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Society’s Sweet Tooth… the Brain’s Response to Sugar | Amanda Maracle | TEDxQueensU


I’d like to start off by telling you a

I’d like to start off by telling you a story it’s about a woman named Barbara

story it’s about a woman named Barbara

story it’s about a woman named Barbara now unfortunately for Barbara when she

now unfortunately for Barbara when she

now unfortunately for Barbara when she was young unhealthy habits were modeled

was young unhealthy habits were modeled

was young unhealthy habits were modeled at home and several of her close

at home and several of her close

at home and several of her close relatives struggled with a very specific

relatives struggled with a very specific

relatives struggled with a very specific type of disorder as Barbara got older

type of disorder as Barbara got older

type of disorder as Barbara got older she realized that exposure to a certain

she realized that exposure to a certain

she realized that exposure to a certain type of substance was highly rewarding

type of substance was highly rewarding

type of substance was highly rewarding for her and she began actively seeking

for her and she began actively seeking

for her and she began actively seeking it out and consuming it without

it out and consuming it without

it out and consuming it without experiencing really any negative

experiencing really any negative

experiencing really any negative consequences over time though Barbara

consequences over time though Barbara

consequences over time though Barbara began to experience the negative health

began to experience the negative health

began to experience the negative health effects associated with taking the

effects associated with taking the

effects associated with taking the substance for a long period of time

substance for a long period of time

substance for a long period of time she had intense cravings she began to

she had intense cravings she began to

she had intense cravings she began to struggle with depression and even though

struggle with depression and even though

struggle with depression and even though she had tried to reduce her intake

she had tried to reduce her intake

she had tried to reduce her intake several times she had been unsuccessful

several times she had been unsuccessful

several times she had been unsuccessful each time now I’m sure you all have an

each time now I’m sure you all have an

each time now I’m sure you all have an idea of what it is that Barbara is

idea of what it is that Barbara is

idea of what it is that Barbara is struggling with and if you had guessed

struggling with and if you had guessed

struggling with and if you had guessed addiction then you would be correct

addiction then you would be correct

addiction then you would be correct Barbara’s not alone in this one in five

Barbara’s not alone in this one in five

Barbara’s not alone in this one in five Canadians will meet the criteria for

Canadians will meet the criteria for

Canadians will meet the criteria for substance use disorder at some point in

substance use disorder at some point in

substance use disorder at some point in their lifetime I want you to think about

their lifetime I want you to think about

their lifetime I want you to think about this I want you to look to the two

this I want you to look to the two

this I want you to look to the two people on your right-hand side and then

people on your right-hand side and then

people on your right-hand side and then the two people on your left-hand side

the two people on your left-hand side

the two people on your left-hand side statistically speaking this means that

statistically speaking this means that

statistically speaking this means that one of you will meet the criteria for

one of you will meet the criteria for

one of you will meet the criteria for substance use disorder at some point in

substance use disorder at some point in

substance use disorder at some point in your lifetime four in ten Canadians will

your lifetime four in ten Canadians will

your lifetime four in ten Canadians will meet their criteria for addiction to

meet their criteria for addiction to

meet their criteria for addiction to tobacco products – and ten Canadians

tobacco products – and ten Canadians

tobacco products – and ten Canadians will meet the criteria for addiction to

will meet the criteria for addiction to

will meet the criteria for addiction to alcohol and six and one-hundred about

alcohol and six and one-hundred about

alcohol and six and one-hundred about six percent of the population will meet

six percent of the population will meet

six percent of the population will meet the criteria for addiction to cannabis

the criteria for addiction to cannabis

the criteria for addiction to cannabis and other illicit substances the social

and other illicit substances the social

and other illicit substances the social cost of this according to a 2006 study

cost of this according to a 2006 study

cost of this according to a 2006 study was approximately thirty nine point

was approximately thirty nine point

was approximately thirty nine point eight billion

eight billion

eight billion each year this means that it costs just

each year this means that it costs just

each year this means that it costs just over $1,200

over $1,200

over $1,200 to every man woman in child in Canada

to every man woman in child in Canada

to every man woman in child in Canada and this includes both direct costs like

and this includes both direct costs like

and this includes both direct costs like the cost of health care and law

the cost of health care and law

the cost of health care and law enforcement and indirect costs like lost

enforcement and indirect costs like lost

enforcement and indirect costs like lost productivity at work now Barbara’s

productivity at work now Barbara’s

