[Music] in the time that it takes you to listen
in the time that it takes you to listen
in the time that it takes you to listen to this talk eight people will be
to this talk eight people will be
to this talk eight people will be diagnosed with Alzheimer’s disease but
diagnosed with Alzheimer’s disease but
diagnosed with Alzheimer’s disease but equally in the next eight minutes
equally in the next eight minutes
equally in the next eight minutes someone could discover the cure to
someone could discover the cure to
someone could discover the cure to Alzheimer’s disease today you could sit
Alzheimer’s disease today you could sit
Alzheimer’s disease today you could sit here and doze off maybe think about what
here and doze off maybe think about what
here and doze off maybe think about what you’re going to have for dinner tonight
you’re going to have for dinner tonight
you’re going to have for dinner tonight or you can take something from these
or you can take something from these
or you can take something from these talks that sparks your curiosity then in
talks that sparks your curiosity then in
talks that sparks your curiosity then in turn take the time to pursue your
turn take the time to pursue your
turn take the time to pursue your curiosity and be inspired to take action
curiosity and be inspired to take action
curiosity and be inspired to take action it all depends on how you are willing to
it all depends on how you are willing to
it all depends on how you are willing to use your time moving forward oftentimes
use your time moving forward oftentimes
use your time moving forward oftentimes we hear people say I don’t have enough
we hear people say I don’t have enough
we hear people say I don’t have enough time for that or there aren’t enough
time for that or there aren’t enough
time for that or there aren’t enough hours in the day for me to possibly get
hours in the day for me to possibly get
hours in the day for me to possibly get all of this done but the problem is not
all of this done but the problem is not
all of this done but the problem is not how much time we do or do not have but
how much time we do or do not have but
how much time we do or do not have but it’s how we are choosing to spend our
it’s how we are choosing to spend our
it’s how we are choosing to spend our time if your priority is social media
time if your priority is social media
time if your priority is social media then you will spend your time on social
then you will spend your time on social
then you will spend your time on social media but if your priority is serving
media but if your priority is serving
media but if your priority is serving others you will then spend your time
others you will then spend your time
others you will then spend your time serving others our priorities are
serving others our priorities are
serving others our priorities are important once we can identify those
important once we can identify those
important once we can identify those priorities we will then have time to
priorities we will then have time to
priorities we will then have time to pursue our passions one of my passions
pursue our passions one of my passions
pursue our passions one of my passions is challenging myself to learn new
is challenging myself to learn new
is challenging myself to learn new things every day and my curiosity for
things every day and my curiosity for
things every day and my curiosity for the human brain invited me or allowed me
the human brain invited me or allowed me
the human brain invited me or allowed me to be invited to do a brain dissection
to be invited to do a brain dissection
to be invited to do a brain dissection at Hershey Medical Center let me tell
at Hershey Medical Center let me tell
at Hershey Medical Center let me tell you it was a humbling experience to see
you it was a humbling experience to see
you it was a humbling experience to see and hold a human brain
and hold a human brain
and hold a human brain I remember thinking wow this is
I remember thinking wow this is
I remember thinking wow this is someone’s every thought dream action and
someone’s every thought dream action and
someone’s every thought dream action and throughout their entire life in my hand
throughout their entire life in my hand
throughout their entire life in my hand eventually during this brain dissection
eventually during this brain dissection
eventually during this brain dissection we discovered some spots of darker
we discovered some spots of darker
we discovered some spots of darker plaques and signs of neuro degeneration
plaques and signs of neuro degeneration
plaques and signs of neuro degeneration now one interesting thing about the
now one interesting thing about the
now one interesting thing about the brain in these donor brains is that we
brain in these donor brains is that we
brain in these donor brains is that we have no knowledge about who the donor
have no knowledge about who the donor
have no knowledge about who the donor was or what their cause of death was
was or what their cause of death was
was or what their cause of death was luckily we had dr. Connor who’s the head
luckily we had dr. Connor who’s the head
luckily we had dr. Connor who’s the head of Neurosurgery there to identify those
of Neurosurgery there to identify those
of Neurosurgery there to identify those plaques as dark spots leading to
plaques as dark spots leading to
