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Concussion Confusion: A Case for Personalized Medicine | Michelle LaPlaca | TEDxEmory


thank you very much I’m very happy to be

thank you very much I’m very happy to be here this morning and to talk to you

here this morning and to talk to you

here this morning and to talk to you about concussions which is something

about concussions which is something

about concussions which is something that we’ve all heard a lot about so

that we’ve all heard a lot about so

that we’ve all heard a lot about so there’s a saying that goes if you’ve

there’s a saying that goes if you’ve

there’s a saying that goes if you’ve seen one concussion you’ve seen one

seen one concussion you’ve seen one

seen one concussion you’ve seen one concussion well the first time I heard

concussion well the first time I heard

concussion well the first time I heard that I had to say it to myself again so

that I had to say it to myself again so

that I had to say it to myself again so I’ll say it to you again if I’ve seen

I’ll say it to you again if I’ve seen

I’ll say it to you again if I’ve seen one concussion I’ve seen one concussion

one concussion I’ve seen one concussion

one concussion I’ve seen one concussion well taken literally that means that

well taken literally that means that

well taken literally that means that every single concussion is different so

every single concussion is different so

every single concussion is different so as a researcher we’ve really known that

as a researcher we’ve really known that

as a researcher we’ve really known that for years actually doctors know that

for years actually doctors know that

for years actually doctors know that parents know that so so what’s the big

parents know that so so what’s the big

parents know that so so what’s the big problem so where are we why is

problem so where are we why is

problem so where are we why is concussion so confusing well part of the

concussion so confusing well part of the

concussion so confusing well part of the reason is is because our brains are all

reason is is because our brains are all

reason is is because our brains are all different they’re not all the same and

different they’re not all the same and

different they’re not all the same and every concussion is different – you can

every concussion is different – you can

every concussion is different – you can get a concussion in a car accident

get a concussion in a car accident

get a concussion in a car accident playing sports even falling down at home

playing sports even falling down at home

playing sports even falling down at home every single brain is different so what

every single brain is different so what

every single brain is different so what exactly is a concussion and why don’t we

exactly is a concussion and why don’t we

exactly is a concussion and why don’t we know more about it well a concussion is

know more about it well a concussion is

know more about it well a concussion is a mild brain injury so it is a brain

a mild brain injury so it is a brain

a mild brain injury so it is a brain injury results from an impact to the

injury results from an impact to the

injury results from an impact to the head so anything that you can impact

head so anything that you can impact

head so anything that you can impact your head results in neurological

your head results in neurological

your head results in neurological symptoms memory problems confusion

symptoms memory problems confusion

symptoms memory problems confusion balance problems forgetfulness so we’ve

balance problems forgetfulness so we’ve

balance problems forgetfulness so we’ve known about the relationship between

known about the relationship between

known about the relationship between getting your head hit and neurological

getting your head hit and neurological

getting your head hit and neurological function for some time or over a century

function for some time or over a century

function for some time or over a century we’ve known this ever since we started

we’ve known this ever since we started

we’ve known this ever since we started ramming our heads together on purpose so

ramming our heads together on purpose so

ramming our heads together on purpose so the first football game the for college

the first football game the for college

the first football game the for college football game was in the late 19th

football game was in the late 19th

football game was in the late 19th century I think everybody knows back

century I think everybody knows back

century I think everybody knows back then there were leather helmets and this

then there were leather helmets and this

then there were leather helmets and this wasn’t such a good idea as we know now

wasn’t such a good idea as we know now

wasn’t such a good idea as we know now but they didn’t know that so there was

but they didn’t know that so there was

but they didn’t know that so there was many deaths some serious injuries then

many deaths some serious injuries then

many deaths some serious injuries then eventually that led to the use of hard

eventually that led to the use of hard

eventually that led to the use of hard helmet

helmet

helmet and different rules as we all know today

and different rules as we all know today

and different rules as we all know today around the same time in the early 20th

around the same time in the early 20th

around the same time in the early 20th century boxing became more and more

century boxing became more and more

century boxing became more and more popular it was as popular then as

popular it was as popular then as

popular it was as popular then as football is today

football is today

football is today soon medical reports started to emerge

soon medical reports started to emerge

soon medical reports started to emerge though that showed a relationship

though that showed a relationship

though that showed a relationship between the impact to the head and brain

between the impact to the head and brain

between the impact to the head and brain damage and then we all have heard about

damage and then we all have heard about

damage and then we all have heard about traumatic brain injury and war

traumatic brain injury and war

traumatic brain injury and war well traumatic brain injury has been a

well traumatic brain injury has been a

well traumatic brain injury has been a war wound for many many years many

war wound for many many years many

war wound for many many years many centuries in the last conflict traumatic

centuries in the last conflict traumatic

centuries in the last conflict traumatic brain injury was known as the signature

brain injury was known as the signature

brain injury was known as the signature wound of the war but perhaps the most

wound of the war but perhaps the most

wound of the war but perhaps the most the most telling and the biggest

the most telling and the biggest

the most telling and the biggest shake-up to the community has been the

shake-up to the community has been the

shake-up to the community has been the finding of degeneration in professional

finding of degeneration in professional

finding of degeneration in professional football players brains it’s been 15

football players brains it’s been 15

football players brains it’s been 15 years since we first saw this and we’ve

years since we first saw this and we’ve

years since we first saw this and we’ve seen player after player we’ve seen this

seen player after player we’ve seen this

seen player after player we’ve seen this discovered in their brain so so now

discovered in their brain so so now

discovered in their brain so so now there’s a lot of talk about concussion

there’s a lot of talk about concussion

there’s a lot of talk about concussion you hear it in the media you hear it all

you hear it in the media you hear it all

you hear it in the media you hear it all the time so what’s going on you know we

the time so what’s going on you know we

the time so what’s going on you know we hear about concussion protocols what’s a

hear about concussion protocols what’s a

hear about concussion protocols what’s a concussion protocol does my kid really

concussion protocol does my kid really

concussion protocol does my kid really need to be doing that tackling technique

need to be doing that tackling technique

need to be doing that tackling technique or that tackling technique are we gonna

or that tackling technique are we gonna

or that tackling technique are we gonna get rid of football well I’m not sure

get rid of football well I’m not sure

get rid of football well I’m not sure that that’s the way that that’s why it’s

that that’s the way that that’s why it’s

that that’s the way that that’s why it’s gonna go but what are we doing what are

gonna go but what are we doing what are

gonna go but what are we doing what are we doing about it why aren’t we doing

we doing about it why aren’t we doing

we doing about it why aren’t we doing better are we doing any better than we

better are we doing any better than we

better are we doing any better than we were 10 15 20 years ago some might say

were 10 15 20 years ago some might say

were 10 15 20 years ago some might say yes we no longer say oh he got his bell

yes we no longer say oh he got his bell

yes we no longer say oh he got his bell rung or how many fingers am i holding up

rung or how many fingers am i holding up

rung or how many fingers am i holding up but I’m here to tell you that no I don’t