productivity at work now Barbara’s specific addiction will cost Canadians

specific addiction will cost Canadians

specific addiction will cost Canadians approximately four point five billion

approximately four point five billion

approximately four point five billion dollars each year now some of you may

dollars each year now some of you may

dollars each year now some of you may have an idea of what the substance

have an idea of what the substance

have an idea of what the substance barbara is addicted to is some of you

barbara is addicted to is some of you

barbara is addicted to is some of you might be guessing tobacco some of you

might be guessing tobacco some of you

might be guessing tobacco some of you might be thinking alcohol some of you

might be thinking alcohol some of you

might be thinking alcohol some of you might be thinking something a little

might be thinking something a little

might be thinking something a little harder like cocaine or heroin in

harder like cocaine or heroin in

harder like cocaine or heroin in actuality Barbara isn’t addicted to any

actuality Barbara isn’t addicted to any

actuality Barbara isn’t addicted to any of these substances Barbara is addicted

of these substances Barbara is addicted

of these substances Barbara is addicted to food now some of you might be

to food now some of you might be

to food now some of you might be surprised by that statement and some of

surprised by that statement and some of

surprised by that statement and some of you might not disagree or what may

you might not disagree or what may

you might not disagree or what may disagree with that statement and in fact

disagree with that statement and in fact

disagree with that statement and in fact the controversy surrounding food

the controversy surrounding food

the controversy surrounding food addiction has been waging for the better

addiction has been waging for the better

addiction has been waging for the better part of the past ten years on two fronts

part of the past ten years on two fronts

part of the past ten years on two fronts the first is what I like to call the

the first is what I like to call the

the first is what I like to call the social media war on one side you have

social media war on one side you have

social media war on one side you have individuals that claim to suffer from

individuals that claim to suffer from

individuals that claim to suffer from food addiction and provide anecdotal

food addiction and provide anecdotal

food addiction and provide anecdotal evidence of their own experiences and

evidence of their own experiences and

evidence of their own experiences and the experiences of the people that they

the experiences of the people that they

the experiences of the people that they know and on the other side is you have

know and on the other side is you have

know and on the other side is you have individuals that claim that the words

individuals that claim that the words

individuals that claim that the words food addiction are simply a cover an

food addiction are simply a cover an

food addiction are simply a cover an excuse for developing obesity or for

excuse for developing obesity or for

excuse for developing obesity or for having low self-control the other front

having low self-control the other front

having low self-control the other front on which this controversy is waged is in

on which this controversy is waged is in

on which this controversy is waged is in the scientific 110 years ago health

the scientific 110 years ago health

the scientific 110 years ago health scientists started saying look we’ve got

scientists started saying look we’ve got

scientists started saying look we’ve got people coming to us and they are showing

people coming to us and they are showing

people coming to us and they are showing hallmark features of addiction they are

hallmark features of addiction they are

hallmark features of addiction they are showing tolerance they’re showing

showing tolerance they’re showing

showing tolerance they’re showing withdrawal they’re showing impulse

withdrawal they’re showing impulse

withdrawal they’re showing impulse control issues and on the other side you

control issues and on the other side you

control issues and on the other side you had individuals that studied the sort of

had individuals that studied the sort of

had individuals that studied the sort of classic drugs of abuse like cocaine and

classic drugs of abuse like cocaine and

classic drugs of abuse like cocaine and like heroin who said that food could not

like heroin who said that food could not

like heroin who said that food could not be classified in the same way as those

be classified in the same way as those

be classified in the same way as those drugs and that the neurobiological

drugs and that the neurobiological

drugs and that the neurobiological things that

things that

things that often when someone becomes addicted

often when someone becomes addicted

often when someone becomes addicted aren’t present in individuals that claim

aren’t present in individuals that claim

aren’t present in individuals that claim to suffer from food addiction now this

to suffer from food addiction now this

to suffer from food addiction now this is where I came in this is when I began

is where I came in this is when I began

is where I came in this is when I began to be interested in research and I had

to be interested in research and I had

to be interested in research and I had been exposed to this controversy in

been exposed to this controversy in

been exposed to this controversy in social media and I’ve been exposed to it

social media and I’ve been exposed to it

social media and I’ve been exposed to it in the scientific field and I was really

in the scientific field and I was really

in the scientific field and I was really interested so when I started my research

