good night to pure life
if now life because I come to talk to you
of life life begins with a
cell that is formed from two
elements an ovule and a sperm
and these cells multiply and grow and
is developing the different lines
cell phones the embryologists that are the
scholars of this subject when this
is very tiny they manage to identify
three layers of cells and today
we can work with the cells of the
middle layer
these cells are the so-called
mesenchymal stem cells or
mesenchymal stem cells these cells
today we can get it and work
to prepare different types of tissues
good this photograph that you see
belongs to a graph of a pregnancy
of a baby of 12 weeks gestation
this baby of 12 weeks of gestation
already has all its parts has
practically all its organs
trained and that baby that you see in
that photograph is not any baby
it’s about the picture of my first grandchild or
granddaughter and at this moment goes of the week
15 of gestation will do in August
so I’m very excited about that
because it has to do precisely from
this of life
well this world is changing in
very important way and that too
It affects medicine when I was a child
the changes happened in ten years
today in what I used to see ten
years
today it happens in less than 1 when the
creators of the film go back to
future
in the eighties visualize the
hard they saw it with cars that were flying and
a series of very interesting things and that
future was 2015 already happened and what
happened it really was that they did not notice
that the tool of change was going to be
the internet and the big networks
that makes me able to sign today
here in front of you that the world is
flat is no longer round when a
researcher a and connoisseur of the
science deepens a knowledge and by
so it advances and publishes a breakthrough
immediately this is known to another
researcher that is on the other side the
world does not matter if it is here in san
josé or in santiago or if they are tokyo or
in paris
immediately that knowledge is
moved and helped him to take the step and
climb the step that was missing in your
development
this makes knowledge advance today
day exponentially
that is going to change radically too
how medicine is practiced all the
way I exercised my profession
the new doctors are going to have to
change radically because they are going to tell
with new diagnostic tools
and therapeutic knowledge
of the human genome will modify many
diagnostic elements and
treatment
today any of you or me
we could study our cen
own genome is a thing of a day
which in the past was unthinkable
on the other hand to mexico also a
new tool
this is a discovery because I was
from already in the bacteria
there are some strains of bacteria that
they have this crist crispe is a
biological tool that allows
Modify
and therefore you could dream that
in the future I will soon be able to
me with him chris perez correct a gene
damaged in some patient the year
2012
the yamanaka doctor who is well there
photography won the Nobel Prize
for having managed to make a cell
very specialized in our body a
skin cell undergoing a process
managed to make a pluripotent cell is
say with more power than those
mesenchymal stem cells that I
I mentioned at the beginning and that
knowledge is already transferred and the year
passed in santiago de chile are due to
a publication of a newspaper in which
the author solitude matus manages to do this
same process a pluripotent cell
but then subjected to a new process
and manages to regenerate a neuron in a
animal model therefore this is going to be
the future what is going to come and how
we will be able to regenerate tissues
so ultra specialized like that
I am a doctor from the old school and
representative of traditional medicine
all my life I have exercised my profession
in that sense I trained in france
91 92 years and I dedicated my expertise to
treat patients with this disease or
weaving is imperfect that corresponds to
a genetic disease what fails is
the gene that encodes the collagen of
bone
collagen is a protein
structural that gives resistance to
bone equivalent to iron in a pillar
of the construction that works in the
moves
well I dedicated myself for many
years to treat patients with those of
genes
these poor patients are invalid
they have a deformity of their skeleton
in the extremities in the column size
low but the effect of teething and
what I did was Harles enclave
bone channel with some nails grows
mers or telescopic and then with
this material inside the bone as it is
steel resistance bone changes
there are fewer fractures and if it is
fracture do not deform good in the
year 2000
I read a job from the Swedes of
karolinska institute
these gentlemen discover a mother who
is pregnant and the baby that is in
the belly of his mother
comes with this disease and then
after many deliberations the
Swedes do a transplant with
mesenchymal stem cells from sacchi
I mentioned him at the beginning in
uterus the baby from a healthy donor and
estévez rejects these cells
makes live with him and radically changes
the structure of the skeleton when they
they published this work
this baby was three years old and the
X-ray I saw of the skeleton
that had nothing to do with the
disease that I knew by heart from
the regions is imperfect in the year
2005
this happened to me but the jump
from the other side
ie you the same challenge is
santiago de chile a doctor friend and
obstetric colleague discovers that a baby
of a mother is pregnant the week
21 dinner and on the ultrasound as you see the
Deformity of the femur bone that shows
this disease and simulated studies and
we show that this is the this gene
it’s imperfect
then I communicated with the
Swedish researchers and they
They generously sent me back from
the method of this work that we had
read me
the year 2000 and that means the step to
step was not easy
We had a hard time finding a series of
elements that were very complex to
us because we do not have the level of
development of sweden but we achieved it and
approximately after 30 days
can mount the whole operation and
then in the year in a couple of months and
we made this application
you see yesterday on the ultrasound and this
this video is happening when the
needle is pricking the umbilical vein
at the exit of the placenta which is a
fixed point
then there we aspire blood and that
blood from the fetal circuit is not from the
mother of the baby and at that point you
are going to see now how are we injecting
the blood cells of the pro
bloodstream of the baby
there are entering the cellulite in
clustered groups and capable ultrasound
to show the good
Estevez Maximiliano was born in August
2005 in August last turned 11
years
this radiography are from the moment of
estévez birth still see the
inculpations of bones product of
she fractured the tube in life
intrauterine
however this bone and its firm bone
it is already a bone that has a resistance
very different from the previous one and that’s why
the contribution that these cells made in
the construction of the bone
we have been able to make four other cases
here we also see Maximilian who
is the one who is sitting in the middle
soccer costume dress because he is
soccer fan
this led me also to know
other options of these cells and
applications and today I was able to
this same cell regenerate bones
joints meniscal cartilages and
ligaments etc. that is the paradigm
that you have to look in a different way
like the doctors we can go to
solve a problem to our
patients
why and if you put all these together
elements that I have given them as
visualization that are in a lot
tune with the same conferences
that you have heard today and
yesterday is that I see myself I dare to
affirm here and convinced until the
marrow from my bones and the baby that
born today will live 150 years as well as
it will be my grandson or my
granddaughter
thank you very much
[Music]
”
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