plaques as dark spots leading to Alzheimer’s disease seeing the actual
Alzheimer’s disease seeing the actual
Alzheimer’s disease seeing the actual effect that the detrimental disease has
effect that the detrimental disease has
effect that the detrimental disease has on the human brain fascinated me and I
on the human brain fascinated me and I
on the human brain fascinated me and I knew that I had to learn more so this
knew that I had to learn more so this
knew that I had to learn more so this was where all of my research began so
was where all of my research began so
was where all of my research began so this was time well spent
this was time well spent
this was time well spent I chose to spend all of my free time the
I chose to spend all of my free time the
I chose to spend all of my free time the following week researching as much as I
following week researching as much as I
following week researching as much as I could about Alzheimer’s disease to try
could about Alzheimer’s disease to try
could about Alzheimer’s disease to try to understand it better in uncovering
to understand it better in uncovering
to understand it better in uncovering the effects of this disease I was made
the effects of this disease I was made
the effects of this disease I was made aware of a lot of statistics that truly
aware of a lot of statistics that truly
aware of a lot of statistics that truly astounded me I chose to serve as an
astounded me I chose to serve as an
astounded me I chose to serve as an advocate for Alzheimer’s awareness
advocate for Alzheimer’s awareness
advocate for Alzheimer’s awareness because not enough people understand the
because not enough people understand the
because not enough people understand the truly detrimental impact that this
truly detrimental impact that this
truly detrimental impact that this disease is expected to have on the
disease is expected to have on the
disease is expected to have on the world’s population in the next 20 to 30
world’s population in the next 20 to 30
world’s population in the next 20 to 30 years according to the Alzheimer’s
years according to the Alzheimer’s
years according to the Alzheimer’s Association one in three people aged 85
Association one in three people aged 85
Association one in three people aged 85 and older are expected to be diagnosed
and older are expected to be diagnosed
and older are expected to be diagnosed with Alzheimer’s disease currently there
with Alzheimer’s disease currently there
with Alzheimer’s disease currently there are five million Americans living with
are five million Americans living with
are five million Americans living with you with Alzheimer’s disease and if the
you with Alzheimer’s disease and if the
you with Alzheimer’s disease and if the current trends continue this number is
current trends continue this number is
current trends continue this number is expected to rise to 16 million Americans
expected to rise to 16 million Americans
expected to rise to 16 million Americans suffering from Alzheimer’s disease by
suffering from Alzheimer’s disease by
suffering from Alzheimer’s disease by the year 2050
the year 2050
the year 2050 and get this since the year 2000 deaths
and get this since the year 2000 deaths
and get this since the year 2000 deaths from heart disease have decreased by 14%
from heart disease have decreased by 14%
from heart disease have decreased by 14% but deaths from Alzheimer’s disease
but deaths from Alzheimer’s disease
but deaths from Alzheimer’s disease have increased by 89% these shocking
have increased by 89% these shocking
have increased by 89% these shocking statistics are what began my passion to
statistics are what began my passion to
statistics are what began my passion to change the future with new motivation
change the future with new motivation
change the future with new motivation and a new sense of urgency I began
and a new sense of urgency I began
and a new sense of urgency I began looking deeper into everything that I
looking deeper into everything that I
looking deeper into everything that I could to understand the pathophysiology
could to understand the pathophysiology
could to understand the pathophysiology of Alzheimer’s disease while looking at
of Alzheimer’s disease while looking at
of Alzheimer’s disease while looking at medical journals I eventually came
medical journals I eventually came
medical journals I eventually came across a group of journals that
across a group of journals that
across a group of journals that highlighted the link between metformin
highlighted the link between metformin
highlighted the link between metformin which is a drug for type 2 diabetes
which is a drug for type 2 diabetes
which is a drug for type 2 diabetes patients and Alzheimer’s disease
patients and Alzheimer’s disease
patients and Alzheimer’s disease according to an article in clinical
according to an article in clinical
according to an article in clinical interventions in aging the risk of
interventions in aging the risk of
interventions in aging the risk of developing Alzheimer’s disease is fifty
developing Alzheimer’s disease is fifty
developing Alzheimer’s disease is fifty to a hundred and fifty percent greater
to a hundred and fifty percent greater
to a hundred and fifty percent greater in patients with type 2 diabetes
in patients with type 2 diabetes
in patients with type 2 diabetes metformin is a drug given to type two
metformin is a drug given to type two