interested so when I started my research

interested so when I started my research I started with a very simple question

I started with a very simple question

I started with a very simple question and that question was can their

and that question was can their

and that question was can their rewarding properties of food produce

rewarding properties of food produce

rewarding properties of food produce addiction now one of the hallmark

addiction now one of the hallmark

addiction now one of the hallmark features of addiction is compulsion and

features of addiction is compulsion and

features of addiction is compulsion and if you look at the definition of

if you look at the definition of

if you look at the definition of compulsion in the dictionary it is the

compulsion in the dictionary it is the

compulsion in the dictionary it is the irresistible urge to behave in a way

irresistible urge to behave in a way

irresistible urge to behave in a way that runs contrary to your Express

that runs contrary to your Express

that runs contrary to your Express conscious wishes in addiction we see

conscious wishes in addiction we see

conscious wishes in addiction we see this present as individuals that are

this present as individuals that are

this present as individuals that are unable to stop themselves from consuming

unable to stop themselves from consuming

unable to stop themselves from consuming a substance even if they no longer wish

a substance even if they no longer wish

a substance even if they no longer wish to and even if they no longer derive any

to and even if they no longer derive any

to and even if they no longer derive any enjoyment from doing so so I went back

enjoyment from doing so so I went back

enjoyment from doing so so I went back to my original question can the

to my original question can the

to my original question can the rewarding properties of food produce

rewarding properties of food produce

rewarding properties of food produce addiction and I modified it to can the

addiction and I modified it to can the

addiction and I modified it to can the rewarding properties of food produce

rewarding properties of food produce

rewarding properties of food produce compulsion this hallmark feature of

compulsion this hallmark feature of

compulsion this hallmark feature of addiction now to do this I used an

addiction now to do this I used an

addiction now to do this I used an already established model and I exposed

already established model and I exposed

already established model and I exposed animals rot specifically to a substance

animals rot specifically to a substance

animals rot specifically to a substance that is commonly found in food and also

that is commonly found in food and also

that is commonly found in food and also happens to be highly rewarding and that

happens to be highly rewarding and that

happens to be highly rewarding and that substance is refined white sugar and I

substance is refined white sugar and I

substance is refined white sugar and I expose these animals to a concentration

expose these animals to a concentration

expose these animals to a concentration that is commonly found in sweetened

that is commonly found in sweetened

that is commonly found in sweetened beverages so I used a 10% concentration

beverages so I used a 10% concentration

beverages so I used a 10% concentration and for comparison the average can of

and for comparison the average can of

and for comparison the average can of Pop has about 11% and I expose these

Pop has about 11% and I expose these

Pop has about 11% and I expose these animals to this concentration of sugar

animals to this concentration of sugar

animals to this concentration of sugar for 12 hours a day every day for about a

for 12 hours a day every day for about a

for 12 hours a day every day for about a month and some very interesting things

month and some very interesting things

month and some very interesting things happened the first is that they began to

happened the first is that they began to

happened the first is that they began to binge they were consuming about 5% of

binge they were consuming about 5% of

binge they were consuming about 5% of their body weight in the first hour

their body weight in the first hour

their body weight in the first hour every time they had access to the sugar

every time they had access to the sugar

every time they had access to the sugar now for comparison you can think of some

now for comparison you can think of some

now for comparison you can think of some in my size and my body weight drinking

in my size and my body weight drinking

in my size and my body weight drinking about three liters of pop or eating

about three liters of pop or eating

about three liters of pop or eating one-third of a kilo of sugar in one hour

one-third of a kilo of sugar in one hour

one-third of a kilo of sugar in one hour they also heavily escalated their intake

they also heavily escalated their intake

they also heavily escalated their intake over time by the end in a 12 hour period

over time by the end in a 12 hour period

over time by the end in a 12 hour period they were consuming roughly 1/5 of their