but I’m here to tell you that no I don’t

but I’m here to tell you that no I don’t think we’re doing that much better than

think we’re doing that much better than

think we’re doing that much better than we were 20 years ago so what’s the big

we were 20 years ago so what’s the big

we were 20 years ago so what’s the big deal why is it so difficult to detect

deal why is it so difficult to detect

deal why is it so difficult to detect this mild brain injury sports announcers

this mild brain injury sports announcers

this mild brain injury sports announcers do it all the time well sometimes it’s

do it all the time well sometimes it’s

do it all the time well sometimes it’s obvious then someone’s had a brain

obvious then someone’s had a brain

obvious then someone’s had a brain injury and sometimes it’s not so obvious

injury and sometimes it’s not so obvious

injury and sometimes it’s not so obvious what we want to know are the ones that

what we want to know are the ones that

what we want to know are the ones that aren’t so obvious so and even when it’s

aren’t so obvious so and even when it’s

aren’t so obvious so and even when it’s obvious sometimes it can still be messy

obvious sometimes it can still be messy

obvious sometimes it can still be messy dehydration for example that can mimic

dehydration for example that can mimic

dehydration for example that can mimic the signs of a concussion can lead to

the signs of a concussion can lead to

the signs of a concussion can lead to inbound

inbound

inbound problems and this and that so what is

problems and this and that so what is

problems and this and that so what is this why I call this a signal-to-noise

this why I call this a signal-to-noise

this why I call this a signal-to-noise problem okay we have the big signal the

problem okay we have the big signal the

problem okay we have the big signal the real signals concussion and then we have

real signals concussion and then we have

real signals concussion and then we have the noise we have all the other noise

the noise we have all the other noise

the noise we have all the other noise like dehydration so when you have a

like dehydration so when you have a

like dehydration so when you have a really large signal like you would for

really large signal like you would for

really large signal like you would for loss of consciousness everybody knows

loss of consciousness everybody knows

loss of consciousness everybody knows that if you see a football player laying

that if you see a football player laying

that if you see a football player laying down during game or soccer player they

down during game or soccer player they

down during game or soccer player they probably have a concussion so there the

probably have a concussion so there the

probably have a concussion so there the signal you can see it among the noise

signal you can see it among the noise

signal you can see it among the noise but most of the time to have small

but most of the time to have small

but most of the time to have small signals and a lot of noise dehydration

signals and a lot of noise dehydration

signals and a lot of noise dehydration different medical conditions different

different medical conditions different

different medical conditions different medications and this is where the

medications and this is where the

medications and this is where the confusion comes in so it’s confusing and

confusion comes in so it’s confusing and

confusion comes in so it’s confusing and now it’s also very messy okay so what

now it’s also very messy okay so what

now it’s also very messy okay so what I’m here to talk to you today about is

I’m here to talk to you today about is

I’m here to talk to you today about is to try to convince you that we can use

to try to convince you that we can use

to try to convince you that we can use data science to clear up this messiness

data science to clear up this messiness

data science to clear up this messiness to clear up this confusion and move

to clear up this confusion and move

to clear up this confusion and move forward so what if we were able to say

forward so what if we were able to say

forward so what if we were able to say that you have a brain fingerprint

that you have a brain fingerprint

that you have a brain fingerprint everybody in this room and everybody

everybody in this room and everybody

everybody in this room and everybody watching they have unique features about

watching they have unique features about

watching they have unique features about their brain so if they have a particular

