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The Challenges with Cancer Trials | Breakthrough


we didn’t had any intention of injecting

we didn’t had any intention of injecting these type of vials to patient because

these type of vials to patient because

these type of vials to patient because we needed a lot of vials to be able to

we needed a lot of vials to be able to

we needed a lot of vials to be able to file a clinical trial application and

file a clinical trial application and

file a clinical trial application and this was planned to be done with

this was planned to be done with

this was planned to be done with University College London before any new

University College London before any new

University College London before any new medication or therapy is considered safe

medication or therapy is considered safe

medication or therapy is considered safe and effective it must first be

and effective it must first be

and effective it must first be rigorously tested through clinical

rigorously tested through clinical

rigorously tested through clinical trials

these trials are fundamental in

these trials are fundamental in determining and experimental treatments

determining and experimental treatments

determining and experimental treatments dosage and safety and to identify any

dosage and safety and to identify any

dosage and safety and to identify any possible side effects at the University

possible side effects at the University

possible side effects at the University College London Great Ormond Street

College London Great Ormond Street

College London Great Ormond Street Institute of Child Health professor

Institute of Child Health professor

Institute of Child Health professor Waseem Kassim was working with selected

Waseem Kassim was working with selected

Waseem Kassim was working with selected as the principal investigator taking the

as the principal investigator taking the

as the principal investigator taking the universal car t-cells from the lab to

universal car t-cells from the lab to

universal car t-cells from the lab to trials normally this process can take

trials normally this process can take

trials normally this process can take over a decade with nearly endless layers

over a decade with nearly endless layers

over a decade with nearly endless layers of approval so our questions were what

of approval so our questions were what

of approval so our questions were what do you do if your patient is already so

do you do if your patient is already so

do you do if your patient is already so unwell that you can’t Excel or is had so

unwell that you can’t Excel or is had so

unwell that you can’t Excel or is had so much chemotherapy that there’s no white

much chemotherapy that there’s no white

much chemotherapy that there’s no white blood cells left to collect that you

blood cells left to collect that you

blood cells left to collect that you think are going to be useful how do you

think are going to be useful how do you

think are going to be useful how do you do this process in a way that can be

do this process in a way that can be

do this process in a way that can be done quickly and delivered back to the

done quickly and delivered back to the

done quickly and delivered back to the patient in a timely manner and the

patient in a timely manner and the

patient in a timely manner and the answer that is perhaps being able to use

answer that is perhaps being able to use

answer that is perhaps being able to use a product the cell product that’s being

a product the cell product that’s being

a product the cell product that’s being made beforehand that can be given back

made beforehand that can be given back

made beforehand that can be given back to multiple patients now in order to do

to multiple patients now in order to do

to multiple patients now in order to do that we have to overcome the barrier of

that we have to overcome the barrier of

that we have to overcome the barrier of transplantation which means if I put my

transplantation which means if I put my

transplantation which means if I put my cells into a non matched individual the

cells into a non matched individual the

cells into a non matched individual the cells were still want to react against

cells were still want to react against

cells were still want to react against that individual because they’ll know the

that individual because they’ll know the

that individual because they’ll know the individuals forum and secondly the

individuals forum and secondly the

individuals forum and secondly the person receiving the cells will try and

person receiving the cells will try and

person receiving the cells will try and reject them because they know the cells

reject them because they know the cells

reject them because they know the cells are not their own in affiliation with

are not their own in affiliation with

are not their own in affiliation with professor Kassim dr. Paul Vaes works on

professor Kassim dr. Paul Vaes works on

professor Kassim dr. Paul Vaes works on the front line with patients who

the front line with patients who

the front line with patients who desperately need new cancer treatment

desperately need new cancer treatment

desperately need new cancer treatment options

options

options I’ll have treated well over 2,000

I’ll have treated well over 2,000

I’ll have treated well over 2,000 patients and at least 600 of those will

patients and at least 600 of those will

patients and at least 600 of those will have gone wrong so there’s a lot of

have gone wrong so there’s a lot of

have gone wrong so there’s a lot of patience as we lose it’s unsuccessful

patience as we lose it’s unsuccessful

patience as we lose it’s unsuccessful and you’ve got to be able to come in the

and you’ve got to be able to come in the

and you’ve got to be able to come in the next day

even from our failures we’ve learned

even from our failures we’ve learned lots and if we hadn’t gone through those

lots and if we hadn’t gone through those

lots and if we hadn’t gone through those failures we wouldn’t be having some of

failures we wouldn’t be having some of

failures we wouldn’t be having some of the successes we have today that’s

the successes we have today that’s

the successes we have today that’s always been good did not have any bait

always been good did not have any bait

always been good did not have any bait just infection let’s warm it up sit

just infection let’s warm it up sit

just infection let’s warm it up sit forward again perfect okay big breath

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