they were consuming roughly 1/5 of their

they were consuming roughly 1/5 of their body weight which again for comparison

body weight which again for comparison

body weight which again for comparison is someone like me consuming 13 liters

is someone like me consuming 13 liters

is someone like me consuming 13 liters of pop or 1.3 kilos of refined white

of pop or 1.3 kilos of refined white

of pop or 1.3 kilos of refined white sugar imagine drinking this or eating

sugar imagine drinking this or eating

sugar imagine drinking this or eating this every day so this was really

this every day so this was really

this every day so this was really shocking to me but what I was interested

shocking to me but what I was interested

shocking to me but what I was interested in was whether exposure to this amount

in was whether exposure to this amount

in was whether exposure to this amount of sugar could produce compulsion now

of sugar could produce compulsion now

of sugar could produce compulsion now unfortunately you can’t ask an animal

unfortunately you can’t ask an animal

unfortunately you can’t ask an animal are you addicted to something you can’t

are you addicted to something you can’t

are you addicted to something you can’t ask an animal are you compulsive so I

ask an animal are you compulsive so I

ask an animal are you compulsive so I had to put them in an evolutionarily

had to put them in an evolutionarily

had to put them in an evolutionarily relevant situation one that pit their

relevant situation one that pit their

relevant situation one that pit their instinctual mechanism for avoiding

instinctual mechanism for avoiding

instinctual mechanism for avoiding danger versus this learned behavior to

danger versus this learned behavior to

danger versus this learned behavior to seek out and consume sugar and when I

seek out and consume sugar and when I

seek out and consume sugar and when I did that the animals that have been

did that the animals that have been

did that the animals that have been consuming massive amounts of sugar

consuming massive amounts of sugar

consuming massive amounts of sugar completely ignored they completely

completely ignored they completely

completely ignored they completely overrode this instinctual mechanism in

overrode this instinctual mechanism in

overrode this instinctual mechanism in favor of seeking out sugar and this is

favor of seeking out sugar and this is

favor of seeking out sugar and this is something that normal healthy animals

something that normal healthy animals

something that normal healthy animals will not do but what was happening

will not do but what was happening

will not do but what was happening neurobiologically what was happening in

neurobiologically what was happening in

neurobiologically what was happening in their brains well there are some very

their brains well there are some very

their brains well there are some very specific changes that happen to a brain

specific changes that happen to a brain

specific changes that happen to a brain when it becomes addicted to a substance

when it becomes addicted to a substance

when it becomes addicted to a substance and the changes that happen are

and the changes that happen are

and the changes that happen are different depending on the type of brain

different depending on the type of brain

different depending on the type of brain area that you’re looking at the specific

area that you’re looking at the specific

area that you’re looking at the specific area that I was interested is implicated

area that I was interested is implicated

area that I was interested is implicated in survival-based motivated behaviors

in survival-based motivated behaviors

in survival-based motivated behaviors and it happens to sit between two other

and it happens to sit between two other

and it happens to sit between two other brain areas that have already been

brain areas that have already been

brain areas that have already been heavily implicated in the development of

heavily implicated in the development of

heavily implicated in the development of addiction

addiction

addiction the first is the amygdala which

the first is the amygdala which

the first is the amygdala which processes emotional and rewarding

processes emotional and rewarding

processes emotional and rewarding information and the other is the

information and the other is the

information and the other is the striatum which is responsible for

striatum which is responsible for

striatum which is responsible for reinforcement based learning and motor

reinforcement based learning and motor

reinforcement based learning and motor control now this area had actually

control now this area had actually

control now this area had actually already been looked at by a colleague of

already been looked at by a colleague of

already been looked at by a colleague of mine and he was looking at it in animals