metformin is a drug given to type two diabetes patients that has been shown to
diabetes patients that has been shown to
diabetes patients that has been shown to induce this beta amyloid plaque
induce this beta amyloid plaque
induce this beta amyloid plaque production and inflammation in the brain
production and inflammation in the brain
production and inflammation in the brain that leads to Alzheimer’s disease
that leads to Alzheimer’s disease
that leads to Alzheimer’s disease currently many type-2 diabetes patients
currently many type-2 diabetes patients
currently many type-2 diabetes patients are prescribed insulin sensitizers that
are prescribed insulin sensitizers that
are prescribed insulin sensitizers that function to help make the body more
function to help make the body more
function to help make the body more sensitive to insulin studies have shown
sensitive to insulin studies have shown
sensitive to insulin studies have shown that metformin which is one of the most
that metformin which is one of the most
that metformin which is one of the most commonly prescribed insulin sensitizers
commonly prescribed insulin sensitizers
commonly prescribed insulin sensitizers has been linked to this beta amyloid
has been linked to this beta amyloid
has been linked to this beta amyloid plaque production and inflammation which
plaque production and inflammation which
plaque production and inflammation which leads to the onset and development of
leads to the onset and development of
leads to the onset and development of Alzheimer’s disease and this is the
Alzheimer’s disease and this is the
Alzheimer’s disease and this is the route that I chose to investigate to
route that I chose to investigate to
route that I chose to investigate to eliminate the connection between this
eliminate the connection between this
eliminate the connection between this drug and Alzheimer’s for the past two
drug and Alzheimer’s for the past two
drug and Alzheimer’s for the past two years I’ve been doing research at the
years I’ve been doing research at the
years I’ve been doing research at the Penn State Hershey Medical Center
Penn State Hershey Medical Center
Penn State Hershey Medical Center College of Medicine in the
College of Medicine in the
College of Medicine in the neurodegenerative diseases lab yes a
neurodegenerative diseases lab yes a
neurodegenerative diseases lab yes a mouthful throughout my research I’ve
mouthful throughout my research I’ve
mouthful throughout my research I’ve been investigating a variety of insulin
been investigating a variety of insulin
been investigating a variety of insulin sensitizers that can decrease this
sensitizers that can decrease this
sensitizers that can decrease this detrimental plaque production I’ve
detrimental plaque production I’ve
detrimental plaque production I’ve chosen to investigate both natural and
chosen to investigate both natural and
chosen to investigate both natural and chemical insulin sensitizers that can
chemical insulin sensitizers that can
chemical insulin sensitizers that can work just as effectively as metformin
work just as effectively as metformin
work just as effectively as metformin but without the detrimental side effects
but without the detrimental side effects
but without the detrimental side effects like Alzheimer’s disease currently my
like Alzheimer’s disease currently my
like Alzheimer’s disease currently my research is try
research is try
research is try to find a balance between these
to find a balance between these
to find a balance between these treatments and the continuation of my
treatments and the continuation of my
treatments and the continuation of my previous studies is showing some
previous studies is showing some
previous studies is showing some promising results
promising results
promising results my ultimate goal with this project is to
my ultimate goal with this project is to
my ultimate goal with this project is to propose an alternative method to manage
propose an alternative method to manage
propose an alternative method to manage type-2 diabetes patients that eliminates
type-2 diabetes patients that eliminates
type-2 diabetes patients that eliminates the risk for Alzheimer’s disease in this
the risk for Alzheimer’s disease in this
the risk for Alzheimer’s disease in this population now this is no overnight
population now this is no overnight
population now this is no overnight process for me I’m two years in and it’s
process for me I’m two years in and it’s
process for me I’m two years in and it’s only just the beginning so I urge you to
only just the beginning so I urge you to
only just the beginning so I urge you to stick with what you love and challenge
stick with what you love and challenge
stick with what you love and challenge yourself to pursue greatness no matter
yourself to pursue greatness no matter
yourself to pursue greatness no matter how long you think it will take or how
how long you think it will take or how
how long you think it will take or how much time you think that you have left
much time you think that you have left
much time you think that you have left this research for me has been time well
this research for me has been time well
this research for me has been time well spent as it afforded me the opportunity
spent as it afforded me the opportunity
spent as it afforded me the opportunity to attend the International Science and
to attend the International Science and