their brain so if they have a particular

their brain so if they have a particular situation that they think is a

situation that they think is a

situation that they think is a concussion we know what their

concussion we know what their

concussion we know what their fingerprint looks like and we know how

fingerprint looks like and we know how

fingerprint looks like and we know how bad their concussion is what if I could

bad their concussion is what if I could

bad their concussion is what if I could say your concussion scores a 9.2 you’ve

say your concussion scores a 9.2 you’ve

say your concussion scores a 9.2 you’ve had a mild traumatic brain injury you’ve

had a mild traumatic brain injury you’ve

had a mild traumatic brain injury you’ve suffered a contusion to your frontal

suffered a contusion to your frontal

suffered a contusion to your frontal brain that’s causing your memory

brain that’s causing your memory

brain that’s causing your memory problems but the good news is that your

problems but the good news is that your

problems but the good news is that your blood work and your imaging work and all

blood work and your imaging work and all

blood work and your imaging work and all of your other signs they tell us that

of your other signs they tell us that

of your other signs they tell us that you need to rest for a few days you need

you need to rest for a few days you need

you need to rest for a few days you need to avoid any heavy extraneous activity

to avoid any heavy extraneous activity

to avoid any heavy extraneous activity for two weeks and if you get at least

for two weeks and if you get at least

for two weeks and if you get at least eight hours of sleep a night

eight hours of sleep a night

eight hours of sleep a night like any of us get that anymore you have

like any of us get that anymore you have

like any of us get that anymore you have a 98% chance of a full recovery or you

a 98% chance of a full recovery or you

a 98% chance of a full recovery or you have a concussion score of 7.1 you’ve

have a concussion score of 7.1 you’ve

have a concussion score of 7.1 you’ve suffered a mild brain injury to your

suffered a mild brain injury to your

suffered a mild brain injury to your parietal cortex that’s causing you all

parietal cortex that’s causing you all

parietal cortex that’s causing you all these problems that you’re having today

these problems that you’re having today

these problems that you’re having today but as of your medical history of

but as of your medical history of

but as of your medical history of frequent migraines your three previous

frequent migraines your three previous

frequent migraines your three previous concussion

concussion

concussion and all of your tests your balance

and all of your tests your balance

and all of your tests your balance problems our most art you’re gonna have

problems our most art you’re gonna have

problems our most art you’re gonna have a 20% chance of continuing those balance

a 20% chance of continuing those balance

a 20% chance of continuing those balance problems and developed dizzy problems

problems and developed dizzy problems

problems and developed dizzy problems and you have to have a now your risk for

and you have to have a now your risk for

and you have to have a now your risk for chronic traumatic encephalopathy or CTE

chronic traumatic encephalopathy or CTE

chronic traumatic encephalopathy or CTE degeneration of the brain that’s gone up

degeneration of the brain that’s gone up

degeneration of the brain that’s gone up from five to ten percent so I’m here to

from five to ten percent so I’m here to

from five to ten percent so I’m here to tell you that this is possible it’s

tell you that this is possible it’s

tell you that this is possible it’s possible for each of us to have our own

possible for each of us to have our own

possible for each of us to have our own profile in the unlikely event that we

profile in the unlikely event that we

profile in the unlikely event that we hit our heads and have a concussion so

hit our heads and have a concussion so

hit our heads and have a concussion so how are we going to do this how is it

how are we going to do this how is it

how are we going to do this how is it that we can we can have a personalized

that we can we can have a personalized

that we can we can have a personalized diagnosis well I think everybody in this

diagnosis well I think everybody in this

diagnosis well I think everybody in this room has probably heard of personalized

