past them and it takes drugs that are just as smart drugs
takes drugs that are just as smart drugs
takes drugs that are just as smart drugs that are targeted to specific cells and
that are targeted to specific cells and
that are targeted to specific cells and drugs that have the ability to get there
drugs that have the ability to get there
drugs that have the ability to get there essentially it comes down to this if a
essentially it comes down to this if a
essentially it comes down to this if a drug cannot be delivered in a way that
drug cannot be delivered in a way that
drug cannot be delivered in a way that it can target a specific disease cell we
it can target a specific disease cell we
it can target a specific disease cell we won’t be able to treat that disease
won’t be able to treat that disease
won’t be able to treat that disease specifically and if you can target the
specifically and if you can target the
specifically and if you can target the disease cell but you don’t have the
disease cell but you don’t have the
disease cell but you don’t have the ability to deliver that drug so it can
ability to deliver that drug so it can
ability to deliver that drug so it can reach that disease zone we won’t be able
reach that disease zone we won’t be able
reach that disease zone we won’t be able to treat that either if you can target
to treat that either if you can target
to treat that either if you can target it and have the ability to reach that
it and have the ability to reach that
it and have the ability to reach that disease cell but you can’t get inside of
disease cell but you can’t get inside of
disease cell but you can’t get inside of it to deliver to the drug specifically
it to deliver to the drug specifically
it to deliver to the drug specifically inside of that cell you won’t be able to
inside of that cell you won’t be able to
inside of that cell you won’t be able to treat it effectively well if you can’t
treat it effectively well if you can’t
treat it effectively well if you can’t treat it effectively you can’t beat it
treat it effectively you can’t beat it
treat it effectively you can’t beat it that’s the challenge that we’re facing
that’s the challenge that we’re facing
that’s the challenge that we’re facing billions of dollars are being spent to
billions of dollars are being spent to
billions of dollars are being spent to develop drugs that fight diseases but
develop drugs that fight diseases but
develop drugs that fight diseases but this will not be well-spent unless we
this will not be well-spent unless we
this will not be well-spent unless we also advance solutions that have the
also advance solutions that have the
also advance solutions that have the capabilities of getting these new drugs
capabilities of getting these new drugs
capabilities of getting these new drugs to where they need to go in the body and
to where they need to go in the body and
to where they need to go in the body and that’s why precision targeted ultra
that’s why precision targeted ultra
that’s why precision targeted ultra small vessels
small vessels
small vessels brought to you by nanotechnology have
brought to you by nanotechnology have
brought to you by nanotechnology have been developed by companies like ours
been developed by companies like ours
been developed by companies like ours and the scientists across the country
and the scientists across the country
and the scientists across the country these developments are revolutionary and
these developments are revolutionary and
these developments are revolutionary and critical let’s connect the dots on
critical let’s connect the dots on
critical let’s connect the dots on nanotechnology and how it can be used in
nanotechnology and how it can be used in
nanotechnology and how it can be used in healthcare imagine two nanotechnology
healthcare imagine two nanotechnology
healthcare imagine two nanotechnology with a brain a nano capsule that
with a brain a nano capsule that
with a brain a nano capsule that effectively is programmed to find a
effectively is programmed to find a
effectively is programmed to find a specific disease based on what we put on
specific disease based on what we put on
specific disease based on what we put on the outside of the nanoparticle this
the outside of the nanoparticle this
the outside of the nanoparticle this ultra small nano capsule then is
ultra small nano capsule then is
ultra small nano capsule then is designed with the ability to navigate
designed with the ability to navigate
designed with the ability to navigate the body’s maze and to find through its
the body’s maze and to find through its
the body’s maze and to find through its stealth pathways to get past the liver
stealth pathways to get past the liver
stealth pathways to get past the liver which by the way is the area that stalls
which by the way is the area that stalls
which by the way is the area that stalls many therapeutic advancements so this
many therapeutic advancements so this
many therapeutic advancements so this nano capsule has the ability to get
nano capsule has the ability to get
nano capsule has the ability to get beyond the liver and deliver cells
beyond the liver and deliver cells
beyond the liver and deliver cells directly into a diseased cell only while
directly into a diseased cell only while
directly into a diseased cell only while leaving healthy cells alone these type
leaving healthy cells alone these type