to attend the International Science and Engineering Fair as a finalist the
Engineering Fair as a finalist the
Engineering Fair as a finalist the pivotal moment for me was seeing all of
pivotal moment for me was seeing all of
pivotal moment for me was seeing all of my peers from around the world reshaping
my peers from around the world reshaping
my peers from around the world reshaping science as we know it and that is what
science as we know it and that is what
science as we know it and that is what motivates me to be excellent every day
motivates me to be excellent every day
motivates me to be excellent every day let me tell you being surrounded by the
let me tell you being surrounded by the
let me tell you being surrounded by the highest achieving people your age is one
highest achieving people your age is one
highest achieving people your age is one so intimidating and – the most
so intimidating and – the most
so intimidating and – the most worthwhile experience that you could
worthwhile experience that you could
worthwhile experience that you could possibly imagine
possibly imagine
possibly imagine whether you’re seventeen or 75
whether you’re seventeen or 75
whether you’re seventeen or 75 challenging yourself to interact with
challenging yourself to interact with
challenging yourself to interact with people with similar priorities will help
people with similar priorities will help
people with similar priorities will help you to grow in some unimaginable ways
you to grow in some unimaginable ways
you to grow in some unimaginable ways from my experience at the International
from my experience at the International
from my experience at the International Science Fair I could not be more proud
Science Fair I could not be more proud
Science Fair I could not be more proud of the things that this generation is
of the things that this generation is
of the things that this generation is doing for the future of humanity I would
doing for the future of humanity I would
doing for the future of humanity I would walk through rows and rows of projects
walk through rows and rows of projects
walk through rows and rows of projects proposing cures to cancer are ways to
proposing cures to cancer are ways to
proposing cures to cancer are ways to track space debris even Bionic arms that
track space debris even Bionic arms that
track space debris even Bionic arms that can feel touch and react to stimuli
can feel touch and react to stimuli
can feel touch and react to stimuli obviously these projects took a
obviously these projects took a
obviously these projects took a significant amount of time and for some
significant amount of time and for some
significant amount of time and for some their work was the result of a two to
their work was the result of a two to
their work was the result of a two to three year study now this
three year study now this
three year study now this is time well spent instead of spending
is time well spent instead of spending
is time well spent instead of spending hours a day on Instagram or scrolling
hours a day on Instagram or scrolling
hours a day on Instagram or scrolling through snapchat these students
through snapchat these students
through snapchat these students challenge the stereotypes of generation
challenge the stereotypes of generation
challenge the stereotypes of generation Z through their commitment to good work
Z through their commitment to good work
Z through their commitment to good work ethic in pursuit of their passions our
ethic in pursuit of their passions our
ethic in pursuit of their passions our generation has a huge responsibility to
generation has a huge responsibility to
generation has a huge responsibility to take action now in one perspective it
take action now in one perspective it
take action now in one perspective it can seem a little overwhelming to think
can seem a little overwhelming to think
can seem a little overwhelming to think of all of the challenges that we are
of all of the challenges that we are
of all of the challenges that we are left to overcome but after seeing the
left to overcome but after seeing the
left to overcome but after seeing the fantastic work that these motivated 15
fantastic work that these motivated 15
fantastic work that these motivated 15 to 18 year olds are currently doing all
to 18 year olds are currently doing all
to 18 year olds are currently doing all over the world I have no doubt that we
over the world I have no doubt that we
over the world I have no doubt that we are capable of making an incredible
are capable of making an incredible
are capable of making an incredible difference in the future it’s only a
difference in the future it’s only a
difference in the future it’s only a matter of time it’s not a matter of how
matter of time it’s not a matter of how
matter of time it’s not a matter of how much time or how little time that we
much time or how little time that we
much time or how little time that we have but it’s how we choose to use our
have but it’s how we choose to use our
have but it’s how we choose to use our time so I ask you this moving forward
time so I ask you this moving forward
time so I ask you this moving forward how will you spend your time will yours
how will you spend your time will yours
how will you spend your time will yours be time well spent
be time well spent
be time well spent thank you
thank you
thank you [Applause]
”
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