room has probably heard of personalized

room has probably heard of personalized medicine there’s a lot of research into

medicine there’s a lot of research into

medicine there’s a lot of research into cancer treatments tailoring cancer

cancer treatments tailoring cancer

cancer treatments tailoring cancer treatments and doing genetic genomic

treatments and doing genetic genomic

treatments and doing genetic genomic sequencing to see what your genetic

sequencing to see what your genetic

sequencing to see what your genetic risks are for a certain disease but in

risks are for a certain disease but in

risks are for a certain disease but in the world of concussion there’s a lot of

the world of concussion there’s a lot of

the world of concussion there’s a lot of research there’s a lot of confounding

research there’s a lot of confounding

research there’s a lot of confounding research there’s a lot of conflicting

research there’s a lot of conflicting

research there’s a lot of conflicting research and we’ve been very slow to

research and we’ve been very slow to

research and we’ve been very slow to adopt this concept in concussion

adopt this concept in concussion

adopt this concept in concussion medicine there’s international

medicine there’s international

medicine there’s international guidelines that have been put out by

guidelines that have been put out by

guidelines that have been put out by experts yet less than 10% of US

experts yet less than 10% of US

experts yet less than 10% of US physicians are using those guidelines so

physicians are using those guidelines so

physicians are using those guidelines so they’re taking lots of data points are

they’re taking lots of data points are

they’re taking lots of data points are taking lots of information but it’s

taking lots of information but it’s

taking lots of information but it’s still very messy we still don’t know

still very messy we still don’t know

still very messy we still don’t know what to do with all this all this

what to do with all this all this

what to do with all this all this messiness so typically concussion

messiness so typically concussion

messiness so typically concussion diagnoses are based on just a few data

diagnoses are based on just a few data

diagnoses are based on just a few data points a few symptoms a clinical exam

points a few symptoms a clinical exam

points a few symptoms a clinical exam your doctors experience of course but

your doctors experience of course but

your doctors experience of course but there’s still just a few data points so

there’s still just a few data points so

there’s still just a few data points so for example if you had a small hit to

for example if you had a small hit to

for example if you had a small hit to the head that means that that’s a low

the head that means that that’s a low

the head that means that that’s a low risk and you have a low chance of having

risk and you have a low chance of having

risk and you have a low chance of having a concussion obviously if you have a

a concussion obviously if you have a

a concussion obviously if you have a higher hit a larger hit you have a

higher hit a larger hit you have a

higher hit a larger hit you have a higher risk and a higher chance of gain

higher risk and a higher chance of gain

higher risk and a higher chance of gain concussion well each clinical symptom

concussion well each clinical symptom

concussion well each clinical symptom each clinical test that they do is going

each clinical test that they do is going

each clinical test that they do is going to tell the doctor something about your

to tell the doctor something about your

to tell the doctor something about your risk

risk

risk and your chances for suffering a brain

and your chances for suffering a brain

and your chances for suffering a brain injury or what your outcome is going to

injury or what your outcome is going to

injury or what your outcome is going to be okay but in reality we eat each and

be okay but in reality we eat each and

be okay but in reality we eat each and every one of us has dozens and even

every one of us has dozens and even

every one of us has dozens and even hundreds of signals we have a brain

hundreds of signals we have a brain

hundreds of signals we have a brain fingerprint okay so we need to be taking

fingerprint okay so we need to be taking

fingerprint okay so we need to be taking all of these factors we need to know how

all of these factors we need to know how

all of these factors we need to know how hard to hit was how many kids you’ve had