leaving healthy cells alone these type of treatments should lower toxicity and
of treatments should lower toxicity and
of treatments should lower toxicity and bad side effects and improve outcomes
bad side effects and improve outcomes
bad side effects and improve outcomes for patients so in order to give you a
for patients so in order to give you a
for patients so in order to give you a little context on size of a nanoparticle
little context on size of a nanoparticle
little context on size of a nanoparticle because I’ll tell you it’s really crazy
because I’ll tell you it’s really crazy
because I’ll tell you it’s really crazy when you think of how small they really
when you think of how small they really
when you think of how small they really are take a look at this vial it’s about
are take a look at this vial it’s about
are take a look at this vial it’s about 1/3 full up to about here it contains
1/3 full up to about here it contains
1/3 full up to about here it contains over 10 million or 10 billion excuse me
over 10 million or 10 billion excuse me
over 10 million or 10 billion excuse me nanoparticles that’s pretty darn small
nanoparticles that’s pretty darn small
nanoparticles that’s pretty darn small 10 billion nanoparticles what’s
10 billion nanoparticles what’s
10 billion nanoparticles what’s interesting about that is that’s 10
interesting about that is that’s 10
interesting about that is that’s 10 billion vehicles for delivering cures
billion vehicles for delivering cures
billion vehicles for delivering cures for cancer and other diseases whether
for cancer and other diseases whether
for cancer and other diseases whether we’re talking about creating therapies
we’re talking about creating therapies
we’re talking about creating therapies for cancer or other genetic diseases at
for cancer or other genetic diseases at
for cancer or other genetic diseases at every turn cell specific targeted drug
every turn cell specific targeted drug
every turn cell specific targeted drug delivery could be transformative
delivery could be transformative
delivery could be transformative yesterday’s Fantastic Voyage that we all
yesterday’s Fantastic Voyage that we all
yesterday’s Fantastic Voyage that we all got a chuckle out of up on the screen
got a chuckle out of up on the screen
got a chuckle out of up on the screen our today’s nano therapeutics these
our today’s nano therapeutics these
our today’s nano therapeutics these solutions can happen and these solutions
solutions can happen and these solutions
solutions can happen and these solutions are happening
are happening
are happening no technology its small but its
no technology its small but its
no technology its small but its potential may pack a punch to knock out
potential may pack a punch to knock out
potential may pack a punch to knock out cancer using nanotechnology we are on
cancer using nanotechnology we are on
cancer using nanotechnology we are on the cusp of enabling precision targeted
the cusp of enabling precision targeted
the cusp of enabling precision targeted drug delivery in a way that could
drug delivery in a way that could
drug delivery in a way that could catalyze the next generation of new
catalyze the next generation of new
catalyze the next generation of new therapeutics so to finish this off I’m
therapeutics so to finish this off I’m
therapeutics so to finish this off I’m gonna have you engage with me again and
gonna have you engage with me again and
gonna have you engage with me again and have you all please stand up if you
have you all please stand up if you
have you all please stand up if you could if you if you will so in twenty
could if you if you will so in twenty
could if you if you will so in twenty thirty the man or the woman standing
thirty the man or the woman standing
thirty the man or the woman standing next to you may still likely have had
next to you may still likely have had
next to you may still likely have had cancer but in twenty thirty when the
cancer but in twenty thirty when the
cancer but in twenty thirty when the TEDx attendees stand here and look to
TEDx attendees stand here and look to
TEDx attendees stand here and look to their right and look to their left with
their right and look to their left with
their right and look to their left with delivery platforms driven by
delivery platforms driven by
delivery platforms driven by nanotechnology like those our scientists
nanotechnology like those our scientists
nanotechnology like those our scientists have developed there is a powerful
have developed there is a powerful
have developed there is a powerful chance that each and every one of you
chance that each and every one of you
chance that each and every one of you could be standing next to a cancer
could be standing next to a cancer
could be standing next to a cancer survivor or be that survivor yourself we
survivor or be that survivor yourself we
survivor or be that survivor yourself we can do better and we will do better the
can do better and we will do better the
can do better and we will do better the life of every third woman and every
life of every third woman and every
life of every third woman and every second man in this room and beyond
second man in this room and beyond
second man in this room and beyond depends on it thank you
depends on it thank you
depends on it thank you [Applause]
[Applause]
[Applause] [Music]
”
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