mine and he was looking at it in animals

mine and he was looking at it in animals that self administered cocaine classic

that self administered cocaine classic

that self administered cocaine classic drug of abuse over a long period of time

drug of abuse over a long period of time

drug of abuse over a long period of time and he was able to show that there’s a

and he was able to show that there’s a

and he was able to show that there’s a very unique change that happens to the

very unique change that happens to the

very unique change that happens to the neurons in this brain area they respond

neurons in this brain area they respond

neurons in this brain area they respond very differently to dopamine which is

very differently to dopamine which is

very differently to dopamine which is the brains primary rewarding

the brains primary rewarding

the brains primary rewarding neurotransmitter then the neurons do in

neurotransmitter then the neurons do in

neurotransmitter then the neurons do in the brains of animals that had either

the brains of animals that had either

the brains of animals that had either had no exposure to cocaine or had been

had no exposure to cocaine or had been

had no exposure to cocaine or had been exposed to cocaine but weren’t self

exposed to cocaine but weren’t self

exposed to cocaine but weren’t self administering it for a long period of

administering it for a long period of

administering it for a long period of time now when I looked at this brain

time now when I looked at this brain

time now when I looked at this brain area in my animals to my astonishment I

area in my animals to my astonishment I

area in my animals to my astonishment I found exactly the same change in their

found exactly the same change in their

found exactly the same change in their brains as what was happening in animals

brains as what was happening in animals

brains as what was happening in animals that were self administering cocaine so

that were self administering cocaine so

that were self administering cocaine so what’s happening what does this mean

what’s happening what does this mean

what’s happening what does this mean well our brains are highly evolved

well our brains are highly evolved

well our brains are highly evolved adapted organs and our brains have

adapted organs and our brains have

adapted organs and our brains have evolved to seek out rewarding substances

evolved to seek out rewarding substances

evolved to seek out rewarding substances and perform rewarding behaviors because

and perform rewarding behaviors because

and perform rewarding behaviors because in our evolutionary history that meant

in our evolutionary history that meant

in our evolutionary history that meant survival things like having sex eating

survival things like having sex eating

survival things like having sex eating good food avoiding danger

good food avoiding danger

good food avoiding danger unfortunately this highly adapted system

unfortunately this highly adapted system

unfortunately this highly adapted system when it’s exposed to unnaturally

when it’s exposed to unnaturally

when it’s exposed to unnaturally reinforcing substances like drugs

reinforcing substances like drugs

reinforcing substances like drugs this formerly adaptive process becomes

this formerly adaptive process becomes

this formerly adaptive process becomes maladaptive there’s this war going on

maladaptive there’s this war going on

maladaptive there’s this war going on between our evolved biology that pushes

between our evolved biology that pushes

between our evolved biology that pushes us to consume rewarding substances and

us to consume rewarding substances and

us to consume rewarding substances and pushes us to perform rewarding behaviors

pushes us to perform rewarding behaviors

pushes us to perform rewarding behaviors versus our modern environment a society

versus our modern environment a society

versus our modern environment a society in which unnaturally reinforcing

in which unnaturally reinforcing

in which unnaturally reinforcing substances are plentifully available

substances are plentifully available

substances are plentifully available this is why we are starting to see

this is why we are starting to see

this is why we are starting to see addictions to things that are

addictions to things that are

addictions to things that are fundamentally new

fundamentally new

fundamentally new you to our modern society addictions to

you to our modern society addictions to

you to our modern society addictions to things like gambling to videogames and

things like gambling to videogames and

things like gambling to videogames and to food now there’s still quite a bit of

to food now there’s still quite a bit of

to food now there’s still quite a bit of controversy in the scientific literature

controversy in the scientific literature

controversy in the scientific literature about what exactly the properties of

about what exactly the properties of

about what exactly the properties of food are that can produce addiction but

food are that can produce addiction but

food are that can produce addiction but I think in general as a society we need

I think in general as a society we need

I think in general as a society we need to start thinking about addiction beyond

to start thinking about addiction beyond

to start thinking about addiction beyond drugs we need to stop having such a

drugs we need to stop having such a

drugs we need to stop having such a rigid idea of what the substances are

rigid idea of what the substances are

rigid idea of what the substances are that can produce addiction we need to

that can produce addiction we need to

that can produce addiction we need to stop thinking about it as drugs versus

stop thinking about it as drugs versus

stop thinking about it as drugs versus other because really any highly

other because really any highly

other because really any highly rewarding substance or behavior can

rewarding substance or behavior can

rewarding substance or behavior can produce the same behavioral and

produce the same behavioral and

produce the same behavioral and neurological things that we see in

neurological things that we see in

neurological things that we see in addiction we need to start thinking of

addiction we need to start thinking of

addiction we need to start thinking of addiction as a very old brains way of

addiction as a very old brains way of

addiction as a very old brains way of trying to deal with a very new problem

trying to deal with a very new problem

trying to deal with a very new problem so I want you to do something for me

so I want you to do something for me

so I want you to do something for me when you leave here today I want you to

when you leave here today I want you to

when you leave here today I want you to just be aware and when you see hotly

just be aware and when you see hotly

just be aware and when you see hotly debated topics like this one in social

debated topics like this one in social

debated topics like this one in social media and other spheres I want you to

media and other spheres I want you to

media and other spheres I want you to think and I want you to question and I

think and I want you to question and I

think and I want you to question and I want you to investigate because as I

want you to investigate because as I

want you to investigate because as I found out addiction doesn’t necessarily

found out addiction doesn’t necessarily

found out addiction doesn’t necessarily look like what it used to anymore

look like what it used to anymore

look like what it used to anymore thank you

thank you

thank you you

you

you [Applause]

”

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