hard to hit was how many kids you’ve had

hard to hit was how many kids you’ve had in the past maybe this was just a

in the past maybe this was just a

in the past maybe this was just a one-time hit you’re not an athlete we

one-time hit you’re not an athlete we

one-time hit you’re not an athlete we need to know what medications you’re on

need to know what medications you’re on

need to know what medications you’re on what your medical history is what your

what your medical history is what your

what your medical history is what your diet is and so on so we can take all of

diet is and so on so we can take all of

diet is and so on so we can take all of these data points and we can use

these data points and we can use

these data points and we can use algorithms to create personalized

algorithms to create personalized

algorithms to create personalized fingerprints that can allow us to have

fingerprints that can allow us to have

fingerprints that can allow us to have diagnoses and treatment plans that are

diagnoses and treatment plans that are

diagnoses and treatment plans that are just for you and your brain so this is a

just for you and your brain so this is a

just for you and your brain so this is a data-driven approach we call this and

data-driven approach we call this and

data-driven approach we call this and what we can do this is we can have

what we can do this is we can have

what we can do this is we can have individual plans for everybody so say a

individual plans for everybody so say a

individual plans for everybody so say a fourteen-year-old has a hit in a

fourteen-year-old has a hit in a

fourteen-year-old has a hit in a football game so based on his symptoms

football game so based on his symptoms

football game so based on his symptoms he has a certain type of concussion a

he has a certain type of concussion a

he has a certain type of concussion a woman Falls from her bike hits her head

woman Falls from her bike hits her head

woman Falls from her bike hits her head she has another set of history facts and

she has another set of history facts and

she has another set of history facts and conditions and symptoms this is a

conditions and symptoms this is a

conditions and symptoms this is a different subtype of injury and then we

different subtype of injury and then we

different subtype of injury and then we have a man who plays soccer on the

have a man who plays soccer on the

have a man who plays soccer on the weekends in an adult league you really

weekends in an adult league you really

weekends in an adult league you really can’t remember if he had any concussions

can’t remember if he had any concussions

can’t remember if he had any concussions as a kid but he has migraines and his

as a kid but he has migraines and his

as a kid but he has migraines and his migraines get worse when he plays soccer

migraines get worse when he plays soccer

migraines get worse when he plays soccer but he doesn’t have a concussion

but he doesn’t have a concussion

but he doesn’t have a concussion based on his tests so how how do we get

based on his tests so how how do we get

based on his tests so how how do we get there

there

there how do we get to this point well we need

how do we get to this point well we need

how do we get to this point well we need to demand personalized health for our

to demand personalized health for our

to demand personalized health for our brains we need to demand this like we

brains we need to demand this like we

brains we need to demand this like we would for chemotherapy like we would for

would for chemotherapy like we would for

would for chemotherapy like we would for genetic risks we need to participate in

genetic risks we need to participate in

genetic risks we need to participate in research there’s a lot of research we

research there’s a lot of research we

research there’s a lot of research we need to do we need to support

need to do we need to support

need to do we need to support crowdsourcing our data because we need

crowdsourcing our data because we need

crowdsourcing our data because we need all those data points to create these

all those data points to create these

all those data points to create these algorithms we need to insist on

algorithms we need to insist on

algorithms we need to insist on concussion education

concussion education

concussion education we need to ask our doctors about the

we need to ask our doctors about the

we need to ask our doctors about the latest concussion guidelines okay we’re

latest concussion guidelines okay we’re

latest concussion guidelines okay we’re not in the darkroom anymore okay what

not in the darkroom anymore okay what

not in the darkroom anymore okay what are the latest guidelines insist that

are the latest guidelines insist that

are the latest guidelines insist that they keep up with that we need to insist

they keep up with that we need to insist

they keep up with that we need to insist that our schools all of our schools have

that our schools all of our schools have

that our schools all of our schools have athletic trainers and school nurses but

athletic trainers and school nurses but

athletic trainers and school nurses but we need to participate in sports we need

we need to participate in sports we need

we need to participate in sports we need to know our risks because data is power

to know our risks because data is power

to know our risks because data is power and the more data you have and the more

and the more data you have and the more

and the more data you have and the more you know the more that you can make

you know the more that you can make

you know the more that you can make decisions so together we can get from

decisions so together we can get from

decisions so together we can get from having very messy messy diagnosis even

having very messy messy diagnosis even

having very messy messy diagnosis even this diagnosis we don’t want to have Mis

this diagnosis we don’t want to have Mis

this diagnosis we don’t want to have Mis diagnosis we want to get it right okay

diagnosis we want to get it right okay

diagnosis we want to get it right okay so we have all this noise we have a lot

so we have all this noise we have a lot

so we have all this noise we have a lot of misdiagnosis

of misdiagnosis

of misdiagnosis but together by using these data science

but together by using these data science

but together by using these data science techniques and by demanding that we have

techniques and by demanding that we have

techniques and by demanding that we have this type of education for our doctors

this type of education for our doctors

this type of education for our doctors in our schools together we can come up

in our schools together we can come up

in our schools together we can come up with precision medicine for our brains

with precision medicine for our brains

with precision medicine for our brains and avoid the concussion confusion thank

and avoid the concussion confusion thank

and avoid the concussion confusion thank you

”

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